What is the chemical structure of 3-cycloproppyl-1- (2-fluoro-4-iodophenyl) -5-hydroxy-6,8-dimethylpyrido [2,3-d] pyrimidine-2,4,7 (1h, 3h, 8h) -trione?

This is the name of an organic compound. To clarify its chemical structure, it is necessary to disassemble it according to the rules of organic chemistry.

Concept its name "3-cyclopropyl-1- (2-fluoro-4-iodophenyl) -5-hydroxy-6,8-dimethylpyrido [2,3-d] pyrimidine-2,4,7 (1H, 3H, 8H) -trione", "pyrido [2,3-d] pyrimidine-2,4,7 (1H, 3H, 8H) -trione" as the basic parent nucleus, this is a fused ring structure, formed by fusing pyridine and pyrimidine rings, and has three carbonyl groups at the 2,4,7 position, and hydrogen atoms at the 1,3,8 position.

"3-cyclopropyl" indicates that there is a cyclopropyl group attached to the 3rd position of the parent nucleus, and the cyclopropyl group is a ternary carbon ring with a compact structure. "1 - (2 - fluoro - 4 - iodophenyl) " means that the 1st position is connected to a phenyl group. The 2nd position of the phenyl group has a fluorine atom and the 4th position has an iodine atom. Both fluorine and iodine are halogen elements and have specific chemical activities. "5 - hydroxy" shows that there is a hydroxyl group at the 5th position, which is hydrophilic and has certain reactivity. "6,8 - dimethyl" indicates that there is a methyl group at the 6th and 8th positions, and the methyl group is an alkyl group, which also affects the properties of the compound.

In summary, this compound has a complex structure and is composed of a specific fused ring parent nucleus and many different substituents. The interaction of each part endows it with unique chemical properties.

What are the physical properties of 3-cycloproppyl-1- (2-fluoro-4-iodophenyl) -5-hydroxy-6,8-dimethylpyrido [2,3-d] pyrimidine-2,4,7 (1h, 3h, 8h) -trione?

3 - cyclopropyl - 1 - (2 - fluoro - 4 - iodophenyl) - 5 - hydroxy - 6,8 - dimethylpyrido [2,3 - d] pyrimidine - 2,4,7 (1H, 3H, 8H) - trione, the physical properties of this compound, let me go one by one.

Looking at its state, under normal temperature and pressure, it is highly likely to be a solid. Due to its molecular structure, it contains many cyclic structures and polar groups, and the intermolecular force is strong, which prompts it to exist in a solid state.

When it comes to melting point, due to various interactions in the molecule, such as hydrogen bonds, van der Waals forces, etc., the melting point is relatively high. The specific value needs to be determined by precise experiments, but it is inferred according to the generality of such structural compounds, or in the range of 150 ℃ - 250 ℃.

In terms of solubility, its molecules contain polar hydroxyl groups, as well as non-polar cyclopropyl groups, aromatic rings, etc. Therefore, in polar organic solvents, such as methanol, ethanol, and dimethyl sulfoxide, there should be a certain solubility; in non-polar solvents, such as n-hexane and cyclohexane, the solubility may be low.

The density of this compound, due to its compact molecular structure and relatively large atomic weight, may be greater than that of water. The specific value also needs to be accurately measured experimentally.

As for its stability, the iodine atom in the molecule is highly active, or under specific conditions, such as light, high temperature or when encountering specific reagents, the reaction occurs, which affects its stability.

The physical properties of this compound are closely related to its unique molecular structure. To obtain accurate data, rigorous experimental investigation is required.

What is the synthesis method of 3-cycloproppyl-1- (2-fluoro-4-iodophenyl) -5-hydroxy-6,8-dimethylpyrido [2,3-d] pyrimidine-2,4,7 (1h, 3h, 8h) -trione?

To prepare 3-cyclopropyl-1- (2-fluoro-4-iodophenyl) -5-hydroxy-6,8-dimethylpyrimido [2,3-d] pyrimidine-2,4,7 (1H, 3H, 8H) -trione, the method is as follows:

First take an appropriate amount of 2-fluoro-4-iodoaniline, place it in a clean reactor, dissolve it in an appropriate organic solvent, such as dichloromethane, etc., and stir well. Another pyrimidine-pyrimidine precursor containing cyclopropyl is taken, carefully weighed and added to the kettle to control the appropriate ratio of the two. Add a suitable amount of shrinkage agent, such as carbodiimide, to promote the progress of the reaction. At an appropriate temperature, usually between room temperature and 50 ° C, when stirring the reaction number, this process requires close monitoring of the reaction process, and thin-layer chromatography and other means can be used.

When the reaction reaches the desired degree, pour the reaction solution into an appropriate amount of dilute acid solution, such as dilute hydrochloric acid, to quench the reaction. Then extract with an organic solvent, collect the organic phase, and dry it with a desiccant such as anhydrous sodium sulfate. After that, the organic solvent is removed by reduced pressure distillation to obtain a crude product.

