As a leading 3-Bromo-4-Iodobenzoic Acid Methyl Ester supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
3-bromo-4-iodobenzoic chemical properties of Acid Methyl Ester
3-Bromo-4-iodobenzoate methyl ester is one of the organic compounds. Its chemical properties are quite unique, and the following is a detailed description for you.
In this compound, both bromine and iodine atoms are halogen atoms, and halogen atoms have strong electronegativity, which makes the molecule exhibit a certain polarity. This polarity has a profound impact on its physical and chemical properties.
Let's talk about the physical properties first. Due to the polarity of the molecule, 3-bromo-4-iodobenzoate methyl ester has good solubility in organic solvents, such as common organic solvents such as ethanol and ether. However, in water, its non-polar part accounts for a large proportion, so its solubility is not good.
When it comes to chemical properties, halogen atoms are abnormally active. Bromine and iodine atoms can undergo nucleophilic substitution reactions. Under suitable conditions, nucleophiles can attack the carbon atoms attached to halogen atoms and replace halogen atoms. For example, using sodium alcohol as a nucleophilic reagent can generate corresponding ether compounds.
Furthermore, ester groups are also important functional groups of this compound. Ester groups can undergo hydrolysis under acidic or basic conditions. Under acidic conditions, the hydrolysis reaction is reversible, resulting in 3-bromo-4-iodobenzoic acid and methanol; under alkaline conditions, the hydrolysis reaction is more thorough, resulting in 3-bromo-4-iodobenzoic acid and methanol.
In addition, the substituents on the benzene ring have a great influence on the electron cloud density distribution of the benzene ring. Bromine and iodine atoms are electron-withdrawing groups, which will reduce the electron cloud density of the benzene ring, thereby affecting the activity of electrophilic substitution reactions on the benzene ring. Generally speaking, electrophilic substitution reactions tend to occur at relatively high electron cloud densities.
Methyl 3-bromo-4-iodobenzoate has rich and diverse chemical properties, which determine its important use in many fields such as organic synthesis. It can be used as a key intermediate to participate in the preparation of various organic compounds.
3-bromo-4-iodobenzoic Acid Methyl Ester
The common methods for preparing methyl 3-bromo-4-iodobenzoate are as follows.
First, using 3-bromo-4-iodobenzoic acid as the starting material, esterification reaction occurs with methanol catalyzed by concentrated sulfuric acid. This reaction needs to be carried out under the condition of heating and reflux. Concentrated sulfuric acid not only acts as a catalyst, but also has the effect of absorbing water, which prompts the reaction equilibrium to move in the direction of ester formation. For specific operation, 3-bromo-4-iodobenzoic acid and methanol are placed in a reaction vessel in a certain proportion, slowly add an appropriate amount of concentrated sulfuric acid, heat and stir. The reaction process needs to be monitored by thin layer chromatography (TLC). After the reaction is completed, the reaction liquid is cooled, poured into ice water, and the product is extracted with an organic solvent. The organic phase is washed and dried with water, the solvent is removed by rotary evaporation, and then purified by column chromatography. Pure methyl 3-bromo-4-iodobenzoate can be obtained.
Second, the halogenation reaction of methyl benzoate can be carried out first. Using methyl benzoate as the substrate, under suitable reaction conditions, the brominating agent and the iodizing agent are halogenated in sequence. First, bromination is carried out. The commonly used brominating agent such as N-bromosuccinimide (NBS), in the presence of an initiator such as benzoyl peroxide (BPO), heats the reaction in a suitable solvent, and bromine atoms can be introduced at specific positions in the benzene ring. Then iodization is carried out, and a suitable iodizing agent such as a mixed system of iodine elemental substance and potassium iodide is used to react under alkaline conditions to obtain methyl 3-bromo-4-iodobenzoate. After the reaction is completed, it is purified by a series of post-processing operations, such as extraction, washing, drying, column chromatographic separation, etc.
Third, it can also be prepared by halogenation of aryl borate esters. First, the borate corresponding to 3-bromo-4-iodobenzoic acid is prepared from suitable raw materials, and then the borate is halogenated with halogenating reagents, and the methyl ester group is introduced at the same time. This method requires specific reaction conditions and catalysts, and regular post-processing steps are required after the reaction to obtain the target product.
