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What are the main uses of 2-iodo-5- (trifluoromethyl) pyri?
2-Iodine-5- (trifluoromethyl) pyridine is a crucial chemical raw material in organic synthesis. It has a wide range of uses and has made outstanding contributions to the field of medicinal chemistry.
The unique structure of the Gein pyridine ring and the introduction of iodine atoms and trifluoromethyl give this compound special physical and chemical properties. In the process of drug development, it can be used as a key intermediate. Through chemical reactions, its pyridine ring and substituents can be modified to connect with other active groups, and then construct drug molecules with complex structures and specific biological activities.
It also has important applications in the field of pesticide chemistry. Due to its structural characteristics, pesticides can be endowed with unique biological activities, such as insecticidal, bactericidal, weeding and other effects. Through rational molecular design and synthesis, new pesticides with high efficiency, low toxicity and environmental friendliness can be created.
In addition, in the field of materials science, 2-iodine-5- (trifluoromethyl) pyridine can also play a role. Or it can be used as a starting material for the synthesis of functional materials, through a series of reactions, to prepare materials with specific optical, electrical or mechanical properties, which can be used in electronic devices, optical materials and many other aspects. Its multi-purpose in organic synthesis is an important force to promote the development of related fields.
What are the physical properties of 2-iodo-5- (trifluoromethyl) pyri?
2-Iodine-5- (trifluoromethyl) pyridine, this is an organic compound. Its physical properties are quite unique, let me talk about them one by one.
Looking at its appearance, under room temperature and pressure, it is often colorless to light yellow liquid, with a clear texture and fluidity. This appearance is like a clear spring, giving people an intuitive feeling.
Talking about the melting point, it is between -20 ° C and -15 ° C. This temperature range determines the physical state transition of the substance in a low temperature environment. When the external temperature drops below the melting point, it will slowly condense from liquid to solid, just like water when it is cold and frozen, and the shape changes significantly.
In terms of boiling point, it is roughly in the range of 190 ° C to 195 ° C. The boiling point is of great significance. When the temperature rises to the boiling point, the substance will change from liquid state to gaseous state sharply, and vaporization will occur. This property plays a key role in many chemical operations such as separation and purification of substances.
As for the density, it is about 1.9 g/cm ³. The physical quantity of density reflects the mass of a substance per unit volume. Compared with common water, its density is higher, just like the difference between heavy metals and light water. If placed in water, it will sink like a stone sinking to the bottom.
Solubility is also an important physical property. The substance is slightly soluble in water, just like oil and water are difficult to blend. Due to its molecular structure, it has a weak force with water molecules. However, it is soluble in common organic solvents, such as ethanol, ether, dichloromethane, etc. This solubility characteristic provides a suitable medium choice for it to participate in various chemical reactions in the field of organic synthesis.
In addition, it has a certain degree of volatility. In the air, it will slowly evaporate and emit a special smell. Although this smell is difficult to describe accurately, it has also become one of the unique signs of its physical properties. These physical properties of 2-iodine-5- (trifluoromethyl) pyridine are related to each other and together constitute their unique physical properties, which have a profound impact on their preparation and application in the field of organic chemistry.
Is 2-iodo-5- (trifluoromethyl) pyri chemically stable?
2-Iodine-5- (trifluoromethyl) pyridine, this is an organic compound. The stability of its chemical properties is really related to many factors.
From the structural point of view, the pyridine ring is aromatic, and the system has certain stability due to the conjugation effect. The nitrogen atom on the ring has a pair of lone pair electrons, which can participate in the conjugation and enhance the stability of the ring. However, in this compound, the pyridine ring is connected with iodine atoms and trifluoromethyl. The iodine atom is relatively large and has a strong induction effect, which can change the electron cloud density distribution of the pyridine ring, which affects the stability. Trifluoromethyl, on the other hand, has strong electron-absorbing properties, which can reduce the electron cloud density of the pyridine ring, especially in its adjacent and para-position, resulting in uneven electron cloud density distribution on the ring.
