2-Iodophenyl Methyl Sulphide~2-(Methylthio)Iodobenzene

2-Iodophenyl methyl sulfide (2 - (methylthio) iodobenzene) has a wide range of uses and plays a significant role in the field of organic synthesis.
One of them can be used as a key intermediate in organic synthesis. When building complex organic molecular structures, its iodine atom and methyl sulfide have high reactivity. Iodine atoms can participate in many classical reactions, such as the Ullmann reaction, which can couple aryl halides with nucleophiles under the action of catalysts such as copper, and then form new carbon-carbon bonds and carbon-nitrogen bonds. Through the participation of 2-iodophenyl methyl sulfide in the Ullman reaction, a biaryl structure containing methionyl groups can be constructed, which is of great significance in many fields such as medicinal chemistry and materials science. Another example is that iodine atoms can also be coupled with corresponding organoboron reagents and organotin reagents as leaving groups in palladium-catalyzed cross-coupling reactions, such as Suzuki reaction and Stille reaction, thus introducing different functional groups or carbon chain fragments, providing diverse possibilities for structural modification of organic molecules. Methionyl, as an important thioether functional group, can also be converted into other sulfur-containing functional groups such as sulfoxide and sulfone through oxidation and other reactions, further enriching the structure types of organic molecules.
Second, in the field of drug development, compounds derived from 2-iodophenyl methyl sulfide exhibit potential biological activities. The structure of thioethers is common in many biologically active natural products and drug molecules, and the presence of methionyl can affect the lipid solubility, electron cloud distribution and interaction with biological targets of molecules. By structural modification of 2-iodophenyl methyl sulfide and the introduction of other pharmacophore, it is possible to develop new drugs with antibacterial, anti-inflammatory, anti-tumor and other biological activities. For example, researchers can use it as a starting material to convert it into molecules with specific pharmacological activities through a series of organic synthesis steps, and then screen and evaluate these molecules for biological activity to find potential drug lead compounds.
Third, in terms of materials science, materials prepared from 2-iodophenyl methyl sulfide may have unique properties. The sulfide structure can endow materials with certain flexibility and stability, while the introduction of iodine atoms may change the electrical and optical properties of materials. For example, by using it as a monomer to participate in the polymerization reaction, the prepared polymer materials may show application potential in the fields of electroluminescence, semiconductors, etc., and can be used to fabricate organic light emitting diodes (OLEDs), organic field effect transistors (OFETs) and other optoelectronic devices.

2-Iodophenyl methyl sulfide (2 - (methylthio) iodobenzene) is also an organic compound. Its physical properties are worth exploring.
Looking at its properties, at room temperature, it is mostly liquid, with a color that is close to colorless or slightly pale, depending on the purity and impurities it contains. Its smell, or a specific sulfur ether smell, although not strong and pungent, it also has distinguishable characteristics.
When it comes to the melting point, the melting point is very low, and it is difficult to condense into a solid state at ordinary temperatures. The boiling point is relatively high. Due to the existence of certain interaction forces between molecules, such as the weak interaction between van der Waals force and sulfur atoms, more energy is required for its gasification to break free from the intermolecular bondage.
As for solubility, this substance exhibits good solubility in organic solvents, such as ethanol, ether, and dichloromethane. Due to the principle of similarity and dissolution between organic substances, its molecular structure is similar to that of organic solvents, and the intermolecular force is appropriate, so it can be mutually soluble. However, in water, the solubility is very small. Due to the obvious non-polar characteristics of its molecules, it is very different from the polarity of water molecules, and it is difficult to form an effective interaction, so it is difficult to dissolve in water.
In terms of density, it is slightly higher than that of water. If mixed with water, it often sinks underwater. This is because its molecular mass is larger and its structure is compact, so that the mass contained in the unit volume is more, so the density is higher than that of water.
In addition, its volatility is relatively low, unlike some small molecule volatile organic compounds, which can exist relatively stably at room temperature and pressure, and are not easy to quickly escape into the air.
In summary, the physical properties of 2-iodophenylmethyl sulfide have their own reasons, which are determined by many factors such as molecular structure, constituent elements and interactions. This is of great significance in the study of its application and related chemical processes.