The crude product is purified by silica gel column chromatography, and a suitable eluent is selected, such as a mixture of petroleum ether and ethyl acetate, and prepared in a specific proportion. The eluent containing the target product was carefully collected and distilled under reduced pressure again to obtain a relatively pure 3-cyclopropyl-1 - (2-fluoro-4-iodophenyl) -5-hydroxy-6,8-dimethylpyrido [2,3-d] pyrimidine-2,4,7 (1H, 3H, 8H) -trione. During the operation, it is necessary to strictly abide by the experimental specifications, pay attention to safety, and ensure the yield and purity.

What are the application fields of 3-cycloproppyl-1- (2-fluoro-4-iodophenyl) -5-hydroxy-6,8-dimethylpyrido [2,3-d] pyrimidine-2,4,7 (1h, 3h, 8h) -trione?

3-Cyclopropyl-1- (2-fluoro-4-iodophenyl) -5-hydroxy-6,8-dimethylpyrido [2,3-d] pyrimidine-2,4,7 (1H, 3H, 8H) -trione is also an organic compound. Its application field is quite extensive, try to be a gentleman.

In the field of medicinal chemistry, such compounds may have potential biological activities and can provide opportunities for the development of new drugs. Its unique chemical structure may be combined with specific targets in organisms, such as enzymes, receptors, etc., to regulate physiological processes in organisms. If this structure can be precisely modified, specific drugs for specific diseases, such as anti-tumor, anti-viral and other drugs, can be developed.

In the field of materials science, this compound may be used to create new functional materials. Due to its structural properties, it may endow materials with unique optical and electrical properties. For example, it may be used to prepare organic Light Emitting Diode (OLED) materials. By virtue of its structure and properties, the material's luminous efficiency and stability can be optimized, and the display technology level can be improved.

Furthermore, in the field of agricultural chemistry, such compounds also have potential uses. Or they can be developed into new pesticides. With their special chemical properties, they can inhibit or kill crop diseases and pests. Compared with traditional pesticides, they may have higher selectivity and lower environmental toxicity, which is conducive to sustainable agricultural development.

From this perspective, 3-cyclopropyl-1- (2-fluoro-4-iodophenyl) -5-hydroxy-6,8-dimethylpyrido [2,3-d] pyrimidine-2,4,7 (1H, 3H, 8H) -trione has potential application value in many fields such as medicine, materials, agriculture, etc. It is a compound worthy of further investigation.

What are the chemical reactions of 3-cycloproppyl-1- (2-fluoro-4-iodophenyl) -5-hydroxy-6,8-dimethylpyrido [2,3-d] pyrimidine-2,4,7 (1h, 3h, 8h) -trione?

3 - cyclopropyl - 1 - (2 - fluoro - 4 - iodophenyl) - 5 - hydroxy - 6,8 - dimethylpyrido [2,3 - d] pyrimidine - 2,4,7 (1H, 3H, 8H) - trione is a complex organic compound with many related chemical reactions.

In this compound, the hydroxyl group (-OH) can undergo esterification reaction. In the case of carboxylic acid, under the catalysis of acid, esters can be formed. Taking acetic acid as an example, under the catalysis of concentrated sulfuric acid and heating conditions, the hydroxyl hydrogen and the carboxyl group of acetic acid remove a molecule of water to form the corresponding ester. This reaction is reversible and restricted by the principle of equilibrium.

Its benzene ring part, due to the influence of fluorine, iodine and other substituents, the distribution of electron cloud changes, and electrophilic substitution reaction can occur. For example, under the catalysis of ferric chloride, reacting with bromine elemental substance, bromine atoms can replace hydrogen atoms at specific positions on the benzene ring. The specific position is determined by the localization effect of the substituent. Fluorine and iodine are ortho-para-sites, so that bromine tends to replace its ortho-para-hydrogen.

Pyrimidine ring system, because of its nitrogen-containing atoms, has a certain alkalinity and can react with acids to form salts. In the case of hydrochloric acid, the nitrogen atom binds protons to lone pairs of electrons to form corresponding salts and change

In addition, if the compound is in a suitable redox environment, the unsaturated bonds and benzene rings on the pyridine pyrimidine ring can be oxidized, and the side chains may also be oxidized due to different types of oxidants and reaction conditions; if a suitable reducing agent is encountered, the unsaturated bonds can be reduced. For example, in a metal catalyst (such as palladium carbon) and hydrogen environment, the unsaturated bonds may be hydrogenated and reduced.

The above are only possible related chemical reactions. The actual reaction is affected by many factors, such as the concentration of the reactants, temperature, solvent, etc., which need to be experimentally explored and precisely regulated.