3 Bromo 5 Iodo Pyridine

The method of preparing 3-bromo-5-iodopyridine is an important topic in the field of organic synthesis. To obtain this compound, several paths can be achieved. Today, I will describe one or two in detail.
First, pyridine can be started, and bromine atoms can be introduced into the appropriate position of the pyridine ring through a bromination reaction. In this bromination step, bromine (Br ²) is often used as the bromine source. In the presence of suitable catalysts such as iron or iron salts, pyridine undergoes electrophilic substitution with bromine. The electron cloud distribution characteristics on the pyridine ring determine that the bromine atoms are mainly replaced at the 3-position or 5-position. However, the selectivity of this reaction is not absolute, so the reaction conditions, such as reaction temperature, reactant ratio, and catalyst dosage, need to be carefully controlled to improve the yield of 3-bromopyridine.
After 3-bromopyridine is obtained, iodine atoms are introduced by iodine substitution reaction. This step usually uses iodides such as potassium iodide (KI), and with the help of suitable oxidants such as hydrogen peroxide (H2O) or potassium persulfate (K2O), under mild reaction conditions, 3-bromopyridine undergoes nucleophilic substitution with iodide, resulting in 3-bromopyridine-5-iodopyridine.
Second, suitable pyridine derivatives can also be used as raw materials to construct target molecules through multi-step reactions. For example, first, pyridine derivatives with suitable protective groups are gradually introduced into bromine and iodine atoms through a series of reactions such as selective deprotection and halogenation. Although this path has many steps, it can effectively improve the selectivity and yield of the reaction through the protection group strategy.
Furthermore, the reaction involving organometallic reagents can also provide an effective way for the synthesis of 3-bromo-5-iodine pyridine. For example, the use of Grignard reagents or lithium reagents to react with halogenated pyridine derivatives, through rational design of reaction sequences and substrate structures, the introduction of bromine and iodine atoms at specific positions in the pyridine ring can be achieved.
There are many ways to synthesize 3-bromo-5-iodopyridine, each with its advantages and disadvantages. In practice, it is necessary to comprehensively consider many factors such as the availability of raw materials, the difficulty of reaction conditions, the high yield and selectivity, and choose the optimal path to achieve the purpose of efficient synthesis.

3-Bromo-5-iodopyridine is also an organic compound. It has a wide range of uses and is often a key intermediate in the field of organic synthesis. Due to the activity of bromine and iodine in its structure, it can initiate a variety of chemical reactions, through nucleophilic substitution, coupling and other reactions, to prepare various nitrogen-containing heterocyclic compounds, and is important in the fields of medicinal chemistry and materials science.
In the field of medicine, it can be used as a lead compound to develop new drugs. In many drug molecular structures, pyridine rings are common. With 3-bromo-5-iodopyridine, pyridine rings can be modified to access different functional groups, change the activity, selectivity and pharmacokinetic properties of drug molecules, and hope to find new drugs with specific pharmacological activities.
In materials science, it can be introduced into polymer or small molecule material structures through organic synthesis steps. With its reactivity, materials with special optoelectronic properties are constructed, such as used in organic Light Emitting Diodes (OLEDs), solar cells and other devices, which endow materials with unique electron transport and optical properties and improve the performance of devices.
In addition, in chemical research, as an important synthetic building block, chemists use it to construct complex organic molecular structures and expand organic synthesis methodologies. Through different reaction conditions and reagent combinations, novel reaction pathways are explored to promote the development of organic chemistry. Therefore, 3-bromo-5-iodopyridine plays an important role in many fields and is an important material basis for the development of organic synthesis and related disciplines.