In chemical reactions, iodine atoms can be used as leaving groups to participate in nucleophilic substitution reactions. This property reflects the relative activity and poor stability of this site. Under suitable conditions, nucleophilic reagents are prone to attack the carbon atoms connected to iodine, causing iodine to leave and causing molecular structure changes.
In terms of thermal stability, the compound has certain thermal stability due to the aromatic conjugate structure of the pyridine ring. However, the existence of trifluoromethyl and iodine atoms will change the intermolecular force, which will affect its melting point, boiling point and other physical properties, and then in high temperature environment, the stability may be reduced due to the change of intermolecular interaction.
In common organic solvents, its stability is also affected by the properties of the solvent. If the solvent and the compound can form hydrogen bonds or have strong interactions, or will change the molecular conformation, affecting the stability.
Overall, the stability of 2-iodine-5- (trifluoromethyl) pyridine is not absolute, and it will behave differently under different conditions. Relatively speaking, due to the substitution of iodine atoms and trifluoromethyl, the stability is lower than that of the parent pyridine.
What are the synthesis methods of 2-iodo-5- (trifluoromethyl) pyri?
There are many ways to synthesize 2-iodine-5- (trifluoromethyl) pyridine, each with its own advantages.
First, using 5- (trifluoromethyl) pyridine as the starting material, the target product can be obtained by iodine substitution reaction. This reaction requires a suitable iodine substitution reagent, such as iodine element with a suitable oxidant, such as hydrogen peroxide, potassium persulfate, etc. During the reaction, in a suitable solvent, such as dichloromethane, N, N-dimethylformamide, etc., control the temperature, reaction time and other conditions. If the temperature is too high, or side reactions increase, the purity of the product decreases; if the time is too short, the reaction may be incomplete. It needs to be carefully regulated to make the reaction proceed efficiently and obtain a product with higher yield and purity.
Second, the iodine-substituted structure can be constructed by multi-step reaction from the compound containing trifluoromethyl and pyridine rings. First, specific functional groups are introduced through reactions such as nucleophilic substitution and electrophilic substitution to create favorable conditions for the iodine-substituted reaction. Subsequently, the introduction of iodine atoms is completed according to the above-mentioned iodine-substituted reaction method. Although this path has many steps, it requires more mild reaction conditions and may be more advantageous for some special needs.
Third, the strategy of combining functional group conversion with halogenation reaction using pyridine derivatives as starting materials. First, the functional groups on the pyridine ring are gradually converted into suitable forms, such as some substituents are converted into groups that are conducive to the subsequent introduction of iodine and trifluoromethyl through oxidation, reduction, substitution and other reactions. Then, the trifluoromethylation and iodine reactions are carried out in sequence. This method needs to precisely control the reaction of each step to ensure the selectivity and yield of each step, and finally reach the synthesis of the target product.
There are various methods for synthesizing 2-iodine-5- (trifluoromethyl) pyridine, and each method has its own application scenarios and advantages and disadvantages. In actual synthesis, according to specific needs, such as yield, purity, cost, difficulty of reaction conditions, etc., comprehensive consideration is required to choose the most suitable method.
What is the price range of 2-iodo-5- (trifluoromethyl) pyri in the market?
The price of 2-iodo-5- (trifluoromethyl) pyridine has not been confirmed in the market, but the price varies due to many reasons. It involves the price of raw materials, the difficulty of preparation, the supply and demand of the market, and the quality specifications.
If the raw materials are easy to obtain and the price is average, and the process of preparation is simple, the price may be low. However, if the raw materials are rare and expensive, the production needs to be developed, which takes a long time and costs a lot, and the price will increase.
The supply and demand of the city also need it. If there are many people who want it, the supply will be small, and the price will increase; if the supply exceeds the demand, the price will drop.
The quality specification is also related to the price. Those with high purity and strict regulations will have a higher price than those with ordinary standards
Under normal circumstances, the price of such compounds for laboratory analytical purity may be between tens and hundreds of yuan per gram. For industrial bulk use, due to large quantities, the unit price may be low, or thousands of yuan per kilogram. However, this is only an approximate estimate. If you want to get a definite price, you can consult the chemical material supplier, the chemical trading platform, or the industry to know the details.