3 Amino 4 Iodoindazole

3-Amino-4-iodoindazole, or 3-amino-4-iodoindazole, has a wide range of uses. In the field of medicinal chemistry, it is often used as a key intermediate to assist in the synthesis of many drugs. Due to its unique structure, amino and iodine atoms endow specific reactive and biological activities, or can participate in the construction of diverse drug molecular skeletons.
For example, when developing new anti-tumor drugs with unique pharmacological activities, 3-amino-4-iodoindazole can combine with other compounds containing active groups through specific chemical reactions to create new compounds with potential anti-cancer effects.
In the field of materials science, or can be used to prepare special functional materials. Its special structure may cause unique electronic effects and spatial effects inside the material, so that the material exhibits special optical and electrical properties. For example, the preparation of optoelectronic device materials with unique response to specific wavelengths of light, through the structural characteristics of 3-amino-4-iodoindazole, the material's light absorption and emission properties are regulated.
In organic synthetic chemistry, it is an important synthetic building block. Chemists can use the activity of amino and iodine atoms to carry out various organic reactions, such as nucleophilic substitution, coupling reactions, etc., to synthesize complex and novel organic compounds, which contribute to the development of organic synthesis chemistry, enrich the variety of organic compounds, and expand the organic synthesis methodology.

The synthesis method of 3-amino-4-iodine indazole has been known for a long time. There are many methods, so I will describe them here.
First, indazole is based, obtained by halogenation and amination. First, indazole and iodine are derived from suitable reaction conditions, and the halogenation reaction is carried out to introduce iodine atoms at the 4 position. This step requires temperature control, selection of suitable solvents and catalysts to make the reaction smooth. Iodine sources are often selected from iodine elements, potassium iodide, etc. There are also many halogenation agents, such as N-iodosuccinimide, etc. Wait for 4-iodine indazole to obtain it, and then the amination reaction is carried out. The ammonia source can be selected to introduce the amino group at the third position of 4-iodine indazole in a specific reaction system. Ammonia sources such as ammonia gas, ammonia water or other amine reagents need to be reacted at appropriate temperature, pressure, or accompanied by a catalyst to increase the yield.
Second, the nitrogen-containing aromatic ring compound is used as the starting material and prepared by multi-step reactions such as cyclization, halogenation, and amination. First, the nitrogenous aromatic ring and appropriate reagents are cyclized to construct the skeleton of the indazole. This step requires careful design of the reaction path and suitable reaction conditions to make the cyclization proceed smoothly. After cyclization, according to the above halogenation and amination methods, iodine atoms are introduced at the 4th position and amino groups are introduced at the 3rd position of the indazole skeleton successively. Each step requires fine regulation of the reaction conditions to achieve the ideal synthesis effect.
Third, the reaction path catalyzed by transition metals is used. Suitable metal catalysts, such as complexes of metals such as palladium and copper, catalyze the coupling reaction of substrates containing specific functional groups to construct the structure of 3-amino-4-iodoindazole. This path requires optimization of reaction conditions such as metal catalysts, ligands, and bases to achieve efficient and highly selective synthesis.
All synthesis methods have their own advantages and disadvantages, and it is necessary to choose the appropriate method according to the actual situation, such as the availability of raw materials, the difficulty of reaction, and the consideration of cost, so as to achieve the optimal production of 3-amino-4-iodoindazole.

