2 Iodobenzyl Bromide

2-Iodobenzyl bromide is an important raw material for organic synthesis and has a wide range of uses in many fields.
First, in the field of medicinal chemistry, its role is significant. Drug developers often use 2-iodobenzyl bromide as a starting material to introduce specific structural fragments to target drug molecules through delicate chemical reactions. Due to the unique activity of iodine atoms and benzyl bromide, it can participate in a variety of bonding reactions to help build complex molecular frameworks with specific pharmacological activities. For example, when synthesizing some anti-cancer drugs, 2-iodobenzyl bromide can be used as a key intermediate to react with other compounds containing specific functional groups to gradually build drug molecular structures with precise anti-cancer activity.
Second, in the field of materials science, it also makes important contributions. When preparing functional organic materials, 2-iodobenzyl bromide can act as a reactive activity check point. For example, synthesizing polymer materials with special optical or electrical properties, through its polymerization with other monomers, its unique structure is integrated into the polymer chain, giving the material special properties such as photochromic and electrical conductivity, so as to meet the needs of special functional materials in different fields.
Third, in the study of organic synthesis chemistry, 2-iodobenzyl bromide is a very commonly used reagent. Chemists use their active halogen atoms to carry out classical organic reactions such as nucleophilic substitution and coupling to synthesize various complex organic compounds, expand the variety and structural diversity of organic compounds, and lay the foundation for the basic research and application development of organic chemistry.

2-Iodobenzyl bromide, this material is special. It is an organic halide with the general properties of halogenated hydrocarbons.
Looking at its physical properties, it is mostly solid at room temperature, but it also changes depending on environmental conditions. Color or nearly colorless, or slightly yellow, often crystalline, fine texture. Smell it, it has a specific smell, but its taste is difficult to determine, your mileage may vary, and its taste is often pungent and irritating.
On its solubility, it is quite soluble in organic solvents, such as ethanol, ether, chloroform, etc. Due to the "similar miscibility" principle, its molecular structure has a certain degree of compatibility with organic solvents. However, it is insoluble in water. Water is a solvent with strong polarity, while the polarity of 2-iodobenzyl bromide is relatively weak, and the polarity difference between the two is large, so it is insoluble.
Its melting point and boiling point are also important physical properties. The melting point has a fixed number, which varies according to the degree of purity. The melting point of the pure is more stable, which can be used to identify its purity. The boiling point is higher. Due to the intermolecular force, the intermolecular force caused by the halogen-containing atom increases, and more energy is required to boil it.
Density is also one of the characteristics, which is larger than that of water. If mixed with water, it will sink to the bottom of the water. This characteristic can be used in separation and other operations.
In conclusion, 2-iodobenzyl bromide has unique physical properties, and its physical properties are a key factor in the consideration of operation and reaction conditions when used in organic synthesis and other fields.

The synthesis method of 2-iodobenzyl bromide (2-iodobenzyl bromide), let me explain in detail.
First, it can be started from o-iodotoluene. First, N-bromosuccinimide (NBS) is used as the bromination reagent, and benzoyl peroxide (BPO) is used as the initiator. In this process, the benzyl hydrogen atom of o-iodotoluene is more active due to the influence of benzene ring and iodine atom, and it is easy to replace with the bromine atom in NBS. The reaction formula is roughly: o-iodotoluene + NBS $\ xrightarrow [] {BPO, light or heat} $2 -iodobenzyl bromide + succinimide. Pay attention to the reaction temperature and the amount of NBS. If the temperature is too high or the NBS is excessive, the by-products of polybromination may occur.
Second, you can also start with o-iodobenzoic acid. First reduce it to o-iodobenzyl alcohol, which can be achieved with strong reducing agents such as lithium aluminum hydride (LiAlH). o-iodobenzoic acid + LiAlH$\ xrightarrow [] {suitable solvent} $o-iodobenzyl alcohol. Then, o-iodobenzyl alcohol is reacted with hydrobromic acid (HBr), and the hydroxyl group is replaced by a bromine atom to generate 2-iodobenzyl bromide. The reaction formula is: o-iodobenzyl alcohol + HBr $\ longrightarrow $2-iodobenzyl bromide + water. In this path, the reduction step needs to be operated in an anhydrous environment, because lithium aluminum hydride reacts violently with water; when reacting with hydrobromic acid, the reaction conditions should also be paid attention to to to to improve the yield.
Third, the Grignard reagent method can also be used. Grignard reagents are prepared from o-iodobromobenzene, such as o-iodobromobenzene + Mg $\ xrightarrow [] {anhydrous ethyl Then it reacts with formaldehyde to form o-iodobenzyl alcohol. After separation and purification, it reacts with hydrobromic acid to obtain 2-iodobenzyl bromide as described above. This method requires attention to the extremely harsh preparation conditions of Grignard reagent, which must be anhydrous and oxygen-free, otherwise Grignard reagent is easy to decompose and affect the subsequent reaction.

