3 Fluoroiodobenzene
Iodobenzene

3-Fluoroiodobenzene

Fengxi Chemical

Specifications

HS Code

615589

Chemical Formula C6H4FI
Molecular Weight 188.00
Appearance Colorless to light yellow liquid
Boiling Point 174 - 176 °C
Density 1.807 g/mL at 25 °C
Flash Point 64 °C
Solubility In Water Insoluble
Refractive Index 1.5905 - 1.5925

As an accredited 3-Fluoroiodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 3 - fluoroiodobenzene packaged in a sealed, corrosion - resistant bottle.
Storage 3 - Fluoroiodobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames as it is flammable. Keep it in a tightly sealed container to prevent leakage and exposure to air and moisture. Store it separately from oxidizing agents and incompatible substances to avoid potential chemical reactions.
Shipping 3 - Fluoroiodobenzene is shipped in well - sealed, corrosion - resistant containers. It's handled with care due to its chemical nature. Shipment follows strict regulations to ensure safe transport, avoiding exposure to heat, moisture, and incompatible substances.
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3-Fluoroiodobenzene
General Information
Historical Development
3 - Fluoroiodobenzene is also an organic compound. Looking back at its historical development, chemists in the past explored the method of organic synthesis, making unremitting research, hoping to create novel compounds.
At that time, organic chemistry was just emerging, and all the sages were carefully seeking the reaction mechanism and synthesis path. 3 - The birth of Fluoroiodobenzene is the result of the exploration of many sages in the field of halogenated aromatic hydrocarbon synthesis. After repeated experiments, the reaction conditions were improved, and the ratio of reactants was adjusted, and the compound was finally obtained.
It is increasingly important in the field of organic synthesis. It provides key intermediates for the subsequent construction of many complex organic molecules. Therefore, the development of 3-Fluoroiodobenzene is an example of the progress of organic synthesis technology in the history of chemistry.
Product Overview
3 - Fluoroiodobenzene
3 - Fluoroiodobenzene is the most important thing in chemical products. Its properties are special, aromatic, and fluorine atoms and iodine atoms are attached to it. The introduction of fluorine makes the molecule have special sub-effects and increases its chemical activity; iodine atoms have good anti-activity, which is important for synthetic anti-activity.
In the field of synthesis, 3 - Fluoroiodobenzene has a wide range of uses. It can be used for several anti-molecules, such as Suzuki and Stille, etc. It can be used to synthesize many bioactive or material-functional molecules. It can be used as a starting material for the synthesis of new kinds of chemical, chemical and functional materials, and is an important position in chemical research. To synthesize this product, it is necessary to precisely control the reverse components, according to different methods, or involve nuclear substitution, transformation, etc., to achieve high efficiency and high resolution, so as to meet the needs of all parties.
Physical & Chemical Properties
3 - Fluoroiodobenzene, organic compounds are also. Its physical and chemical properties are particularly important. Looking at its physical properties, at room temperature, it is in a liquid state, with a clear color and different taste. The boiling point is suitable for a specific temperature, which is due to the force between molecules. Its density also has a certain number, which is related to the ratio of its mass to volume.
On its chemical properties, fluorine and iodine atoms in 3 - Fluoroiodobenzene give their unique reactivity. Fluorine atoms have high electronegativity, causing electron clouds to diverge and change the electron density of the benzene ring. Iodine atoms can participate in reactions such as nucleophilic substitution due to their large atomic radius. This compound can react with a variety of reagents, or be substituted on aromatic rings, or be replaced by other halogens, and has a wide range of uses in the field of organic synthesis.
Technical Specifications & Labeling
3 - Fluoroiodobenzene is an important compound in organic synthesis. Its preparation process needs to be precisely controlled. The raw materials should be selected carefully. The purity and ratio of fluorobenzene and iodine sources are related to the quality of the product. The reaction conditions are also critical. The temperature needs to be maintained in a specific range. If it is too low, the reaction will be slow, and if it is too high, it will cause frequent side reactions.
The operation process must be standardized. The reaction device must be clean and dry to prevent impurity interference. The reaction process should be closely monitored, and the degree of reaction should be controlled by means of high-performance liquid chromatography.
