3 Bromo 2 Iodophenol
Iodobenzene

3 Bromo 2 Iodophenol

Fengxi Chemical

Specifications

HS Code

821384

Chemical Formula C6H4BrIO
Molecular Weight 298.804 g/mol
Appearance Solid (likely white to off - white)
Melting Point Data needed from literature
Boiling Point Data needed from literature
Solubility In Water Low (phenols with halogen substituents are generally sparingly soluble in water)
Solubility In Organic Solvents Soluble in common organic solvents like ethanol, diethyl ether, chloroform
Density Data needed from literature
Vapor Pressure Low, as it is a solid at room temperature
Pka Data needed from literature, but phenol pKa is around 10, halogen substitution may shift it
Name 3-bromo-2-iodophenol
Molecular Formula C6H4BrIO
Molecular Weight 299.899 g/mol
Appearance Solid
Boiling Point Approx. 288 - 290 °C
Melting Point 87 - 91 °C
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in common organic solvents like ethanol, ether
Hazard Class Irritant (skin, eyes)
Chemical Formula C6H4BrIO
Molar Mass 300.80 g/mol
Appearance Solid (likely white or off - white)
Melting Point Data needed from literature
Boiling Point Data needed from literature
Solubility In Water Low solubility
Solubility In Organic Solvents Soluble in common organic solvents like ethanol, dichloromethane
Density Data needed from literature
Pka Data needed from literature (phenolic - OH)
Reactivity Reactive due to presence of halogens and phenolic - OH, can undergo substitution, oxidation reactions
Chemical Formula C6H4BrIO
Molecular Weight 298.804 g/mol
Appearance Solid (predicted)
Solubility In Water Low (predicted due to non - polar aromatic part)
Vapor Pressure Low (predicted for solid at room temperature)
Stability May be sensitive to light and air
Packing & Storage
Packing 100g of 3 - bromo - 2 - iodophenol packaged in a sealed, chemical - resistant bottle.
Storage 3 - bromo - 2 - iodophenol should be stored in a cool, dry place away from heat sources and direct sunlight. It should be kept in a tightly - sealed container to prevent exposure to air and moisture, which could potentially cause degradation. Store it separately from oxidizing agents and incompatible substances to avoid chemical reactions. Ensure the storage area is well - ventilated.
Shipping 3 - bromo - 2 - iodophenol is a chemical. For shipping, it must be properly packaged in accordance with hazardous material regulations. Ensure containers are secure to prevent leakage during transit. Documentation about the chemical should accompany the shipment.
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3-bromo-2-iodophenol 3-bromo-2-iodophenol 3-bromo-2-iodophenol
General Information
Frequently Asked Questions
What are the chemical properties of 3-bromo-2-iodophenol?
3-Bromo-2-iodophenol is an organic compound. In its molecular structure, the hydroxyl group (-OH) occupies the main position above the phenyl ring, and the bromine (Br) and iodine (I) atoms are respectively connected to the specific position of the phenyl ring. The chemical properties of this compound are very interesting.
First of all, its acidity and alkalinity. Because it has a phenolic hydroxyl group, it is weakly acidic. The hydrogen atom of the phenolic hydroxyl group can be partially ionized, but its acidity is weaker than that of common inorganic acids and carboxylic acids. In alkali, it can react with bases to form corresponding phenolates and water. This is because the oxygen atom has strong electronegativity, and the electron cloud formed by the covalent bond with the hydrogen atom is biased towards oxygen, making it easier for the hydrogen to leave in the form of protons.
times and substitution reactions. The benzene ring has a certain electron cloud density and is susceptible to attack by electrophilic reagents. On the benzene ring of 3-bromo-2-iodophenol, the electron cloud density of the benzene ring decreases due to the electron-absorbing groups of bromine and iodine, but the hydroxyl group acts as the power supplier, which can increase the electron cloud density of the adjacent and para-position. Therefore, during the electrophilic substitution reaction, the substituent groups multiply into the adjacent and para-position of the hydroxyl group. For example, when reacting with bromine water catalyzed by iron halide, bromine atoms can be introduced into the benzene ring to obtain brominated products.
Furthermore, the halogen atom is related to the reaction. Bromine and iodine atoms can undergo nucleophilic substitution reactions. Under appropriate nucleophilic reagents and reaction conditions, such as with nucleophilic reagents such as sodium alcohol or amines, halogen atoms can be replaced to form new organic compounds. In this reaction process, the nucleophilic reagent provides an electron pair to attack the carbon atom attached to the halogen atom, and the halogen atom leaves with a pair of electrons.
