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What is the chemical structure of the 3 ', 5' -di-o-acetyl-2 '-deoxy-5-iodouridine?
3% 27% 2C5% 27 - di - o - acetyl - 2% 27 - deoxy - 5 - iodouridine, which is the name of an organic compound. Its chemical structure is as follows:
This compound is based on uridine, which is formed by connecting uridine to ribose through β-N- glycoside bonds.
Among its structures, "2% 27 - deoxy" indicates that the 2-hydroxy (- OH) of ribose lacks oxygen atoms, which is the structural characteristic of deoxyribonucleoside, and the compound belongs to the deoxyribonucleoside class.
"5-iodo" indicates that there is an iodine atom attached to the fifth carbon atom of uracil. The introduction of this halogen atom may cause changes in the physical, chemical and biological activities of the compound.
Furthermore, "3% 27% 2C5% 27-di-o-acetyl" means that the 3rd and 5th hydroxyl groups of ribose are estered with acetyl groups (CH 🥰 CO -), respectively. The presence of acetyl groups also affects the properties of compounds, such as enhancing fat solubility or protecting hydroxyl groups in specific reactions.
In summary, the chemical structure of 3% 27% 2C5% 27 - di - o - acetyl - 2% 27 - deoxy - 5 - iodouridine consists of iodouracil and 3,5 - di - O - acetyl - 2 - deoxyribose linked by glycosidic bonds, thus endowing the compound with unique physicochemical and biological properties.
What are the main uses of 3 ', 5' -di-o-acetyl-2 '-deoxy-5-iodouridine?
3% 27% 2C5% 27 - di - o - acetyl - 2% 27 - deoxy - 5 - iodouridine, this is an organic compound. Its main uses are quite extensive.
In the field of medicine, it is often used as a key component of antiviral drugs. Because of the unique structure of this compound, it can have a significant impact on the replication process of viruses. To reproduce and proliferate, viruses need to rely on various mechanisms of host cells. This compound can precisely act on the synthesis of viral nucleic acid, inhibit the generation of viral genetic material, and then effectively contain the spread and spread of viruses, providing a powerful means for antiviral therapy.
It is also of great value in the field of scientific research and exploration. Scientists often use it as a research tool to delve deeper into the mysteries of nucleic acid biology. By observing the interaction patterns between this compound and nucleic acids, and the pathways that affect nucleic acid metabolism, etc., it can improve the understanding of the basic processes of life. For example, when studying the mechanisms of DNA and RNA synthesis, repair and transcription, this compound can be used as a marker or inhibitor to help researchers analyze relevant molecular mechanisms, providing key clues for basic biomedical research.
Furthermore, in the process of drug development, it plays an indispensable role. Medicinal chemists use it as a lead compound to modify and modify its chemical structure in order to develop new drugs with better efficacy and fewer side effects. Based on the structural properties of this compound, a series of derivatives can be designed and synthesized, which are screened and optimized by pharmacological activity, and are expected to obtain more potential drug candidates, which will promote the progress of drug research and development.
What is the preparation method of 3 ', 5' -di-o-acetyl-2 '-deoxy-5-iodouridine?
To prepare 3% 27% 2C5% 27 - di - o - acetyl - 2% 27 - deoxy - 5 - iodouridine, the method is as follows:
Take 2 '-deoxyuridine as the starting material, which is the key thing. React with an appropriate amount of acetylation reagent, such as acetic anhydride, and often pyridine as the catalyst in the presence of a suitable catalyst. This reaction needs to be controlled at an appropriate temperature range, generally between low temperature and room temperature, so that it can fully acetylate to obtain 2', 5 '-di - o - acetyl - 2' -deoxyuridine.
Then, add the obtained product to an iodizing reagent. Commonly used iodizing agents such as N-iodosuccinimide (NIS) are iodized in a suitable solvent system, such as dichloromethane and other inert organic solvents. This step also requires careful temperature control and reaction time to avoid side reactions. After careful reaction operation and conditions control, 3% 27% 2C5% 27 - di - o - acetyl - 2% 27 - deoxy - 5 - iodouridine can be obtained. After the reaction, it needs to go through separation and purification steps, such as column chromatography, to obtain a high-purity target product. Thus, the method of preparing 3% 27% 2C5% 27 - di - o - acetyl - 2% 27 - deoxy - 5 - iodouridine.