Quality Standards are clear. The appearance should be colorless to light yellow liquid without obvious impurities. The purity must reach a specific ratio to ensure product performance. The impurity content is strictly limited to avoid affecting subsequent applications. In this way, we can obtain high-quality 3-Fluoroiodobenzene products to meet the needs of scientific research and industry.
Preparation Method
The method for making 3-Fluoroiodobenzene is as follows. Take the raw material first, which needs to be pure and good. Begin with benzene, through the process of halogenation, fluorobenzene is introduced to obtain fluorobenzene. Later, in a suitable environment, iodine-substituted reagents and fluorobenzene are used to respond to temperature control and timing. The first step is to mix the raw materials, and slowly stir to promote melting. Heat up to a suitable temperature, observe the situation, and observe the change of color and taste. After the application is completed, the refined 3-Fluoroiodobenzene is obtained by the method of separation and purification. The mechanism of its transformation is halogenated and electrophilic substitution. Fluoro-based stable benzene ring, iodine substitution site selection is regular. This method is based on the principle of transformation, which can be efficiently produced and is the basis for professional use.
Chemical Reactions & Modifications
Nowadays, there is a chemical substance called 3-Fluoroiodobenzene, and the study of its chemical reaction and modification is quite important to our generation. To study its properties, we must study its reaction principles in detail.
This substance can interact with various reagents under specific conditions. Or nucleophilic substitution, or addition reaction, are all related to the characteristics of its structure. The location of its fluorine and iodine atoms has a great impact on the direction of the reaction.
In order to improve the modification, the catalytic method is often used to adjust the rate and selectivity of the reaction. With the power of the catalyst, the reaction is smoother and the purity of the product is also improved.
And explore different reaction media, hoping to find a suitable environment, so that 3-Fluoroiodobenzene shows a different nature. This is the unremitting pursuit of my chemical researchers, hoping to gain a deeper understanding of chemical reactions and modification.
Synonyms & Product Names
"On the Congeners and Product Names of 3-Fluoroiodobenzene"
The chemical substance, 3-Fluoroiodobenzene, has unique characteristics. The name of its congener is related to its quality and use.
Looking at the past, such compounds first appeared, and people explored their properties, so they named them in the name of precision. 3 - Fluoroiodobenzene, fluorine and iodine are co-attached to the benzene ring, and the structure is exquisite. The name of the congener varies according to the change of its atom and structure. The name of the congener also changes due to the change of position of fluorine or the change of state of iodine.
As for the name of the product, it is related to practicality and identification. Businesses are marked by the name of easy to remember and easy to use, and they are expected to show their characteristics in the market. In the academic world, the name seeks accuracy to clarify its nature; in the market, the name seeks popularity to make it widely used. Therefore, the same thing and product name of 3-Fluoroiodobenzene are essential for learning and business.
Safety & Operational Standards
3 - Code of Practice for Safe Production and Operation of Fluoroiodobenzene
3 - Fluoroiodobenzene is an important chemical in chemical research. During its experimental operation and production process, safe and standardized operation is of paramount importance, which is related to the safety of the experimenter and the accuracy of the experimental results.
#1. Storage Safety
3 - Fluoroiodobenzene should be stored in a cool and ventilated warehouse. Keep away from fire and heat sources, and the storage temperature should not exceed 30 ° C. It should be stored separately from oxidants and food chemicals, and should not be mixed. The storage area should be equipped with suitable materials to contain leaks. Because of its certain chemical activity, improper storage can easily cause it to react with surrounding substances and cause danger.
#2. Operating Specifications
When experimenters operate 3 - Fluoroiodobenzene, they need to wear appropriate protective equipment. Protective gloves should be worn. Rubber gloves that are resistant to chemical corrosion are generally selected, which can effectively block their contact with the skin. Eye protection is indispensable. Wear chemical safety glasses to prevent them from splashing into the eyes. The experimental operation should be carried out in a well-ventilated fume hood to ensure that the volatile harmful gases are discharged in time and reduce the indoor concentration.
