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What are the physical properties of 2-iodo-5- (trifluoromethyl) benzylbromide?
2-Iodine-5- (trifluoromethyl) benzyl bromide is one of the organic compounds. According to its physical properties, under normal temperature and pressure, this substance is mostly in the shape of a solid state, and its color may be white to off-white, and it has a certain crystallinity.
In terms of its melting point, after many experiments, it is within a specific temperature range, but this value will also vary slightly due to subtle differences in experimental conditions. This compound exhibits a certain solubility in organic solvents. For example, in common polar organic solvents such as dichloromethane and chloroform, it can be better dissolved. Due to the molecular structure of the compound, it contains groups such as iodine, trifluoromethyl, and benzyl bromide, so that the molecule has the appropriate polarity, and the polar organic solvent can form an intermolecular force, and then dissolve.
As for its boiling point, there is also a corresponding value. However, if you want to measure its boiling point, you need to be careful, because during the heating process or due to the halogen atoms in the structure, side reactions such as decomposition occur. And the vapor pressure of this substance is low, and the volatilization at room temperature is not very significant.
In addition, the density of 2-iodine-5- (trifluoromethyl) benzyl bromide is also one of its important physical properties. Compared with water, its density is higher, and if placed in water, it will sink to the bottom. Its appearance is often powdery or fine crystalline solid, which is easy to store and use. However, because of its halogen atoms, especially iodine and bromine, the chemical properties are more active, and it is necessary to avoid contact with reactive substances when storing to prevent deterioration.
What are the chemical synthesis methods of 2-iodo-5- (trifluoromethyl) benzylbromide
To prepare 2-iodo-5- (trifluoromethyl) benzylbromide, the following synthesis methods can be selected.
First, 2-methyl-5- (trifluoromethyl) aniline is used as the starting material. First, it is reacted with sodium nitrite and hydroiodic acid at low temperature to obtain diazonium salt, which is then replaced by iodine atom to obtain 2-iodo-5- (trifluoromethyl) toluene. Then, 2-iodo-5- (trifluoromethyl) toluene is combined with N-bromosuccinimide (NBS) and an initiator such as benzoyl peroxide in an inert solvent such as carbon tetrachloride, and the radical reaction is initiated by heating or lighting. The hydrogen atom on the methyl group is replaced by the bromine atom, and the final product is 2-iodo-5- (trifluoromethyl) benzylbromide.
Second, 2 - (trifluoromethyl) benzoic acid is used as the starting material. First, it is reduced to 2 - (trifluoromethyl) benzoyl alcohol, which is a commonly used reducing agent such as lithium aluminum hydride. Next, 2 - (trifluoromethyl) benzyl alcohol is reacted with hydrobromic acid, and the hydroxyl group is replaced by a bromine atom to obtain 2 - (trifluoromethyl) benzyl bromide. Then iodine substitution reagents such as iodine and oxidants such as concentrated sulfuric acid or hydrogen peroxide are combined to iodize the specific position on the benzene ring, and the target product 2 - iodo - 5 - (trifluoromethyl) benzylbromide can be obtained under suitable conditions.
Third, 2 - (trifluoromethyl) benzaldehyde is used as the starting material. First, it is reacted with Grignard reagent, and the corresponding alcohol is obtained after hydrolysis. Then the alcohol is converted into a halogen by the above method. Subsequently, the benzene ring was iodized to obtain 2-iodo-5- (trifluoromethyl) benzylbromide under suitable iodization conditions.
The above methods have their own advantages and disadvantages. The appropriate synthesis path should be carefully selected according to the actual availability of raw materials, the ease of control of reaction conditions, the purity and yield of the product and many other factors.
What is the main use of 2-iodo-5- (trifluoromethyl) benzylbromide?
2-Iodo-5- (trifluoromethyl) benzylbromide is an organic compound. Its main use is more common in the field of organic synthesis.
