3 Cyclopropyl 1 2 Fluoro 4 Iodophenyl 6 Methylamino 1h Pyrimidine 2 4 Dione

3-Cyclopropyl-1- (2-fluoro-4-iodophenyl) -6-methylamino-1H-pyrimidine-2,4-dione is a key substance. In the field of medicine, it may have unique medicinal effects. In the process of developing new antimalarial drugs, it may be used as a key intermediate. Due to the complex survival mechanism of Plasmodium in the human body, many drugs are difficult to deal with effectively. Such compounds containing special structures may interfere with the metabolic pathways of Plasmodium or damage its cell structure through their unique chemical properties, achieving the purpose of antimalarial.
Furthermore, in the field of agriculture, it may also play an important role. In the creation of new pesticides, it may become a core active ingredient. Nowadays, pests are becoming increasingly resistant to traditional pesticides, and it is urgent to develop pesticides with new mechanisms of action. The structural properties of the compound may target specific pest physiological functions, such as interfering with the nervous system conduction of the pest, or inhibiting the activity of its growth and development-related enzymes, in order to achieve efficient insecticidal, and it is environmentally friendly, has little residue, and has little impact on non-target organisms.
Or emerge in the field of materials science. When preparing functional organic materials, its unique structure can endow the materials with special photoelectric properties. For example, it can be used as an organic semiconductor material in devices such as organic Light Emitting Diodes (OLEDs) or organic solar cells to improve the photoelectric conversion efficiency of devices through their intramolecular charge transfer characteristics, providing new ideas for the development of new materials.

In order to obtain the synthesis method of 3-cyclopropyl-1 - (2-fluoro-4-iodophenyl) -6-methylamino-1H-pyrimidine-2,4-dione, the following paths can be considered.
The construction of pyrimidine diketone precursor is first introduced. Suitable nitrogen-containing and carbonyl-containing compounds, such as diethyl malonate, can be selected, and specific amines and halogenated aromatics can be initiated by condensation reaction. With appropriate bases as catalysts, nucleophilic substitution and cyclization processes occur between molecules in the reaction system. In this step, it is crucial to precisely regulate the proportion of reactants, reaction temperature and time. If the cap temperature is too high or the time is too long, it is easy to cause side reactions to occur, which affects the purity and yield of the target product.
Furthermore, for the introduction of cyclopropyl. A suitable halogenated hydrocarbon, such as cyclopropyl halide, can be reacted with the corresponding nucleophilic reagent to generate an active intermediate. Then, by reacting with the parent pyrimidine diketone, the cyclopropyl group can be ingeniously integrated into the molecular structure. In the meantime, the choice of solvent is crucial, and it is necessary to choose a solvent that has good solubility to the reactants and does not interfere with the reaction process, such as dichloromethane, N, N-dimethylformamide and the like.
As for the addition of methylamino groups, halogenated pyrimidinedione intermediates can be used to react with methylamine. In this reaction, the concentration of methylamine and the mildness of the reaction conditions need to be carefully controlled. Excessive methylamine concentration or too strong reaction conditions may lead to side reactions such as excessive alkylation.
In addition, the linkage of 2-fluoro-4-iodophenyl groups cannot be ignored. Aryl halides containing fluorine and iodine can be combined with pyrimidinedione derivatives through a palladium-catalyzed coupling reaction. The activity of palladium catalysts and the structure of ligands have a significant impact on the efficiency and selectivity of the reaction. Careful screening is required to achieve the optimal reaction effect.
Overall, the synthesis of this compound requires in-depth insight and precise control of the conditions of each step of the reaction and the characteristics of the reactants in order to obtain the ideal synthesis effect.

