3-bromo-5-iodo-2-aminopyridine

3-Bromo-5-iodo-2-aminopyridine is a kind of organic compound. Its main uses are quite extensive, and it is often a key intermediate in the field of medicinal chemistry. The special structure of the geinpyridine ring and the chemical activities of bromine, iodine and amino groups can be used to construct complex drug molecular structures through many chemical reactions, such as nucleophilic substitution, coupling reactions, etc.
In the field of materials science, it also has applications. It can participate in the synthesis of materials with special photoelectric properties. By precisely regulating the molecular structure, the material is endowed with unique optical and electrical properties, such as in the research and development of organic Light Emitting Diode (OLED), organic photovoltaic cells and other devices.
In addition, in organic synthetic chemistry, this compound is often used as a starting material or an important intermediate, which helps to synthesize a variety of organic compounds and provides important support for the development of organic synthetic chemistry. With its diverse reaction check points, chemists can design and implement the synthesis of complex organic molecules according to specific needs. In short, 3-bromo-5-iodo-2-aminopyridine has indispensable and important uses in many fields such as drugs, materials and organic synthesis.

There are several common methods for synthesizing 3-bromo-5-iodine-2-aminopyridine.
First, pyridine is used as the starting material. First, the pyridine is aminylated. Appropriate aminylating reagents can be selected. Under suitable reaction conditions, an amino group is introduced into the pyridine ring to generate 2-aminopyridine. Subsequently, in a specific reaction system, bromine atoms are introduced. For example, choose a suitable brominating reagent, such as N-bromosuccinimide (NBS), etc., under the action of a suitable solvent, temperature and catalyst, introduce bromine atoms at the 3rd position of 2-aminopyridine to obtain 3-bromo-2-aminopyridine. Finally, introduce an iodine atom, select a suitable iodizing reagent, such as iodine elemental and a suitable oxidant combination, and introduce an iodine atom at the 5th position of 3-bromo-2-aminopyridine in a suitable reaction environment to obtain 3-bromo-5-iodine-2-aminopyridine.
Second, other nitrogen-containing heterocyclic compounds can also be used as starting materials. If a specific nitrogen-containing heterocyclic derivative is used as the raw material, it will undergo a series of functional group conversion reactions. The pyridine ring is first constructed through suitable reaction steps, and the amino group, bromine atom and iodine atom are introduced in a specific order during the construction process or after the construction is completed. For example, the iodine atom is introduced first, and then the amino group and bromine atom are introduced. The specific reaction conditions need to be carefully optimized according to the selected starting material and reaction path, such as the choice of reaction solvent, the regulation of temperature, and the screening of catalyst, which will all affect the reaction process and product yield.
Third, the coupling reaction strategy of transition metal catalysis can also be considered. Using a pyridine derivative with a suitable substituent as the substrate, with the help of transition metal catalysts such as palladium catalysts, the coupling reaction is carried out with bromine and iodine-containing reagents respectively. First, the coupling reaction occurs with the bromine-containing reagent, the bromine atom is introduced at a specific position of the pyridine ring, and then the iodine atom is introduced at another specific position. At the same time, the amino group is introduced by a suitable method. In this process, precise control of the reaction conditions, such as the amount of metal catalyst, the choice of ligand, the type and amount of base, etc., is essential for the successful synthesis of 3-bromo-5-iodine-2-aminopyridine.

