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What is the main use of 3- (3-iodopropyl) -7,8-dimethoxy-1, 3-dihydro-2h-3-benzazepin-2-one
3- (3-iodopropyl) -7,8-dimethoxy-1,3-dihydro-2H-3-benzazepine-2-one, this is an organic compound. Its main use involves the field of pharmaceutical chemistry.
In the process of drug development, such compounds are often used as key intermediates. Through organic synthesis, its structure can be modified and modified to derive new compounds with specific biological activities. It may be able to target specific disease targets and exhibit pharmacological activities, such as anti-tumor, antibacterial, antiviral equivalents, laying the foundation for the creation of innovative drugs.
In addition, in the field of organic synthesis chemistry, various functional groups in its structure, such as iodine atom, methoxy group, ketone carbonyl group, etc., endow it with rich reactivity. Iodine atoms can participate in various reactions such as nucleophilic substitution and coupling, which helps to construct complex organic molecular structures; methoxy groups and ketone carbonyl groups can also participate in various reactions, providing the possibility for the synthesis of more complex and special functional organic materials. Therefore, this compound has great significance and broad potential in the field of organic synthesis and medicinal chemistry.
What are the synthesis methods of 3- (3-iodopropyl) -7,8-dimethoxy-1, 3-dihydro-2h-3-benzazepin-2-one
There are various ways to prepare 3- (3-iodopropyl) -7,8-dimethoxy-1,3-dihydro-2H-3-benzazepine-2-one.
First, it can be started from 7,8-dimethoxy-1,3-dihydro-2H-3-benzazepine-2-one to carry out nucleophilic substitution with 3-iodohalopropane in the presence of suitable bases and solvents. In this process, the alkali can be selected from potassium carbonate, sodium carbonate, etc., and the solvent is N, N-dimethylformamide (DMF), acetonitrile, etc. When reacting, it is necessary to pay attention to the control of temperature, usually under moderate heating conditions, the reaction can proceed smoothly, and the nitrogen atom can launch a nucleophilic attack on the halogen atom of 3-iodohalopropane, and then generate the target product.
Second, the parent nuclear structure of benzoxazepine can be constructed first, and then 3-iodopropyl is introduced. For example, a suitable anthranilic acid derivative and a dihalogen are cyclized to form the skeleton of benzoxazone, and then 3-iodopropyl is connected to a specific location by halogenation. In this path, the cyclization reaction conditions are quite critical, and specific catalysts and reaction media may be required to ensure the selectivity and yield of cyclization. In the halogenation reaction, the activity of the reaction substrate and the effect of reaction conditions on the substitution position need to be considered.
Furthermore, a stepwise synthesis strategy can be tried. First, an intermediate containing a partial structure is prepared, and then through a multi-step reaction, it is gradually spliced into a complete target molecule. In this process, each step of the reaction needs to be precisely controlled to ensure the smooth progress of the reaction and the purity of the product. After each step of the reaction, separation and purification operations may be required to remove impurities and provide pure raw materials for the next reaction. In this way, a series of carefully designed and operated reactions can yield 3- (3-iodopropyl) -7,8-dimethoxy-1,3-dihydro-2H-3-benzazepine-2-one.
What are the physical properties of 3- (3-iodopropyl) -7,8-dimethoxy-1,3-dihydro-2h-3-benzazepin-2-one
3- (3-iodopropyl) -7,8-dimethoxy-1,3-dihydro-2H-3-benzazepine-2-one, is an organic compound. Its physical properties can be viewed from the following points.
The appearance of the first word is often solid, but its specific color state may vary depending on the purity and crystallization conditions, or it may be white to white powder. Due to the arrangement and interaction of atoms in its molecular structure, it forms a relatively regular lattice structure under normal conditions, and then presents such an appearance.
As for the melting point, the melting point of this compound also has a specific value, which reflects the size of its lattice energy. Intermolecular forces, such as van der Waals forces, hydrogen bonds, etc., are crucial in determining the melting point. Functional groups such as methoxy and carbonyl contained in its structure affect the lattice stability through weak intermolecular interactions, resulting in its melting point being maintained within a certain range. However, the exact value needs to be accurately determined by experiments.