2-Iodobenzyl bromide is a chemical substance. When storing and transporting, it is necessary to pay more attention to ensure its stability and avoid all kinds of risks.
First, store in a cool and dry place. Cover this thing in case of moisture, it is easy to react and cause quality deterioration; if it is in a high temperature environment, it may increase the risk of its volatilization and cause the risk of explosion. Therefore, a cool and dry place is the basis for its proper storage.
Furthermore, the storage place must be well ventilated. Because 2-iodobenzyl bromide may evaporate harmful gases, if the ventilation is not smooth, the gas will accumulate, which will be harmful to human health and the environment. If the ventilation is good, the harmful gases can be dispersed, reducing the risk to the invisible.
And must be kept away from fire and heat sources. This material is flammable, and in case of open flames and hot topics, it is very easy to ignite and explode, resulting in major disasters. Therefore, in the place of storage, fireworks are strictly prohibited, and heat sources should also be avoided to ensure the stability of the environment.
Also, 2-iodobenzyl bromide should be stored in parts with oxidants and alkalis. Because of its active chemical properties, it coexists with them, which is prone to chemical reactions, or the risk of combustion or explosion. Classified storage can prevent the interaction of different chemicals and keep it safe.
As for transportation, the packaging must be solid. Pack with suitable materials to prevent its leakage. If the package is damaged and 2-iodobenzyl bromide spills out, it will not only stain the environment, but also endanger the transported people and the surrounding things.
During transportation, the temperature must also be controlled to avoid high temperature. Choose a smooth transportation path, drive slowly and steadily, and avoid bumps and vibrations. Due to vibration or damage to the package, leakage will be caused, and bumps or chemical reactions will be promoted, increasing the danger.
The escort must know the characteristics of 2-iodobenzyl bromide and emergency response methods. In case of emergencies, such as leaks, etc., appropriate measures can be taken quickly to reduce losses and ensure safety.

I look at the "2-iodobenzyl bromide" you are inquiring about, that is, 2-iodobenzyl bromide, which is an organic compound. Its market price range is difficult to determine precisely, due to the intertwined influence of many factors.
First, the preparation cost has a deep impact on its price. To prepare 2-iodobenzyl bromide, the selection and price of raw materials, the complexity of synthesis steps and the required reaction conditions are all related to cost. If raw materials are scarce and expensive, the synthesis process is complicated, special catalysts or harsh reaction conditions are required, the cost will increase, and the market price will also rise.
Second, the state of market supply and demand is a key factor. If the market demand for 2-iodobenzyl bromide is strong, such as in medicine, material science and other fields, but the supply is relatively insufficient, its price will rise; conversely, if the demand is low and the supply is abundant, the price will decline.
Third, the quality grade also affects the price. High-purity 2-iodobenzyl bromide, due to the difficulty of preparation, can meet high-end scientific research or special industrial needs, and the price is much higher than that of ordinary purity products.
Overall, in the general market, the price of low-purity 2-iodobenzyl bromide per gram may be in the tens of yuan; for high-purity products, the price per gram can reach hundreds of yuan, and even more. However, this is only a rough estimate, and the actual price depends on specific market conditions, the number of transactions, and supplier differences.