3-Chloroiodobenzene

Fengxi Chemical

Specifications

HS Code	393922
Name	3 - Chloroiodobenzene
Molecular Formula	C6H4ClI
Molar Mass	238.45 g/mol
Appearance	Colorless to light - yellow liquid
Boiling Point	227 - 228 °C
Melting Point	−33 °C
Density	1.887 g/mL at 25 °C
Flash Point	101 °C
Solubility In Water	Insoluble
Solubility In Organic Solvents	Soluble in common organic solvents like ethanol, ether, and benzene
Cas Number	626 - 54 - 0
Purity	Typically available in high purity grades (e.g., 98%+)

As an accredited 3-Chloroiodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	100g of 3 - chloroiodobenzene packaged in a sealed, chemical - resistant bottle.
Storage	3 - Chloroiodobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly - sealed container, preferably made of a suitable corrosion - resistant material. This helps prevent decomposition, evaporation, and potential reactions that could pose safety risks.
Shipping	3 - Chloroiodobenzene is shipped in sealed, corrosion - resistant containers. It's carefully handled to prevent leakage during transit, following strict hazardous chemical shipping regulations due to its potential risks.

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General Information

Historical Development

3-Chloroiodobenzene is also an organic compound. The process of its research and development is worth exploring. In the past, the art of organic synthesis was not as delicate as it is today, and it was difficult to make this product. However, the sages worked tirelessly, and at the beginning, only a small amount of products could be obtained in the laboratory by complicated methods. At that time, the raw materials were not easy to obtain, and the reaction conditions were harsh, which could not be obtained without careful handling.
As the years passed, science and technology gradually advanced, the principles of organic chemistry became clearer, and the synthesis method became simpler. Chemists used their wisdom to improve the reaction path and optimize the ratio of raw materials, so that the yield of 3-chloroiodobenzene gradually increased and the quality was also excellent. From the initial difficult trial production, it can now be prepared on a large scale. This is one of the major advances in the field of organic synthesis, paving the way for its application in chemical, pharmaceutical and other industries.

Product Overview

About the product description of 3-chloroiodobenzene
3-chloroiodobenzene is also an important raw material for organic synthesis. Its properties are colorless to light yellow liquid with a unique odor. In the chemical and pharmaceutical fields, it has a wide range of uses.
As for its preparation, it is often obtained by a specific halogenation reaction. During the reaction, it is necessary to control the temperature and pressure, and select the appropriate catalyst to obtain a higher yield.
In terms of properties, 3-chloroiodobenzene has high chemical activity. Chlorine and iodine atoms are on the benzene ring, so that the product has the characteristics of both chlorine substitutes and iodine substitutes. It can participate in many nucleophilic substitution reactions, coupling reactions, etc., laying the foundation for the synthesis of complex organic compounds.
In terms of storage, it needs to be placed in a cool, dry place, protected from direct light and heat sources, to prevent deterioration. Because of its certain toxicity and irritation, when operating, it must follow safety procedures and wear protective equipment to ensure personal and environmental safety.
In short, 3-chloroiodobenzene plays an important role in the field of organic synthesis, and its rational use can promote the development of the chemical and pharmaceutical industries.

Physical & Chemical Properties

3-Chloroiodobenzene is also an organic compound. Its physical properties are mostly solid at room temperature and have a certain melting point. Looking at its color, it may be white to light yellow crystalline, depending on the preparation process and purity. Its texture is brittle and fragile to the touch.
When it comes to chemical properties, chlorine and iodine atoms give it active properties. Chlorine and iodine atoms on the benzene ring can participate in many substitution reactions. Such as nucleophilic substitution, chlorine or iodine atoms can be replaced by other groups under suitable reagents and conditions. Because of its halogen-containing atoms, it can react with metal reagents to form organometallic compounds, which are widely used in organic synthesis. These are all important physical and chemical properties of 3-chloroiodobenzene.

