2 Iodo 5 Bromopyrimidine

2-Iodine-5-bromopyrimidine is one of the organic compounds. Its chemical properties are of great interest and are described in detail by you.
First of all, its reactivity, the bromine and iodine atoms in this compound are both halogen atoms, which are quite active. Halogen atoms are electron-absorbing, causing the electron cloud density of the pyrimidine ring to decrease, resulting in uneven distribution of electron clouds on the ring. This property makes 2-iodine-5-bromopyrimidine easily react with nucleophiles. Nucleophiles, which are electron-rich substances, can attack the lower electron cloud density on the pyrimidine ring, and the halogen atoms are then replaced by nucleophiles.
For example, if you react with a hydroxyl-containing nucleophile, such as an alcohol, under suitable conditions, a halogen atom or an alkoxy group can be substituted to obtain an ether derivative. If you react with an amino-containing nucleophile, such as ammonia or amine, the halogen atom can be substituted with an amino group to obtain a nitrogen-containing derivative. These reactions are often used in the field of organic synthesis to prepare a variety of pyrimidine compounds, which have important uses in pharmaceutical chemistry, materials science, and other fields.
Furthermore, the halogen atom of 2-iodine-5-bromopyrimidine also plays a key role in metal-catalyzed reactions. In palladium-catalyzed coupling reactions, such as Suzuki coupling reaction, Stille coupling reaction, etc., halogen atoms can be coupled with organoboron reagents, organotin reagents, etc. under the action of palladium catalyst to form carbon-carbon bonds. With this reaction, complex organic molecular structures can be constructed, which is effective in synthesizing organic materials and bioactive molecules with specific functions.
In addition, the pyrimidine ring of the compound has a certain alkalinity. The nitrogen atom on the pyrimidine ring can accept protons and is basic. This alkalinity makes it under specific acid-base conditions, or participate in acid-base related reactions, or form salts with acidic substances. The alkalinity of 2-iodine-5-bromopyrimidine is related to the substituents on the ring. The electron-absorbing property of the halogen atom in 2-iodine-5-bromopyrimidine will affect the basicity of the pyrimidine ring, causing its basicity to change compared with the pyrimidine itself.
2-iodine-5-bromopyrimidine has various chemical properties due to its halogen atom and pyrimidine ring properties. It is an important intermediate in many fields such as organic synthesis and drug research and development, and can provide rich possibilities for the creation of new compounds.

2-Iodine-5-bromopyrimidine is also an important intermediate in organic synthesis. Its common synthesis methods follow the following methods.
First, pyrimidine is used as the starting material and halogenated to prepare it. First, pyrimidine is reacted with brominating reagents, such as bromine ($Br_2 $), under suitable reaction conditions, such as in the presence of appropriate solvents (such as carbon tetrachloride, etc.) and catalysts (such as iron powder, etc.), and an electrophilic substitution reaction is performed to introduce bromine atoms at the 5-position of the pyrimidine ring to obtain 5-bromopyrimidine. Then, 5-bromopyrimidine and iodizing reagents, such as potassium iodide ($KI $) and appropriate oxidants (such as hydrogen peroxide, etc.), in a specific reaction system, a halogen atom exchange reaction occurs, and iodine atoms are introduced at the 2-position, resulting in 2-iodine-5-bromopyrimidine. In this approach, the control of halogenation conditions is critical, and factors such as temperature, reagent dosage, and reaction time all have a significant impact on the yield and purity of the product.
Second, pyrimidine derivatives containing specific substituents can also be used as raw materials. For example, if the starting compound is a compound with groups that can be converted into bromine and iodine on the pyrimidine ring, the corresponding groups can be selectively converted into bromine and iodine through appropriate chemical reactions. For example, some pyrimidine derivatives with functional groups (such as hydroxyl groups, etc.) that can be replaced by halogenated atoms, first use a halogenated reagent to replace the hydroxyl group with a bromine atom, and then introduce an iodine atom with a suitable iodizing reagent through another reaction step. This synthesis method requires fine design of the reaction steps to ensure the selectivity and efficiency of each step of the reaction.
Furthermore, organometallic reagents are also commonly used in the synthesis of such compounds. React with organometallic reagents (such as lithium reagents, magnesium reagents, etc.) containing pyrimidine rings with halogenated reagents. The metal reagent containing pyrimidine ring is prepared first, then reacted with brominating reagent and iodizing reagent in sequence, and selectively introduced iodine and bromine atoms at the 2-position and 5-position of pyrimidine ring. In this process, the precise regulation of the activity of organometallic reagents and reaction conditions is crucial to the success of the synthesis.
Although there are many ways to synthesize 2-iodine-5-bromopyrimidine, it is necessary to carefully consider the reaction conditions, reagent selection and reaction step design in order to achieve the purpose of high yield and high purity synthesis.

