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What are the main uses of 2- (trifluoromethyl) -6-iodopyridine?
There is no "2- (triethyl) -6-pyrimidine" related content in "Tiangong Kaiwu", because it was written in the Ming Dynasty, when the field of chemistry had not yet developed to the extent that it could identify and explain the structure and use of such modern chemical substances. However, from the perspective of the ancients' possible cognition of similar substances, a reasonable speculative discussion can be made in classical Chinese form:
If Fu Ruo talks about this unknown thing, although we have not heard of it, it is common sense. Looking at all things in the world, they have their own properties and uses. This "2- (triethyl) -6-pyrimidine" may have special properties because of its unique structure.
If it is used in medicine, it may be a way to cure diseases and save people. Ancient healers often sought medicinal stones to cure the diseases of the people. If this thing can adjust yin and yang, qi and blood, or can be incorporated into the prescription, it is a good prescription for the world. Looking at all medicines in the world, they all use their deviations to correct the deviations of the human body and make them return to peace. If this "2- (triethyl) -6-pyrimidine" has the properties of cold, heat and cold, it will surely be used by physicians to relieve the pain of the common people.
In the matter of craftsmanship, it may also have a wonderful use. Ancient skilled craftsmen were good at using various things to make exquisite tools. If this thing can help in melting and casting, it will make the tools of gold and iron stronger; or in the method of dyeing, it will make the color brighter and longer lasting, it is also unknown. The beauty of craftsmanship lies in making good use of all things. If you can recognize the nature of this "2- (triethyl) -6-pyrimidine", you will be able to add luster to the craftsmanship and create infinite beauty.
In terms of farming, it may also be beneficial. Farmers depend on the land to live and seek abundant grain. If this product can fertilize the soil and make the crops thrive; or it can repel pests and keep the crops intact, it is the luck of farmers. Agriculture is the foundation of the country. If all things can benefit farmers, they will be treasures. If this "2- (triethyl) -6-pyrimidine" has this ability, it should be a great help for farming.
Although we are only speculating, the things in the world are waiting for those who know to explore their uses, so as to benefit all people and become a beautiful thing in the world.
What are the synthesis methods of 2- (trifluoromethyl) -6-iodopyridine?
To prepare 2 - (triethylmethyl) -6 -quinoline, there are many ways to synthesize it, the following are common methods:
Synthesis of
via Skraup reaction This reaction uses aniline, glycerol, concentrated sulfuric acid and nitrobenzene as raw materials. The mechanism is that glycerol is dehydrated by concentrated sulfuric acid to form acronaldehyde, acronaldehyde and aniline are added, dehydrated by concentrated sulfuric acid and oxidized by nitrobenzene, and finally cyclized to obtain 2 - (triethylmethyl) -6 -quinoline. When operating, first take an appropriate amount of glycerol and place it in the reactor, slowly add concentrated sulfuric acid and stir, and heat it up to a specific temperature to fully dehydrate glycerol into acronaldehyde. Next, aniline is slowly dripped in and reacted for a period of time to add the two. Then add nitrobenzene, continue to heat up and stir to complete the cyclization and oxidation steps. This reaction condition is harsh, the temperature needs to be precisely controlled, and nitrobenzene is toxic, so the operation must be cautious.
Synthesis with the help of Doebner-von Miller reaction
With aromatic amines and α, β-unsaturated carbonyl compounds as starting materials, the reaction is carried out under the action of acidic catalysts. For example, when aniline and crotonaldehyde are catalyzed by protonic acid, aniline nucleophilic attacks the β-carbon of crotonaldehyde to form an intermediate, which is then cyclized and dehydrated to obtain the target product. The specific operation is to mix aniline and crotonaldehyde in a certain proportion, add an appropriate amount of acidic catalyst, such as p-toluenesulfonic acid, and reflux at an appropriate temperature. The advantage of this reaction is that the raw materials are relatively easy to obtain and the conditions are relatively mild, but the reaction selectivity needs to be carefully controlled to prevent side reactions.
Synthesis of
by Friedländer reaction uses o-aminobenzaldehyde (or o-aminobenzophenone, etc.) and a carbonyl compound containing α-active hydrogen to react under alkali catalysis. Taking o-aminobenzaldehyde and 2-pentanone as an example, under the action of alkali, the α-hydrogen of 2-pentanone leaves, forming carbon negative ions, attacking the carbonyl carbon of o-aminobenzaldehyde, and generating 2- (triethylmethyl) -6-quinoline through a series of rearrangement and dehydration cyclization. During operation, dissolve o-aminobenzaldehyde and 2-pentanone in a suitable solvent, such as ethanol, add an appropriate amount of alkali, such as potassium carbonate, and heat the reflux reaction. This reaction step is relatively simple, and the yield is usually considerable, but the preparation of raw materials may require some steps.
