What is the chemical structure of 2 - methyl - 4 - iodoanisole?

The chemical structure of 2 + -methyl-4-iodoanisole is described as follows: The core of this compound is a benzene ring, which is a typical structure of aromatic hydrocarbons. Above the benzene ring, there is a methyl group (-CH 🥰) at position 2, which is composed of one carbon atom and three hydrogen atoms, and is connected to the benzene ring in a tetrahedral shape. At position 4, there is an iodine atom (-I), which is relatively large and has a great influence on molecular properties. At the same time, the first position of the benzene ring is connected to a methoxy group (-OCH 🥰). The methoxy group is composed of an oxygen atom and a methyl group. The oxygen atom is covalently connected to the benzene ring, and the methyl group at the other In this way, the atoms and groups are connected by covalent bonds in a specific order and spatial position to construct the chemical structure of 2-methyl-4-iodoanisole, which endows the compound with specific physical and chemical properties. It is of great significance in many reactions and application fields of organic chemistry.

What are the main physical properties of 2 - methyl - 4 - iodoanisole?

The main physical properties of 2 + -methyl-4-iodoanisole are as follows:

This substance is mostly liquid at room temperature, with a clear and transparent appearance or a slight yellowish sheen. The color state is due to factors such as electronic transitions and conjugated systems in the molecular structure. It has a special odor. This odor is derived from the molecular composition and structure of the organic substance. The smell is emitted, which can be sensed by the sense of smell or has a certain irritation. However, due to individual differences in the sense of smell, the perception is also different.

When it comes to the melting point, its melting point is about -13 ° C, and the boiling point is about 247 ° C. The value of the melting point reflects the strength of the force between molecules. Below -13 ° C, the thermal motion of the molecules weakens, and the arrangement of each other gradually becomes orderly, so they become solid states; the value of the boiling point indicates that when the temperature reaches 247 ° C, the molecules gain enough energy to break free from the attractive forces between molecules, and change from liquid to gaseous state.

In terms of density, it is about 1.65 g/cm ³, which is heavier than water. If mixed with water, it will sink underwater. This density characteristic is determined by the relative mass of the molecules and the degree of accumulation between molecules. The molecules contain iodine atoms, and the atomic weight is large, resulting in an increase in the overall relative mass and then a higher density. In terms of solubility, it is slightly soluble in water, but easily soluble in organic solvents such as ethanol, ether, and chloroform. This is because water is a polar solvent, and although 2-methyl-4-iodoanisole contains methoxy groups with a certain polarity, the polarity is weaker overall due to factors such as benzene rings and iodine atoms. According to the principle of "similar miscibility", it is more soluble in non-polar or weakly polar organic solvents.

What are the common applications of 2 - methyl - 4 - iodoanisole in organic synthesis?

2 + -Methyl-4-iodoanisole, which is widely used in organic synthesis.

First, it can be used as a key intermediate for the synthesis of other organic compounds. Due to its structure containing both methyl, iodine atoms and methoxy groups, these functional groups have unique reactivity and can be converted into other functional groups through many organic reactions, such as nucleophilic substitution, coupling reactions, etc., to construct more complex organic molecules. For example, in the Suzuki coupling reaction, the iodine atom in 2-methyl-4-iodoanisole can react with boron-containing reagents to form new carbon-carbon bonds, providing an effective way for the synthesis of polyaryl compounds, which is of great significance in the fields of medicinal chemistry and materials science.

Second, in the field of drug synthesis, it is often regarded as a starting material. Its structure can be modified and modified to meet the needs of specific drug targets. Pharmaceutical chemists can develop new drugs with specific pharmacological effects by derivatizing its functional groups and adjusting the physicochemical properties and biological activities of molecules.

Third, in the field of materials science, it is also useful. Introducing it into the structure of a polymer material through a suitable reaction can endow the material with unique properties, such as changing the optical and electrical properties of the material. For example, by connecting it to the polymer backbone through a specific reaction, it is expected to prepare organic polymer materials with special photoelectric properties, which may have applications in fields such as organic Light Emitting Diodes (OLEDs) and solar cells.

What are the synthesis methods of 2 - methyl - 4 - iodoanisole?

The synthesis of 2 + -methyl-4-iodoanisole is an important topic in organic synthetic chemistry. There are two common methods for preparing this substance.

First, 2-methyl-4-hydroxyanisole is used as the starting material and can be obtained by halogenation reaction. In this reaction, it is crucial to select a suitable halogenating reagent. Commonly used ones are the combination of potassium iodide and hydrogen peroxide. In an acidic environment, potassium iodide can be oxidized by hydrogen peroxide to an active iodine elemental substance, and then the phenolic hydroxyl group of 2-methyl-4-hydroxyanisole undergoes electrophilic substitution reaction to form 2-methyl-4-iodoanisole. During the reaction, it is necessary to pay attention to the regulation of the reaction temperature and time. If the temperature is too high or the time is too long, it may cause side reactions, such as the formation of polyhalogenated products.

Second, it can be synthesized from 2-methylanisole through multiple steps such as nitration, reduction, diazotization and iodine substitution. First, 2-methylanisole and mixed acid (a mixture of sulfuric acid and nitric acid) undergo nitration reaction, and nitro is introduced into the phenyl ring. This step requires strict control of the temperature and the ratio of mixed acid to prevent excessive nitrification. The resulting nitro compound can be converted into the corresponding amino compound after reduction, such as iron powder and hydrochloric acid as reducing agents. Then, the amino compound reacts with sodium nitrite and hydrochloric acid to undergo diazotization to form a diazonium salt. Finally, the diazonium salt reacts with potassium iodide, and the diazonium group is replaced by the iodine atom to obtain the target product 2-methyl-4-iodoanisole. Although this route has many steps, the reaction selectivity of each step is better and the product purity is easy to control.

The above two methods have advantages and disadvantages. The former step is relatively simple, but the selectivity of the halogenation reaction is sometimes poor; the latter step is complicated, but it can better control the structure and purity of the product. In actual synthesis, the optimal method should be selected according to specific needs and conditions.

What is the approximate market price for 2 - methyl - 4 - iodoanisole?

I don't know what the market price of 2 - + - methyl - + - 4 -iodoanisole is. The market price of these substances often changes due to various reasons, such as the trend of supply and demand, the distance of origin, the difficulty of preparation, the quality and quality, and the price demanded by the vendors in the market may also be different.

If you want to know the exact price, you should consult the chemical material merchants, chemical mall platforms, or in the chemical industry forums and communities, and ask those who know this. They may be able to give a more accurate price according to the current market situation. However, the price is difficult to say in a word, and it must be checked in real time before it can be accurate.