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What are the main uses of 3,5-diiodopyridine-2-amine?
3,5-Dinitropyridine-2-carboxylic acid, within the scope of "Tiangong Kaiwu", is mostly used in the preparation of nitrate for gunpowder. In the manufacture of black powder, it is one of the key components. For black powder, saltpeter, sulfur, and charcoal are prepared in a specific ratio. 3,5-dinitropyridine-2-carboxylic acid can help adjust the combustion rate and explosive power of gunpowder.
When preparing black powder, saltpeter is the main oxidant, sulfur and charcoal are the reducing agents. The addition of 3,5-dinitropyridine-2-carboxylic acid can change the reaction course and rate. In ancient warfare, black powder was used to fire firearms, such as guns, and its explosive power and firing efficiency were crucial to the outcome of the battle. The presence of this compound allows gunpowder to burn rapidly in a limited space, generating a large amount of gas and heat, which in turn prompts the projectile to be shot out and kill the enemy.
Furthermore, in the production of fireworks, 3,5-dinitropyridine-2-carboxylic acid also plays a role. For fireworks to have a splendid effect, the combustion and explosion process needs to be precisely controlled. This compound can help the fireworks potion react at a predetermined rhythm, making the fireworks bloom in different colors and shapes, adding a joyous atmosphere to the festival.
Therefore, although 3,5-dinitropyridine-2-carboxylic acid is not described in detail in "Tiangong Kaiwu", it plays an important role in the ancient gunpowder and fireworks related processes, affecting the performance of gunpowder and fireworks effect.
What are the synthesis methods of 3,5-diiodopyridine-2-amine?
There are many methods for synthesizing 3,2,5-dichloropyridine-2-carboxylic acids, and the following are common ones:
First, pyridine is used as the starting material. Pyridine is first halogenated, and chlorine atoms are introduced at a specific position on the pyridine ring through careful selection of halogenation reagents and precise regulation of reaction conditions, thereby generating 2,3,5-trichloropyridine. Subsequently, 2,3,5-trichloropyridine undergoes hydrolysis in a suitable basic environment, prompting one of the chlorine atoms to be replaced by a carboxyl group, and finally successfully obtained 3,2,5-dichloropyridine-2-carboxylic acid. In this path, the control of the halogenation reaction conditions is the key, and a slight deviation in temperature and reagent ratio may lead to changes in the selectivity of the product.
Second, 2-methylpyridine is used as the starting material. First, 2-methylpyridine is oxidized to convert methyl groups to carboxyl groups to obtain 2-pyridine carboxylic acid. Then a halogenation reaction is carried out, and chlorine atoms are introduced at the 3,5 positions of the pyridine ring to achieve the synthesis of 3,2,5-dichloropyridine-2-carboxylic acid. During the oxidation process, the selection of suitable oxidizing agents and reaction solvents has a profound impact on the reaction efficiency and product purity.
Third, the coupling reaction is catalyzed by palladium. Select suitable halogenated pyridine derivatives and boric acid compounds containing carboxyl groups, and under the action of palladium catalyst, the coupling of carbon-carbon bonds can be achieved under mild reaction conditions to generate the target product. The advantage of this method is that the reaction selectivity is high and the conditions are relatively mild, but the cost of palladium catalyst is higher, and the requirements for reaction equipment and operation are also stricter.
In addition, there are other synthesis ideas, such as using specific substituted pyridinone compounds as raw materials, dehydration, halogenation and a series of reactions to obtain the target product. Each synthesis method has its own advantages and disadvantages. In practical application, it is necessary to comprehensively weigh many factors such as the availability of raw materials, cost considerations, and product purity requirements to choose the most suitable synthesis route.
What are the physical properties of 3,5-diiodopyridine-2-amine?
3,2,5-Dichloropyridine-2-carboxylic acid is an organic compound. Its physical properties are as follows:
Under normal conditions, it is mostly white to light yellow crystalline powder, visible to the eye, with a fixed shape.
Smell it, the smell is slight, not pungent and intolerable, but it also has its own unique smell, which can be felt around it for a long time.
As for the melting point, the melting point is about 157-160 ° C. When the temperature reaches this point, the solid liquid can be dissolved. The boiling point varies depending on the conditions, and usually requires a higher temperature to boil and vaporize. This is the boundary point where it changes from liquid phase to gas phase.
In terms of solubility, in water, the solubility is limited, only a little can be dissolved, and it is difficult to form a homogeneous solution. However, in organic solvents, such as methanol, ethanol, acetone, etc., the solubility is quite good, and it can be miscible with them to form a uniform phase.
Density is also one of its physical properties, which is heavier than water. If it is placed in one place with water, it often sinks under water after standing.
The physical properties of this compound are of key significance in its preparation, separation, purification and application. When preparing, it is necessary to control the temperature according to its melting and boiling point to obtain a pure product. Separation and purification are based on the difference in solubility. When applying, it is necessary to consider its appearance, smell, and other properties in order to meet practical needs.
What are the chemical properties of 3,5-diiodopyridine-2-amine?
3,5-Dinitrobenzoic acid-2-carboxylic acid, this is an organic compound. It is acidic and can partially ionize hydrogen ions in water due to its carboxyl group. It can neutralize and react with alkali substances, such as reacting with sodium hydroxide to form the corresponding carboxylate and water.
The compound has a nitro group, which is a strong electron-absorbing group, so that this substance has a certain degree of oxidation. Under suitable conditions, the nitro group can be reduced, for example, under the action of a specific reducing agent, the nitro group can be gradually converted into an amino group.
Because of its benzene ring structure in the molecule, it has aromaticity and can undergo reactions such as electrophilic substitution. Like under suitable catalyst and reaction conditions, it can react with halogens, nitric acid and other electrophilic reagents, and hydrogen atoms on the benzene ring are replaced.
In addition, 3,5-dinitrobenzoic acid-2-carboxylic acid is flammable and may burn or even explode in case of open flames, hot topics, etc., because it contains potentially oxidizing and reactive groups such as nitro groups. When storing and using, be sure to pay attention to fire and explosion protection, and strictly follow relevant safety regulations to prevent dangerous accidents.
What is the price range of 3,5-diiodopyridine-2-amine in the market?
I have heard your inquiry about the price range of 3,5-diphenyl-2-furanone in the market. The price of this 3,5-diphenyl-2-furanone is in the market and often varies depending on quality, supply and demand, and provenance.
Generally speaking, if it is an ordinary quality industrial-grade product, the price per kilogram may be between hundreds and thousands of dollars. Industrial use requires slightly lower purity, the preparation process may be simpler, and the cost is slightly reduced, so the price is in this range.
However, if it is high purity, suitable for pharmaceutical research and development, fine chemicals, etc., the price is much higher. Its price per kilogram may reach thousands of dollars, or even higher. Because the preparation of high-purity products requires fine craftsmanship and strict purification, it consumes huge manpower, material resources and financial resources, so its price rises.
And the market supply and demand situation also affects its price. If there are many applicants and few suppliers, the price will rise; on the contrary, the supply exceeds the demand, and the price may fluctuate.
And the prices sold by different origins and suppliers also vary. Well-known manufacturers and reputable ones have stable product quality and slightly higher prices; while emerging manufacturers compete for the market, the price may be slightly lower.