Technical Specifications & Labeling

For 3-chloroiodobenzene, organic compounds are also used. Its process specifications and identification (product parameters) are of paramount importance. To make this product, it is necessary to follow a precise method. The choice of raw materials, when pure and free of impurities, must be appropriate in proportion. The temperature and time of the reaction must be strictly controlled. If the temperature is high, the side should be raw, and if the temperature is low, the speed will be slow. If the time is not fully met, the energy consumption will increase.
On the label, it is necessary to indicate its name "3-chloroiodobenzene", list the chemical formula, and detail the physicochemical properties, such as color, state, and the number of melting boils. Mark the warning language to indicate its poison, rot and other hazards, so as to ensure the safety Precise process specifications and labels are the foundation for product quality and user safety, and must not be ignored.

Preparation Method

The method of preparing 3-chloroiodobenzene is related to the raw materials and production process, reaction steps and catalytic mechanism. First, benzene is taken as the initial raw material, chlorine is used as the halogenating agent, and under the catalysis of ferric chloride, an electrophilic substitution reaction occurs to obtain chlorobenzene. This step requires temperature control at 50-60 degrees Celsius, and polychlorination by-products are prone to occur due to high temperatures.
Then, chlorobenzene and iodine are co-heated at 120-130 degrees Celsius in the presence of an appropriate amount of copper oxide catalysis and potassium carbonate acid binding agent. This reaction goes through the steps of oxidation addition, metal transfer, reduction and elimination. Under copper oxide catalysis, the activity of iodine and chlorobenzene is enhanced, and potassium carbonate neutralizes the generated hydrogen iodide
After this operation, the product of 3-chloroiodobenzene can be obtained. However, the product or containing impurities needs to be purified by distillation, recrystallization, etc. to achieve high purity products. This preparation process pays attention to the control of each step conditions to ensure the yield and purity of the product.

Chemical Reactions & Modifications

3-Chloroiodobenzene is also an organic compound. Its chemical reaction and modification are of great importance to our research. In previous experiments, the common halogenated aromatics reaction method was used to make 3-chloroiodobenzene participate in nucleophilic substitution, but the activities of chlorine and iodine are different, the reaction is not easy to control, and the yield is not ideal.
After thinking about it, I changed it to a catalytic system. Try to use palladium catalysis to optimize the choice of ligands and bases. Looking at it, the combination of specific ligands and weak bases can increase the selectivity of the reaction. The palladium catalyst is good for activating halogen atoms, the ligand adjusts its electron cloud and space conformation, and the weak base avoids side reactions.
With this method, the reactivity of 3-chloroiodobenzene is increased. In the coupling reaction, different groups can be precisely joined, and the product purity is also high. This chemical modification method paves the way for its subsequent application in materials and drug synthesis, making it more potential in various fields.

Synonyms & Product Names

3-Chloroiodobenzene is also a chemical substance. Its synonymous name has many other names in the industry. This substance, with its unique chemical composition, is quite useful in various fields of chemical industry.
In the past, various parties explored this chemical substance, each with its legal name. Although the names are different, they all refer to 3-chloroiodobenzene. Or because of the order and structure of chlorine and iodine atoms, or the method and properties of synthesis, they have different names.
The names of its products also vary with merchants and uses. However, they are all the same thing. These synonymous names and trade names are like a list of stars, all revolving around the core of 3-chloroiodobenzene. Chemists must be well aware of their various titles in order to be correct and smooth in their research and application.

Safety & Operational Standards

3-Chloroiodobenzene is an important substance in chemical research. During the experimental operation, safety regulations should be kept in mind first.
Its properties are dangerous, which is related to people and the environment. Therefore, when operating, protective equipment is essential. Experimenters must wear protective clothing, goggles and gloves to protect against possible hazards.
As for the operating space, it is necessary to ensure good ventilation. This is because 3-chloroiodobenzene or volatile harmful gases can be quickly dispersed with good ventilation to prevent its accumulation and endanger personnel.
Storage methods are also exquisite. It should be placed in a cool, dry and ventilated place, away from fire sources and oxidants. Cover 3-chloroiodobenzene in case of heat or oxidant, fear chemical reaction and cause dangerous state.
The operation process should be carried out according to the specifications. When taking it, the action should be slow and stable to prevent it from spilling. If there is an accidental spill, do not panic, and dispose of it quickly according to emergency methods. First cut off the fire source, then absorb it with suitable materials, and dispose of it properly.
The equipment of the experiment should be used with Bi Bijing. Due to the residue of 3-chloroiodobenzene, it may affect the follow-up experiment, or cause corrosion of the equipment.
Furthermore, the waste of the experiment should not be discarded at will. When classified and collected, treat according to environmental regulations to protect the safety of the environment.
In short, in the research operation of 3-chloroiodobenzene, safety and standardization are always in mind. In this way, the purpose of research can be achieved, and the safety of personnel and the environment can be ensured.

