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What are the main uses of 2-pyridinecarboxylic Acid, 4-iodo-, Methyl Ester?
Methyl 4-iodine-2-pyridinecarboxylate, this compound has a wide range of uses and can be used as a key intermediate in the field of medicine to create new drugs. Due to the structural properties of pyridine and ester groups, it can interact with specific targets by chemical modification. For example, in the development of some antimalarial drugs and antimicrobial drugs, it can provide a structural basis, help improve drug activity and selectivity, enhance curative effect and reduce side effects.
In the field of materials science, it may be able to participate in the preparation of functional materials. The conjugated structure of the pyridine ring and the special properties of the iodine atom endow the material with unique optical and electrical properties. For example, in the synthesis of organic optoelectronic materials, the energy level structure and charge transport ability of the material can be adjusted, and it is applied to organic Light Emitting Diodes (OLEDs), solar cells, etc., to improve device performance.
In the field of organic synthetic chemistry, it is an important synthetic building block. With its own active groups, it participates in a variety of reactions, such as substitution reactions with nucleophiles, and builds complex organic molecular structures, providing an effective way for the synthesis of organic compounds with specific structures and functions, promoting the development of organic synthetic chemistry, and helping to create more high-value-added compounds.
2-pyridinecarboxylic Acid, 4-iodo-, Methyl Ester
If you want to make 2-pyridinecarboxylic acid, 4-iodine-methyl ester, you can think about the following path. First, 4-iodine-2-pyridinecarboxylic acid is used as the starting material, which is the foundation of synthesis. Mix it with an appropriate amount of methanol, the amount of methanol needs to be precisely controlled, too little will make the reaction difficult, and too much will increase the separation. Then, concentrated sulfuric acid is introduced as a catalyst, and the amount of concentrated sulfuric acid should be moderate. If it is too high, the product will decompose easily, and if it is too low, the reaction rate will be slow. During the reaction process, pay close attention to the progress of the reaction, which can be monitored by thin-layer chromatography and other means. When the reaction is complete, the product is extracted with an appropriate organic solvent to remove impurities, such as unreacted raw materials and catalysts. After distillation, recrystallization and other operations, the product is purified to obtain high-purity 2-pyridinecarboxylic acid, 4-iodine -, methyl ester.
Another route is to take 2-pyridinecarboxylic acid as the starting material and perform an iodine-substitution reaction to obtain 4-iodine-2-pyridinecarboxylic acid. In the iodine-substitution reaction, the selection of iodine source and the control of reaction conditions are quite critical. The source of iodine or the elemental substance selected from iodine, the reaction temperature, time and other conditions need to be carefully optimized. After the iodine substitution is completed, the esterification reaction with methanol catalyzed by concentrated sulfuric acid is carried out as before, and the product is purified by extraction, distillation, recrystallization and other processes. Such various paths need to be repeatedly explored and optimized in experiments to achieve the ideal synthesis effect.
What are the physical properties of 2-pyridinecarboxylic Acid, 4-iodo-, Methyl Ester
2-Pyridinecarboxylic acid, 4-iodo-, methyl ester, the physical properties of this substance are as follows:
Under normal temperature and pressure, it is mostly white to light yellow crystalline powder, pure in appearance and uniform in texture, and there is no significant color difference or impurities mixed in it.
When it comes to melting point, it is about a specific range, because the exact melting point often varies slightly depending on the preparation method and purity, and probably hovers around [X] ° C. This property is of great significance in the identification and purity determination of substances.
Solubility is also one of the key physical properties. In organic solvents, such as common ethanol, acetone, etc., this substance exhibits a certain solubility. In ethanol, under moderate temperature and stirring conditions, it can dissolve an appropriate amount to form a uniform solution; acetone also has considerable solubility and can better disperse it. However, in water, its solubility is relatively weak, and only a small amount can be dissolved. This is determined by its molecular structure. The groups such as pyridine ring and ester group contained in the molecule make it poorly hydrophilic.
In addition, in terms of density, it can be obtained by precise determination that its density is about [X] g/cm ³. This value reflects the mass of the substance per unit volume. In chemical production and related fields, it has important reference value for the measurement and mixing of materials.
Its stability cannot be ignored. Under normal storage conditions, in a dry, cool and non-bright place, the substance can maintain a relatively stable state without significant changes in chemical properties. However, if exposed to special environments such as high temperature, high humidity or strong oxidants, it may cause chemical reactions and cause changes in its structure and properties.
The above physical properties are indispensable basic information in many fields such as chemical synthesis, drug development and materials science, and are of great significance for the application and research of this substance.
2-pyridinecarboxylic chemical properties of Acid, 4-iodo-, Methyl Ester
Methyl 4-iodine-2-pyridinecarboxylate is a kind of organic compound. In terms of physical properties, it is often solid at room temperature. Due to the arrangement and interaction of atoms in the molecule, it has a specific melting point and boiling point. Generally speaking, the melting point and boiling point are affected by the intermolecular forces, which determine the phase transition temperature of this compound.
Its chemical properties, due to the ester group, can occur hydrolysis reaction. Under acidic or basic conditions, the carbon and oxygen double bonds in the ester group are easily attacked by nucleophiles. In acidic media, the hydrolysis reaction is reversible, and 4-iodine-2-pyridinecarboxylic acid and methanol are gradually formed; in alkaline environment, the hydrolysis is more complete, and carboxylate and methanol are formed, which are common reaction characteristics of ester compounds.
Furthermore, the pyridine ring endows it with unique chemical activity. The pyridine ring is aromatic, and the nitrogen atom makes the ring electron cloud unevenly distributed, and the specific position is more prone to electrophilic substitution. The 4-position iodine atom is also a reactive activity check point and can participate in a variety of organic reactions, such as nucleophilic substitution reactions. The iodine atom can be replaced by other nucleophilic groups to derive a series of new compounds, providing rich possibilities for organic synthesis.
At the same time, the interaction between the atoms in the molecule of the compound results in unique spectral properties such as infrared spectroscopy and nuclear magnetic resonance spectroscopy. With the help of these spectral characteristics, its structure and purity can be accurately identified, which is of great significance for compound analysis, identification and quality control.
2-pyridinecarboxylic Acid, 4-iodo-, Methyl Ester in the market price range
I look at your question, but I am inquiring about the price range of 2-pyridinecarboxylic acid, 4-iodine-methyl ester in the market. However, the price of this chemical is difficult to sum up in a single word, and its price often varies due to many factors.
First, the price of raw materials has a great impact. If the raw materials required to synthesize this chemical are scarce or the price fluctuates, the price of the finished product will also be implicated. If the price of iodine fluctuates, the cost and selling price of this compound will also fluctuate.
Second, the difficulty of the production process is also the key. If the process is complicated, high-end equipment and professional technology are required, the cost will rise, and the price will also rise. And if the production process has strict environmental requirements and additional investment increases, it will also lead to price changes.
Third, the market supply and demand situation determines the price. If there are many applicants and few suppliers, the price will rise; on the contrary, if the supply exceeds the demand, the price may fall.
Fourth, the difference between manufacturers also has an impact. Different manufacturers have different pricing due to different technical levels, economies of scale, and operating costs. Large manufacturers are large in scale and have low costs; small manufacturers or due to technical limitations, the cost is higher and the price is also different.
As for the specific price range, it is difficult to specify precisely. If you want to know the details, you can consult the chemical trading platform and chemical raw material suppliers in detail to get more accurate price information.