2 O Methyl 5 Iodo Uridine

"2 '-O-methyl-5' iodine-uridine" has a unique chemical structure. Uridine is a kind of nucleoside, which is composed of uracil and ribose connected by β-glycoside bond. On the basis of the structure of uridine, this compound undergoes two key modifications.
First, at the 2 'hydroxyl group of ribose, a methyl group is added to form the structural characteristics of 2' -O-methyl. The introduction of methyl groups can change the spatial conformation and physicochemical properties of molecules, such as affecting their lipophilicity and stability. This modification is commonly found in many natural and synthetic nucleoside compounds, and has a significant regulatory effect on their biological activities.
Second, iodine atoms are introduced into the 5 position of the uracil ring to form the 5-iodine structure. Iodine atoms have a large atomic radius and electronegativity, and the existence of this substituent greatly affects the electron cloud distribution and stereochemistry of the molecule. This structural change can significantly change the mode and intensity of the interaction between the compound and biological macromolecules, such as nucleic acids, proteins, etc., thereby endowing it with unique biological activities.
The chemical structure of this 2 '-O-methyl-5' -iodine-uridine is modified on the matrix of uridine by methyl and iodine atoms. The synergistic effect of the two gives the compound potential unique application value in the fields of medicine, biochemistry, etc., such as potential to become an important lead compound in the development of new antiviral and antitumor drugs.

2% 27-o-methyl-5-iodo-uridine, commonly known as 2 '-O-methyl-5-iodouridine in Chinese. This is an important nucleoside analogue and has a wide range of uses in biomedicine and scientific research.
It has a significant effect in drug development. Because its structure is similar to that of natural nucleosides, it can participate in the nucleic acid metabolism process of cells. It can interfere with the nucleic acid synthesis of viruses and show therapeutic potential for some viral infectious diseases. For example, in the study of some RNA viruses, 2' -O-methyl-5-iodouridine can be embedded in the viral RNA strand, hindering the normal replication and transcription of viruses, and then inhibiting viral proliferation.
It also has important functions in the field of gene expression regulation. It can modify the structure of mRNA, affecting its stability and translation efficiency. The stability and translation process of intracellular mRNA have a great impact on the level of gene expression. 2 '-O-methyl-5-iodouridine can interact with specific protein factors, regulate the binding of mRNA to ribosomes, and precisely regulate gene expression, which is of great significance in gene therapy and biopharmaceuticals.
Furthermore, in the field of nucleic acid chemical synthesis, it is an important synthetic building block. Researchers use its unique structure to synthesize oligonucleotides with special functions. These oligonucleotides can be used as molecular probes to detect specific genetic sequences, play a key role in disease diagnosis, genotyping, etc., and contribute to the development of precision medicine.
2 '-O-methyl-5-iodouridine has become an indispensable substance in the field of biomedicine and scientific research due to its important uses in the treatment of viral infections, gene expression regulation and nucleic acid chemical synthesis, and continues to promote the progress and development of related fields.

To prepare 2 '-O-methyl-5' -iodine-uridine, the method is as follows:
Take uridine as the starting material first. Uridine is an important nucleoside and has many applications in the field of biochemistry. Only on this basis can the subsequent reaction be carried out.
The first step is usually the reaction of methylation. To methylate the 2 '-hydroxyl group of uridine, an appropriate methylation reagent can be selected. If a reagent such as dimethyl sulfate is used, under suitable reaction conditions, such as in an alkaline environment, the base can be potassium carbonate, etc., and in a suitable solvent, such as acetonitrile or dichloromethane, the two interact. The alkali can capture the hydrogen of uridine 2 '-hydroxy group, so that oxygen negative ions can be formed. This negative ion has strong nucleophilicity and can attack the methyl group of dimethyl sulfate, thereby generating 2' -O-methyluridine. This step requires attention to the reaction temperature and time. If the temperature is too high or the time is too long, it may cause side reactions and affect the purity and yield of the product. The next step is iodization at 5 '-position. After obtaining 2' -O-methyluridine, put it into the iodization reaction. Iodine elemental substance and appropriate reducing agent system, such as iodine and phosphoric acid, can be used. In a suitable solvent, such as glacial acetic acid, heat and stir to promote the reaction to occur. Under the action of the reducing agent, the iodine elemental substance generates active species such as iodine positive ions. This species can attack the 5-position of 2 '-O-methyluridine to achieve iodization, and finally obtain 2' -O-methyl-5-iodine-uridine. After the reaction is completed, the product can be separated from the reaction mixture through separation and purification steps, such as column chromatography, using silica gel as the stationary phase, and rinsing with a suitable eluent to obtain a pure 2 '-O-methyl-5-iodine-uridine.

