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What is the chemical structure of 3-cyclopropyl-1- (2-fluoro-4-iodophenyl) -5-hydroxy-6,8-dimethylpyrido [2,3-d] pyrimidine-2,4,7 (1h, 3h, 8h) -trione
This is a rather complex organic compound. According to its name "3-cyclopropyl-1- (2-fluoro-4-iodophenyl) -5-hydroxy-6,8-dimethylpyridino [2,3-d] pyrimidine-2,4,7 (1H, 3H, 8H) -trione", its chemical structure can be gradually analyzed.
"Pyridino [2,3-d] pyrimidine" is the core parent nucleus structure of this compound, which is formed by fusing the pyrimidine ring with the pyrimidine ring. Among them, the pyridine ring and the pyrimidine ring are fused to each other at a specific position (2,3-d) to form a unique cyclic skeleton.
On the parent nuclear structure, the third position is connected with a cyclopropyl group. Cyclopropyl is a ternary carbon ring with high cyclic tension, which has a great impact on the properties and reactivity of compounds. The first position is connected to (2-fluoro-4-iodophenyl), and the second position of the phenyl ring has fluorine atom substitution and the fourth position has iodine atom substitution. Both fluorine and iodine atoms are halogen atoms, and their electronegativity and atomic radius characteristics will significantly affect the electron cloud distribution and spatial structure of the compound. There are hydroxyl groups at the
5 position. Hydroxyl groups are strong polar groups, which can participate in the formation of hydrogen bonds, which plays an important role in the solubility, acidity and biological activity of compounds. The 6th and 8th positions are connected with methyl groups, respectively, and methyl groups are used as power supply groups, which will change the electron cloud density of the parent nucleus and affect the stability and reactivity of the compound.
2,4,7 positions have carbonyl groups, respectively. At 1H, 3H, and 8H, the existence of these carbonyl groups makes the compound have specific chemical properties and reactivity, and can participate in many organic reactions, such as nucleophilic addition.
In summary, the chemical structure of this compound is composed of a specific fused parent nucleus and many different substituents, and the interaction of each part endows the compound with unique physicochemical properties and potential biological activities.
What are the physical properties of 3-cyclopropyl-1- (2-fluoro-4-iodophenyl) -5-hydroxy-6,8-dimethylpyrido [2,3-d] pyrimidine-2,4,7 (1h, 3h, 8h) -trione
This is the chemical substance of 3-cyclopropyl-1- (2-fluoro-4-iodophenyl) -5-hydroxy-6,8-dimethylpyridino [2,3-d] pyrimidine-2,4,7 (1H, 3H, 8H) -trione. Its physical properties are as follows:
This substance is mostly in solid form, because many atoms in its molecular structure are connected to each other, forming a relatively tight structure, which promotes the strengthening of intermolecular forces, so it tends to exist in a solid state at room temperature and pressure.
In terms of melting point, due to the interaction of hydrogen bonds and van der Waals forces between molecules, it requires specific energy to overcome these forces before it can transform from a solid state to a liquid state, with a melting point of about [X] ° C. This specific melting point is closely related to the compactness of the molecular structure and the strength of the interaction between atoms.
In terms of solubility, in view of its molecular structure, there are both polar groups, such as hydroxyl groups, and non-polar parts, such as cyclopropyl groups, aromatic rings, etc., in polar solvents such as ethanol, the hydroxyl groups can form hydrogen bonds with ethanol molecules, showing a certain solubility; in non-polar solvents such as n-hexane, the solubility is poor, because the force between the non-polar parts and n-hexane molecules is weak. The density of
is also affected by the molecular structure and atomic composition. The relative mass of the molecules and the spatial arrangement of the atoms determine the mass of the substance per unit volume. The density is about [X] g/cm ³.
The appearance may be white to light yellow powder. The formation of this color is derived from the absorption and reflection characteristics of molecules to different wavelengths of light. The electron transition and other factors in the molecular structure affect the effect on light, thus showing the corresponding color.
The above physical properties are derived based on their chemical structure. The type, quantity and connection mode of each atom in the molecular structure play a decisive role in the physical properties by affecting the intermolecular forces and the distribution of electron clouds.
What is the synthesis method of 3-cyclopropyl-1- (2-fluoro-4-iodophenyl) -5-hydroxy-6,8-dimethylpyrido [2,3-d] pyrimidine-2,4,7 (1h, 3h, 8h) -trione
To prepare 3-cyclopropyl-1- (2-fluoro-4-iodophenyl) -5-hydroxy-6,8-dimethylpyrido [2,3-d] pyrimidine-2,4,7 (1H, 3H, 8H) -trione, the method is as follows:
First, take an appropriate starting material, take 2-fluoro-4-iodoaniline as the base, react it with a suitable cyclization reagent, and construct the parent nuclear structure of pyrimidine. In the reaction system, precise temperature control to ensure that the reaction proceeds according to the expected path. When heated to a specific temperature and maintained, the reactants can fully function. When the reaction is near the end, it can be monitored by thin-layer chromatography and other means to confirm that the reaction is complete.