2-Iodine-5-bromopyrimidine, which is used in many fields such as medicinal chemistry, materials science, and organic synthesis.
In the field of medicinal chemistry, it is often used as a key intermediate. Because pyrimidine rings are common in many bioactive molecules, 2-iodine-5-bromopyrimidine can be modified to introduce specific functional groups to construct bioactive compounds. For example, when developing new antibacterial and antiviral drugs, this is used as a starting material to build complex structures through organic synthesis to obtain drug molecules with inhibitory activity against specific pathogens. The structure of iodine and bromine atoms is highly active, which is conducive to reactions such as nucleophilic substitution, creating conditions for the introduction of various pharmacoactive groups.
In the field of materials science, 2-iodine-5-bromopyrimidine also plays a role. Organic optoelectronic materials are developing rapidly, and this compound can participate in the preparation of materials with specific optoelectronic properties. By integrating it into a polymer or small molecule system through a chemical reaction, the electronic structure and energy level of the material can be changed, and the light absorption, emission and charge transport properties can be regulated. For example, when preparing organic Light Emitting Diode (OLED) materials, the introduction of this structure can optimize the luminous efficiency and stability of the material, and improve the performance of OLED devices.
In the field of organic synthesis, 2-iodine-5-bromopyrimidine is an important synthetic block. Because it contains two different halogen atoms, the reactivity is different, and Iodine atoms are more easily substituted under certain conditions, while bromine atoms can react under other conditions to achieve step-by-step and selective construction of complex organic molecular structures. Organic synthesis chemists can use this to precisely design synthetic routes to synthesize organic compounds with special structures and functions to meet the needs of specific organic molecules in different fields.

Today, there is 2-iodo-5-bromopyrimidine, which is priced in the market. However, the market situation is complicated, and the price is difficult to determine.
First, consider the difficulty of its preparation. The synthesis path of this compound is related to the acquisition of raw materials and the conditions for the reaction. If the raw materials are rare, or the reaction requires severe temperature and pressure, or the yield of the multi-step reaction is not high, the cost will rise, and the price will follow.
Second, it depends on the supply and demand of the market. If various industries such as pharmaceutical research and development, material science, etc., have a strong demand for this product, but the supply is limited, and the price will rise. On the contrary, if the supply exceeds the demand, the price will decline.
Third, consider the grade of purity. For high purity, due to the complex purification process, it consumes manpower and material resources, and the price should be higher than that of ordinary purity.
Fourth, observe the differences in regions. In different places, due to factors such as logistics, taxation, and industrial agglomeration, the price may be different. In prosperous cities, due to complete supporting facilities and concentrated demand, the price may be different from remote places.
To sum up, if you want to determine the market price of 2-iodo-5-bromopyrimidine, you must gather extensive information and carefully review the preparation, supply and demand, purity, and region to obtain a more accurate price.

2-Iodine-5-bromopyrimidine is an organic compound. Its physical properties are as follows:
Looking at its appearance, under room temperature and pressure, 2-iodine-5-bromopyrimidine is a white to light yellow crystalline powder, which is easy to observe and operate. Its color and morphology can be one of the important basis for identifying this substance.
When it comes to the melting point, it is about 119-121 ° C. The melting point is the temperature at which a substance changes from a solid state to a liquid state. This property is of great significance in the identification of the purity of the substance and the separation and purification. From this, the purity of 2-iodine-5-bromopyrimidine can be determined. If its melting point is consistent with the established value, the purity is higher; if the melting point deviates, it may contain impurities.
As for solubility, 2-iodine-5-bromopyrimidine is slightly soluble in water, because water is a polar solvent, and the structure of this compound makes it less polar, so it is difficult to dissolve in water. However, it is soluble in some organic solvents, such as dichloromethane, N, N-dimethylformamide (DMF), etc. The polarity and molecular structure of organic solvents are compatible with 2-iodine-5-bromopyrimidine, so it can be dissolved. This solubility is crucial in organic synthesis reactions, providing a basis for the selection of reaction media and assisting the smooth progress of the reaction.