2 O Methyl 5 Iodouridine

2% 27 - (o - methyl) - 5 - iodouridine is also a chemical substance. To clarify its chemical properties, the name of the chemical.
"2% 27 -" refers to the 2 'position of the ribose; " (o - methyl) ", there is a methyl substitution at the 2' position; "5 - iodouridine" indicates that there is an iodine atom at the 5 position of uridine.
Uridine is composed of uracil ribose with β-N-glycoside. In this compound, the 5th position of uracil is added with an iodine atom, and the 2nd 'position of ribose is increased with a methyl group. The reduction is roughly as follows: the 1st position of uracil is connected to the 1st' position of ribose, and the 5th position has an iodine atom; the 2nd 'position of ribose is connected to the methyl group, and the 3rd, 4th, and 5th' positions still have the normal formation of ribose. Thus, the reduction is 2% 27 - (o-methyl) - 5 - iodouridine.

2% 27 - (o - methyl) - 5 - iodouridine is a chemical substance. It has a wide range of uses and is often a key player in the field of biomedicine.
First, in nucleic acid research, this substance can be used as a tool to help researchers understand the structure and function of nucleic acids. Because nucleic acids are an important cornerstone of life and are related to the transmission and expression of genetic information, it is crucial to explore their mysteries. 2% 27 - (o-methyl) - 5 - iodouridine can use its unique chemical properties to play a role in the nucleic acid system, or to mark specific nucleic acid fragments, or to affect the folding and hybridization of nucleic acids, enabling researchers to gain a deeper understanding of the mechanism of nucleic acid operation.
Second, it is also of great value in the field of drug development. Many drugs today target nucleic acids, and 2% 27 - (o-methyl) - 5 - iodouridine can mimic part of the structure or function of nucleic acids, or as a lead compound, providing ideas for the development of new antiviral, antitumor and other drugs. Through structural modification and activity studies, it is expected to find innovative drugs with better efficacy and less side effects.
Third, at the level of molecular biology experimental technology, it can be used for the preparation of nucleic acid probes. Nucleic acid probes can accurately identify and bind specific nucleic acid sequences, and assist researchers in detecting and analyzing the existence, expression level and distribution of specific genes in gene detection, gene mapping and other experiments, thus providing strong technical support for life science research.
In short, 2% 27 - (o-methyl) - 5 - iodouridine is used in various fields of biomedicine and has made great contributions to promoting life science research and medical development.

2%27-%28o-methyl%29-5-iodouridine is 2 '- (O-methyl) - 5' -iodouridine, and its synthesis method is as follows:
To prepare 2 '- (O-methyl) - 5' -iodouridine, uridine is often used as the starting material. In the uridine structure, the 2 '-hydroxy, 3' -hydroxy, 5 '-hydroxy of the sugar ring and the N-3 position of the uracil ring are reactive. It is necessary to rationally utilize these active check points and achieve the synthesis of the target product through selective protection and de-protection strategies.
The first step can selectively protect some hydroxyl groups of uridine. Generally, protective groups such as benzyl or tert-butyldimethylsilyl are used. For example, the reaction of tert-butyldimethylchlorosilane (TBDMSCl) with uridine in the presence of a suitable base (such as imidazole) can selectively protect the 5 '-hydroxy group of uridine to generate 5' -O -tert-butyldimethylsilyluridine. This step is mild. In an organic solvent such as dichloromethane, it can be stirred at low temperature. Because the steric resistance of the 5 '-hydroxy group is relatively small, it is easier to react with TBDMSCl.
Next step, the 5-position of the uracil ring is iodized. Using N-iodosuccinimide (NIS) as iodizing reagent, in the presence of suitable catalyst (such as Lewis acid), the reaction is carried out in an organic solvent (such as acetonitrile). Lewis acid can enhance the activity of NIS, making it easier for iodine positive ions to attack the 5-position of uracil ring, realize the 5-iodine reaction, and obtain 5-iodine-5 '-O-tert-butyl dimethylsilyluridine.
Further, methylation of 2' -hydroxy group. Reaction with methylating reagent (such as iodomethane or dimethyl sulfate) under the action of base (such as potassium carbonate). However, because 3 '-hydroxy group also has reactivity, the reaction conditions need to be precisely controlled. With the assistance of a phase transfer catalyst (e.g. tetrabutylammonium bromide), the reaction selectivity can be improved, and the methyl group can be preferentially substituted for the 2 '-hydroxy group to obtain 2' -O-methyl-5-iodine-5 '-O-tert-butyl dimethylsilyluridine.
Last step, remove the 5' -hydroxy protecting group. For the tert-butyl dimethylsilyl protecting group, the tetrahydrofuran solution of tetrabutylammonium fluoride (TBAF) can be used to gently remove the protecting group, resulting in 2 '- (O-methyl) -5-iodouridine.
The whole synthesis process needs to strictly control the reaction conditions and pay attention to the selectivity of each step in order to efficiently obtain the target product 2 '- (O-methyl) -5-iodouridine.

In today's world, it is not easy to know the market price of "2 '- (o-methyl) -5-iodouridine". This is because the market conditions are changing rapidly, and the price is also fluctuating. And the price of this item often varies due to many factors.
First, the situation of supply and demand has a great impact on the price. If there are many people who want it, and there are few suppliers, the price will rise; on the contrary, if the supply exceeds the demand, the price may drop. Second, the quality is also related to the price. Those with high quality are often expensive; those with lower quality may have different prices. Third, the source and origin are also variables in the price. Produced in different places, due to cost, process, etc., the price varies.
Furthermore, there are often no fixed rules for inter-market trading. Or there is an exclusive operation, and the price can be determined at your discretion; or in the open market, the price is determined by the competition of the crowd.
If you want to get an accurate price, go to the chemical market and the trading house of pharmaceutical raw materials to consult the merchants in detail. Or on the online professional trading platform, carefully observe the price trend. Or negotiate with industry experts to get the actual price. However, no matter what method, you must judge the situation and move according to the times to get the true appearance of the price.

2% 27 - (o-methyl) - 5 - iodouridine, that is, 2 '- (o-methyl) - 5 - iodouridine, is quite useful in the field of medicine.
This compound plays a significant role in the development of antiviral drugs. Its unique structure can mimic natural nucleosides and participate in the synthesis process of viral nucleic acid. However, when it is incorporated into viral nucleic acid, it will cause abnormal nucleic acid structure, thereby hindering the replication of viruses. For example, in the study of some RNA viruses, 2' - (o-methyl) - 5 - iodouridine has shown the potential to inhibit the proliferation of viruses, providing new ideas and directions for the development of antiviral drugs.
It has also made its mark in the field of anti-tumor drug research and development. Tumor cells proliferate rapidly and have a strong demand for nucleic acid synthesis raw materials. 2 '- (o-methyl) - 5-iodouridine can enter the nucleic acid synthesis pathway of tumor cells with nucleoside-like properties. Once incorporated into the DNA or RNA of tumor cells, it will interfere with their normal nucleic acid metabolism and cell division, thereby inhibiting the growth of tumor cells. Studies have found that some tumor cell lines are sensitive to it, suggesting that it may become a key component of new anti-tumor drugs.
In addition, in nucleic acid probe labeling technology, 2' - (o-methyl) - 5-iodouridine also plays an important role. Due to its special marker of iodine atom, specific nucleic acid sequences can be tracked and detected by radioactive iodine labeling or other detection methods. In experiments such as gene diagnosis and gene expression analysis, nucleic acid probes labeled with this compound can accurately identify target nucleic acids, helping researchers to deeply explore the function and expression regulation mechanism of genes.