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What are the main application fields of 3-fluoro-4- (2-iodothieno [3,2-b] pyridin-7-yloxy)
3-Fluoro-4- (2-iodothieno [3,2-b] pyridin-7-yloxy) This substance has a wide range of uses and plays a significant role in the field of medicinal chemistry. It can be used as a key intermediate to create new drugs. Due to its unique structure and specific biological activity, it can precisely bind to biological targets in vivo, or regulate specific physiological processes, providing new opportunities for the treatment of specific diseases, such as in the development of anti-tumor drugs, or can inhibit tumor cell proliferation and induce apoptosis.
In the field of pesticide chemistry, it also has important applications. It can be used as an active ingredient to prepare high-efficiency pesticides. With its chemical properties, it may be highly toxic to certain pests, and has a small impact on the environment, contributing to the development of green and environmentally friendly pesticides, contributing to the control of agricultural pests, and ensuring crop yield and quality.
In the field of materials science, it has also emerged. Due to its special structure, it may endow materials with unique photoelectric properties. In the preparation of organic photoelectric materials, it may improve the conductivity and optical properties of materials, and play a role in the research and development of materials such as organic Light Emitting Diode (OLED) and solar cells, promoting the development of materials science and providing the possibility for technological innovation in related fields.
What is the synthesis method of 3-fluoro-4- (2-iodothieno [3,2-b] pyridin-7-yloxy)
The preparation of 3-fluoro-4- (2-iodothiopheno [3,2-b] pyridine-7-yloxy) requires delicate design and complex operation.
The first step is to choose the appropriate starting material, which is based on thiophenopyridine compounds. This is the key starting structure. The iodine atom can be introduced at the 2-position of thiophenopyridine through a halogenation reaction. This halogenation method is often achieved by iodine reagents, such as potassium iodide, and appropriate oxidizing agents, under suitable solvents and reaction conditions. During the reaction, the temperature and the polarity of the solvent need to be carefully adjusted to ensure that the iodine atoms are accurately connected to the target check point and avoid side reactions.
Then, for another key part, the fluorophenol derivatives. Through a proper synthesis path, fluorine atoms are introduced at the 3-position of the benzene ring, and the 4-position reserves an active check point that can be connected to the thiophenopyridine 7-position oxygen group.
When the above two are properly prepared, the key etherification reaction is carried out. Using a base as a catalyst, in a suitable organic solvent, the activity checking point of the hydroxyl group at the 7-position of thiophenopyridine and the fluorophenol derivative is induced to undergo nucleophilic substitution reaction, and then the target ether bond is formed to construct the 3-fluoro-4- (2-iodothiopheno [3,2-b] pyridine-7-yloxy) structure.
During the reaction process, real-time monitoring by analytical means such as thin-layer chromatography and nuclear magnetic resonance is required to ensure that the reaction proceeds in the expected direction. After the reaction is completed, the product needs to be separated and purified, such as column chromatography, to obtain a high-purity target product. The entire synthesis process, the control of the reaction conditions at each step, and the trade-off of the proportion of raw materials are all related to the yield and purity of the final product, and caution is required before the effective synthesis of this compound can be achieved.
What are the physicochemical properties of 3-fluoro-4- (2-iodothieno [3,2-b] pyridin-7-yloxy)?
The physicochemical properties of 3-fluoro-4- (2-iodothiopheno [3,2-b] pyridine-7-yloxy) are as follows:
It is either a solid state or a liquid state, which is related to the characteristics of intermolecular forces and structures. The polarity of the molecule is increased due to the presence of halogen atoms such as fluorine and iodine. The fluorine atom has strong electronegativity, which causes the electron cloud to be biased. Although the electronegativity of the iodine atom is slightly inferior, its atomic radius is large and the polarizability is high, which also affects the intermolecular forces.
In terms of solubility, because it contains heterocycles and halogen atoms, it may have a certain solubility in polar organic solvents such as methanol, ethanol, dichloromethane, etc. The cap polar solvent and the polar part of the compound can form hydrogen bonds or dipole-dipole interactions to help it dissolve. However, in non-polar solvents, such as n-hexane and cyclohexane, the solubility may be low, because the forces between the two do not match.
