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3-bromo-5-iodobenzoic Acid, what is the chemical property of 98 +%
3-Bromo-5-iodobenzoic acid, content 98 +%, this is an organic compound with unique chemical properties. Its appearance is usually white to light yellow crystalline powder, which is stable at room temperature and pressure. However, in case of open flame, hot topic or strong oxidant, there is a risk of combustion and explosion.
From the perspective of physical properties, its melting point and boiling point are key characteristics. The melting point is about 195-199 ° C. At this temperature, the substance changes from solid to liquid, which is of great significance for identification and purity determination. Although the exact data on boiling point is not available, its boiling point will change due to environmental pressure.
Solubility is also an important property. 3-Bromo-5-iodobenzoic acid is slightly soluble in water, because of the strong hydrogen bond between water molecules, and the weak interaction between the compound and water, it is difficult to break the attractive force between water molecules to dissolve into it. However, it is soluble in organic solvents, such as dichloromethane, chloroform, tetrahydrofuran, etc. In dichloromethane, the compound molecule and dichloromethane can form a van der Waals force, which makes it miscible. This property is widely used in the separation and purification step of organic synthesis.
Chemically, due to the carboxyl group, 3-bromo-5-iodobenzoic acid is acidic and can neutralize with bases. When reacted with sodium hydroxide, the hydrogen in the carboxyl group dissociates, combines with hydroxide to form water, and generates the corresponding carboxylate and water. This reaction is acid-base neutralization.
In addition, bromine and iodine atoms endow their halogenated aromatic hydrocarbon properties. Bromine and iodine atoms can participate in nucleophilic substitution reactions, and the electron cloud density and atomic activity of aromatic rings determine the reaction activity. Under appropriate conditions, nucleophiles such as sodium alcohols and amines can attack the halogen atoms attached to carbon, and the halogen atoms leave to form new carbon-heterobond compounds. This reaction is of great significance for the construction of complex organic molecular structures. The chemical properties of 3-bromo-5-iodobenzoic acid make it an important intermediate in organic synthesis in the fields of medicine, pesticides, materials science, etc. Compounds with special biological activities or material properties can be prepared through various reactions.
3-bromo-5-iodobenzoic Acid, 98 +% mainly used in which areas
3-Bromo-5-iodobenzoic acid, with a purity of more than 98%, has a wide range of uses and has its own impact in many fields.
In the field of medicinal chemistry, it is often an important synthetic intermediate. In drug development, when chemists want to make drug molecules with specific structures and functions, 3-bromo-5-iodobenzoic acid can be introduced into the target molecular structure through a series of organic reactions, such as nucleophilic substitution, coupling reactions, etc., to help build drug compounds with specific activities. Taking the development of anti-cancer drugs as an example, researchers hope to design drugs that can precisely act on cancer cell targets. 3-Bromo-5-iodobenzoic acid may act as a key building block in the synthesis route, and through clever reaction steps, finally generate drug molecules with potential anti-cancer activity.
In the field of materials science, it also has its uses. When preparing some functional organic materials, it can be used as a starting material or structural modification unit. For example, when synthesizing materials with special photoelectric properties, through chemical modification and polymerization reactions, the materials may be endowed with unique optical and electrical properties, which can be used in the fabrication of organic Light Emitting Diodes (OLEDs), solar cells and other devices to improve device performance and efficiency.
Furthermore, in the field of organic synthetic chemistry research, it is a common substrate for organic chemists to explore new reactions and new synthesis methods. Scientists conduct various reaction studies based on 3-bromo-5-iodobenzoic acid to explore the reaction mechanism and product selectivity under different reaction conditions, thereby expanding the boundaries of organic synthetic chemistry and providing new ideas and methods for the synthesis of new organic compounds.
3-bromo-5-iodobenzoic Acid, what are the preparation methods of 98 +%
There are several ways to prepare 3-bromo-5-iodobenzoic acid (3-bromo-5-iodobenzoic Acid, 98 +%).