Application Area

3-Chloroiodobenzene is also an organic compound. Its application field is quite wide, and it can be a key intermediate for the synthesis of many special drugs in the field of medicinal chemistry. Taking anti-cancer drugs as an example, through delicate chemical reactions and integration into their molecular structures, the activity of compounds can be changed and the anti-cancer efficacy can be improved.
In the field of materials science, 3-chloroiodobenzene also has important functions. It can be used to prepare materials with special photoelectric properties, such as organic Light Emitting Diode (OLED) materials. After rational design and synthesis, it can optimize the luminous efficiency and stability of materials and promote the progress of display technology.
In organic synthetic chemistry, it is an important building block for the construction of complex organic molecules. Chemists can use its unique chemical activity to precisely construct various carbon-carbon and carbon-heteroatom bonds through halogenation reactions, coupling reactions, etc., to achieve effective synthesis of target compounds and contribute to the development of organic synthetic chemistry.

Research & Development

Nowadays, there is a chemical substance called 3-Chloroiodobenzene, and I have devoted myself to studying it. Looking at its structure, chlorine and iodine are co-attached to the benzene ring. This unique structure gives it a different nature.
During the synthesis process, I tried many times. At first, the common method was used, but the yield did not meet expectations. Then I consulted ancient books and found other methods to improve. After repeated investigation, I finally found a solution that can improve the yield.
This substance has great potential in many fields. In the field of medicine, it may be used as an intermediate to help the research and development of new drugs. The field of materials is also expected to contribute to the creation of new materials due to its special properties. I will continue to study it, with the hope of expanding its application, promoting the development of this chemical product, and making a modest contribution to academia and industry.

Toxicity Research

Toxicity of Chloroiodobenzene. The structure of this substance is unique, chlorine and iodine atoms are combined in benzene ring. After a series of experiments, it may be toxic in a specific environment.
The mice were tested and fed with food containing this substance, and their physiological indicators were measured regularly. For a few weeks, some of the mice were in a depressed state, with reduced food intake and weight. From the anatomical point of view, there were signs of damage to the organs, especially the liver and kidneys.
The plant was tested again, and this substance was added to the culture solution to observe its growth. The growth of plants was sluggish, and the leaves were gradually yellow, which seemed to affect their metabolism due to the substance.
In summary, 3-Chloroiodobenzene is toxic and has adverse effects on animals and plants. The follow-up should study its mechanism of action and seek ways to avoid harm in order to protect ecology and health.

Future Prospects

Fu 3 - Chloroiodobenzene has shown its unique quality and use in today's chemical research. Looking back on the past, chemical sages have exhausted their wisdom and explored the secrets of matter to obtain this compound. Its unique properties can be the basis of all kinds of reactions, and it is of great help in organic synthesis.
Although one or two of them are known today, the future prospects are still vast. Or we can focus on more refined synthesis methods to make the yield higher and the cost lower. And it is also expected to open up new paths in the fields of new drug research and material creation. Our generation of chemical researchers, with great ambitions, are eager to explore, hoping to use new techniques and new methods to tap its endless potential, so that it can shine in the future, for human well-being, scientific and technological progress, and become a treasure of future chemistry. It is our eagerness for its future development.

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Frequently Asked Questions

As a leading 3-Chloroiodobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 3-chloroiodobenzene?

