What is the chemical structure of (2S) -2-amino-3- [4- (4-hydroxyphenoxy) -3,5-diodol-phenyl] propanoic Acid
(2S) -2 -amino-3- [4- (4 -hydroxyphenoxy) -3,5 -diiodophenyl] propionic acid, this is an organic compound. To clarify its chemical structure, it is necessary to analyze its name, and deduce the structure of each part one by one according to the organic chemical nomenclature.
" (2S) " Chiral central configuration, "2-amino" shows that the amino group is attached to the second carbon of the propionic acid backbone. " 3 - [4- (4-hydroxyphenoxy) -3,5-diiodine-phenyl] "The third carbon of the main chain of epipropionic acid is connected to a benzene ring, the fourth position of the benzene ring is connected to a 4-hydroxyphenoxy group, and the 3rd and 5th positions of the benzene ring are connected to an iodine atom.
In ancient Chinese, this compound has the base of propionic acid, and the side chain is complex. The structure of the main chain propionic acid is established, the amino group is conjugated in the secondary position, and the three-carbon is connected to the benzene ring. The iodine atom and the hydroxyphenoxy group on the ring are arranged in an orderly manner. Looking at its name, it is like the map of After analysis, its structure gradually becomes clear, and it is still visible through clouds and fog. The atoms, group positions and connection methods can be clearly seen in the heart.
What are the physical properties of (2S) -2-amino-3- [4- (4-hydroxyphenoxy) -3,5-diodol-phenyl] propanoic Acid
(2S) -2-Amino-3- [4- (4-hydroxyphenoxy) -3,5-diiodophenyl] propionic acid, which is an organic compound. Its physical properties are quite important and are related to many practical applications of this compound.
Looking at its morphology, under normal circumstances, it is mostly white to quasi-white crystalline powder. This morphology is easy to store and transport. Due to its powder characteristics, it is easy to disperse and mix in subsequent processing operations, which provides convenience for the preparation of various preparations.
On the melting point, it has been accurately determined to be about [specific melting point value]. As one of the important physical properties of a compound, the melting point can be used to determine the purity. If the purity of the compound is quite high, the melting point range is usually narrow; if impurities are doped, the melting point may decrease and the melting range becomes wider.
In terms of solubility, this compound has a certain solubility in organic solvents such as methanol and ethanol. In methanol, with the increase of temperature, the solubility also increases significantly. Moderate heating can dissolve more compounds. This property is of great significance in chemical synthesis and drug preparation, and helps the separation, purification and reaction process of compounds. However, its solubility in water is relatively low, which needs to be taken into account in the design of pharmaceutical dosage forms, or special means are required to improve its dispersibility and solubility in water in order to meet pharmaceutical needs.
Furthermore, the compound has a certain degree of hygroscopicity. In a high humidity environment, it will absorb moisture in the air, causing its own weight to increase and its shape to change. Therefore, it is necessary to strictly control the ambient humidity during storage. It is often placed in a dry and sealed container to prevent the quality and stability from being affected by moisture absorption.
In addition, its density also has a specific value. Density, as the basic physical property of a substance, is indispensable in the process of material measurement and precise control of mixing ratio. It ensures that the ingredients are mixed in a predetermined proportion to achieve the expected product Quality Standards.
What is the main use of (2S) -2-amino-3- [4- (4-hydroxyphenoxy) -3,5-diodol-phenyl] propanoic Acid
(2S) -2 -Amino-3- [4- (4-hydroxyphenoxy) -3,5-diiodophenyl] propionic acid, an organic compound. Its main use covers the field of medicinal chemistry.
In the field of drug development, such compounds may have unique pharmacological activities. The specific functional groups contained in its structure, such as amino, carboxyl, hydroxyl and iodine atoms, can interact with targets in organisms. From the perspective of its structure, hydroxyl and amino groups may participate in the formation of hydrogen bonds, which help them bind to biological macromolecules such as proteins and enzymes, or affect related biological activities. The existence of diiodophenyl, or due to the relatively large atomic radius and electronegativity of iodine atoms, has an impact on the lipophilicity and steric resistance of molecules, which in turn affects their absorption, distribution, metabolism and excretion in vivo.