There is an oxidation reaction. Phenolic compounds are easily oxidized, and 3-bromo-2-iodophenol is no exception. In case of strong oxidants, such as potassium permanganate, the phenolic hydroxyl group can be oxidized, and the phenyl ring structure may also be destroyed, forming complex oxidation products. Even in air, long-term exposure may slowly oxidize, causing color changes.
In summary, 3-bromo-2-iodophenol has important potential applications in organic synthesis and other fields due to its unique molecular structure, acidity and alkalinity, substitution and oxidation.
What are the main uses of 3-bromo-2-iodophenol?
3-Bromo-2-iodophenol, this substance has a wide range of uses and is useful in various fields.
In the field of medicinal chemistry, it can be a key intermediate for the synthesis of special drugs. Due to the unique activities of bromine and iodine atoms in its structure, it can use organic synthesis techniques to ingeniously react with other compounds to construct molecular structures with specific pharmacological activities. Through exquisite design and synthesis, drugs with antibacterial, antiviral and even anti-tumor effects can be prepared.
In the field of materials science, it also plays an important role. It can be used as a starting material for the synthesis of special functional materials. For example, by polymerizing with a specific organic monomer and introducing it into the main chain or side chain of a polymer material, the material is endowed with unique optical, electrical or thermal properties. Or it can make the material have excellent photoelectric conversion efficiency for the preparation of new optoelectronic devices; or enhance the heat resistance and chemical corrosion resistance of the material, which is applied to material protection in extreme environments.
It is a commonly used synthetic block in the process of organic synthesis chemistry. Its phenolic hydroxyl groups, bromine atoms and iodine atoms are all reactive, and their activities are different. They can undergo many reactions such as nucleophilic substitution and coupling in sequence, providing a convenient way to construct complex organic molecules. Organic chemists can design exquisite synthesis routes accordingly to realize the complete synthesis of complex natural products or new organic functional molecules.
In addition, in agricultural chemistry, with appropriate modification and transformation, it may become an important precursor structure for the creation of pesticides. Using its halogen atom properties to enhance the biological activity and targeting of specific pests or pathogens, the development of high-efficiency, low-toxicity and environmentally friendly new pesticides.
In summary, 3-bromo-2-iodophenol is an extremely important chemical substance in many fields such as medicine, materials, organic synthesis and agricultural chemistry, and plays an extraordinary role in promoting technological innovation and development in various fields.
What are 3-bromo-2-iodophenol synthesis methods?
3-Bromo-2-iodophenol is an important intermediate in organic synthesis. The methods of its synthesis are quite diverse, and are described in detail below.
First, phenol is used as the starting material, which can be prepared by halogenation reaction. First, a brominating agent is used to interact with it, introducing bromine atoms at specific positions in phenol. Commonly used brominating agents, such as liquid bromine, hydrogen bromide, etc. Under suitable reaction conditions, such as the presence of specific temperatures, solvents and catalysts, bromine atoms can selectively replace hydrogen atoms on the phenol ring to obtain bromine-containing phenol derivatives. Then, the derivative is treated with an iodizing agent and iodine atoms are introduced. Commonly used iodizing agents such as potassium iodide, iodine element, etc. In an appropriate reaction system, iodine atoms can replace hydrogen at a specific position on the benzene ring to obtain 3-bromo-2-iodophenol.
