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What is the main use of 2 '-iodo-5' -fluoroacetophenone?
2%27+-iodo-5%27+-fluoroacetophenone is 2 '-iodine-5' -fluoroacetophenone, which has a wide range of uses.
In the field of pharmaceutical synthesis, it has a significant position. It can be used as a key intermediate to prepare many drugs with specific biological activities. Due to the unique properties of iodine and fluorine atoms, it can endow the synthesized drugs with different pharmacological properties. For example, in the development and synthesis path of some anti-tumor drugs, 2 '-iodine-5' -fluoroacetophenone can be introduced through a series of reactions to introduce a specific chemical structure. Fluorine atoms enhance the binding force between the drug and the target, and iodine atoms may affect the pharmacokinetic properties, thereby improving the efficacy of the drug.
In the field of materials science, it is also useful. Due to the presence of fluorine and iodine atoms, it can participate in the synthesis of functional materials with special properties. For example, in the creation of organic optoelectronic materials, it is introduced as a structural unit. The electronegativity of fluorine atoms and the polarizability of iodine atoms may optimize the electronic transmission and optical properties of materials, contributing to the development of new optoelectronic materials.
In the field of organic synthetic chemistry, 2 '-iodine-5' -fluoroacetophenone is an important synthetic building block. With the characteristics of iodine atoms prone to nucleophilic substitution reactions and acetophenone structures that can carry out various carbonyl-related reactions, chemists can use this as a starting material to construct complex and diverse organic compounds through ingenious design of reaction routes, which greatly enriches the variety of organic compounds and promotes the development of organic synthetic chemistry.
What are the physical properties of 2 '-iodo-5' -fluoroacetophenone
2%27+-iodo-5%27+-fluoroacetophenone is 2 '-iodine-5' -fluoroacetophenone, which has unique physical properties. It is a colorless to light yellow liquid, which exists stably at room temperature and pressure. In terms of purity, it is clear and translucent, but it may be slightly darker for a long time or under certain conditions.
Smell, it has a special aromatic smell, not pungent and unpleasant smell, but it is also different from common floral and fruity scents, and is a unique smell of organic compounds.
Its density is greater than that of water, about [X] g/cm ³, so if mixed with water, it will sink underwater, and the two are clearly defined. The melting point is about [X] ° C. Under this temperature, it is in a solid state, like crystalline, textured or brittle. When heated above the melting point, it melts into a flowing liquid. The boiling point of
is about [X] ° C. At this temperature, the liquid vaporizes rapidly and converts to a gaseous state. This compound is slightly soluble in water, and has good solubility in organic solvents such as ethanol and ether. It can be miscible with these organic solvents in any ratio to form a uniform solution.
Its vapor pressure is low at room temperature, and its volatilization rate is relatively slow. The refractive index also has a specific value, about [X]. When light passes through the substance, it will be refracted. This property may have applications in the field of optics and analysis. Overall, the physical properties of 2 '-iodine-5' -fluoroacetophenone are of great significance for its extraction, separation and application in many fields such as organic synthesis and drug development.
What are the synthesis methods of 2 '-iodo-5' -fluoroacetophenone?
To prepare 2 '-iodine-5' -fluoroacetophenone, there are two common methods. First, 5 '-fluoroacetophenone is used as the starting material, and it is reacted with iodine with the help of appropriate oxidizing agents and catalysts. This oxidizing agent is often nitric acid or hydrogen peroxide, and the catalyst is mostly sulfuric acid or acetic acid. At a suitable temperature and reaction time, a specific position on the benzene ring of 5' -fluoroacetophenone is substituted with iodine to obtain 2 '-iodine-5' -fluoroacetophenone. Second, 5 '-fluorobenzoyl chloride is taken first, and it is reacted with iodomethane by Fu-gram acylation. In this process, anhydrous aluminum trichloride or anhydrous zinc chloride are used as catalysts in organic solvents such as dichloromethane or nitrobenzene. Under a certain temperature and time control, the two react to produce 2 '-iodine-5' -fluoroacetophenone after acylation. These two methods have their own advantages and disadvantages. The first method is easy to obtain raw materials, and the operation is relatively simple. However, the reaction selectivity or fine regulation is required. The second method step is slightly complicated, but the reaction check point selectivity or more advantages. The actual preparation needs to be carefully selected according to factors such as raw material availability, cost and product purity requirements.
What are the precautions for 2 '-iodo-5' -fluoroacetophenone during storage and transportation?
2%27+-iodo-5%27+-fluoroacetophenone, it is an organic compound. During storage and transportation, there are many things to pay attention to, which cannot be ignored.
First word storage, this compound should be placed in a cool, dry and well-ventilated place. Its properties may be affected by changes in temperature and humidity. If it is in a high temperature and humid environment, it may deteriorate. A suitable environment is required in a Jewish place to be healthy. Therefore, the temperature of the warehouse should be controlled within a certain range, and the humidity should also be paid attention to to to ensure the stability of its chemical properties.
Furthermore, when storing, it needs to be stored separately from oxidants, acids, bases and other substances. This is because of its chemical activity. If it comes into contact with these substances, or causes a violent chemical reaction, such as dry firewood in case of fire, the disaster will be immediate. Therefore, when planning storage, it is necessary to carefully separate to prevent accidents.
As for transportation, there are also many points. Before transportation, ensure that the packaging is complete. The packer, like a person's armor, can protect it from damage. If the packaging is damaged, compounds or leaks will endanger the safety of transportation and pollute the environment. During transportation, the speed should be stable, and violent actions such as sudden braking and sharp turning should be avoided to avoid damage to the packaging due to vibration.
At the same time, the transportation vehicle should also be clean and free of other residual chemicals to prevent cross-contamination. And transport personnel should be familiar with the characteristics of this compound and emergency treatment methods, in case of emergencies, they can be in danger and properly disposed of.
All these are the precautions for 2%27+-iodo-5%27+-fluoroacetophenone storage and transportation, related to safety and quality, and cannot be slack.
What is the approximate market price of 2 '-iodo-5' -fluoroacetophenone?
2%27+-iodo-5%27+-fluoroacetophenone is 2 '-iodine-5' -fluoroacetophenone, which is an important intermediate in the field of organic synthesis. As for its market price, it is difficult to say exactly, because it is affected by many factors.
First, the market supply and demand of the following pairs have a great impact on the price. If the market has strong demand for 2 '-iodine-5' -fluoroacetophenone and the supply is relatively short, the price will rise; conversely, if the supply exceeds the demand, the price may drop. For example, if the pharmaceutical industry has a surge in the development and production of drugs containing this ingredient, the demand will increase sharply, and the price may rise.
Second, the production cost is also a key factor. The cost of raw materials, the complexity of the production process and energy consumption will all affect the final price. The synthesis of this compound may require specific raw materials such as iodide and fluoride. If the price of raw materials fluctuates, the price of the product will also change. And complex production processes require higher technology and equipment investment, which increases costs and affects prices.
Third, the product quality and purity grades are different, and the price difference is obvious. High-purity 2 '-iodine-5' -fluoroacetophenone is often used in fields with strict purity requirements such as medicine and electronics, and its price will be much higher than that of ordinary industrial-grade products.
Fourth, the market competition situation should not be underestimated. When many production enterprises compete fiercely, in order to seize market share, they may attract customers with price advantages, resulting in lower prices; conversely, if the market monopoly is strong, the price may be higher.
Overall, the market price of 2 '-iodine-5' -acetophenone may range from tens to thousands of yuan per kilogram. The specific price needs to be investigated in detail in light of the current market conditions.