3-Chloroiodobenzene is a crucial compound in the field of organic synthesis and has a wide range of uses in many chemical processes. Its main applications are as follows:
First, as an intermediary in organic synthesis. This compound can be used to form carbon-carbon bonds and carbon-heteroatomic bonds through a series of chemical reactions, such as nucleophilic substitution reactions and metal-catalyzed cross-coupling reactions, etc., and then to prepare organic compounds with diverse structures. In the field of medicinal chemistry, it can be converted into bioactive molecules through specific reactions, laying the foundation for the development of new drugs. Taking the Suzuki coupling reaction catalyzed by palladium as an example, 3-chloroiodobenzene can react with aryl boronic acid to form biaryl compounds, which have important applications in drugs, materials and other fields.
Second, it also has outstanding performance in the field of materials science. With its unique chemical structure and reactivity, it can participate in the preparation of functional polymer materials, organic semiconductor materials, etc. In the synthesis of organic Light Emitting Diode (OLED) materials, 3-chloroiodobenzene can be used as a key structural unit. After chemical modification, it can be introduced into the polymer skeleton to endow the material with specific optoelectronic properties, improve the luminous efficiency and stability of the material, and enhance the performance of OLED devices.
Third, it plays an important role in the synthesis of fine chemicals. It can be used to synthesize fine chemicals such as dyes and fragrances with special structures. For example, through appropriate reaction steps, it can be converted into dye molecules with specific color and light stability, which can be used in textiles, printing and other industries; or synthesized fragrance compounds with unique odors for use in perfumes, cosmetics and other products.
In short, 3-chloroiodobenzene plays a key role in many fields such as organic synthesis, materials science, and fine chemicals due to its unique chemical properties, and promotes the development and progress of related fields.

What are the physical properties of 3-chloroiodobenzene?

3-Chloroiodobenzene is also an organic compound. Its physical properties are particularly important, let me describe them in detail.
First of all, its appearance, at room temperature, 3-chloroiodobenzene is often colorless to light yellow liquid, clear and transparent, and it looks quite fluid. Its color is light, just like the first light of morning, elegant and unobtrusive.
Melting point and boiling point. The melting point is about -3 ° C. This temperature is like a boundary, below which the substance gradually condenses into a solid state, like winter water into ice. The boiling point is quite high, about 227-228 ° C. When the temperature rises, 3-chloroiodobenzene is like a butterfly of feather, jumping from liquid state to gaseous state, transpiring between heaven and earth.
Furthermore, its density is also considerable. The density is about 1.878g/cm ³, which is heavier than water. If it is juxtaposed with water, it will sink like a stone in water and naturally settle at the bottom.
In terms of solubility, 3-chloroiodobenzene has very little solubility in water, just like the incompatibility of oil and water, and the two are distinct. However, it can dissolve well in organic solvents, such as ethanol, ether, benzene, etc., just like a wanderer returning home and fusing with organic solvents.
In addition, 3-chloroiodobenzene has a certain volatility. In the air, its molecules are like unruly birds, slowly escaping. However, its volatility is not rapid, but a relatively mild process.
In summary, 3-chloroiodobenzene occupies a place in the field of organic chemistry due to its unique physical properties, and is valued by many chemical research and industrial applications.

What are the chemical properties of 3-chloroiodobenzene?

3-Chloroiodobenzene is also an organic compound. It has the characteristics of halogenated aromatic hydrocarbons and has a wide range of uses in the field of organic synthesis. In this substance, chlorine and iodine dihalogen atoms are combined on the benzene ring, giving it unique chemical properties.
In terms of its reactivity, halogen atoms can lead to nucleophilic substitution reactions. Due to the better departure of iodine atoms, nucleophilic reagents are often easy to attack, causing iodine atoms to leave and form new carbon-nucleophilic reagent bonds. For example, when co-heated with alkoxides, iodine can be replaced by alkoxy groups to obtain corresponding aromatic ethers.
And because it is an aromatic hydrocarbon with an electron cloud structure of aromatic rings, it can perform electrophil However, the halogen atom is a blunt group, which reduces the electron cloud density of the benzene ring, and the reactivity is slightly lower than that of benzene. Chlorine and iodine are both ortho-para-sites, and electrophilic reagents mostly attack the ortho and para-sites of the benzene ring, which is determined by the induction effect of the halogen atom and the conjugation effect.
In addition, 3-chloroiodobenzene also shows outstanding performance in metal-catalyzed reactions. For example, the coupling reaction catalyzed by palladium can be combined with reagents containing boron and tin to expand its carbon-carbon bond, which increases its application in the synthesis of complex organic molecules. In conclusion, 3-chloroiodobenzene, with its unique chemical properties, plays an important role in many fields of organic synthetic chemistry, providing organic chemists with a powerful tool for constructing complex molecular structures.

