3-Acetamido-2,4,6-triiodo-5- (n-methylacetamido) -n- ((3r, 4r, 5s, 6r) -2,4,5-trihydroxy-6- (hydroxymethyl) tetrahydro-2h-pyran-3-yl) What is the chemical structure of benzamide?

Alas! Now to understand the chemical structure of this "3 - acetamido - 2,4,6 - triiodo - 5- (n - methylacetamido) -n- ((3r, 4r, 5s, 6r) -2,4,5 - trihydroxy - 6- (hydroxymethyl) tetrahydro - 2h - pyran - 3 - yl) benzamide". This is a difficult problem in organic chemistry, and it is necessary to study its naming rules in detail to analyze its structure.

Looking at its name, "benzamide" indicates the basic structure of this compound containing benzamide. " 3-Acetamido "indicates that the third position of the phenyl ring is connected with an acetamido group;" 2,4,6-triiodo "indicates that the second, fourth, and sixth positions of the phenyl ring are each connected with an iodine atom;" 5- (n-methylacetamido) "indicates that the fifth position is connected with an N-methylacetamido group.

Furthermore, "n- ((3r, 4r, 5s, 6r) -2, 4, 5 - trihydroxy - 6 - (hydroxymethyl) tetrahydro - 2h - pyran - 3 - yl) " part, showing that it is connected to the nitrogen atom of benzamide, which is a tetrahydropyran derivative with a specific stereoconfiguration (3r, 4r, 5s, 6r). This derivative has a hydroxyl group at the second, fourth and fifth positions, and a hydroxymethyl group at the sixth position.

In summary, this compound uses benzamide as the parent nucleus, and the benzene ring is connected with a specific substituent, and the nitrogen atom is connected with the tetrahydropyran derivative with a specific three-dimensional configuration and substituent, thus forming its unique chemical structure. Although the text is difficult to fully express its complexity and delicacy, its general outline can be obtained according to this analysis.

3-Acetamido-2,4,6-triiodo-5- (n-methylacetamido) -n- ((3r, 4r, 5s, 6r) -2,4,5-trihydroxy-6- (hydroxymethyl) tetrahydro-2h-pyran-3-yl) What are the physical properties of benzamide?

3-Acetamido-2,4,6-triiodine-5- (N-methylacetamido) -N - ((3R, 4R, 5S, 6R) -2,4,5-trihydroxy-6- (hydroxymethyl) tetrahydro-2H-pyran-3-yl) benzamide, which is an organic compound with complex structure. Its physical properties contain various characteristics, let me tell them one by one.

Looking at its morphology, it is mostly white to off-white crystalline powder under normal circumstances, with fine and uniform texture, just like fine frost and snow. This compound is quite stable at room temperature and pressure. When it encounters a hot topic, an open flame or a strong oxidant, it is at risk of decomposition, just like a tame beast that is frightened by fire and has a great change in temperament.

Solubility is also an important physical property. This substance is slightly soluble in water, just like a canoe in a shallows, making it difficult to travel unimpeded. However, in some organic solvents, such as dimethyl sulfoxide (DMSO), N, N-dimethyl formamide (DMF), it can show good solubility, just like a wanderer returning home and stretching freely. This property is due to the fact that there are both polar groups, such as amide groups and hydroxyl groups, as well as relatively non-polar carbon chains and iodine atoms in its molecular structure, which make it different in solubility in different solvents.

Melting point is another key physical constant. After determination, its melting point is in a specific temperature range, which is just like the "transformation point" of the compound. At this temperature, the solid state will gradually melt into a liquid state, realizing the transformation of the state of matter. Accurate determination of the melting point can not only help to identify its purity, but also provide important parameters for its production, storage and application.

In terms of density, the compound has a specific value. Although it is invisible and colorless, it determines its space in the mixed system and its interaction with other substances. This density value is like its "weight mark", which is of great significance in the process of chemical production, such as material ratio, separation and purification.

In summary, the physical properties of 3-acetamido-2,4,6-triiodo-5- (N-methylacetamido) -N - ((3R, 4R, 5S, 6R) -2,4,5-trihydroxy-6- (hydroxymethyl) tetrahydro-2H-pyran-3-yl) benzamide, from morphology, stability, solubility, melting point to density, are all related to each other, together constituting its unique physical "portrait", laying the foundation for its application in medicine, chemical industry and other fields.

3-Acetamido-2,4,6-triiodo-5- (n-methylacetamido) -n- ((3r, 4r, 5s, 6r) -2,4,5-trihydroxy-6- (hydroxymethyl) tetrahydro-2h-pyran-3-yl) What are the main uses of benzamide?

3-Acetamido-2,4,6-triiodine-5- (N-methylacetamido) -N - (3R, 4R, 5S, 6R) -2,4,5-trihydroxy-6- (hydroxymethyl) tetrahydro-2H-pyran-3-yl) benzamide, which is more common in the field of medicine and is mainly used for angiography.