3-Cyclopropyl-1- (2-fluoro-4-iodophenyl) -6-methylamino-1H-pyrimidine-2,4-dione, this is an organic compound. Its physical and chemical properties are quite important and are related to many practical applications.
First of all, the appearance is white to light yellow crystalline powder at room temperature and pressure. This form is easy to store and transport, because of its relatively high stability, it is not easy to change significantly under conventional environmental conditions.
In terms of solubility, it may exhibit good solubility in organic solvents such as dichloromethane, N, N-dimethylformamide. This is because certain groups in the molecular structure of the compound can form specific interactions with organic solvent molecules, such as van der Waals forces, hydrogen bonds, etc., which in turn promote its dissolution. However, the solubility in water may be poor, due to the polarity difference between the polarity of water and the molecule of the compound, resulting in weak interaction between the two.
Melting point is also one of the important characteristics. After determination, its melting point may be in a specific temperature range, such as 180-185 ° C. The melting point is an important indicator of the purity and structural stability of a compound. This range indicates that the intermolecular force of this compound is relatively stable, the structure has a certain rigidity, and a specific energy is required to destroy the lattice structure and undergo phase transformation.
In terms of stability, under normal storage conditions, in a dry and cool place, this compound is relatively stable. However, when it encounters strong oxidizing agents, strong acids or strong bases, or chemical reactions occur, resulting in structural changes. This is because some functional groups in the compound, such as pyrimidine rings, amino groups, etc., are more sensitive to acid-base and oxidizing environment.
In addition, the spectral properties of this compound cannot be ignored. In the infrared spectrum, different chemical bonds will appear at specific wavenumbers, thereby confirming the functional groups contained in the molecule. In NMR spectroscopy, hydrogen and carbon atoms in different chemical environments exhibit specific chemical shifts, which help to analyze molecular structures. These spectral properties provide powerful means for structural identification and purity analysis.

I don't know the price of 3 - cyclopropyl - 1 - (2 - fluoro - 4 - iodophenyl) - 6 - methylamino - 1H - pyrimidine - 2,4 - dione in the market. This compound is not a common thing, and its price is rarely described in various classics and market records.
Or because it is difficult to prepare, the raw materials are rare, and the synthesis method needs to be carefully researched and made, so the cost is high, and the price is also not cheap. However, due to the lack of demand, it is not widely circulated in the market, and the public knows little about its price.
Or this object is used for specific research, necessary for a certain type of experiment or process, and its price may vary according to the contract between the buyer and the seller, the situation of supply and demand, and it is difficult to determine.
Although it is difficult to find its price in ancient books such as "Tiangong Kaiwu", in today's world, information is gradually becoming available, or you can consult chemical material merchants, scientific research institutes, or those who know its price.

3 - cyclopropyl - 1 - (2 - fluoro - 4 - iodophenyl) - 6 - methylamino - 1H - pyrimidine - 2,4 - dione is an organic compound. In order to know its safety and toxicity, a series of experiments and studies must be conducted before a conclusion can be reached.
The experiments of various things in the past, when considering toxicity, mostly start with animal experiments. If you take rats as a test, give this substance and observe its eating, activity and growth. If the dosage is too large, or when the behavior of rats is abnormal, such as slow movement, loss of appetite, and even life-threatening, this shows that it has a certain toxicity.
On the safety side, it is not only related to the direct impact of biological organisms, but also to the potential effects of the environment. If this substance enters the environment, is transmitted through water and soil, or is decomposed and transformed by microorganisms, its products also need to be carefully examined. Or in water bodies, it affects the reproduction and growth of aquatic organisms and causes ecological imbalance.
It also considers its effect on the human body. Although it has not been tested directly in humans, it can be inferred based on the experience and pharmacological models of similar compounds. If its chemical structure is similar to that of known toxic or harmful substances, or if it is specific to the human metabolic pathway, it must be treated with caution. If it enters the human body, or binds to specific proteins, it interferes with physiological functions and causes allergies, poisoning and other diseases. Therefore, the safety and toxicity of 3 - cyclopropyl - 1 - (2 - fluoro - 4 - iodophenyl) - 6 - methylamino - 1H - pyrimidine - 2, 4 - dione must be comprehensively tested and carefully studied.