#3. Emergency treatment
If a 3 - Fluoroiodobenzene leak occurs inadvertently, the personnel in the leaked area should be quickly evacuated to a safe area and quarantined to strictly restrict access. Emergency personnel wear self-contained positive pressure breathing apparatus and anti-toxic clothing. Cut off the source of leakage as much as possible. Small leakage: absorb with sand, vermiculite or other inert materials. Large leakage: build a dike or dig a pit to contain. Cover with foam to reduce vapor disasters. Transfer to a tanker or special collector with an explosion-proof pump, recycle or transport to a waste disposal site for disposal.
If skin contact, immediately remove contaminated clothing, rinse with plenty of flowing water for at least 15 minutes, and seek medical attention. Eye contact, immediately lift the eyelids, rinse thoroughly with plenty of flowing water or normal saline for at least 15 minutes, and seek medical attention. Inhalers, quickly remove from the scene to a fresh air place, keep the respiratory tract unobstructed, such as breathing difficulties, give oxygen, if breathing stops, immediately perform artificial respiration and seek medical attention.
Adhering to the above safety and operation specifications for 3-Fluoroiodobenzene can effectively reduce the risk during the experimental and production process, and ensure the safety of personnel and the environment.
Application Area
3 - Fluoroiodobenzene is also an organic compound. Its application field is quite wide. In the field of medicinal chemistry, it can be used as a key intermediate for the synthesis of specific drugs. Covered with its unique chemical structure, it can make drug molecules have specific activities and targeting, which is conducive to the development of precision medicine.
In materials science, it is also important. It can participate in the preparation of materials with special properties, such as those with unique optical or electrical properties, for advanced electronic devices, optical instruments, etc.
In organic synthetic chemistry, it is an important building block for the construction of complex organic molecules. Chemists can use it to participate in various chemical reactions to achieve precise construction of complex structures and promote the progress of organic synthetic chemistry. 3 - Fluoroiodobenzene has significant application fields.
Research & Development
There is a chemical substance today, called 3 - Fluoroiodobenzene. As a chemical researcher, I have dedicated myself to the research and development of this substance.
This 3 - Fluoroiodobenzene has unique chemical properties and is of extraordinary use in the field of organic synthesis. Its structure is exquisite and its properties are active, and it can be used as a key intermediate to assist in the preparation of various compounds.
We study its synthesis method and strive to improve it. After repeated experiments, we explore various conditions, such as temperature and catalyst, in order to obtain an efficient and pure synthesis path.
We also consider its application in industrial production and seek a strategy to expand the scale, in order to reduce costs and increase efficiency. It is hoped that the development of this product will contribute to the chemical industry and promote the progress of related fields, so that it can be widely used in practice and benefit the world.
Toxicity Research
Modern chemical refinement, in the analysis of various substances into the micro. Today there is 3 - Fluoroiodobenzene, its toxicity research is quite important.
Looking at the properties of this substance, the molecular configuration is specific, fluorine and iodine co-attach benzene ring. Fluoride is active, and iodine also has its characteristics. The coexistence of the two may cause chemical activity changes, affecting the biochemical path in organisms.
After various experiments, it has been observed that it enters the organism, or disturbs the order of cell metabolism. In the microhabitat, or interacts with key substances such as proteins and nucleic acids, disrupting its normal function. For example, the process of cell proliferation and differentiation may be hindered by it.
Although the current research is not complete, the signs of toxicity have emerged. Follow-up data should be collected to study its effects in different biological systems, in order to clarify its harm, as a guide for protection and application.
Future Prospects
In the future, 3 - Fluoroiodobenzene will be flourishing. It is a key material in the way of organic synthesis, and can open up new reaction paths and expand the new territory of chemical synthesis.
Looking at the present, although the preparation method may be complicated, the yield still needs to be improved. However, with the new technology and advanced research, we will definitely be able to find efficient and green methods. In the future, the cost will decrease and the output will increase. In the creation of medicine, it may help to develop new drugs and overcome difficult diseases. In the field of materials, or to give birth to new materials with strange functions, applied to electronics and energy.
Our generation of chemical researchers should have great ambitions and study diligently. Over time, 3 - Fluoroiodobenzene will shine brightly, pave the way for human well-being, and become a solid pillar of future development.
Where to Buy 3-Fluoroiodobenzene in China?
As a trusted 3-Fluoroiodobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 3-Fluoroiodobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the chemical properties of 3-fluoroiodobenzene?