First, benzoic acid can be started. First, the benzoic acid is brominated, and the specific brominating reagent, such as bromine (Br), can be obtained under appropriate catalysts, such as iron powder (Fe) or iron tribromide (FeBr), at appropriate temperatures and reaction conditions. In this step, attention should be paid to controlling the reaction temperature and the amount of reagents to avoid excessive bromination. Then, the isobromobenzoic acid is then iodized to produce 3-bromo-5-iodobenzoic acid in a suitable solvent and reaction environment with iodine (I ³) and an appropriate oxidant, such as hydrogen peroxide (H2O ³) or periodic acid (HIO). This iodization process also requires precise control of the conditions to ensure a smooth reaction and product purity.
Second, benzene can be started from benzene. Benzene is first acylated by Fu-Ke, and acetyl chloride (CH 🥰 COCl) is catalyzed by anhydrous aluminum trichloride (AlCl 🥰) to obtain acetophenone. Acetophenone is brominated to produce isobromoacetophenone under specific conditions with bromine and an appropriate base or catalyst. Isobromoacetophenone is oxidized, such as potassium permanganate (KMnO) and other oxidants, in a suitable acid-base environment, the acetyl group is converted into a carboxyl group to obtain isobromobenzoic acid. Subsequent to the above method, 3-bromo-5-iodobenzoic acid is prepared by iodization. There are many steps in this route, but the reaction conditions of each step are relatively mature, and high-purity products can be obtained after proper operation.
Or other novel synthesis strategies can be used. With the progress of chemical research, new reagents and new methods continue to emerge, which may optimize the reaction steps, improve the yield and product purity. In the preparation process, after each step of the reaction, it is often necessary to separate and purify, such as recrystallization, column chromatography, etc., to remove impurities and obtain high-purity 3-bromo-5-iodobenzoic acid, up to 98 +% purity requirements.
3-bromo-5-iodobenzoic Acid, what is the market price of 98 +%?
3-Bromo-5-iodobenzoic acid, 98 +%, the quality of its market can be determined quickly.
First, the difference between the two places, the cost is low. If it is well-crafted and the raw materials are easy to use, it is low or slightly cheaper; if the land is biased, the raw materials are low, high or high.
Second, the supply and demand are low, and the impact is large. If the market is high and the supply is limited, the supply will rise; if the supply is high and the demand is low, it will decline.
Third, the degree of improvement is also low.
Fourth, the quantity is large, and the quantity is also low. Bulk sales, merchants may give discounts, and retail sales are low.
Generally speaking, the market situation is not yet known, so we will report it. However, as an example of past transactions, if a small amount is sold, it may cost 10 to 100 yuan per gram; if a large amount is sold, it may be reduced to 10 yuan per gram. However, this is a rough estimate, and the price must be determined according to the situation of the next market.
3-bromo-5-iodobenzoic Acid, what is the storage condition of 98 +%?
3-Bromo-5-iodobenzoic acid, content 98 +%, this is a chemical substance, and its storage conditions are extremely critical. According to the concept of "Tiangong Kaiwu", when storing chemical substances, check their physical properties to ensure their purity and stability.
This 3-bromo-5-iodobenzoic acid has certain chemical activity and should be protected from heat and moisture to prevent deterioration. It should be stored in a cool place, because heat can easily promote its chemical reaction and cause decomposition or deterioration. The warehouse temperature should be controlled between 15 ° C and 25 ° C. If it is too high, it will be dangerous.
Furthermore, moisture is also a big enemy. This substance is damp, or causes reactions such as hydrolysis, which damages its purity and quality. Therefore, when placed in a dry place, the relative humidity of the air should be maintained at 40% to 60%. It can be stored and disposed of as a desiccant, such as silica gel, to absorb moisture.
Because it is a chemical, or has certain toxicity and corrosiveness, it must be isolated from other substances during storage. Do not co-store with oxidizing agents, reducing agents, etc., to prevent violent reactions. And should be kept away from fire and heat sources, because it may be flammable, in case of open flame, hot topic or dangerous.
Containers containing this substance should also be carefully selected. When using corrosion-resistant materials, such as glass or specific plastic containers, tightly seal to prevent leakage and volatilization. The storage area should be clearly marked as 3-bromo-5-iodobenzoic acid, with warning signs to remind users to pay attention to safety. Regularly check the storage status to see if the packaging shows any signs of damage or deterioration to ensure safe storage.
