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What is the chemical structure of 3 ', 5' -diacetyl-5-iodo-2 '-deoxyuridine?
3% 27% 2C5% 27 - diacetyl - 5 - iodo - 2% 27 - deoxyuridine, its name is 3 ', 5' -diacetyl-5-iodo-2 '-deoxyuridine. This is an organic compound, a nucleoside analogue, which is quite important in the field of medicine and biochemical research.
To observe its chemical structure, deoxyuridine is used as the basic structure. Deoxyuridine is formed by connecting deoxyribose to uridine through β-N-glycoside bonds. On this basis, acetylation reactions occur at the hydroxyl groups at the 3' and 5 'positions, each introducing an acetyl group, that is, a -COCH group. The hydrogen atom at position 5 is replaced by the iodine atom.
This structure endows it with unique physicochemical and biological activities. The iodine atom in its structure increases the molecular volume and electron cloud density, affects molecular polarity and fat solubility, and is of great significance for its transmembrane transportation and cell uptake. The presence of 3 ', 5' -diacetyl group enhances molecular stability. Under specific conditions in vivo, acetyl groups can be hydrolyzed and separated, releasing active forms to play a role.
In medical research, due to its structure similar to natural nucleosides, it can participate in nucleic acid metabolism and interfere with DNA synthesis, so it is often used as a lead compound for the development of antiviral and anti-tumor drugs.
What are the main uses of 3 ', 5' -diacetyl-5-iodo-2 '-deoxyuridine?
3% 27% 2C5% 27-diacetyl-5-iodine-2% 27-deoxyuridine, this is a very useful organic compound. Its main use is manifested in the field of pharmaceutical research and treatment.
In the field of pharmaceutical research, it is often used as a key tool in nucleic acid metabolism research. Because of its structure resembling natural nucleoside substances, it can participate in the process of nucleic acid biosynthesis. By tracking its metabolic pathway and mechanism in cells, it helps researchers to deeply understand the mysteries of nucleic acid metabolism and lay a solid foundation for the study of the pathogenesis of many diseases.
In the field of therapy, this compound shows unique potential in antiviral and antitumor therapies. When anti-viral, it can effectively inhibit the replication and transmission of the virus in the host by interfering with the synthesis of viral nucleic acid, and then achieve the purpose of anti-viral infection. In anti-tumor therapy, it can interfere with the nucleic acid metabolism of tumor cells, hinder the division and proliferation of tumor cells, and provide an effective means for the treatment of specific tumor diseases.
Overall, 3% 27% 2C5% 27-diacetyl-5-iodine-2% 27-deoxyuridine contributes an important force to the development of human health due to its important use in the field of medical research and treatment.
What is the synthesis method of 3 ', 5' -diacetyl-5-iodo-2 '-deoxyuridine?
3% 27% 2C5% 27-diacetyl-5-iodine-2% 27-deoxyuridine, the synthesis of this substance is a complicated and delicate process.
At the beginning, it is necessary to prepare suitable raw materials, such as sugar derivatives containing specific structures, supplemented by corresponding iodine-containing reagents and acetylation reagents. The reaction path is first based on sugar derivatives, and under appropriate reaction conditions, iodine atoms are precisely introduced into specific positions. This step requires strict control of the reaction temperature, pH and the ratio of the reactants. The location and degree of introduction of caine iodine are related to the purity and activity of the product.
Next, acetylation reagents are used to acetylate specific hydroxyl groups in the molecule to form diacetyl structures. This process also needs to be carefully regulated to ensure that the acetyl group only modifies the target hydroxyl group and does not affect other functional groups.
During the whole process of synthesis, the cleanliness of the reaction environment and the precise control of the reaction conditions are essential. After each step of the reaction, separation and purification methods such as column chromatography and recrystallization are often used to obtain high-purity products. And during the synthesis process, the equipment used also needs to be accurately calibrated to ensure the stability and reliability of the reaction conditions. In this way, through multi-step fine operation, 3% 27% 2C5% 27-diacetyl-5-iodine-2% 27-deoxyuridine can be obtained.
What are the precautions for the use of 3 ', 5' -diacetyl-5-iodo-2 '-deoxyuridine in the experiment?
3% 27% 2C5% 27-diacetyl-5-iodine-2% 27-deoxyuridine, used in experiments, many matters need to be paid attention to.
First, it is related to the storage method. The nature of this substance may be unstable, and it needs to be properly stored according to its characteristics. Generally speaking, it should be placed in a low temperature, dry and dark place to prevent it from deteriorating due to environmental factors, which in turn affects the experimental results. For example, if the storage temperature is too high, or it accelerates its decomposition, the active ingredients must be reduced.
Second, when taking it, the operation must be accurate. Because of the amount used, it has a great impact on the experimental results. It is necessary to use a precise measuring tool and measure it accurately according to the experimental design. During the weighing process, ensure that the measuring tool is clean and dry to avoid impurities from mixing in and interfering with the experiment.
Third, safety issues cannot be ignored. This substance may be toxic and irritating to a certain extent. Appropriate protective equipment should be worn during operation, such as gloves, goggles and experimental clothes, etc., to prevent direct contact with the skin and eyes. In case of inadvertent contact, it is necessary to deal with it immediately according to the correct treatment method, such as rinsing with a lot of water and seeking medical attention in time.
Fourth, in the process of solution preparation, the correct solvent and ratio should be selected. Different experimental requirements, or different concentrations of solutions are required. The preparation process should be strictly followed to ensure that it is fully dissolved and evenly dispersed, otherwise it will lead to abnormal local concentrations and affect the experimental effect.
Fifth, during the experiment, the reaction conditions should be strictly controlled. Temperature, pH and reaction time may all affect the reaction process and results. It must be precisely regulated to achieve the expected experimental purpose.
What is the market price range for 3 ', 5' -diacetyl-5-iodo-2 '-deoxyuridine?
3% 27% 2C5% 27-diacetyl-5-iodine-2% 27-deoxyuridine, this product is in the market, its price is variable, due to multiple reasons. First, the source is different, the price is different. If you know it is purchased by a famous big merchant, it focuses on quality and the process is strict. Although the cost is high, the price is high; if it is made by a small factory, although the quality is poor, the price is low. Second, the quantity is also related to the price. If you buy a small quantity, you may be given a discount. If the quantity is small, the price will be difficult to reduce. Third, the change of time is also related to the price. Market supply and demand, the price of raw materials can fluctuate. If the raw materials are rare, the cost of the system will increase, and the price will rise; if the supply exceeds the demand, the merchant will sell the goods, and the price may drop. Overall, the market price ranges from tens to hundreds of gold per gram, but the actual price must be consulted in detail before it can be determined.