In terms of solubility, due to the presence of groups with certain polarities in the molecule, such as methoxy and carbonyl, as well as relatively non-polar benzene rings and alkyl groups, its solubility performance is relatively unique. In polar organic solvents, such as ethanol and acetone, or with a certain solubility, its polar groups can form hydrogen bonds or dipole-dipole interactions with solvent molecules; while in non-polar solvents, such as n-hexane, the solubility is relatively small, due to the weak interaction between the non-polar part and the non-polar solvent.
Density is also one of its important physical properties. The density of this compound is closely related to the type, quantity and spatial arrangement of molecules. The relative atomic mass of each atom and the distribution in space jointly determine the mass of its unit volume, but the exact density value also needs to be determined experimentally.
In addition, its refractive index cannot be ignored. The refractive index reflects the change of the propagation speed of light in the substance, and is related to the distribution of electron clouds and the properties of chemical bonds in molecules. The existence of π electron clouds in molecules and the polarity of chemical bonds both affect the propagation of light, resulting in a specific refractive index. This value is of great significance in identification and purity analysis.
What are the chemical properties of 3- (3-iodopropyl) -7,8-dimethoxy-1,3-dihydro-2h-3-benzazepin-2-one
3- (3-iodopropyl) -7,8-dimethoxy-1,3-dihydro-2H-3-benzazepine-2-one is an organic compound with specific chemical properties.
Its physical properties are either solid at room temperature. Due to the structure of the molecule containing aromatic rings, carbonyl groups and methoxy groups, the intermolecular force has a certain strength. The melting point may be affected by the interaction between molecules, and the specific melting point value needs to be accurately determined by experiments. In terms of solubility, in view of the polarity of the molecule, it may have a certain solubility in polar organic solvents such as ethanol and acetone, but in non-polar solvents such as n-hexane, the solubility may be low.
Chemically, the iodine atom of the iodopropyl group in this compound has high reactivity and can undergo nucleophilic substitution reactions. For example, when encountering nucleophilic reagents such as sodium alcohol and amines, the iodine atom is easily replaced to form new carbon-oxygen or carbon-nitrogen bonds. This property can be used to construct complex molecular structures in organic synthesis. Its benzoxazepine ring system also has certain reactivity, because the nitrogen atom in the ring has lone pair electrons, which can participate in electrophilic reactions. Although the methoxy group on the ring is relatively stable, under specific conditions, such as strong acidic or basic environments, or demethylation reactions, the molecular structure and properties are affected. In addition, the 2-position carbonyl group can undergo typical carbonyl reactions, such as addition reactions with nucleophiles, or reduction under the action of reducing agents.
The chemical properties of this compound provide many possibilities for organic synthesis, medicinal chemistry and other fields. According to its properties, researchers can design synthetic routes and prepare derivatives with specific functions for application in medicine, materials and other fields.
3- (3-iodopropyl) -7,8-dimethoxy-1,3-dihydro-2h-3-benzazepin-2-one What is the price range in the market?
I do not know that "3- (3-iodopropyl) -7,8-dimethoxy-1,3-dihydro-2H-3-benzazepine-2-one" is in the market price range. The price of this compound may vary widely due to various factors such as application, purity, supply and demand. If you want to know its price, you can explore it in the following ways:
First, consult the chemical reagent supplier. Many professional chemical reagent suppliers often supply such compounds, and you can directly inquire about their price, and the price varies with different purity and packaging specifications.
Second, look at the online chemical trading platform. Nowadays, there are many online platforms that list the prices of various chemicals, or you can find relevant price information here.
Third, ask scientific research institutions or enterprises. Institutions or enterprises involved in the research and development and production of this compound may be able to tell the approximate price range. However, market conditions are changing rapidly, and the pricing strategies of various suppliers are different, so the exact price needs to be consulted with all relevant parties before it can be obtained.