What are the physical and chemical properties of 3 ', 5' -di-o-acetyl-2 '-deoxy-5-iodouridine?
3% 27% 2C5% 27-di-O-acetyl-2% 27-deoxy-5-iodouridine, this is an organic compound. It has many physical and chemical properties.
Looking at its solubility, the solubility of this substance varies in organic solvents. In polar organic solvents such as dimethyl sulfoxide (DMSO), it has good solubility and can be well dispersed. Due to the strong polarity of DMSO, various intermolecular forces can be formed with the compound, such as hydrogen bonds, van der Waals forces, etc., to help it dissolve. However, in non-polar organic solvents such as n-hexane, the solubility is not good. Because of its non-polarity, the intermolecular force between the molecule and the polar compound is weak, and it is difficult to interact with the polar compound to cause dissolution.
When it comes to stability, under normal temperature and dry environment, it is relatively stable and the chemical structure can be maintained for a certain period of time. However, in high temperature, high humidity or strong light environment, the stability is affected. At high temperature, the thermal motion of molecules intensifies, the vibration of chemical bonds increases, and some chemical bonds may break and cause structural changes. In high humidity environment, water molecules can participate in chemical reactions, or initiate reactions such as hydrolysis, which destroy the molecular structure. Under strong light irradiation, photon energy can stimulate molecular electron transitions, causing photochemical reactions and changing their chemical structures.
In terms of melting point, it has a specific melting point value after determination, which is an important physical parameter for the identification of this compound. The melting point can reflect the strength of intermolecular forces and the regularity of crystal structure. Its melting point is determined by intermolecular forces, such as hydrogen bonds, van der Waals forces, etc. The intermolecular forces are strong and the melting point is usually high.
From the perspective of chemical properties, due to the acetyl group, it has ester properties, and can undergo hydrolysis reaction under acid or alkali catalysis. Under acidic conditions, the hydrolysis reaction is relatively mild, gradually breaking the ester bond between the acetyl group and other parts of the molecule; under alkaline conditions, the hydrolysis reaction is usually more rapid and complete, and the acetyl group is quickly removed. In addition, the iodine atoms in the molecule have certain reactivity and can participate in some nucleophilic substitution reactions, providing the possibility for chemical modification and derivatization.
3 ', 5' -di-o-acetyl-2 '-deoxy-5-iodouridine What are the precautions during use?
3% 27% 2C5% 27 - di - o - acetyl - 2% 27 - deoxy - 5 - iodouridine is also a chemical substance. When using, many things should be paid attention to.
First, safety is essential. This substance may be toxic and dangerous to a certain extent. When coming into contact, be sure to wear appropriate protective equipment, such as gloves, goggles and protective clothing, to prevent it from contacting the skin, eyes and respiratory tract and causing damage to the body. The operation should be carried out in a well-ventilated environment, or with the help of a fume hood, so that harmful gases can be discharged in time to ensure the safety of the operator.
Second, precise operation. Because it is a chemical substance, all operations such as weighing, dissolving, and mixing need to be accurate. Use accurate measuring instruments and follow established operating procedures to ensure the accuracy and reliability of experimental results. And when preparing a solution, you must pay attention to the choice of solvent. Different solvents may have different effects on their solubility and chemical properties.
Furthermore, storage should not be underestimated. It should be stored in a dry, cool and dark place, away from fire sources and oxidants. According to its chemical properties, choose an appropriate storage container to prevent it from chemically reacting with the container material and causing material deterioration.
In addition, waste disposal is also key. After use, the remaining substances and related waste should not be discarded at will, and must be properly disposed of in accordance with relevant regulations to prevent pollution to the environment.
In short, when using 3% 27% 2C5% 27 - di - o - acetyl - 2% 27 - deoxy - 5 - iodouridine, all matters such as safety, precision operation, suitable storage and proper disposal of waste need to be treated carefully to ensure the safety and effectiveness of the use process.