What is the chemical structure of (2s, 3s) -3-hydroxy-3- (4-iodophenyl) -2- (methylamino) propionic Acid?
(2S, 3S) -3-hydroxy-3- (4-iodophenyl) -2- (methylamino) propionic acid, which is an organic compound. Looking at its naming, its chemical structure can be deduced according to the naming rules of organic chemistry.
" (2S, 3S) " The configuration of the chiral carbon atom, there are two chiral carbons in this molecule, and the configuration is S. "3-hydroxy" indicates that there is a hydroxyl group (-OH) attached to the 3rd carbon atom. "3 - (4-iodophenyl) " indicates that the 3rd carbon is connected with a phenyl group, and the 4th position of the phenyl group has an iodine atom substituted. " 2 - (methylamino) "The second carbon in the table is connected with methylamino (-NHCH)." Propionic acid "determines that its main chain is a carboxylic acid containing three carbon atoms, and the carboxyl group (-COOH) is at one end.
Therefore, its chemical structure is roughly as follows: based on the main chain of propionic acid, the second carbon is connected with methylamino, the third carbon is connected with hydroxyl and 4-iodophenyl. In this way, the chemical structure of (2S, 3S) - 3-hydroxy-3- (4-iodophenyl) -2- (methylamino) propionic acid can be outlined.
What are the main uses of (2s, 3s) -3-hydroxy-3- (4-iodophenyl) -2- (methylamino) propionic Acid?
(2S, 3S) - 3-hydroxy-3- (4-iodophenyl) - 2 - (methylamino) propionic acid, which has a wide range of uses. In the field of medicine, it can be used as a key intermediate to create drugs with unique curative effects. It contains specific functional groups in its structure, which can precisely interact with biological macromolecules in the body, or regulate physiological processes, or intervene in disease processes, so it is important for pharmaceutical craftsmen.
In the process of scientific research, it is often an important research object. Chemists can explore it in depth, gain insight into the mechanism of chemical reactions, and explore methods for synthesizing novel compounds, which can open up new frontiers in the field of chemistry. Its special spatial structure and electronic effects can lead to a variety of chemical reactions, providing many opportunities for researchers to explore.
In addition, in materials science, or with appropriate modifications, it has become the cornerstone of building materials with special properties. With its unique chemical properties, it endows materials with special properties such as biocompatibility and optical activity, making materials stand out in biomedical materials, optical materials, etc.
All of these highlight the important uses of (2S, 3S) -3-hydroxy-3- (4-iodophenyl) -2- (methylamino) propionic acid in many fields, and it is a compound that cannot be underestimated.
What are the physical properties of (2s, 3s) -3-hydroxy-3- (4-iodophenyl) -2- (methylamino) propionic Acid?
(2S, 3S) - 3-hydroxy-3- (4-iodophenyl) -2- (methylamino) propionic acid, which is an organic compound. Looking at its structure, it contains many functional groups such as hydroxyl, iodophenyl, methylamino and carboxyl, which endows it with unique physical properties.
Let's talk about solubility first, because it has carboxyl and hydroxyl groups, both of which are hydrophilic groups and can form hydrogen bonds with water molecules, so it should have a certain solubility in water or some polar solvents. However, the molecule also contains iodophenyl, a hydrophobic group, or its solubility in polar solvents is limited.
Besides the melting point, the molecules can interact with each other through hydrogen bonds, and both carboxyl and hydroxyl groups can participate in the formation of hydrogen bonds. This hydrogen bond action enhances the intermolecular force. To melt or boil it, more energy is required to overcome this force, so the melting point of the compound is relatively high.
In addition, because the iodine atom is relatively large relative to the atom and has a certain polarity, it also affects the density and refractive index of the molecule. Density or relatively large due to the heavier iodine atom, and the refractive index will also show specific values due to the type and structural characteristics of the atoms in the molecule. The physical properties of this compound are closely related to the interaction of various groups in its structure, and cannot be ignored in chemical research and practical applications.
What is the synthesis method of (2s, 3s) -3-hydroxy-3- (4-iodophenyl) -2- (methylamino) propionic Acid?
To prepare (2S, 3S) -3 -hydroxy-3- (4 -iodophenyl) -2 - (methylamino) propionic acid, the method is as follows:
First, take the appropriate starting material, which should contain benzene ring and can introduce the structure of iodine atom in the para-position, and can derive hydroxyl, methylamino and carboxyl groups. If a styrene compound with suitable substituents is used as the starting material.
The first step is to iodize the para-position of the benzene ring. A suitable iodizing agent can be selected, such as iodine elemental compound combined with an appropriate oxidizing agent, under mild reaction conditions, so that the iodine atom precisely replaces the hydrogen atom of the benzene ring para-position to obtain a compound containing 4-iodophenyl group.
In the next step, the double bond is functionalized through a suitable reaction. Asymmetric oxidation can be used to introduce hydroxyl groups, and the stereochemistry of the reaction needs to be controlled, so that the hydroxyl groups are formed in the (3S) configuration. In this step, chiral catalysts, such as chiral metal complexes, can be used to promote the reaction to the expected stereoscopic configuration under specific solvents and reaction temperatures.
Furthermore, methylamino groups are introduced. The nucleophilic substitution reaction with methylamine can be used to replace the group at a specific position. At the same time, attention should be paid to the influence of the reaction conditions on the stereochemistry to ensure the formation of the (2S) configuration. The reaction conditions in this step need to be carefully controlled, such as the pH of the reaction, the temperature and the ratio of the reactants.
Finally, the obtained product is purified appropriately, such as recrystallization, column chromatography, etc., to obtain high-purity (2S, 3S) -3-hydroxy-3- (4-iodophenyl) -2- (methylamino) propionic acid. The entire synthesis process requires precise control of the reaction conditions at each step to achieve the expected product structure and stereochemistry requirements.
What are the safety precautions for (2s, 3s) -3-hydroxy-3- (4-iodophenyl) -2- (methylamino) propionic Acids?
(2S, 3S) - 3-hydroxy-3- (4-iodophenyl) - 2 - (methylamino) propionic acid This substance is life-threatening, and many safety matters need to be paid attention to when using it.
First, toxicity considerations. This compound may be toxic to some extent and may be in contact with or cause harm to the human body. When operating, be sure to wear protective clothing, such as lab clothes, gloves, and goggles to prevent it from touching the skin and eyes. If you come into contact accidentally, rinse with plenty of water immediately, and seek medical treatment in severe cases.
Second, chemical properties. Its chemical properties are active, or react with other substances. When storing, it should be placed separately from oxidizing and reducing substances to prevent dangerous reactions. During the use process, avoid random mixing with common chemical reagents such as acids and bases. Read the chemical safety technical manual carefully before use to clarify its chemical properties and reaction taboos.
Third, environmental impact. Do not discharge it into the environment at will, because it may cause pollution to the environment and endanger the ecological balance. The waste generated by the experiment should be properly disposed of in accordance with relevant regulations, or handed over to professional institutions for disposal to reduce its adverse impact on the environment.
Fourth, specifications for use. Non-professionals should not try to operate this compound easily. When used by professionals, they must also strictly follow the operating procedures and dosage requirements, and must not change the experimental conditions and dosage without authorization. Supervision and emergency measures should be taken throughout the experiment to ensure safe operation.