What are the physical properties of 2- (trifluoromethyl) -6-iodopyridine?
Sanxiang methyl ester is unique in its nature and has several physical characteristics.
First of all, under normal circumstances, Sanxiang methyl ester is mostly in the form of a clear liquid, like jade dew, agile and clear in appearance, without the slightest variegation and turbidity, reflecting light and shadow like a mirror, which is conducive to its flow, transmission and integration in many scenes.
Second and its taste, it has a unique smell. Although it is not rich and pungent, it also has its special smell, just like the subtle fragrance floating from the depths of the forest. Although this smell is not strong, it is unique and recognizable. During its use and contact, it can be detected by people, and this smell is also related to its application in some fields.
Furthermore, in terms of its solubility, Sanxiang methyl ester exhibits good solubility in many organic solvents, and can be miscible with alcohols, ethers and other organic solvents, just like water and emulsion, and it is integrated. This property makes it very useful in chemical synthesis, material preparation and other fields. It can be used as an excellent solvent to help various chemical reactions, so that the reactants are uniformly dispersed, and the reaction occurs fully and efficiently.
As for its boiling point, it is in a certain temperature range. This temperature value enables it to realize the transformation of liquid and gas states under specific conditions. When the temperature rises near the boiling point, Sanxiang methyl ester gradually turns into steam and rises. This property plays a key role in distillation, separation and other process operations. It can be precisely separated and purified by controlling the temperature to obtain high-purity products.
has its density. Compared with water, it has a specific value. With this property, in the process of liquid-liquid separation, it can be effectively separated according to the difference in density from other liquids, just as a wise man can distinguish between each other according to the characteristics in various things.
Sanxiang methyl ester has diverse and unique physical properties. These properties cooperate with each other, making it play an important role in many fields such as chemical industry and materials.
What are the chemical properties of 2- (trifluoromethyl) -6-iodopyridine?
Triethyl boron is as strong as fire, and it burns easily. It explodes in contact with water, just like a beast lurking in the dark. If it is touched slightly, it will cause disaster. This is because of its strong reducibility, it can spontaneously ignite in the air, just like dry wood meets fire and ignites in an instant. And when triethyl boron meets water, it is like an enemy against an enemy, reacting violently, releasing flammable hydrogen, causing the risk of explosion.
Furthermore, triethyl boron is highly toxic, just like an invisible blade, quietly arriving, damaging people's internal organs. Inhalation, touching or accidental ingestion can cause poisoning, ranging from discomfort to dizziness, and serious to life-threatening. Its poison is like a hidden killer, which can take people's lives silently.
Because of its characteristics, triethylboron must be stored and used with extreme caution. It needs to be placed in a cool and dry place, protected from water and oxygen, to prevent accidents. Users can also act in front of protective objects, such as armor, to protect themselves, and operate in a well-ventilated place, just like a safe area. If it is not handled properly, it is like an abyss, and if it is a little careless, it will fall into the abyss of disaster.
What is the price range of 2- (trifluoromethyl) -6-iodopyridine on the market?
Today, there is a price range of di- (Sanxiang methyl) -hexa-azole in the market, which is actually an important factor involved in the price of the market. However, if you want to know its price in detail, you need to consider many reasons.
Looking at all kinds of market goods, the price changes, or because of the source of materials. If the production of Sanxiang methyl and hexa-azole is different, the price will be flat if the material source is wide, and the price will be high if the material source is narrow. For example, if the wood of the mountain forest is easy and abundant, the price of wood will stabilize; if the mountain forest is banned and the wood source is suddenly reduced, the price will rise.
It is also related to the skill of craftsmanship. Those who are skilled in this art are easy and good to make, the cost can be saved, and the price can be cheap; those who are poor in this art are labor-intensive and time-consuming, and the cost of the goods is high, and the price is not low. I am like a smelter of iron, and those who are good at smelting are sharp and save materials. Those who are not good cost materials and are dull, and their prices vary.
Furthermore, the supply and demand of the city is the key to the price. Everyone wants two - (Sanxiang methyl) -six-azole. If the demand is greater than the supply, the price will rise; if the city accumulates this item, the supply will exceed the demand, and the price will be reduced. If the clothes and accessories of the times are prosperous, and there are many people who want them, the price will be expensive; outdated clothes,
However, I have not obtained a detailed number, so it is difficult to determine the range of its price. But according to these reasons, we can observe the materials, observe the manufacturing process, and review the supply and demand in the city, or we can know the approximate price of di- (Sanxiang methyl) -hexa-azole.