What is the chemical structure of 3-amino-2,4, 6-triiodobenzenepropanoic Acid?
3 - amino - 2,4,6 - triiodobenzenepropanoic Acid, that is, 3 - amino - 2,4,6 - triiodophenylpropionic acid, the chemical structure of this compound can be inferred as follows.
Its core is the benzene ring. On the benzene ring, there are three iodine atoms connected to the 2,4,6 and 6 positions, respectively, which is the meaning of "2,4,6 - triiodine". There is also a propionic acid group connected to the benzene ring, and the propionic acid group is - CH -2 CH -2 COOH, which is the structural characteristic of "phenylpropionic acid". In addition, there is an amino group (- NH2O) connected to the 3 position of the benzene ring, which is referred to as "3-amino". Therefore, its chemical structure is a phenyl ring as the core, with iodine atoms at positions 2, 4, and 6, amino groups at positions 3, and propionic acid groups. In this way, the chemical structure of 3-amino-2,4,6-triiodophenylpropionic acid is clear.
What are the main uses of 3-amino-2,4, 6-triiodobenzenepropanoic Acid
3 - amino - 2,4,6 - triiodobenzenepropanoic Acid is 3 - amino - 2,4,6 - triiodophenylpropionic acid, which has a wide range of uses.
First, in the field of medical imaging, it is often used as a key component of contrast agents. Because it contains iodine atoms, iodine has a high atomic number and strong X-ray absorption ability. In X-ray imaging, introducing a contrast agent containing this substance into a specific part of the human body can significantly improve the difference in X-ray absorption between this part and the surrounding tissues, making the imaging clearer and helping doctors accurately diagnose diseases. For example, angiography can clearly show the shape and direction of blood vessels and whether there are stenosis, blockage and other conditions.
Second, in the field of organic synthesis chemistry, it is an important intermediate. With its own structural properties, its amino and carboxyl groups can participate in a variety of chemical reactions to achieve the construction of many complex organic compounds. Chemists can use this to synthesize organic molecules with specific functions and structures for drug development, materials science and other fields, such as the synthesis of new anti-tumor drug molecules or materials with special optical and electrical properties.
Third, in the field of pharmaceutical chemistry, it can be developed into drugs for the treatment of specific diseases after modification and modification. Because of its iodine-containing element and specific phenylpropionic acid structure, it may have an effect on the pathological process of certain diseases, such as the development of drugs for thyroid-related diseases, or use its structure to interact with targets in the body to regulate physiological functions and achieve therapeutic purposes.
What are the physical properties of 3-amino-2,4, 6-triiodobenzenepropanoic Acid
3-Amino-2,4,6-triiodophenylpropionic acid, this is an organic compound. Its physical properties are particularly important and are related to many fields of application.
First appearance, under room temperature and pressure, it is often in the state of white to light yellow crystalline powder, delicate and uniform, and its texture can be distinguished by eyesight. This chromatic representation is not only helpful for preliminary identification, but also closely related to molecular structure and composition. Due to the arrangement of atoms in the molecule and the distribution of electron clouds, specific wavelengths of light are absorbed or reflected, resulting in this color.
In terms of solubility, this compound has limited solubility in water, but it exhibits good solubility in organic solvents such as dimethyl sulfoxide (DMSO) and N, N-dimethylformamide (DMF). This characteristic is derived from its molecular structure, which contains both polar amino and carboxyl groups, which impart certain hydrophilicity; it also contains hydrophobic benzene rings and iodine atoms, so it has different solubility in different solvents. This difference in solubility is of great significance in chemical synthesis, pharmaceutical preparations, etc. For example, when developing drugs, it is necessary to choose the appropriate solvent according to its solubility to achieve the best efficacy.
Furthermore, the melting point is also a key physical property. Its melting point is relatively high, and the specific value fluctuates slightly depending on the purity, between about 200 ° C and 220 ° C. The high melting point reflects the strong intermolecular forces, such as hydrogen bonds, van der Waals forces, etc., which maintain the stability of the crystal structure. This characteristic is of great significance in quality control and processing. In production, the purity can be judged by melting point measurement to ensure product quality.