3-Bromo-5-iodopyridine, this is an organic compound, and its physical properties are of great research value.
Looking at its properties, under room temperature and pressure, 3-bromo-5-iodopyridine is mostly solid, or powdery, or crystalline. The color is usually white to light yellow, and the pure one is lighter. This is due to the presence of bromine and iodine atoms in the molecular structure, which affects the interaction between molecules, causing its crystalline morphology to exhibit such characteristics.
When it comes to melting point, the melting point of 3-bromo-5-iodopyridine is moderate, about a certain temperature range, which is caused by the force between molecules. The relative mass of bromine and iodine atoms is relatively large and has a certain polarity, which enhances the intermolecular force, so that the molecule needs a specific energy to overcome this force and transform from solid to liquid, so the melting point presents a specific value.
In terms of boiling point, due to the existence of bromine and iodine atoms in the molecule, the molecular mass increases, and the intermolecular force is enhanced, resulting in a higher boiling point. More energy is required to make the molecule overcome the intermolecular force and transform from liquid to gaseous.
Solubility is also an important physical property. 3-Bromo-5-iodopyridine has good solubility in organic solvents, such as common ethanol, ether, dichloromethane, etc. This is because the compound molecule has a certain polarity, and can form such as van der Waals force and dipole-dipole interaction with organic solvent molecules, making it soluble in such solvents. However, the solubility in water is poor, because water is a strong polar solvent, while 3-bromo-5-iodopyridine is polar, but it is not enough to form an effective interaction with water molecules to overcome the strong forces such as hydrogen bonds between water molecules, so it is difficult to dissolve in water.
In terms of density, due to the large relative atomic mass of bromine and iodine atoms, the density of 3-bromo-5-iodopyridine is greater than that of common organic solvents and water. In experimental operations, this property can be used for substance separation and identification.
In addition, 3-bromo-5-iodopyridine is relatively stable chemically at room temperature, but under specific conditions, such as high temperature, strong acid-base environment or the presence of specific catalysts, bromine and iodine atoms in the molecule can undergo substitution, elimination and other reactions, which are also related to their physical properties, such as melting point and solubility, which will affect the reaction rate and reaction pathway.

3-Bromo-5-iodopyridine is a kind of organic compound. Its physical properties are mostly solid at room temperature, but the specific melting and boiling point is difficult to determine because the relevant literature is not detailed. This compound may be soluble in organic solvents, such as common ethanol, ether, dichloromethane, etc. Due to the characteristics of the pyridine ring in its structure, the pyridine ring has a certain polarity and interacts with organic solvents.
In terms of chemical properties, the bromine atom and iodine atom in 3-bromo-5-iodopyridine are both active functional groups. Bromine atom and iodine atom can undergo nucleophilic substitution reaction due to the characteristics of halogen atom. When encountering a nucleophilic reagent, the halogen atom can be replaced by a nucleophilic group. If sodium alcohol is used as a nucleophilic reagent, the halogen atom may be replaced by an alkoxy group to generate the corresponding ether compound; if an amine is used as a nucleophilic reagent, a nitrogen-containing derivative can be generated. The mechanism of this nucleophilic substitution reaction is probably that the nucleophilic reagent attacks the carbon atom connected to the halogen atom, and the halogen atom leaves with a pair of electrons, thus forming a new compound.
Furthermore, the pyridine ring also has certain chemical activity. The nitrogen atom of the pyridine ring has a lone pair of electrons and can bind with protons, so 3-bromo-5-iodopyridine is alkaline and can react with acids And the pyridine ring can undergo electrophilic substitution reaction, but because the electronegativity of the nitrogen atom is larger than that of the carbon atom, the electron cloud density on the ring is reduced, and the electrophilic substitution reaction activity is slightly lower than that of the benzene ring. In electrophilic substitution reactions, the substituents often enter the β position of the pyridine ring, which is due to the relatively high electron cloud density at the β position.
In addition, 3-bromo-5-iodopyridine can participate in metal-catalyzed reactions under appropriate conditions, such as palladium-catalyzed coupling reactions. In the presence of palladium catalysts, ligands and bases, its halogen atoms can be coupled with other organometallic reagents to form carbon-carbon bonds or carbon-heteroatom bonds, which is of great significance in the field of organic synthesis and can be used to synthesize more complex organic compounds.
In summary, 3-bromo-5-iodopyridine has potential applications in many fields such as organic synthesis due to its unique structure and diverse chemical properties.

3-Bromo-5-iodopyridine is on the market, and its price range is difficult to determine. The price of this compound often varies due to many factors. First, the amount of output is also a factor. If the production is abundant and the market supply is abundant, the price may become cheaper; if the production is limited, the supply is difficult to meet the demand, and the price must rise. Second, the difficulty of preparation also has a great impact. If the preparation of this substance requires complexity, many consumables and high technical requirements, the cost will increase and the price will also be high. Third, the state of market demand also affects its price. If an industry has strong demand for it, but the supply is relatively small, the price will rise; if the demand is weak, the price may fall.
Looking at the example of "Tiangong Kaiwu", the price of ancient things varies according to production and demand. As recorded in the book, the price of silk and silk, when the silkworm is in its prime, produces more and the price is flat; when the silkworm is thin, when it produces less, the price is high. 3-Bromo-5-iodopyridine is the same. According to market conditions, its price may range from tens to hundreds of yuan per gram. However, this is only a rough estimate. To obtain a definite price, you need to carefully observe the current chemical raw material market and consult suppliers to know the exact price range in the near future.