2% 27-o-methyl-5-iodo-uridine is a rather special compound. In living organisms, its mechanism of action is profound and complex.
This compound can affect the synthesis and metabolism of nucleic acids. The process of nucleic acid synthesis is like a precise weaving, and the nucleotides are strands and interwoven in an orderly manner. After 2% 27-o-methyl-5-iodo-uridine enters the cell, it can be mixed into RNA synthesis like a foreign guest in disguise. The 5-iodine substituent and 2% 27-o-methyl modification in its structure give it unique chemical properties.
When involved in RNA synthesis, its structure is different from that of normal nucleotides, which can cause changes in RNA structure. This change may be like a variation of a tune, affecting the interaction between RNA and protein. Many proteins need to bind to RNA of specific structures to perform functions, such as the translation process of mRNA, and the ribosome needs to accurately recognize the mRNA structure. RNA structure changes caused by 2% 27-o-methyl-5-iodo-uridine may interfere with ribosome binding, which in turn hinders protein synthesis and makes cell physiological function disordered.
Furthermore, it also plays a role in cell signaling pathways. Intracellular signaling is like a sophisticated communication network, and signaling molecules transmit information in an orderly manner. This compound may interfere with the function of key RNA molecules in certain signaling pathways, such as miRNA-mediated signaling pathways. MiRNAs can regulate gene expression. 2% 27-o-methyl-5-iodo-uridine affects the structure of miRNAs or their binding to target mRNAs, thereby disrupting gene expression regulation and causing cell growth and differentiation to go off track.
In addition, in virus-infected cells, 2% 27-o-methyl-5-iodo-uridine may specifically interfere with viral RNA synthesis. The virus relies on the nucleic acid synthesis mechanism of the host cell to reproduce. This compound is mixed into the viral RNA synthesis process, such as wedging into the foreign body of the machine, destroying the structure and function of the viral RNA, hindering the proliferation of the virus, and demonstrating the potential of antivirus.

2% 27-o-methyl-5-iodo-uridine, Chinese name or 2 '-O-methyl-5-iodouridine. This substance has great potential in the field of biomedicine, and the market prospect is promising.
Looking at the current situation, scientific research demand is a major driving force for its market. When many researchers explore the structure, function and related biological processes of RNA, they often use nucleoside analogs as tools. 2' -O-methyl-5-iodouridine can add help to RNA research due to its unique structure and properties, such as RNA interference, antisense oligonucleotide therapy research, etc. Therefore, the demand for it in the scientific research market may grow.
Furthermore, in the field of pharmaceutical research and development, there are also opportunities. In the research and development of nucleic acid drugs, especially RNA-targeted drugs, this compound may be able to optimize drug properties, such as improving stability and enhancing targeting. With the rise of nucleic acid drug research and development, the demand for 2 '-O-methyl-5-iodouridine may increase.
However, its market also has challenges. The synthesis process may be complicated and the cost may be high, which may hinder large-scale production and marketing activities. And the market competition situation also needs attention. If more congeneric products or alternatives emerge, the competition will become fierce.
Overall, although 2 '-O-methyl-5-iodouridine faces challenges, its market prospects are expected to improve with scientific research and pharmaceutical R & D requests. If problems such as synthesis costs can be overcome, it may occupy an important place in the biomedical market.