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What is the chemical structure of 3 ', 5' -di-o-acetyl-5-iodo-2 '-deoxyuridine?
3% 27% 2C5% 27 - di - o - acetyl - 5 - iodo - 2% 27 - deoxyuridine, this is the name of an organic compound, and its chemical structure is quite complex. This compound is a derivative of deoxyuridine, which is modified at a specific position.
Its core structure is deoxyuridine, which is formed by connecting one molecule of deoxyribose to one molecule of uracil base. On this basis, the hydroxyl group is modified in the deoxyribose part at the 2 'position. Specifically, the hydroxyl group at the 2 'and 5' positions is esterified with the acetyl group (-COCH
), respectively, to form the 2 ', 5' -di-o-acetyl structure. Furthermore, on the carbon atom at the 5 position of the uracil base, the hydrogen atom is replaced by the iodine atom, which forms a 5-iodine structure. In this way, through the specific modification of deoxyuridine, the unique chemical structure of 3% 27% 2C5% 27 - di - o - acetyl - 5 - iodo - 2% 27 - deoxyuridine is constructed. This structure endows the compound with specific physical and chemical properties, which may have unique uses and research value in the fields of medicine, biology, etc.
What are the main uses of 3 ', 5' -di-o-acetyl-5-iodo-2 '-deoxyuridine?
3% 27% 2C5% 27 - di - o - acetyl - 5 - iodo - 2% 27 - deoxyuridine, Chinese name is often 3 ', 5' -di - O - acetyl - 5 - iodo - 2 '-deoxyuridine, which is mainly used in pharmaceutical research and other fields.
In the field of medicine, it is often the key raw material for the synthesis of antiviral drugs. The unique structure of Gain can mimic natural nucleosides, which can inhibit virus replication by interfering with the synthesis of viral nucleic acid. In the development of antiviral drugs, researchers often use it as a starting material and modify it through various chemical reactions to obtain new drugs with better efficacy and fewer side effects.
In the field of biochemical research, it also has important functions. It can be used as a probe to trace the metabolic process of nucleic acid in cells. By labeling this compound, researchers can gain insight into a series of dynamic changes such as nucleic acid synthesis, repair and degradation in cells under specific physiological or pathological states, providing key clues for analyzing the mechanism of cell life activities.
Furthermore, it is a powerful tool in drug screening experiments. Researchers can use it to construct specific cell models or animal models to screen compounds with potential antiviral activity. To evaluate the interaction between the test compound and 3 ', 5' -di-O-acetyl-5-iodine-2 '-deoxyuridine, and the degree of inhibition of viral replication, in order to determine the potential of new drug development and promote the development of antiviral drugs.
3 ', 5' -di-o-acetyl-5-iodo-2 '-deoxyuridine What are the precautions during use?
3% 27% 2C5% 27 - di - o - acetyl - 5 - iodo - 2% 27 - deoxyuridine is a special compound. When using, many precautions must be observed.
bear the brunt, the toxicity of this substance should be paid attention to. It may cause certain hazards to organisms, so comprehensive protective measures must be taken during operation. Such as wearing protective clothing, wearing gloves, masks and goggles to avoid contact with the skin, respiratory tract and eyes, causing damage to the body.
Furthermore, its stability cannot be ignored. The compound may decompose or deteriorate under specific temperature, humidity and light conditions. Therefore, it should be properly stored in a dry, cool and dark place to maintain the stability of its chemical properties and ensure the use effect.
During use, precise dosage control is the key. If the dose is too small, it may not achieve the expected effect; if the dose is too large, it is easy to cause adverse reactions. Be sure to use it accurately according to the experimental purpose or treatment needs, strictly refer to relevant standards and guidelines.
In addition, its interaction with other substances should not be underestimated. Or chemically react with certain compounds, change their properties or reduce their efficacy. Before mixing, study their compatibility carefully to prevent adverse consequences.
In conclusion, when using 3% 27% 2C5% 27 - di - o - acetyl - 5 - iodo - 2% 27 - deoxyuridine, care should be taken with regard to toxicity, stability, dose and interaction to ensure the safety and effectiveness of use.
What is the synthesis of 3 ', 5' -di-o-acetyl-5-iodo-2 '-deoxyuridine?
3% 27% 2C5% 27 - di - o - acetyl - 5 - iodo - 2% 27 - deoxyuridine, Chinese name is often 3 ', 5' -di - O - acetyl - 5 - iodine - 2 '-deoxyuridine, the synthesis method is as follows:
First take 2' -deoxyuridine as the starting material, which is the basis of synthesis. Place it in an appropriate reaction vessel and add an appropriate amount of acetylating reagents, such as acetic anhydride and catalysts, common catalysts such as pyridine. The purpose of this step is to acetylate the 3 'and 5' hydroxyl groups of 2 '-deoxyuridine. When reacting, attention should be paid to the control of temperature and reaction time. Generally speaking, the temperature should be maintained in the range of room temperature to moderate heating, about 20 ° C - 50 ° C. The reaction lasts for several hours, such as 3 - 5 hours. The reaction process is monitored by thin layer chromatography. When the reaction reaches the expected level, an intermediate product containing 3', 5 '-di-O-acetyl-2' -deoxyuridine is obtained.
Subsequently, the above intermediate product is iodized. The intermediate product is dissolved in a suitable solvent, such as dichloromethane and other inert solvents, and an iodine source, such as N-iodosuccinimide (NIS), is added. During the reaction process, the temperature and time also need to be adjusted, and the temperature may be between 0 ° C and 30 ° C. The reaction takes several hours, about 2-4 hours. This iodine step is designed to introduce iodine atoms at the 5 position, and finally be separated and purified by means such as column chromatography to obtain high-purity 3 ', 5' -di-O-acetyl-5-iodine-2 '-deoxyuridine products. The entire synthesis process requires careful operation and strict control of various reaction conditions to ensure the purity and yield of the product.
What is the market price of 3 ', 5' -di-o-acetyl-5-iodo-2 '-deoxyuridine?
3% 27% 2C5% 27 - di - o - acetyl - 5 - iodo - 2% 27 - deoxyuridine, this is the name of a chemical substance, often used as a reagent in the field of pharmaceutical research. However, its market price is difficult to generalize, because many factors have an impact.
First, the price varies depending on the manufacturer. Products produced by famous factories with exquisite craftsmanship and strict quality control may have high prices; while some small factories, although the cost is controllable and the price is low, the quality may vary.
Second, product purity is the key factor. Those with high purity are indispensable for fine experiments and high-end research, so the price is high; those with low purity are only suitable for ordinary basic experiments, and the price is relatively close to the people.
Third, the purchase quantity also affects the price. For bulk purchases, manufacturers may give discounts due to scale effects; for small purchases, the unit price is often higher.
Fourth, the market supply and demand relationship has a great impact. If demand is strong and supply is limited, prices will rise; if supply exceeds demand, prices will fall.
To know the exact price, consult major chemical reagent suppliers, such as Sinopharm Group Chemical Reagent Co., Ltd., search banner reagent network, etc., compare their quotations, and combine their own needs to obtain the right choice and price.