Then, introduce cyclopropyl. Select an appropriate cyclopropylation reagent and react with the intermediate under mild conditions. In this step, pay attention to the dosage of the reagent and the reaction environment to avoid side reactions. The pH of the reaction can be regulated by alkali substances to make the reaction proceed smoothly. After the reaction is completed, it is purified by extraction, column chromatography, etc., to obtain an intermediate product containing cyclopropyl.
Then perform a hydroxylation reaction to introduce hydroxyl groups at a specific position. Choose a hydroxylation reagent with suitable activity and react in a suitable solvent. At the same time, care should be taken to protect other sensitive groups from being affected by the hydroxylation process. After the reaction, it is carefully separated and purified to remove impurities and obtain 5-hydroxy intermediates.
Finally, methyl is introduced at a predetermined position. The methylation reagent is used, and the appropriate reaction procedure is followed. After separation and purification, 3-cyclopropyl-1- (2-fluoro-4-iodophenyl) -5-hydroxy-6,8-dimethylpyridino [2,3-d] pyrimidine-2,4,7 (1H, 3H, 8H) -trione is finally obtained. After each step of the reaction, the structure and purity of the product must be confirmed by spectral analysis to ensure that the synthesis path is correct.
In which fields is 3-cyclopropyl-1- (2-fluoro-4-iodophenyl) -5-hydroxy-6,8-dimethylpyrido [2,3-d] pyrimidine-2,4,7 (1h, 3h, 8h) -trione used?
This compound is called 3-cyclopropyl-1- (2-fluoro-4-iodophenyl) -5-hydroxy-6,8-dimethylpyrimido [2,3-d] pyrimidine-2,4,7 (1H, 3H, 8H) -trione. It has applications in many fields, and now it is for you.
In the field of pharmaceutical research and development, such pyrimidine-pyrimidine trione structures containing specific substituents often have unique biological activities. Or it can be used as a potential drug lead compound. By modifying and optimizing its structure, it is expected to obtain drugs with high selectivity and strong activity. Or can act on specific biological targets, such as certain enzymes or receptors, emerging in the treatment of diseases, such as cancer, inflammation and other diseases, drug creation has potential.
In the field of agricultural chemistry, its structural properties or endow compounds with certain biological activities, which can be developed into new pesticides. Or show inhibitory or killing effects on specific pests and pathogens, and compared with traditional pesticides, it is expected to have the advantages of high efficiency, low toxicity and environmental friendliness, adding a new weapon for crop pest control.
In the field of organic synthetic chemistry, this complex structure compound is an excellent synthesis target. Chemists can achieve its construction and modification through various synthesis strategies and methodologies. This process can not only promote the innovation and development of organic synthesis methods, but also provide reference and reference for the synthesis of other similar complex structure compounds, and help the frontier exploration of organic synthesis chemistry.
In addition, in the field of materials science, if the compound is reasonably designed and functionalized, it may exhibit unique optical, electrical or self-assembly properties, providing new ideas and options for the preparation of new functional materials, such as photoelectric materials, sensor materials, etc.
What is the market outlook for 3-cyclopropyl-1- (2-fluoro-4-iodophenyl) -5-hydroxy-6,8-dimethylpyrido [2,3-d] pyrimidine-2,4,7 (1h, 3h, 8h) -trione?
Today there is a product called 3-cyclopropyl-1 - (2-fluoro-4-iodophenyl) -5-hydroxy-6,8-dimethylpyrido [2,3-d] pyrimidine-2,4,7 (1H, 3H, 8H) -trione. The market prospects of this product are quite worth exploring.
In today's world, the field of medicine and chemical industry is developing rapidly. Such organic compounds with special structures are often key components in the development of new drugs and new materials. As far as medicine is concerned, its unique molecular structure may endow it with specific biological activities. If it can precisely act on specific targets in the body, it may have a miraculous effect on the treatment of certain diseases.
In the chemical industry, it can be used as an intermediate for synthesizing high-end materials due to the particularity of its structure, in order to improve the properties of materials, such as stability and optical properties.
However, its market prospects are also influenced by many factors. First, the difficulty of synthesis. If the synthesis steps are complicated and costly, large-scale production and promotion will be hindered. Second, regulations and approval. In pharmaceutical applications, it must go through strict clinical trials and regulatory approval, which is time-consuming and laborious. Third, the competitive situation. Products that have similar effects in the market need to have unique advantages if they want to stand out.
Even if there are challenges, there are also opportunities. With the advance of science and technology, there may be breakthroughs in synthesis technology, and costs can be reduced. And the demand for new medicines and new materials is on the rise. If they can demonstrate their unique value and find suitable application fields, they will be able to win a place in the market, and the future may also be bright.
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