The above methods have their own advantages and disadvantages. The actual synthesis needs to be based on the availability of raw materials, the controllability of reaction conditions, and the purity requirements of the product. Factors such as comprehensive consideration, choose the most suitable synthesis route.
What are the main uses of 3-bromo-4-iodobenzoic Acid Methyl Ester?
Methyl 3-bromo-4-iodobenzoate has a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate. Gein bromine and iodine atoms have high reactivity, and can introduce other functional groups or carbon chains through many chemical reactions, such as nucleophilic substitution, coupling reactions, etc., to construct complex organic molecular structures.
In the field of medicinal chemistry, the products of organic synthesis may have biological activity and can be used as lead compounds for drug development. The methyl benzoate structure of this compound is used in the design of drug molecules, or affects the physical and chemical properties of molecules, such as solubility, stability, and even interaction with biological targets.
In materials science, derivatives obtained by organic synthesis, or with unique optical and electrical properties, can be used to prepare optoelectronic materials. For example, conjugated systems are constructed by coupling reactions to change the photoelectric properties of compounds, which are used in the preparation of organic Light Emitting Diodes, solar cells and other materials.
In summary, methyl 3-bromo-4-iodobenzoate has important uses in organic synthesis, medicinal chemistry, materials science and other fields due to its unique structure and reactivity. It is an important starting material for the preparation of various functional compounds and materials.
3-bromo-4-iodobenzoic Acid Methyl Ester during storage and transportation
Methyl 3-bromo-4-iodobenzoate is also an organic compound. During storage and transportation, all precautions should not be ignored.
First words storage, this compound should be placed in a cool, dry and well-ventilated place. Because it is more sensitive to heat, if it is in a high temperature environment, it may decompose or deteriorate, so it is important to keep away from heat sources and fire sources. And it should be stored separately from oxidants, acids, alkalis and other substances. Due to its active chemical properties, contact with them can easily cause chemical reactions and cause danger. Furthermore, the storage container must be tightly sealed to prevent it from interacting with moisture, oxygen and other components in the air and affecting the quality.
As for transportation, it is necessary to ensure that the packaging is intact and can effectively resist vibration and collision. Choose suitable transportation tools and follow relevant regulations on the transportation of hazardous chemicals. During transportation, pay close attention to environmental factors such as temperature and humidity to avoid extreme conditions. Escort personnel should also be familiar with the characteristics of this compound and emergency treatment methods. In case of unexpected situations, they can quickly and properly respond. If you accidentally leak, you must not panic. You should immediately isolate the scene, evacuate personnel, and take appropriate cleaning and disposal measures according to its characteristics. In this way, you must ensure the safety of methyl 3-bromo-4-iodobenzoate during storage and transportation.
What is the market price range for 3-bromo-4-iodobenzoic Acid Methyl Ester?
I don't know if 3-bromo-4-iodobenzoic Acid Methyl Ester (3-bromo-4-iodobenzoic acid methyl ester) can be cut in the market. The market of this compound is affected by many factors, so it is necessary to determine its price.
First, its ease of operation affects the price. If the synthesis requires complex steps, special raw materials or harsh parts, the cost will be high, and the price will also rise. To synthesize this compound, bromine atoms and iodine atoms are introduced into benzene, and to control its position, and methester groups must be generated. If the reverse parts require precision, the synthesis degree is large, and the price is not low.
Second, the supply and demand of the market are important factors. If the demand for this compound is strong, such as in some synthetic fields, and the supply is limited, the price will rise due to demand push. On the contrary, if the demand is low and the supply is sufficient, the price may be reduced.
Third, the cost of raw materials also affects its price. The starting materials used in synthesis, such as compounds containing bromine and iodine and methyl benzoate phase raw materials, if the price is low, the price of the product will be the highest. If the sources of bromine and iodine are scarce, and the price of raw materials is high, the price of 3-bromo-4-iodobenzoate methyl ester will also be high.
Fourth, the price difference between suppliers and suppliers is also different. Different industries have low productivity and cost control capabilities. Large-scale chemical companies have high cost and low cost, and the price may also be more cost-effective. Small-scale companies have high cost, low cost or high cost. And different suppliers are based on their own profit strategies, sales domains and other factors, and there are also waves.
> If you want to know the market value, you need to check the chemical products trading platform, the supplier or the research bank to get the price.