In the field of medicine, it may be expected to become a lead compound of new drugs. Appropriate structural modification and optimization may enhance its affinity and selectivity to specific disease targets, such as targeting certain inflammation-related enzymes or specific receptors, and then exhibit pharmacological effects such as anti-inflammatory and immune regulation. Or it may make a difference in the development of anti-tumor drugs, by binding to specific targets in tumor cells, interfering with the growth, proliferation and metastasis of tumor cells.
In addition, in organic synthetic chemistry, this compound may serve as an important synthesis intermediate. With its diverse functional groups, compounds with more complex and diverse structures can be derived through various organic reactions, such as esterification, amidation, alkylation, etc., providing an important material basis for the research and development of organic synthetic chemistry.
What are the synthetic methods of (2S) -2-amino-3- [4- (4-hydroxyphenoxy) -3,5-diodol-phenyl] propanoic Acid
The synthesis of (2S) -2-amino-3- [4- (4-hydroxyphenoxy) -3,5-diiodophenyl] propionic acid is a key exploration in the field of organic synthesis. The synthesis of this compound often follows multiple paths.
First, it can be constructed from the starting material through a multi-step reaction. First, a suitable benzene-containing compound is taken, and under specific conditions, a hydroxyphenoxy group is introduced. This step may be catalyzed by a base, so that the phenolic hydroxyl group undergoes a nucleophilic substitution reaction with the halogenated benzene to precisely integrate the 4- (4-hydroxyphenoxy) structure. Subsequently, iodine atoms are introduced at the 3,5 positions of the phenyl ring by halogenation. In the halogenation reaction, the choice of iodine source and catalyst is very important. Commonly used iodine sources such as iodine elemental substance, combined with appropriate oxidizing agent, can promote the directional introduction of iodine atoms into the predetermined position.
Second, the construction of propionic acid side chain is also the key. Reagents such as aldehyde or ketone and diethyl malonate can be used to form corresponding unsaturated esters through Knoevenagel condensation reaction, and then the corresponding unsaturated esters can be obtained through reduction, hydrolysis and other steps to obtain propionic acid structure. And during the synthesis process, attention should be paid to the construction and maintenance of chiral centers. If chiral additives or chiral catalysts are used, to ensure that the product is in the (2S) configuration. In the step of introducing amino groups, suitable amination reagents can be selected, and under appropriate conditions, they can be reacted with intermediates to obtain the key structure of the target product.
Synthesis of this compound requires fine regulation of the reaction conditions at each step, including temperature, reaction time, and ratio of reactants, etc., in order to improve the yield and purity, and obtain high-quality (2S) -2-amino-3- [4- (4-hydroxyphenoxy) -3,5-diiodophenyl] propionic acid.
What is the market outlook for (2S) -2-amino-3- [4- (4-hydroxyphenoxy) -3,5-diodol-phenyl] propanoic Acid?
(2S) -2 -Amino-3- [4- (4 -hydroxyphenoxy) -3,5 -diiodophenyl] propionic acid, this is an organic compound. To observe its market prospects, it needs to be observed by many parties.
It may have potential in the field of medicine. New molecular entities are being developed in medicine to solve the problem of diseases. The structural properties of this compound may interact with specific biological targets, which may have the potential to control diseases. If drugs targeting specific receptors are developed, they may be candidates. However, the road to pharmaceutical research and development is difficult. From laboratory to clinical application, it requires many trials and errors. After cell experiments, animal experiments and human clinical trials, it takes a long time and costs a lot.
In the chemical industry, or as an intermediate. After chemical transformation, a variety of compounds are derived for use in coatings, plastics and other industries. Chemical production is heavy on scale and cost. If this compound can be synthesized efficiently and costs can be reduced, it may have a place in the chemical industry chain.
However, its market also has challenges. Synthesis of the compound may require complex processes and special raw materials, and the cost is difficult to control. And similar competitors or existing markets, in order to occupy market share, need to have unique advantages. Furthermore, environmental regulations are becoming stricter, and the production process needs to comply with the concept of green chemistry, otherwise it may be limited.
In summary, (2S) -2 -Amino-3- [4- (4-hydroxyphenoxy) -3,5 -diiodophenyl] propionic acid has addressable market opportunities, but there are challenges in research and development, cost, competition and environmental protection. Practitioners should be cautious and seek opportunities for development.