3-(Difluoromethoxy)Iodobenzene

3- (diethylamino) pyridine has a wide range of uses in the field of organic synthesis.
Its primary use is as an organic base catalyst. Among many organic reactions, such as esterification, amidation, and nucleophilic substitution of halogenated hydrocarbons, 3- (diethylamino) pyridine can exhibit high catalytic performance. Taking esterification as an example, traditional esterification reactions often require strong acids as catalysts, but strong acids are prone to side reactions, resulting in poor product purity. When 3- (diethylamino) pyridine is used as a catalyst, the reaction conditions are mild, which can effectively promote the esterification reaction, and there are few side reactions, and the product is easy to separate and purify. In the amidation reaction, it can promote the reaction of acyl chloride and amine, and improve the reaction rate and yield.
Furthermore, it can be used as a ligand. In the field of metal organic chemistry, 3- (diethylamino) pyridine can coordinate with a variety of metal ions to form metal complexes. These metal complexes have unique catalytic activity and selectivity in catalytic reactions. For example, when coordinated with transition metals, they can catalyze the formation of carbon-carbon bonds, providing novel strategies and methods for organic synthesis.
In addition, in the field of medicinal chemistry, the structure of 3- (diethylamino) pyridine is often introduced into drug molecules. Due to its alkaline and spatial structure, it can change the physical and chemical properties of compounds, such as solubility, acidity and alkalinity, etc., which in turn affect the biological activity and pharmacokinetic properties of drugs. In the process of drug development, the introduction of this structural unit can improve the ability of drug binding to targets and enhance the efficacy of drugs.
In terms of materials science, 3- (diethylamino) pyridine can participate in the synthesis of some polymers. By adjusting its dosage and reaction conditions, the structure and properties of polymers can be adjusted, such as changing the hydrophobicity and thermal stability of polymers, so as to meet the needs of different material application scenarios.

(2) The synthesis methods of acetoxybenzoic acid are as follows:
First, salicylic acid and acetic anhydride are used as raw materials, and under the catalysis of an appropriate amount of concentrated sulfuric acid, they are obtained by heating and reacting. In this process, the phenolic hydroxyl group of salicylic acid and the acetyl group of acetic anhydride undergo acylation reaction. The specific operation is as follows: in a clean reaction vessel, take a precise amount of salicylic acid and acetic anhydride, mix them in an appropriate proportion, and then drop a little concentrated sulfuric acid as a catalyst. Then, place the reaction vessel in a heating device at a suitable temperature and continue to stir to make the reaction fully proceed. After the reaction is completed, the finished product can be obtained through various post-processing processes such as cooling, crystallization, filtration, washing, and drying. This method is relatively simple to operate, and the raw materials are relatively easy to obtain. However, the reaction conditions need to be carefully controlled, otherwise side reactions will easily occur.
Second, salicylic acid and acetyl chloride are used as raw materials to react in the presence of acid binding agent. The acid binding agent can be selected as pyridine, etc., whose function is to neutralize the hydrogen chloride generated by the reaction and promote the positive progress of the reaction. First dissolve the salicylic acid in a suitable organic solvent, and then slowly add acetyl chloride and acid binding agent. During the reaction process, pay close attention to the reaction temperature and reaction process. After the reaction is completed, the product can be obtained through separation and purification. This method has a fast reaction rate and a high yield. However, acetyl chloride is active and highly corrosive, which requires strict operation. The use of acid binding agent will also increase the cost and difficulty of post-treatment.
Third, the transesterification method is adopted. Methyl salicylate and ethyl acetate are used as raw materials and synthesized by transesterification reaction under the action of a catalyst. The catalyst is often organotin compounds, etc. Methyl salicylate, ethyl acetate and catalyst are put into the reaction kettle in a certain proportion and reacted at a specific temperature and pressure. This method is green and environmentally friendly, and the atomic utilization rate is high. However, the reaction conditions are more severe, the equipment requirements are also high, and the catalyst price is expensive, resulting in an increase in cost.