3-Fluoroiodobenzene, which is an organic compound with both fluorine and iodine atoms on the benzene ring. This compound has unique chemical properties due to the atomic properties of fluorine and iodine.
First, the fluorine atom has extremely high electronegativity. In the 3-fluoroiodobenzene molecule, the electron cloud will be biased towards itself, causing the electron cloud density of the benzene ring to change. This change affects the electrophilic substitution reaction activity of the benzene ring. Generally speaking, the electrophilic substitution reaction activity is reduced. And the presence of fluorine atoms enhances the polarity of the molecule, which also plays a role in its physical properties such as boiling point and solubility.
Furthermore, iodine atoms have a larger atomic radius and a more dispersed electron cloud. In 3-fluoroiodobenzene, the iodine atom can participate in the nucleophilic substitution reaction as a leaving group. Due to the relatively small bond energy of C-I, it is easy to break, so 3-fluoroiodobenzene can react with nucleophilic reagents under appropriate conditions, and the iodine atom is replaced by the nucleophilic group.
In addition, the benzene ring of 3-fluoroiodobenzene is aromatic and can undergo typical electrophilic substitution reactions of aromatic compounds such as halogenation, nitrification, and sulfonation. However, due to the electron-withdrawing effect of fluorine atoms, the reaction check point may be different from that of benzene, and the reaction conditions may be more severe.
In the field of organic synthesis, 3-fluoroiodobenzene is often used as an important intermediate. With the unique reactivity of fluorine and iodine, complex organic molecular structures can be constructed through various chemical reactions, which has important application value in many fields such as medicinal chemistry and materials science.
What are the main uses of 3-fluoroiodobenzene?
3-Fluoroiodobenzene is an important raw material for organic synthesis and has a wide range of uses in many fields.
First, in the field of medicinal chemistry, this compound has a wide range of uses. Due to its unique chemical structure, it can act as a key intermediate for the synthesis of various drug molecules with specific biological activities. By modifying and transforming its structure, drugs with antibacterial, antiviral, anti-tumor and other effects can be prepared, making great contributions to human health.
Second, in the field of materials science, 3-fluoroiodobenzene is also indispensable. It can participate in the synthesis of polymer materials, and its structure can be introduced into polymers by polymerization and other means, giving the materials special electrical, optical or mechanical properties. For example, it is used to prepare organic optoelectronic materials, improve the photoelectric conversion efficiency of materials, and play an important role in the application of solar cells, Light Emitting Diodes and other devices.
Furthermore, in the study of organic synthesis chemistry, 3-fluoroiodobenzene is a commonly used reagent, providing an effective way to construct complex organic molecular structures. The difference in the activity of fluorine atoms and iodine atoms allows chemists to selectively perform various chemical reactions, such as nucleophilic substitution reactions, metal catalytic coupling reactions, etc., to help synthesize organic compounds with special structures and functions, and promote the development of organic synthesis chemistry.
To sum up, 3-fluoroiodobenzene occupies an important position in the fields of medicine, materials and organic synthesis, and is of great significance to technological progress and innovation in various fields.
What are the synthesis methods of 3-fluoroiodobenzene?
There are several common methods for preparing 3-fluoroiodobenzene. One is to use 3-fluoroaniline as the starting material, which can be obtained by diazotization and iodo substitution reaction. Take 3-fluoroaniline first, dissolve it in an appropriate amount of inorganic acid, such as hydrochloric acid or sulfuric acid, add sodium nitrite solution at low temperature, and undergo a diazotization reaction to generate 3-fluorobenzene diazonium salt. This process requires strict temperature control to prevent the decomposition of diazonium salts. Subsequently, potassium iodide or sodium iodide solution is added to the system, and the diazoyl group is replaced by an iodine atom to obtain 3-fluoroiodobenzene.
Furthermore, 3-fluorobenzoic acid can be used. First, 3-fluorobenzoic acid is converted into the corresponding acyl chloride, which is often treated with thionyl chloride to obtain 3-fluorobenzoyl chloride. Then the acyl chloride is converted into an aldehyde by Rosemond reduction reaction. Then, the aldehyde can be haloformed to introduce iodine atoms, and subsequent appropriate treatment can also produce 3-fluoroiodobenzene.