When imaging, it is necessary to observe the state of the internal structure and organs of the human body. However, many tissues and organs of the human body respond similarly to imaging methods such as X-ray and magnetic resonance, which is difficult to clearly distinguish. This compound contains iodine, which has a high atomic number and strong X-ray absorption capacity. After injecting or orally taking a contrast agent containing this compound, it will accumulate in a specific tissue or organ, change the local X-ray absorption characteristics, and show the difference from the surrounding tissue on the imaging map, so that the contour, shape and internal details of the target site can be clearly identified, which can help physicians accurately diagnose diseases, such as tumors, vascular diseases, and organ deformities.

In angiography, injecting a contrast agent containing this ingredient into the blood vessel can clearly show the direction of the blood vessel, whether it is narrow or blocked; in urography, it can make the kidney, ureter, bladder and other shapes and lesions appear. Overall, it is of great significance in medical imaging, providing a key basis for disease diagnosis, enabling physicians to diagnose and treat patients early, and enhancing their hope of recovery.

3-Acetamido-2,4,6-triiodo-5- (n-methylacetamido) -n- ((3r, 4r, 5s, 6r) -2,4,5-trihydroxy-6- (hydroxymethyl) tetrahydro-2h-pyran-3-yl) What are the synthetic methods of benzamide?

The synthesis of 3-acetamido-2,4,6-triiodo- 5- (N-methylacetamido) -N - [ (3R, 4R, 5S, 6R) -2,4,5-trihydroxy-6- (hydroxymethyl) tetrahydro- 2H-pyran-3-yl] benzamide is described in detail below.

The synthesis of this compound often requires multiple and delicate reactions. The choice of starting materials is a matter of success or failure. Or select active benzene derivatives. On the benzene ring, there needs to be a modifiable check point to introduce groups such as acetamido, iodine atom and N-methylacetamido group.

When introducing iodine atom, it is often necessary to borrow specific iodizing reagents. For example, with an appropriate amount of iodine source and a catalyst, in a suitable reaction environment, it can be substituted with the benzene ring. The reaction temperature, time and type of solvent need to be precisely controlled. If the temperature is too high or the side reactions occur frequently, if it is too low, the reaction will be slow and the efficiency will be poor.

The introduction of acetamido and N-methylacetamido also needs to find suitable acylating reagents. Under the condition of alkali catalysis, the acylation reaction with the corresponding amino group occurs under the condition of acid chloride or acid anhydride. In this process, the amount of base and the reaction time are all key elements.

As for the part connected to (3R, 4R, 5S, 6R) -2,4,5-trihydroxy-6- (hydroxymethyl) tetrahydro-2H-pyran-3-yl, or the pyran ring is modified first to have an active group that can be connected to benzamide. It can be converted to hydroxyl groups on the pyran ring, such as the formation of halogenates or sulfonates, etc., and then nucleophilic substitution reaction with compounds containing benzamide structure to achieve the purpose of connection.

The whole process of synthesis requires a variety of analytical methods to monitor the reaction process. For example, thin layer chromatography can observe the consumption of reactants and the formation of products; nuclear magnetic resonance spectrometry, mass spectrometry, etc., can confirm the structure of the product. And after each step of the reaction, the separation and purification of the product is also crucial. Column chromatography, recrystallization, etc. are often used to obtain pure intermediate products and final target products, which is the right way to synthesize.

3-Acetamido-2,4,6-triiodo-5- (n-methylacetamido) -n- ((3r, 4r, 5s, 6r) -2,4,5-trihydroxy-6- (hydroxymethyl) tetrahydro-2h-pyran-3-yl) What are the safety precautions for benzamide?

3-Acetamido-2,4,6-triiodo- 5- (N-methylacetamido) -N - [ (3R, 4R, 5S, 6R) -2,4,5-trihydroxy-6- (hydroxymethyl) tetrahydro-2H-pyran-3-yl] benzamide, a rather complex chemical. Regarding its safety precautions, the details are as follows:

First, this substance is potentially toxic. Although the specific toxicological mechanism is unknown, it should not be exposed to the skin, eyes and mouth during operation. If you accidentally touch it, if the skin is contaminated, rinse it with plenty of water as soon as possible; if the eyes splash in, you should immediately open the eyelids, rinse with flowing water or normal saline, and seek medical attention immediately; if you take it by mistake, do not induce vomiting by yourself, and seek medical attention immediately.

Second, chemical stability. Pay attention to the temperature, humidity and pH of the environment in which it is located. High temperature or extremely cold environment, or conditions of acid and alkali may cause it to undergo chemical reactions, or decompose, or produce harmful by-products. Generally, it should be stored in a cool, dry and well-ventilated place, away from fire and heat sources.

Third, during operation, protective measures must be comprehensive. It is necessary to wear protective clothing, protective gloves and protective glasses for effective protection. It is best to operate in a fume hood, which can remove harmful gases that may escape in time, reduce the concentration of harmful substances in the air, and ensure the safety of operators.

Fourth, due to its complex chemical structure, there are limitations in its nature cognition. Therefore, when conducting experiments or using, it should be gradual, and small-scale tests should be carried out first to observe its reaction and characteristics in detail. During operation, always be alert. If there is any abnormal smell, color change or other abnormal conditions, immediately stop the operation and dispose of it properly.

In short, when dealing with this chemical substance, it is necessary to be rigorous and meticulous, and strictly follow safety regulations to avoid potential safety risks.