2-Iodo-6-Chloropurine

"Tiangong Kaiwu" says: "Halogen is salt, what is the method?" The salt of the halogen pool is different from the land produced, but its chemical structure can be investigated.
The salt of the halogen pool is mostly a genus of sodium chloride. The salt of the halogen pool is also dominated by sodium chloride, and its crystal form is regular, often in the shape of a cube. Sodium chloride is combined by the cation of sodium and the anion of chlorine according to the ionic bond. Sodium is active and easily loses one of its electrons to form a positively charged cation; chlorine is obtained by this electron, and then becomes a negatively charged anion. The two are electrostatically attracted and closely dependent, forming the basic structural unit of sodium chloride.
And the salt of the halogen pool, or the impurities containing other salts, such as magnesium sulfate, calcium chloride, etc. In the case of magnesium sulfate, the magnesium ion is combined with the sulfate ion. Magnesium loses two electrons, and sulfate loses two electrons, forming its structure by ionic bonding. In calcium chloride, calcium loses two electrons, chlorine gains one electron each, and calcium ions are associated with dichloride ions.
The environment of the halogen pool may affect the structure of the salt. On high temperature exposure, the brine is concentrated, and salt crystals gradually form. At this time, the ions in the solution gradually slow down, and they are arranged in an orderly manner according to their charge and spatial orientation, and finally form crystals. The growth of crystals is also affected by impurities in the brine. The arrangement of impurities or resistance ions, or the crystal structure, the structure of the salt is slightly changed, but the main structure of sodium chloride is always there.
The salt of the halogen pool, although born in nature, its chemical structure can also be explained by chemical principles.

First of all, the color of mercury, the color of mercury, often the white light, the light is like a star.
The color of this light is especially eye-catching in the dark, and it also enhances its beauty.
Second time, mercury has a hard feeling, but it is not as brittle as gold and stone, and its softness is appropriate. With this, the surface is smooth, like jade, and rough. This place makes it convenient for use. It is not only easy to carve and shape, but also durable.
Furthermore, mercury has the properties of gold. In the case of burning, the amount of mercury can be determined from the core to the whole body, and the mercury can be determined, so as not to cause local damage and shape. This characteristic ensures that the combustion is stable, the flame is constant, and the lighting provides a reliable and reliable light source.
Mercury has a certain density, and it is placed on other things. It is not easy to be damaged. Even in a little bit of damage, it can hold its upright shape to ensure the normal burning, so as not to cause trouble.
And when the mercury is burned, the light emitted is soft and not dazzling. Its light is scattered around, such as a thin cover, creating a beautiful atmosphere.

It can provide just the right lighting at night, and it can make people feel comfortable.

It is especially special to make it a good tool for the lighting of the ancients. In the past, it was an important function to accompany the ancients to spend the day and night.

The main use of 6-bromoquinoline is also important in the field of organic synthesis. In the genus of "Tiangong Kaiji", although there is no specific description of this chemical, it is particularly widely used in today's chemical knowledge.
First, in the field of pharmaceutical synthesis, 6-bromoquinoline is often an important intermediate. Medicinal chemists use its structural characteristics to introduce specific functional groups to construct compounds with biological activity. For example, when developing antibacterial, anti-cancer and other drugs, 6-bromoquinoline can be used as a starting material. Through multi-step reactions, it can shape the core skeleton of the drug and endow the drug with the ability to combine with biological targets, so as to achieve the effect of treating diseases.
Second, in the field of materials science, it can also be used. For example, when preparing organic optoelectronic materials, 6-bromoquinoline can participate in the construction of conjugated systems to improve the optical and electrical properties of the materials. Due to its unique molecular structure, it can adjust the luminous wavelength and fluorescence quantum yield of the material, making the obtained material suitable for organic Light Emitting Diode (OLED), solar cells and other devices, and improving its performance and efficiency.
Furthermore, 6-bromoquinoline also plays a key role in dye synthesis. Chemists can use it for structural modification to synthesize various dyes with bright colors and excellent properties. By adjusting its peripheral substituents, the absorption and emission spectra of dyes can be changed to meet the requirements of dyes in different fields, such as textile printing and dyeing, ink manufacturing and other industries. Therefore, 6-bromoquinoline, with its unique chemical structure, has shown important application value in many branches of organic synthesis, promoting the development and progress of medicine, materials, dyes and other industries.