In organic synthesis, this compound is often used as a key intermediate. In its structure, both iodine atoms and bromomethyl have high reactivity. Iodine atoms can participate in many coupling reactions, such as Suzuki coupling, Stille coupling and the like. Such coupling reactions can effectively form carbon-carbon bonds and play a major role in the construction of complex organic molecules. Through the Suzuki coupling reaction, the molecules containing this compound can be connected to the compounds containing borate esters to achieve the formation of carbon-carbon bonds, and then the carbon skeleton of the molecule can be expanded, paving the way for the synthesis of organic compounds with specific structures.
Furthermore, its bromomethyl can also participate in nucleophilic substitution reactions. Many nucleophilic reagents, such as alcohols and amines, can attack this bromomethyl to realize the conversion of functional groups. Taking alcohol as an example, the oxygen atom of the alcohol acts as the nucleophilic center to attack the carbon atom of bromomethyl, and the bromide ions leave to form ether compounds. This process can enrich the functional groups of the compounds and endow the products with new chemical properties and uses.
In addition, in the field of medicinal chemistry, 2-iodo-5- (trifluoromethyl) benzylbromide may also have potential application value. Drug development often requires the synthesis of molecules with complex structures and specific biological activities. This compound can be used as a starting material to construct structural fragments related to drug activity through a series of chemical transformations. Because it contains trifluoromethyl, this functional group can significantly affect the physicochemical properties of molecules, such as lipophilicity, metabolic stability, etc., or help to improve the medicinal properties of synthesized drug molecules, providing a possible way for the creation of new drugs.
What are the precautions for 2-iodo-5- (trifluoromethyl) benzylbromide in storage and transportation?
2-Iodine-5- (trifluoromethyl) benzyl bromide is one of the organic compounds. During storage and transportation, many matters must be paid attention to to to ensure its safety and stability.
First words storage. This compound should be placed in a cool and dry place, away from fire and heat sources. Cover because of its certain chemical activity, heat can easily cause chemical reactions, cause it to deteriorate, or even cause safety accidents. And humid environment may also promote its hydrolysis and other reactions, so dry storage conditions are essential. It needs to be packed in a sealed container to prevent contact with air. Because it may react with oxygen, moisture and other components in the air, sealing can effectively reduce the occurrence of such reactions. The storage place should be separated from oxidizing agents, strong alkalis and other substances to avoid danger caused by interaction.
Secondary transportation. During transportation, it is necessary to strictly follow the relevant chemical transportation regulations. Appropriate packaging materials should be selected to ensure that the packaging is strong and well sealed to prevent leakage during transportation. During transportation, severe vibration and collision should be avoided, because the compound may undergo unstable changes when subjected to strong external impact. At the same time, the temperature of the transportation environment should also be controlled and maintained within an appropriate range, not too high or too low. Transportation personnel should also have professional chemical knowledge and emergency response capabilities. In case of emergencies, effective measures can be taken in a timely manner to reduce hazards.
What is the market price range for 2-iodo-5- (trifluoromethyl) benzylbromide?
I look at what you are asking about "2-iodo-5 - (trifluoromethyl) benzylbromide", which is the name of an organic compound. As for its market price range, it is difficult to determine abruptly. The price of this compound is determined by many factors.
First, the difficulty of preparation is also. If its synthesis requires complicated steps, rare raw materials, or strict requirements for reaction conditions, the cost will be high, and the price will rise accordingly. Second, the supply and demand situation of the market. If there are many people who want it, and the supply is limited, the so-called "rare is expensive", the price will rise; on the contrary, if the supply exceeds the demand, the price will inevitably fall. Third, the difference between manufacturers. Different manufacturers have different product prices due to different technical levels and economies of scale.
Based on the past market conditions of organic compounds, such halobenzyl derivatives containing iodine and trifluoromethyl, if they are of ordinary purity, the price per gram may be between tens of yuan and hundreds of yuan. However, if the purity requirements are extremely high, reaching the scientific research grade or even higher standards, the price may rise sharply, and it is unknown whether each gram or more than 1,000 yuan.
However, the market is unpredictable, and the price fluctuations of raw materials and the improvement of production processes can change the price. Therefore, to know the exact price range, you need to consult the relevant chemical product suppliers in detail, or refer to the recent market transaction data.