3 - (diethylamino) naphthol, also known as N, N - diethyl - 1 - naphthol amine, is a kind of organic compound. Its physical and chemical properties are as follows:
Looking at its properties, it is usually in the state of white to light yellow crystalline powder, which is distinguishable by the naked eye.
When it comes to solubility, it is slightly soluble in water. Water is the source of life, and many substances are dissolved in it, while 3 - (diethylamino) naphthol has limited solubility in water, but it can be soluble in organic solvents such as ethanol and ether. Ethanol and ether are common organic solvents. Its molecular structure is compatible with 3- (diethylamino) naphthol, so it can be dissolved.
The boiling point is related to the temperature at which the substance changes from liquid to gaseous state. The boiling point of 3- (diethylamino) naphthol is quite high, reaching about 346 ° C. This high temperature indicates that the intermolecular force is strong, and more energy is required to make it boil into a gaseous state.
The melting point is also an important property, and its melting point is in the range of 86-88 ° C. When the temperature rises to the melting point, the solid 3- (diethylamino) naphthol begins to melt into a liquid state. This temperature range is relatively fixed, which can be used as one of the basis for identifying the substance.
In terms of chemical properties, its molecular structure contains phenolic hydroxyl groups, so it has a certain acidity. The phenolic hydroxyl group, the active group, can react with bases to form corresponding salts. At the same time, its amino part has a certain alkalinity and can react with acids. This amphoteric characteristic enables 3- (diethylamino) naphthol to participate in many chemical reactions and is widely used in the field of organic synthesis. And because of the conjugated system of naphthalene ring, amino group and hydroxyl group in its structure, it has certain optical activity and chemical stability, and plays an important role in the synthesis of dyes and drugs.

The price of (diethylamino) pyridine cannot be generalized between today's markets. Its price often changes for many reasons, such as the quality of the quality, the amount of quantity, the demand for supply, or the distance of the product, the time difference.
If the quality is better, the price may be slightly higher. Because it is more effective among many uses, it can save the industry a lot of trouble, so it is worth the price. And those with lower quality, although the price is slightly lower, when using it, you may need to pay more attention to prevent the risk of failure.
The amount is also the key. If the buyer wants a lot, the merchant may be promoting the sale, and the price can be slightly reduced. This is a common strategy of merchants. If they want to attract customers, they will accumulate profits.
Furthermore, the trend of demand and supply also affects the price. If there are many people who ask for it, but the supply is small, the price will rise. The cover is rare and expensive, and everyone wants it. The merchant must check the opportunity and adjust the price. On the contrary, if the supply exceeds the demand, the merchant will reduce the price to attract customers in order to sell his goods quickly.
The distance of the factory also affects the distance. If the factory is far away, the transportation fee will be high. This fee is included in the price, so the price may be high. If the product is close to the market, the transportation fee can be saved, and the price may be slightly lower.
The price varies depending on the time. As the years go by, the conditions of production and demand are different, and the price also changes accordingly.
Therefore, in order to know the exact price of (diethylamino) pyridine in the market, it is necessary to widely observe various quotients, measure its quality, quantity, supply, production and time conditions, in order to know its approximate price, so as not to be deceived by the false price, and to get the good price and buy what you need.

3 - (diethylamino) pyridine should be stored in a cool, dry and well-ventilated place. This substance is more sensitive to light and should be strictly avoided to prevent it from deteriorating due to light, affecting its chemical properties and use efficiency.
At the same time, it should be stored separately from oxidants and acids, and must not be mixed. Because of its active chemical properties, contact with oxidants can easily lead to violent chemical reactions, which pose potential safety risks; coexistence with acids may cause reactions such as acid-base neutralization, which will also change its composition and characteristics.
In terms of storage temperature, it should be kept in a more suitable low temperature environment, but it should not be too low temperature to cause it to solidify or produce other physical changes. The storage place needs to have good fire and explosion-proof facilities, because if the substance encounters an open flame or high temperature, it is very likely to cause serious accidents such as combustion or even explosion.
The storage area should also be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment. In the event of a leak, emergency treatment can be carried out quickly to prevent its spread and cause greater harm. In addition, special personnel should be arranged to conduct regular inspections of the storage situation to check whether the packaging is intact, whether there are any signs of leakage, and whether the storage environment meets the requirements to ensure that 3 - (diethylamino) pyridine is always in a safe storage state.