The melting point and boiling point are also affected by the molecular structure. The presence of halogen atoms and heterocycles increases the intermolecular forces, and the melting point, boiling point or similar compounds without such groups are higher. Molecules can be attracted to each other by van der Waals force and dipole-dipole interaction. To make a substance melt or boil, more energy is required to overcome these forces.
In terms of stability, due to iodine atoms, the carbon-iodine bond is relatively weak, and it may be prone to fracture under light, heat or specific chemical environments, resulting in structural changes of compounds. The bond formed by fluorine atoms and carbon is stronger, which can increase molecular stability to a certain extent.
Spectral characteristics are also characteristic. In infrared spectroscopy, each functional group has its own characteristic absorption peak. For example, carbon-fluorine bonds and carbon-iodine bonds have unique absorption frequencies, which can be used to identify molecular structures. In nuclear magnetic resonance spectroscopy, hydrogen and carbon atoms in different chemical environments exhibit characteristic peaks due to differences in electron cloud environments and different resonance frequencies, providing key information for determining molecular structures.
What is the price range of 3-fluoro-4- (2-iodothieno [3,2-b] pyridin-7-yloxy) in the market?
I don't know the price range of 3-fluoro-4- (2-iodothieno [3,2-b] pyridin-7-yloxy) in the market. The price of this compound or an uncommon and general-purpose product is affected by many factors.
First, the difficulty of synthesis has a great impact. If the synthesis method is cumbersome, requires multiple steps of reaction, and the yield of each step is not high, and rare or expensive raw materials and reagents are required, the cost will increase greatly and the price will be high. If the synthesis requires a special catalyst, the preparation of this catalyst is not easy and the price will rise.
Second, the amount of market demand is also the key. If there is a strong demand for this product in the fields of pharmaceutical research and development, materials science, etc., but the supply is limited, the price will rise according to the reason of supply and demand. On the contrary, if there is little demand, even if the synthesis is not difficult, the price may not be high.
Third, the purity requirements are related to the price. For high purity, the preparation requires fine separation and purification steps, which consume more resources and energy, and the price is higher than that of low purity. For example, for high-end scientific research experiments, the purity requirements are harsh, and the price will far exceed that of general industrial use.
Fourth, the production scale also plays a role. During large-scale production, due to the scale effect, the unit cost may be reduced, and the price will also change. If only a small amount of customized production is required, the cost will be high, and the price will be expensive.
However, I have not heard the exact price of this product, and there is no example of past transactions. It is difficult to determine its price range in the market. Or you need to ask a merchant specializing in chemical reagents and chemical products, or check a professional chemical product trading platform to get a more accurate price range.
What are the manufacturers of 3-fluoro-4- (2-iodothieno [3,2-b] pyridin-7-yloxy)?
I have been searching for ancient books, but I have not found a clear manufacturer of "3-fluoro-4- (2-iodothieno [3,2-b] pyridin-7-yloxy) ". This compound may be a new special category, or its information has not been widely disseminated in the world.
However, if you want to find its manufacturer, you can explore it in several ways. First, the chemical professional directory, manufacturer's book, etc., check the relevant classification of fine chemicals, pharmaceutical intermediates, etc., or there are those who produce this product. Second, the chemical product trading platform, where many manufacturers display their products, can be viewed page by page, search for relevant entries, or get something. Third, academic literature, if this thing is popular in scientific research, the synthesizer may be mentioned in the literature, and the manufacturer may be known.
You can also ask experts and scholars in the chemical industry, who have been in the industry for a long time and have extensive knowledge, or can point the way. Or participate in chemical industry events and seminars, where manufacturers gather and inquire face-to-face, and you can get accurate information. However, it will take time and effort to explore carefully, and it is expected to be the manufacturer of "3-fluoro-4 - (2-iodothieno [3,2-b] pyridin-7-yloxy) ".