To prepare 2-iodophenyl methyl sulfide (2 - (methylthio) iodobenzene), the following ancient method can be used.
First take o-iodobromobenzene as the starting material, and put it together with sodium sulfide and iodomethane in an appropriate reactor. Dimethylformamide (DMF) is used as the solvent in the kettle, because it has good solubility to many organic reactions and a stable chemical environment, which is conducive to the reaction. Under mild heating and moderate stirring, the bromine atom of o-iodobrobenzene is highly active, and it is easy to undergo nucleophilic substitution reaction with sulfur ions in sodium sulfide. Sulfur ions replace bromine atoms to initially form sulfur-containing intermediates. Subsequently, the sulfur atom of this intermediate is nucleophilic and can react with the methyl group of iodomethane to eventually form the target product 2-iodophenyl methyl sulfide.
There are also other methods. Using o-iodophenol as the starting material, it first interacts with sodium hydride, and the hydrogen of the phenolic hydroxyl group is replaced by sodium to form a sodium phenolic intermediate. This is because sodium hydride is strongly basic and can capture the active hydrogen of the phenolic hydroxyl group. Then, the sodium phenol intermediate reacts with iodomethane, and the phenoxy negative ion attacks the methyl group of iodomethane as a nucleophilic agent to form o-methoxyiodobenzene. Then Lawesson reagent is used to treat o-methoxy iodobenzene. Lawesson reagent can effectively convert methoxy to methylthio. After this series of reactions, 2-iodophenyl methyl sulfide can also be obtained.
When operating, pay attention to the control of the reaction temperature. If the temperature is too high or side reactions are caused, the purity of the product will be reduced; if it is too low, the reaction rate will be slow and time-consuming. And the reagents used need to be pure, and the solvent should also be dried and dehydrated to prevent impurities from affecting the reaction process. After the reaction, the product needs to be purified by methods such as column chromatography and recrystallization to obtain pure 2-iodophenyl methyl sulfide.

2-Iodophenyl methyl sulfide (2 - (methylthio) iodobenzene) is an organic compound. When storing it, all matters should be carefully paid attention to.
First environment. It should be placed in a cool place away from direct sunlight. Hot sunlight can promote its chemical reaction and cause deterioration of substances. And it needs a dry place. Moisture can easily lead to adverse reactions such as hydrolysis, which will damage its purity and quality.
Second words container. When used in a sealed container. Sealing can block air and prevent it from oxidizing when it comes into contact with oxygen. It is better to use containers made of glass or specific plastic materials. Such materials are chemically stable and do not react with the compound.
Furthermore, keep away from fire and heat sources. This compound may be flammable, and in case of open flames and hot topics, it is dangerous to start a fire and endanger safety.
Also, the storage place should be separated from oxidizing agents, acids and other substances. Because of its active chemical properties, coexisting with them can easily trigger violent chemical reactions and cause dangerous life.
And the storage area should be equipped with suitable fire fighting equipment and leakage emergency treatment equipment. In case of leakage, it can be dealt with in time to minimize harm.
In conclusion, when storing 2-iodophenyl methyl sulfide, careful consideration is required in many aspects such as the environment, containers, surrounding materials, and emergency equipment to ensure its quality and storage safety.

2-Iodophenyl methyl sulfide (2 - (methylthio) iodobenzene) This substance is related to many potential safety risks. It is flammable and easy to burn in case of open flames and hot topics, causing the fire to spread rapidly and cause the risk of fire. When burned, harmful gases such as sulfur oxides and hydrogen iodide will be released, which are toxic and irritating.
On the one hand of health hazards, if people inadvertently inhale it, it will irritate the respiratory tract, causing cough, asthma, breathing difficulties, etc.; if the skin comes into contact with it, it may cause skin allergies, redness, swelling, itching, etc.; if it is not carefully entered into the eyes, it will strongly irritate the eyes, causing pain, tears and even visual damage. Long-term or large-scale contact, or damage to the nervous system, liver, kidneys and other important organs.
In terms of storage, be sure to place in a cool and well-ventilated place, away from fire and heat sources, and store separately from oxidants and acids. Do not mix storage to prevent severe reactions. When handling, it should be handled lightly to avoid damage to packaging and containers and cause leakage.
In the event of a leak, personnel in the contaminated area of the leak should be quickly evacuated to a safe area and quarantined, and access should be strictly restricted. Emergency personnel must wear self-priming filter gas masks (full masks) and gas suits. Do not let leaks come into contact with flammable substances (such as wood, paper, oil, etc.). Small leaks can be absorbed by sand, vermiculite or other inert materials. Large leaks need to be built embankments or excavated for containment, covered with foam to reduce vapor disasters, and then transferred to tanks or special collectors for recycling or transportation to waste disposal sites. In this way, the safety risks caused by 2-iodophenyl methyl sulfide can be avoided as much as possible.