There are also those who use 3-fluorobromobenzene as a raw material. In the presence of a suitable catalyst, such as palladium catalyst, a halogen exchange reaction occurs with the iodizing reagent. This reaction condition is mild, and the yield and selectivity of the reaction can be improved by selecting a suitable ligand and reaction solvent, and then 3-fluoroiodobenzene can be obtained. All methods have their own advantages and disadvantages. The actual preparation needs to be comprehensively considered according to factors such as raw material availability, cost and reaction conditions, and the best one should be selected.
What are the precautions for 3-fluoroiodobenzene during storage and transportation?
3-Fluoroiodobenzene is also an organic compound. When storing and transporting, many matters need to be paid attention to.
The first thing to pay attention to is its storage environment. This substance should be stored in a cool and ventilated warehouse. Due to high temperature or poor ventilation, it is easy to change its properties. The temperature of the warehouse should be strictly controlled, usually not exceeding 30 ° C, to prevent its volatilization or other adverse reactions. At the same time, humidity should also be concerned. Too humid environment may cause it to react with water vapor, which will damage the quality.
Second, its packaging. 3-Fluoroiodobenzene packaging must be tight and reliable, mostly in glass bottles or specific plastic containers. The packaging should be resistant to corrosion and well sealed to avoid contact with the air. Due to the oxygen, water vapor and other components in the air, or chemical reaction with 3-fluoroiodobenzene, it deteriorates.
When transporting, there are also many rules. The transport vehicle needs to choose a suitable one, with good shock absorption and fixing devices, to prevent the package from being damaged due to bumps and collisions during transportation. Transport personnel should be familiar with the characteristics of 3-fluoroiodobenzene, and can handle it properly in case of emergencies. And the transportation process should avoid open flames, hot topics, and keep away from fire and heat sources to prevent the risk of explosion or combustion.
In addition, 3-fluoroiodobenzene has certain toxicity and irritation, and corresponding protective equipment and emergency treatment equipment should be prepared at storage and transportation sites. In case of inadvertent contact, personnel can save themselves and each other in time to reduce injuries. In short, the storage and transportation of 3-fluoroiodobenzene is related to safety and quality, and all details should not be ignored, and must be strictly implemented in accordance with regulations.
What are the effects of 3-fluoroiodobenzene on the environment and human health?
3-Fluoroiodobenzene is an organic compound that does have potential effects on the environment and human health.
First talk about its impact on the environment. If this substance is released in the natural environment, it is difficult to be rapidly decomposed by microorganisms due to its chemical properties, so it is environmentally persistent. In the soil, it may accumulate, affect the balance of the soil ecosystem, interfere with the normal metabolism and reproduction of soil microorganisms, and then have adverse effects on the absorption of nutrients and moisture by plant roots, hindering plant growth and development. In the water environment, it may spread with the current, posing a threat to aquatic organisms. After fish, shellfish and other aquatic organisms come into contact with or ingest this substance, their physiological functions may be damaged. If it interferes with the normal function of its nervous system, the aquatic organisms' behavior is abnormal, the ability to forage and escape natural enemies is reduced, and in severe cases, the population can decrease and the biodiversity of aquatic ecosystems can be destroyed.
Re-discuss its impact on human health. Inhalation through the respiratory tract, skin contact or accidental ingestion of substances containing 3-fluoroiodobenzene can cause harm to the human body. When inhaled by the respiratory tract, it may irritate the mucosa of the respiratory tract, causing symptoms such as cough, asthma, and breathing difficulties. Long-term exposure to this environment may cause damage to lung tissue, decrease lung function, and increase the risk of respiratory diseases. Skin contact can cause skin allergies, redness, swelling, itching, and rashes and other allergic reactions. If left untreated, damage to the skin may cause the substance to further invade the human body and affect internal organs. Accidentally ingesting this substance can damage the digestive system, cause nausea, vomiting, abdominal pain, diarrhea and other symptoms. In severe cases, it may damage important organs such as the liver and kidneys, affect their normal metabolism and detoxification functions, and endanger life and health.
In summary, 3-fluoroiodobenzene poses a potential threat to the environment and human health. During its production, use and disposal, proper protection and management measures should be taken to reduce its harm to the environment and human health.