2 Iodo 9h Fluorene

2-Iodo-9H-fluorene is an organic compound with unique chemical properties and is very important in the field of organic synthesis.
This compound has the characteristics of halogenated aromatics, and the activity of iodine atoms is quite high. In many reactions, iodine atoms can be used as leaving groups, so that the compound can participate in nucleophilic substitution reactions. For example, when encountering nucleophiles, such as alkoxides and amines, iodine atoms are easily replaced, and then novel carbon-heteroatom bonds can be formed, whereby a variety of organic molecular structures can be constructed.
And because it contains a 9H-fluorene skeleton, which gives it a certain rigidity and conjugate structure, it is unique in electronic properties. Conjugated systems can affect their photophysical properties, such as fluorescence properties. Conjugated structures can cause molecules to absorb and emit light of specific wavelengths, which can be used in the field of optoelectronic materials, or can be used to prepare organic Light Emitting Diodes, fluorescence sensors, etc.
2-iodo-9H-fluorene may also participate in metal catalytic reactions. Under the action of transition metal catalysts, iodine atoms can initiate coupling reactions, such as Suzuki coupling, Stille coupling, etc. These coupling reactions can effectively form carbon-carbon bonds, greatly expanding their application range in the synthesis of complex organic molecules and materials, and assisting in the synthesis of organic compounds with specific structures and functions.

The common synthesis methods of 2-iodo-9H-fluorene, 2-iodo-9H-fluorene, are as follows:
The first method is to use fluorene as the starting material. Fluorene has active methylene and is used in suitable organic solvents such as tetrahydrofuran (THF). Under the action of strong bases such as n-butyllithium (n-BuLi), methylene hydrogen is extracted to form fluorene lithium intermediates. This intermediate has strong nucleophilicity. When it reacts with iodine substitutes, such as iodomethane (CH < unk > I) or iodine element (I < unk >), an iodine atom will replace a hydrogen atom on the methylene group to obtain 2-iodine-9H-fluorene. The reaction process needs to be carried out at a low temperature and in an anhydrous and oxygen-free environment to avoid side reactions and improve the purity and yield of the product.
Furthermore, fluorene can be functionalized first. For example, fluorene and acetyl chloride are first synthesized by Fu-gram acylation under the catalysis of aluminum trichloride (AlCl < unk >) and other Lewis acids, and the acetyl group is introduced at the 9 position of fluorene to generate 9-acetylfluorene. Next, under suitable conditions, such as in glacial acetic acid solvent, 9-acetylfluorene is halogenated with iodine and potassium iodate as halogenated reagents, and the iodine atom selectively replaces the 2-position hydrogen atom to obtain 2-iodine-9-acetylfluorene. Finally, through a reduction reaction, such as the Clemmensen reduction method using zinc amalgam and concentrated hydrochloric acid, the 9-position acetyl group is reduced to methylene, and then the target product 2-iodine-9H-fluorene is obtained. Although there are many steps in this route, the selectivity of each step is relatively good, which can effectively reduce the formation of impurities.
Others use 2-bromo-9H-fluorene as raw materials. Halogen exchange reaction with potassium iodide (KI) occurs in the presence of suitable metal catalysts, such as palladium catalysts, such as tetra (triphenylphosphine) palladium (Pd (PPh)), and ligands. This reaction is carried out in a suitable organic solvent, such as N, N-dimethylformamide (DMF). The bromine atom in 2-bromo-9H-fluorene is replaced by an iodine atom to generate 2-iodine-9H-fluorene. This method is relatively simple to operate, but attention needs to be paid to the selection of suitable catalysts and reaction conditions to ensure the smooth progress of the reaction and the quality of the product.

2-Iodo-9H-fluorene is also an organic compound. It has applications in many fields.
In the field of materials science, it can be used as an organic optoelectronic material. The cover can participate in the photoinduced charge transfer process due to its unique electronic properties due to its molecular structure. Taking organic Light Emitting Diode (OLED) as an example, derivatives of 2-iodo-9H-fluorene can be reasonably designed and modified as a light-emitting layer material. Its iodine atom can adjust the electron cloud distribution of molecules, optimize the luminous efficiency and color purity, so that OLED devices can show more brilliant colors, which is of great significance in display technology.
In the field of medicinal chemistry, this compound also has potential value. Its unique structure can provide a novel skeleton for the design of drug molecules. By chemically modifying it and introducing different functional groups, its biological activity and pharmacological properties can be changed. For example, it may be able to have specific targeting properties and can precisely act on diseased cells, paving the way for the development of new drugs.
In the field of organic synthesis, 2-iodo-9H-fluorene is an important synthetic intermediate. Its iodine atom has high reactivity and can participate in many classic organic reactions, such as Suzuki coupling reaction, Stille coupling reaction, etc. With the help of such reactions, it can be connected with other organic fragments to build complex organic molecules, providing an effective way for the synthesis of organic compounds with specific functions, and is widely used in the total synthesis of natural products and the preparation of functional materials.

2-Iodo-9H-fluorene, Chinese name 2-iodo-fluorene, is a kind of organic compound. Its physical properties are quite unique, let me tell them one by one.
When it comes to appearance, under room temperature and pressure, 2-iodo-fluorene is often in the state of white to light yellow crystalline powder with fine texture. This form is easy to store and use, and also reflects the order of its molecular arrangement.
The melting point is between 107-111 ° C. The characteristics of the melting point are crucial for identifying the compound and considering its physical state changes at different temperatures. At this melting point, the solid state of 2-iodine fluorene will gradually transform into a liquid state, the balance of intermolecular forces will be broken, and the molecular motion will be intensified.
In addition to solubility, 2-iodine fluorene shows a certain affinity for organic solvents, such as dichloromethane, chloroform, toluene, etc. Organic solvents can dissolve it. This characteristic is due to the existence of aromatic rings and iodine atoms in its molecular structure, which endows it with a certain lipid solubility. However, in water, its solubility is very small, because water is a polar solvent, and the molecular polarity of 2-iodine fluorene is relatively weak. According to the principle of "similar miscibility", it is difficult to dissolve in water.
Although there is no exact conventional value for its density, based on the general characteristics of fluorene derivatives and the relative atomic mass of iodine atoms, it can be inferred that its density is higher than that of water. If it is mixed with water, it should sink to the bottom.
In addition, the stability of 2-iodine fluorene is acceptable under conventional conditions. However, due to the existence of iodine atoms, its chemical properties are more active than fluorene itself. Under specific conditions, such as light, heating or the presence of catalysts, iodine atoms can undergo chemical reactions such as substitution and elimination, which in turn affect the stability of their physical properties.
All these physical properties are of great significance in the fields of organic synthesis and materials science. For example, in organic synthesis, appropriate reaction conditions and separation and purification methods can be selected according to their melting point and solubility; in materials science, their appearance and stability are related to the properties and application range of materials.

I don't know what the market value of 2-iodo-9h-fluorene is. This is a matter of transformation, and its quality is often affected by various reasons. Such as the quality of the product is poor, the quality of the product is high, or high; the quality of the product is low, or low. It is also easy. If the method is complex, multiple materials are required, and the strength of the product is high, and if the method is easy, it is low or low. Furthermore, the supply and demand of the market are low. If there is a shortage of supply, the supply will rise; if the supply is low, the supply will fall.
In addition, the different suppliers also have a difference. Different merchants have different strategies, either small profits and high profits, or seek high profits, so the same thing, the price of different suppliers, can be much different. And the amount of money also has an impact, the batch is low, or the benefits are high; a small amount is low, or low.
If you want to know the market value of it, the price of it can be obtained.