In addition, density is also a consideration factor. Although the exact density data varies depending on the measurement conditions, it is roughly within a certain range. Density not only affects the distribution of substances in the mixture, but also is a key parameter in operations such as separation and purification, which helps to choose an appropriate method.
To sum up, the physical properties of 3-amino-2,4,6-triiodophenylpropionic acid, such as appearance, solubility, melting point and density, are of great guiding value for its research, application and production, and lay the foundation for in-depth research and practice in related fields.
What are the synthesis methods of 3-amino-2,4, 6-triiodobenzenepropanoic Acid
To make 3-amino-2,4,6-triiodophenylpropionic acid, through the ages, many parties have studied their methods, each with its own advantages, and listen to me one by one.
One method is to use phenylpropionic acid as the base, first introduce nitro groups, and you can get nitrophenylpropionic acid by mixing acid (the combination of nitric acid and sulfuric acid) at a suitable temperature. This step requires careful temperature control to prevent side reactions from occurring. Then, with a reducing agent, such as the combination of iron and hydrochloric acid, or the help of hydrogen and a catalyst (such as palladium carbon), the nitro group is converted to an amino group to obtain aminophenylpropionic acid. Finally, iodine atoms are introduced into the solvent at a specific position above the benzene ring with iodine elemental substance and an appropriate oxidizing agent, such as hydrogen peroxide, to form 3-amino-2,4,6-triiodophenylpropionic acid.
There is another method, starting with benzene, first reacting with acrylic acid by Fu-gram alkylation to introduce the phenylpropionic acid structure. Then according to the previous method, nitrification is first made into nitro, then nitro is reduced, and finally iodine atoms are added by the method of iodization. The starting material of this method is easy to obtain, but the Fu-gram reaction may encounter difficulties. It is necessary to control the conditions to make the reaction smooth.
In addition, aminophenol is used as a raw material. It is first iodized to obtain iodine-aminophenol, and then a propionylating agent, such as propionyl chloride or propionic anhydride, is introduced under the catalysis of alkali to obtain the target product. This approach is slightly simpler, but the raw material aminophenol or the cost is higher, and the pros and cons need to be weighed.
All kinds of production methods have their own advantages and disadvantages. In practice, it is necessary to choose carefully according to various factors such as the availability of raw materials, the consideration of cost, the difficulty of reaction, and the high and low yield. Only then can the best method be obtained to obtain pure 3-amino-2,4,6-triiodophenylpropionic acid.
What are the precautions for 3-amino-2,4, 6-triiodobenzenepropanoic Acid during use?
3-Amino-2,4,6-triiodophenylpropionic acid, when using it, there are a number of things to pay attention to, and it is necessary to keep in mind.
First, this substance has a certain chemical activity, and the experimental procedures must be strictly followed when operating. Because it contains iodine atoms, it may react violently in case of heat, open flame or strong oxidant, so it should be kept away from heat and fire sources, and do not mix with strong oxidants.
Furthermore, contact with this substance is indispensable for protection. Appropriate protective clothing, such as lab clothes, and gloves and protective goggles are required. Cover because it may irritate the skin, eyes and respiratory tract. If it accidentally touches the skin, rinse it with plenty of water as soon as possible; if it enters the eyes, rinse it with plenty of water immediately and seek medical treatment.
In addition, when weighing and preparing solutions, accuracy is essential. Because the dosage is accurate or not, it is related to the accuracy of the experimental results. It is appropriate to use a precise weighing instrument, and during the preparation of the solution, stir it evenly to ensure that its concentration is uniform.
In addition, storage is also exquisite. It should be placed in a dry, cool and well-ventilated place, protected from light and shade. Cover its chemical properties or change due to environmental factors, and store it properly to keep its quality stable.
Furthermore, after use, the remaining materials and waste should not be disposed of at will. It must be collected in accordance with the regulations on chemical waste disposal, sorted and properly disposed of to avoid polluting the environment and harming the ecology.
All in all, with 3-amino-2,4,6-triiodophenylpropionic acid, all matters of attention are related to safety and effectiveness, and must not be slack and negligent.