What are the synthesis methods of 3-chloroiodobenzene?

There are several common methods for the synthesis of 3-chloroiodobenzene.
First, benzene is used as the starting material. Under the action of catalysts such as iron chloride, shilling benzene and chlorine undergo an electrophilic substitution reaction to obtain chlorobenzene. Subsequently, chlorobenzene reacts with iodine in the presence of specific oxidants (such as nitric acid, etc.). In this process, the oxidant oxidizes iodine to a more active iodine positive ion, thereby replacing the hydrogen atom on the chlorobenzene ring to generate 3-chloroiodobenzene. This approach is relatively simple, but the reaction conditions need to be finely regulated to improve the selectivity and yield of the product.
Second, starting from aniline. Aniline is reacted by diazotization to form diazonium After that, the diazonium salt is reacted with cuprous chloride, potassium iodide and other reagents to achieve the introduction of chlorine atoms and iodine atoms. First, it reacts with cuprous chloride, and the diazonium group is replaced by chlorine atoms to obtain chlorobenzene derivatives, and then reacts with potassium iodide. Iodine atoms are introduced into the benzene ring at a suitable position to obtain 3-chloroiodobenzene. This method can precisely control the substitution position and improve the purity of the product. However, the diazonation reaction requires low temperature operation and strict reaction conditions.
Third, the Grignard reagent method is used. Halobenzene is used as raw material and reacts with magnesium to form Grignard reagent. Then the Grignard reagent is reacted with the corresponding halogen (a For example, the chlorine-containing Grignard reagent is first prepared, and then reacted with the iodine-containing halogen, through a series of reaction processes, the structure of 3-chloroiodobenzene can be constructed. This method is highly flexible and can modify the benzene ring substituents by selecting different halogens. However, Grignard reagents are sensitive to water and air, and the reaction needs to be carried out in an anhydrous and anaerobic environment.

What are the precautions for 3-chloroiodobenzene during storage and transportation?

3-Chloroiodobenzene is also an organic compound. During storage and transportation, many matters must be paid attention to.
When storing, the first priority environment. It should be placed in a cool and ventilated warehouse. Because of its certain chemical activity, high temperature or deterioration, the temperature of the warehouse should not be too high. And keep away from fire and heat sources to prevent the risk of fire. The relative humidity of the warehouse should also be appropriate. If the humidity is too high, it may affect its stability.
Furthermore, 3-chloroiodobenzene should be stored separately from oxidants, acids, bases, etc., and must not be mixed. Due to its chemical properties, it encounters with the above substances, or reacts violently, causing safety accidents. The storage area should be equipped with suitable materials to contain leaks in case of leakage, which can be dealt with in time.
When transporting, do not slack off. Before transporting, make sure that the packaging is complete and sealed. Packaging materials need to be able to resist certain external forces and chemical erosion to avoid material leakage caused by package damage during transportation. During transportation, ensure that the container does not leak, collapse, fall, or damage. Transportation vehicles should be equipped with corresponding varieties and quantities of fire fighting equipment and leakage emergency treatment equipment.
The choice of driving route is also very important. It should be driven according to the specified route, and do not stop in residential areas and densely populated areas. Due to the leakage of 3-chloroiodobenzene, it may cause harm to people and the environment. Transport personnel should also be familiar with its characteristics and emergency handling methods, so as to ensure the safety of storage and transportation.