3-Bromo-5-iodo-2-aminopyridine is an organic compound. Its physical properties are as follows:
Under normal conditions, it may be a solid. Due to the presence of halogen atoms such as bromine and iodine, the intermolecular force is enhanced, resulting in a relatively high melting point. Its color may be white to pale yellow solid, which is due to the interaction of conjugated systems and heteroatoms in the molecular structure, which affects light absorption.
On the melting point, due to the presence of halogen atoms and amino groups, hydrogen bonds and van der Waals forces can be formed between molecules, and the melting point may be within a certain range. Specifically, bromine and iodine atoms increase the molecular mass and volume, making the intermolecular forces more complex. The expected melting point is higher than that of ordinary pyridine derivatives, but the exact value needs to be determined experimentally.
In terms of boiling point, the compound has a higher boiling point due to strong intermolecular forces. Bromine and iodine atoms increase the polarity of the molecule, and amino groups can participate in the formation of hydrogen bonds, which enhances the intermolecular interaction and increases the energy required for gasification, so the boiling point is higher than that of simple pyridine compounds.
In terms of solubility, due to its polar amino and halogen atoms, it may have a certain solubility in polar organic solvents such as methanol, ethanol, and dichloromethane. The amino group can form hydrogen bonds with polar solvents. Although the halogen atom increases the non-polar part of the molecule, the whole still makes the compound have a certain affinity for polar solvents. However, the solubility in water may be limited, and it is difficult to fully miscible with water due to the influence of non-polar parts such as the pyridine ring and the halogen atom in the molecule.
The density is due to the relative atomic weight of bromine and iodine atoms, or greater than that of water. The heavier bromine and iodine atoms make the molecular weight increase significantly, while the molecular structure is relatively compact, so the unit volume mass increases, that is, the density is greater than that of common organic solvents and water.
The physical properties of this compound are affected by the synergistic effect of various groups in the molecular structure, which is of great significance

3-Bromo-5-iodine-2-aminopyridine is also an organic compound. Its chemical properties are unique and it has many interesting properties.
First of all, its reactivity. The presence of amino groups makes this compound active in electrophilic substitution reactions. Amino groups are the power supply groups, which can increase the electron cloud density of the pyridine ring, especially in adjacent and para-sites, so electrophilic reagents are easy to attack here. Bromine and iodine atoms also affect the reactivity. Although they are electron-absorbing groups, they can also participate in the reaction under specific conditions because of their lone pairs of electrons.
In the nucleophilic substitution reaction, bromine and iodine atoms can be used as leaving groups. Due to its large atomic radius, the bond energy between C-Br and C-I is relatively low, and it is easy to be replaced under appropriate nucleophilic reagents and reaction conditions. For example, when encountering nucleophilic reagents, such as alkoxides, amines, etc., bromine or iodine atoms can be replaced by corresponding groups to form new carbon-heteroatom bonds.
This compound also exhibits in redox reactions. Amino groups can be oxidized to form derivatives such as nitroso or nitro, depending on the oxidation conditions. At the same time, the pyridine ring may also be destroyed under strong oxidation conditions. During reduction reactions, the pyridine ring can be hydrogenated and reduced, changing its unsaturated structure.
In addition, its acid-base properties cannot be ignored. Amino groups have certain alkalinity and can form salts with acids. In different pH environments, the existence form and reactivity of this compound will change, affecting its performance in various reactions.
In summary, 3-bromo-5-iodine-2-aminopyridine exhibits diverse chemical properties in various organic reactions due to its unique chemical structure, making it an important research object in the field of organic synthetic chemistry.

In today's world, it is difficult to determine the price of 3-bromo-5-iodo-2-aminopyridine in the market. The price often varies due to various factors, such as the supply and demand of materials, the difficulty of manufacturing, and the competition in the market.
Looking back at the past, in the market of chemical raw materials, the price of such fine chemicals often fluctuated greatly. If the raw materials are easy to extract, the preparation method is simple and all factories can do it, the price may become more affordable. However, if the raw materials are rare, the production requires high skills and techniques, and the supply is not enough, the price will be high.
Although "Tiangong Kaiwu" does not specify the price of this specific chemical, it does mention various technological creations, all of which show that the price of the product depends on the simplicity of the production and the abundance of materials. 3-Bromo-5-iodo-2-aminopyridine If the preparation process requires multiple steps of reaction, rare reagents are used, and purification is difficult, its price should be high. On the contrary, if the preparation is convenient and the raw materials are widely available, the price may be close to the people.
Competition in the market is also a major reason. If multiple manufacturers compete to produce this product, they may compete for market share or reduce the price, which will make the price lower. And the only one, or a few families can make it, without the worry of competition, the price may be high.
If you want to know the exact price today, you should consult the chemical raw material supplier, or refer to the quotation of the chemical product trading platform to get a near-real price. However, this price is not constant, and it varies from time to time with changes in the market.