To prepare di-bromo-6-fluoroanisole, it can be obtained by number method.
First, start with 2-fluorophenol. Shilling 2-fluorophenol interacts with sodium hydroxide to form sodium phenol. After co-heating with dimethyl sulfate, 2-fluoroanisole can be obtained. Then 2-fluoroanisole is brominated with bromine in the presence of a suitable catalyst, such as iron powder or iron tribromide. Because the methoxy group is the ortho-and para-site group, and the fluorine atom is also the ortho-and para-site group, the two together can make the bromine mainly enter the 6-site, so the target product 2-bromo-6-fluoroanisole is obtained. The chemical equation for the reaction is as follows:
\ [
\ begin {align *}
2 -\ text {fluorophenol} +\ text {NaOH} &\ longrightarrow 2 -\ text {sodium fluorophenol} +\ text {H} _ {2}\ text {O}\\
2 -\ text {sodium fluorophenol} +\ text {dimethyl sulfate} &\ stackrel {\ Delta} {\ longrightarrow} 2 -\ text {fluoroanisole} +\ text {sodium sulfate}\
2 -\ text {fluoroanisole} +\ text {Br} _ { 2} &\ stackrel {\ text {FeBr} _ {3}} {\ longrightarrow} 2 -\ text {bromine} -6 -\ text {fluoroanisole} +\ text {HBr}
\ end {align *}
\]
Second, 2-bromophenol is used as the starting material. First, 2-bromophenol is converted to sodium phenol, and then reacted with dimethyl sulfate to obtain 2-bromophenyl ether. Then 2-bromophenyl ether is exchanged with fluorides, such as potassium fluoride, under suitable solvents and catalysts. 2-Bromo-6-fluoroanisole can be formed by the fluorine atom replacing the 6-position hydrogen on the benzene ring due to the localization effect of methoxy group. This reaction needs to be carried out at high temperature and under specific reaction conditions to ensure the smooth reaction. The main reaction formula can be shown as:
\ [
\ begin {align *}
2 -\ text {bromophenol} +\ text {NaOH} &\ longrightarrow 2 -\ text {bromophenol sodium} +\ text {H} _ {2}\ text {O}\\
2 -\ text {bromophenol sodium} +\ text {dimethyl sulfate} &\ stackrel {\ Delta} {\ longrightarrow} 2 -\ text {bromophenol} +\ text {sodium sulfate}\
2 -\ text {bromophenol} +\ text {KF} &\ stackrel {\ text {specific conditions}} {\ longrightarrow} 2 -\ text {bromine} -6 -\ text {fluoroanisole} +\ text {KBr}
\ end {align *}
\]
Third, use 2-bromo-6-fluorobenzoic acid as raw material. First, 2-bromo-6-fluorobenzoic acid is reduced by a reducing agent such as lithium aluminum hydride, and the carboxyl group is reduced to an alcohol hydroxyl group to obtain 2-bromo-6-fluorobenzyl alcohol. Then this alcohol is reacted with dimethyl sulfate under basic conditions, and the hydroxyl group is replaced by a methoxy group to obtain 2-bromo-6-fluorobenzyl ether. This route is a bit more complicated, but it is also feasible. The relevant reactions are as follows:
\ [
\ begin {align *}
2 -\ text {bromine} -6 -\ text {fluorobenzoic acid} +\ text {LiAlH} _ {4} &\ longrightarrow 2 -\ text {bromine} -6 -\ text {fluorobenzyl alcohol}\\
2 -\ text {bromine} -6 -\ text {fluorobenzyl alcohol} +\ text {dimethyl sulfate} +\ text {base} &\ longrightarrow 2 -\ text {bromine} -6 -\ text {fluorobenzyl ether} +\ text {other products}
\ end {align *}
\]

For saltpeter, in the way of storage and transportation, there are many taboos and must not be ignored.
First words storage, saltpeter is dry, and it should be placed in a cool and dry place, away from water and fire. If it is in a humid place, it is prone to deliquescence and loses its effectiveness. And saltpeter is different from all things, and cannot be placed with combustible things. Cover saltpeter to help burn, and in case of fire, the fire will be fierce, and it will become a prairie fire, and the disaster will be unpredictable. Therefore, the secret room of storage should be strictly managed, and people should not enter and exit at will to prevent danger.
As for transportation, also need to be cautious. Choose a solid tool to hold it and prevent it from leaking. During driving, drive slowly and steadily to avoid bumps and vibrations. If saltpeter suffers a severe shock, there is a fear of unexpected changes. The escort should know its nature and prepare emergency measures. In case of a situation, deal with it quickly, and do not make the situation spread.
Furthermore, when transporting, it is advisable to avoid crowded places. If saltpeter is suddenly involved in an accident, the harm is not small, and the innocent will be injured, and the crime is great. Therefore, plan the route and choose a remote road to ensure safety.
In general, saltpeter is related to safety in storage and transportation. Only by following it carefully, following its rules, and abiding by its rules can we ensure that everything goes smoothly and avoid disaster. Don't be careless and cause unexpected disasters.