Second, other compounds containing benzene ring can also be used as starting materials and obtained through multi-step reactions. For example, using a substituted benzene as raw material, a specific functional group conversion reaction is first carried out to construct a suitable substituent distribution on the benzene ring. Bromine and iodine atoms can be gradually introduced by means of many organic reaction types such as nucleophilic substitution and electrophilic substitution, and through precise control of reaction conditions, such as the ratio of reactants, reaction temperature, reaction time and catalyst selection, bromine and iodine atoms reach a specific position distribution of 3-bromo-2-iodine on the benzene ring, and then complete the synthesis of 3-bromo-2-iodophenol.
Third, the coupling reaction strategy of metal catalysis can also be used. Using bromine or iodine-containing benzene derivatives as substrates, with the help of metal catalysts such as palladium and copper, different halogenated benzene derivatives can be coupled in the presence of suitable ligands and bases. By ingeniously designing the structure and reaction conditions of the substrate, bromine and iodine atoms can be introduced into specific positions of the benzene ring at the same time to achieve effective synthesis of 3-bromo-2-iodophenol. This method often exhibits high selectivity and reaction efficiency, providing a valuable way to synthesize such compounds.
3-bromo-2-iodophenol are there any precautions during storage and transportation?
3 - bromo - 2 - iodophenol is an organic compound, and many things need to be paid attention to when storing and transporting it.
When storing, the first choice of environment. It should be placed in a cool, dry and well-ventilated place. This is because it is more sensitive to heat, high temperature or decomposition, which damages its purity and quality. If stored in a humid place, water vapor may react with the compound and change its chemical properties. For example, water vapor may interact with phenolic hydroxyl groups, affecting its chemical stability.
Furthermore, keep away from fire sources and oxidants. 3 - bromo - 2 - iodophenol has certain flammability and is easy to burn in case of open flames and hot topics. The oxidizing agent can react violently with it, or cause the danger of combustion or even explosion.
Packaging is also crucial. Packaging materials with good sealing performance should be used to prevent contact with air. Due to oxygen in the air or its oxidation, especially phenolic hydroxyl groups are easily oxidized, resulting in color changes and quality degradation.
When transporting, ensure that the container is stable and avoid collision and vibration. Because it is a chemical substance, violent collision or damage to the container, causing leakage. Once leaked, it not only pollutes the environment, but also endangers those who come into contact.
The transportation process must follow relevant regulations and standards, and be equipped with corresponding protective and emergency treatment equipment. If a leak occurs on the way, effective measures can be taken in time to reduce the harm. For example, prepare adsorption materials to absorb leaking liquids; prepare personal protective equipment to ensure the safety of handling personnel.
What are the effects of 3-bromo-2-iodophenol on the environment and human health?
3-Bromo-2-iodophenol is an organic compound, but we have not heard of these substances in ancient times, so it can only be deduced according to the current knowledge of chemistry and toxicity principles.
This compound contains bromine, iodine halogen atoms and phenolic hydroxyl groups. Phenols are many toxic substances, which can be absorbed through the skin or ingested by the respiratory tract and digestive tract to affect the human body. Phenolic hydroxyl groups have high activity, can react with various substances in the body, or cause protein denaturation, and disrupt the normal physiological function of cells.
Although bromine and iodine are trace elements required by the human body, they exist in organic binding states in this compound, or change their chemical properties and biological activities. Bromine and iodine substituents may make molecules more lipophilic, which is easy to penetrate biofilms and enhance their accumulation ability in organisms.
In the environment, this compound may persist due to chemical stability and is not easy to degrade. Transmitted through the food chain or enriched in organisms, endangering the ecosystem. Aquatic organisms are particularly sensitive to it, or affect its growth, reproduction and survival, destroying the balance of aquatic ecology.
Although we have not seen any real examples of its harm, according to chemical principles, this 3-bromo-2-iodophenol may pose a potential threat to the environment and human health. It should be treated with caution to avoid its unprovoked release into the environment to prevent it from happening.