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What is the main use of -bromo-4-iodo-biphenyl?
3-Bromo-4-iodobiphenyl, an organic compound. It has a wide range of uses and is often used as a key intermediate in the field of organic synthesis. With the bromine and iodine atoms in its structure, more complex organic molecular structures can be constructed through various chemical reactions, such as nucleophilic substitution, metal catalytic coupling, etc.
Taking the nucleophilic substitution reaction as an example, the bromine or iodine atoms can be replaced by other nucleophilic reagents, thereby introducing completely new functional groups. In metal catalytic coupling reactions, it can react with reagents such as borate esters, halogenated hydrocarbons, etc., to realize the construction of carbon-carbon bonds, and plays a crucial role in the synthesis of organic materials and drug molecules with specific structures and functions.
In the field of materials science, 3-bromo-4-iodobiphenyl also has extraordinary performance. Because of its special electronic structure and chemical properties, it can be used to prepare optoelectronic materials. For example, through appropriate chemical modification and synthesis methods, it can be integrated into organic semiconductor materials to improve the electrical and optical properties of the materials, and then applied to the manufacture of optoelectronic devices such as organic Light Emitting Diodes (OLEDs) and organic solar cells.
In the field of medicinal chemistry, it also shows unique value. Because its structure can be used as the basic skeleton for the design of drug molecules, by modifying bromine, iodine atoms and other positions on the benzene ring, it can adjust the activity, selectivity and pharmacokinetic properties of drug molecules. Researchers can use its structural properties to design and synthesize compounds with potential biological activities, providing key lead compounds for the development of new drugs.
What are the synthetic methods of 3 '-bromo-4-iodo-biphenyl
To prepare 3-bromo-4-iodobiphenyl, there are various methods. The common ones can be obtained from biphenyl and obtained by halogenation.
First take the biphenyl, use an appropriate halogenating agent, such as bromine and an appropriate catalyst, such as iron powder or iron tribromide, at a suitable temperature and reaction conditions, so that the bromine atom selects the position to replace the hydrogen atom on the biphenyl ring to obtain 3-bromobiphenyl. In this step of reaction, attention must be paid to the control of the reaction conditions. If the temperature is too high or too low, and the amount of halogenating agent is improper, it can cause side reactions, such as the formation of polybrominated compounds.
After obtaining 3-bromobiphenyl, proceed to iodization. The iodine atom is often substituted for the hydrogen at a specific position in the 3-bromobiphenyl ring in a specific solvent with an iodine elemental substance and an appropriate oxidizing agent, such as hydrogen peroxide or nitric acid, to obtain 3-bromo-4-iodobiphenyl. This step also requires careful control of the reaction conditions. The amount of oxidizing agent, reaction temperature and time all have a great impact on the purity and yield of the product.
In another way, other compounds can also be used as starting materials. After multi-step reaction, the biphenyl structure is gradually constructed and bromine and iodine atoms are introduced. However, these methods may require multi-step reactions, which are complicated to operate, and each step of the reaction needs to pay attention to the control of yield and purity to achieve the requirements of the final product. In conclusion, the synthesis of 3-bromo-4-iodobiphenyl requires fine planning of the reaction path, strict selection of reaction conditions, and careful control of each step of the reaction in order to obtain satisfactory results.
What are the physical properties of -bromo-4-iodo-biphenyl?
3% 27-Bromo-4-iodine-biphenyl is one of the organic compounds. Its physical properties are crucial, and it is related to many uses and reactions of this compound.
First of all, its appearance is mostly white to light yellow crystalline powder at room temperature. This form is easy to store and handle, because its solid state is stable, it is not easy to volatilize or lose.
As for the melting point, it is about a specific temperature range, and this characteristic has a great influence on its state maintenance and application in different ambient temperatures. The exact value of the melting point can help to determine its purity. If the purity is high, the melting point is stable and close to the theoretical value; if it contains impurities, the melting point may be deviated.
Solubility is also an important physical property. In organic solvents such as ethanol, ether, chloroform, etc., 3% 27-bromo-4-iodine-biphenyl exhibits a certain solubility, which makes it effectively dispersed in the reaction system in the organic synthesis reaction and promotes the reaction. However, in water, its solubility is extremely low, because its molecular structure has strong hydrophobicity and the force between water molecules is weak.
In addition, the density of this compound is also a specific value. This value is very important in application scenarios such as mass and volume conversion, as well as layering of mixed systems. Knowing the density can accurately control its dosage in various experiments or industrial production. The physical properties of 3% 27-bromo-4-iodine-biphenyl are interrelated, which is of great significance to its research, synthesis and practical application in the field of organic chemistry.
What are the chemical properties of -bromo-4-iodo-biphenyl?
3% 27-Bromo-4-iodine-biphenyl, which is an organic compound with specific chemical properties.
In this compound, the presence of bromine and iodine atoms makes it uniquely reactive. Both bromine and iodine are halogen elements. The electronic effect of halogen atoms can affect the electron cloud distribution of molecules, resulting in active chemical properties.
As far as nucleophilic substitution reactions are concerned, the electron cloud density of the benzene ring is reduced due to the electron absorption of halogen atoms, which is conducive to the attack of nucleophilic reagents. Especially iodine atoms, due to their large atomic radius, relatively small C-I bond energy, and easy to leave, so in nucleophilic substitution reactions, the location of iodine atoms is often a check point for reactivity.
In redox reactions, this compound may participate in related processes. The oxidation state of bromine and iodine is variable, and under suitable conditions, oxidation or reduction reactions can occur, changing its chemical structure.
In addition, its physical properties are also affected by bromine and iodine atoms. Due to the introduction of halogen atoms, the polarity of the molecule increases, resulting in changes in its boiling point and melting point compared with biphenyl. And because the halogen atom has a certain electronegativity, in terms of intermolecular forces, it may form dipole-dipole interactions, which affect its solubility in different solvents.
In short, the existence of 3% 27-bromo-4-iodine-biphenyl bromine and iodine atoms has active reactivity and unique physical properties, and has potential application value in many fields such as organic synthesis.
What is the price range of 3 '-bromo-4-iodo-biphenyl in the market?
I have not been able to confirm the market price range of 3-bromo-4-iodine-biphenyl. The price of this compound often varies due to various reasons. One is purity. Those with high purity are expensive, and those with more impurities are cheap. The second is supply and demand. If there are many requests and less supply, the price will rise; if supply exceeds demand, the price may drop. The third is related to the difficulty of production, the complexity of synthesis, and the scarcity of raw materials. The price is also high.
If you want to know the approximate price, you can find it from the chemical product trading platform and suppliers. The chemical platform lists the prices of various chemicals. Although there may be fluctuations, it can also be used for reference. Ask suppliers for more accurate quotations, because they are priced according to current costs and market conditions.
Or you can check academic literature and industry reports, which may involve the market analysis of related compounds and price patterns to help Junming's approximate price range. Unfortunately, I don't have real-time market conditions and cannot confirm its price. You can follow the above path to explore the market price of 3-bromo-4-iodine-biphenyl.