3-Amino-4-iodoindazole is an organic compound whose physical properties are crucial. The appearance of this compound is often in a solid state. As for the color, or white to light yellow powder, this color characteristic is easy to identify.
In terms of melting point, the exact value often depends on experimental determination, but generally speaking, the melting point is in a specific range, which is of great significance for material identification and purity determination. The melting point of this compound with different purity may be deviated.
Solubility is also an important property. In common organic solvents, such as dichloromethane, N, N-dimethylformamide (DMF), etc., it may have some solubility. In dichloromethane, due to the non-polar characteristics of dichloromethane, some of the structures are in harmony with it, making the compound soluble and easy to use as a reaction medium in organic synthesis reactions. In DMF, with the strong polarity of DMF, it can form intermolecular forces with compounds to improve solubility. However, in water, due to its relatively hydrophobic molecular structure, the solubility is poor.
In addition, although the density of this compound is rarely reported accurately, it can be inferred that its density is similar to that of common organic solids based on the comparison of its molecular composition and similar structural compounds. Its density affects the distribution of substances in the mixed system, and this factor also needs to be considered during separation and reaction.
Furthermore, the stability of this compound is acceptable under certain conditions. However, due to the iodine atoms, they are slightly sensitive to light, heat or. Under light or high temperature environment, iodine atoms may undergo reactions such as dissociation, resulting in molecular structure changes. Therefore, when storing, it should be placed in a cool and dark place to ensure the stability of its chemical structure and properties.

3-Amino-4-iodoindazole, this is an organic compound with unique chemical properties. Its molecule contains an indazole ring, with an amino group at the 3rd position and an iodine atom at the 4th position on the ring, and its structural characteristics give it a variety of chemical behaviors.
From the perspective of reactivity, amino groups are nucleophilic and easily participate in many nucleophilic substitution reactions. It can react with halogenated hydrocarbons. Nitrogen atoms attack the positively charged carbon in halogenated hydrocarbons, and halogens leave to form new nitrogen-containing compounds, which is very important for the construction of complex organic molecular structures.
Iodine atoms also affect their reactivity. Although the electronegativity of the iodine atom causes the C-I bond to have a certain polarity, the C-I bond energy is relatively small, which makes the iodine atom participate in the reaction as a leaving group. For example, in some metal catalytic coupling reactions, 3-amino-4-iodoindazole can be coupled with substrates containing alkenyl groups, aryl halides, etc., under the action of palladium, copper and other metal catalysts, to realize the connection of the indazole ring with other groups, expand the molecular skeleton, and synthesize compounds with special functions or structures.
Because of the conjugated system in the molecule, 3-amino-4-iodoindazole has certain stability and electronic delocalization characteristics. The conjugated system affects the distribution of molecular electron clouds and has an effect on their spectral properties such as ultraviolet-visible absorption spectra, which can be identified and studied by spectral analysis technology. And the conjugated system imparts a certain planarity to the molecule, which affects the intermolecular interaction and crystal accumulation mode, and then affects the physical properties such as melting point and solubility.
In terms of solubility, the compound has a certain solubility in some polar organic solvents such as dimethyl sulfoxide, N, N-dimethyl formamide, but the overall solubility is affected by the hydrophobicity of the indazole ring, and the solubility in water is limited. 3-Amino-4-iodoindazole has unique chemical properties and has potential application value in organic synthesis, medicinal chemistry and other fields. It can be used as a key intermediate to synthesize biologically active or special functional organic compounds.

I haven't heard of the price of "3-amino-4-iodoindazole" in the market. However, if you want to know its price, you can explore it from many places. First, visit chemical raw material suppliers, who often sell various chemical products, or know the price of this product. Chemical raw material trading places, such as professional chemical markets, online chemical product trading platforms, can find their traces. Second, ask scientific research reagent suppliers, because "3-amino-4-iodoindazole" or for scientific research, such suppliers mostly supply reagents for scientific research, or they can tell the price. Furthermore, with reference to past transaction records, if there are relevant industry reports, chemical product price databases, which may store their past price information, the current approximate price can be deduced based on this. However, its price is also influenced by a variety of factors, such as the level of purity, the price of high purity will be high; the amount of output, the price of rare will be expensive; the state of market supply and demand, the price will rise if the demand exceeds the supply, and the price will fall if the supply exceeds the demand; in addition, preparation costs, transportation costs, regional differences, etc., can all make the price different. Therefore, in order to obtain an accurate price, it is necessary to carefully investigate, and the current market situation shall prevail.