3 Hydroxy 2 Iodopyridine

3-Hydroxy-2-iodopyridine is an organic compound with a wide range of main uses. In the field of organic synthesis, it is often used as a key intermediate. Because its structure contains both hydroxyl and iodine atoms, this unique structure endows it with various reactivity.
Hydroxyl groups are nucleophilic, and iodine atoms can be converted through nucleophilic substitution, coupling and other reactions. Through nucleophilic substitution reactions, iodine atoms can be replaced by other functional groups, such as alkyl groups, aryl groups, etc., to expand the structural complexity of molecules and lay the foundation for the construction of various complex organic molecules.
In the field of medicinal chemistry, 3-hydroxy-2-iodopyridine also plays an important role. Studies have shown that such compounds containing specific functional groups may have potential biological activities. They can be modified and modified to meet the needs of specific drug targets, used to develop new drugs, or to exert therapeutic effects for specific diseases.
In the field of materials science, it may also have applications. With its reactivity, it can participate in the material synthesis process and endow materials with unique properties, such as improving the optical and electrical properties of materials, so as to meet the special requirements of different application scenarios for material properties.
In short, 3-hydroxy-2-iodopyridine has shown important uses in many fields such as organic synthesis, medicinal chemistry and materials science due to its unique structure, providing a key material basis and reaction raw materials for research and development in various fields.

3-Hydroxy-2-iodopyridine is also an organic compound. It has unique physical properties, let me tell you in detail.
First of all, its properties are mostly solid at room temperature. Looking at its color, or white to white powder, this is a common appearance, easy to observe and distinguish.
When it comes to melting point, the melting point of this substance is quite important, because the melting point is related to its phase transition. Its melting point is within a certain range, but the exact value varies slightly depending on the experimental conditions and purity. Generally speaking, accurate determination of melting point can help determine its purity. If the purity is high, the melting point range is narrow and approaches the theoretical value.
Solubility is also a key property. In organic solvents, 3-hydroxy-2-iodopyridine exhibits different solubility characteristics. Common organic solvents, such as ethanol, dichloromethane, etc., have certain solubility. In ethanol, with moderate stirring, it can be partially dissolved to form a uniform solution; in dichloromethane, the solubility is also different, or the solubility is better, or it needs to be properly heated to increase its solubility. In water, its solubility is relatively poor, and it is mostly insoluble, due to the difference between the structure of the compound and the polarity of water.
Furthermore, its density also has a certain value. Although it is not a property that can be easily observed in daily life, in specific chemical and experimental scenarios, it is very important to know the density, which is related to its ratio and phase distribution when mixed with other substances.
Because its molecular structure contains hydroxyl and iodine atoms, these two give the compound a certain polarity, which affects its interaction with other substances, and also has many subtle effects on its physical properties. Properties such as boiling point are closely related to the functional groups in the structure.

The synthesis method of 3-hydroxy-2-iodopyridine has been explored by many scholars in the past, and now I will describe it in detail.
First, 2-amino-3-hydroxypyridine is used as the starting material, and the diazotization reaction is first performed. Dissolve 2-amino-3-hydroxypyridine in an appropriate amount of acid solution, and slowly add sodium nitrite solution dropwise at low temperature to form diazonium salts. This process needs to be carefully controlled to prevent the decomposition of diazonium salts. Subsequently, potassium iodide solution is added, and the diazonium group is replaced by iodine atom, so 3-hydroxy-2-iodopyridine is obtained. However, in this method, the diazotization reaction conditions are severe, and the dosage of sodium nitrite and the rate of dripping need to be precisely controlled, otherwise side reactions will easily occur.
Second, 3-hydroxypyridine is used as the raw material. First, the 3-hydroxypyridine is protected, and the hydroxyl group is masked with a specific protective group to avoid its interference in the subsequent reaction. Then, the 2-position halogenation on the pyridine ring is made, and an iodine substitution reagent can be selected. In the presence of an appropriate solvent and catalyst, the 2-position iodine substitution is achieved. After the reaction is completed, the protective group is removed, and the target product can be obtained through separation and purification. Although this path is a little complicated, the reaction steps are relatively mild and the product purity is also good.
Third, the coupling reaction is catalyzed by transition metals. Using suitable halogenated pyridine derivatives and iodine-containing reagents as raw materials, under the action of transition metal catalysts such as palladium catalysts, in the reaction system where specific ligands and bases exist, a coupling reaction occurs, and the structure of 3-hydroxy-2-iodopyridine is directly constructed. This method has high selectivity, but the catalyst cost is high, and the reaction equipment and operation requirements are also strict.
The above synthesis methods have their own advantages and disadvantages, and need to be selected according to actual needs, such as raw material availability, cost considerations, product purity requirements, etc.

3-Hydroxy-2-iodopyridine is an organic compound. Many matters need to be paid attention to during storage and transportation.
First, storage, because of its certain chemical activity, should be stored in a cool, dry and well-ventilated place. This environment can avoid the risk of deterioration due to excessive temperature and humidity. Do not place it in direct sunlight, the sun's energy may cause photochemical reactions to occur, which will damage its quality. In addition, it should be separated from oxidizing agents, acids, bases and other chemicals. Due to these substances or chemical reactions with 3-hydroxy-2-iodopyridine, it is dangerous. The storage place should be clearly marked, indicating its name, nature and precautions for easy access and management.
As for transportation, it should not be neglected. Before transportation, make sure that the packaging is complete and well sealed. To prevent the package from being damaged due to vibration and collision during transportation, causing 3-hydroxy-2-iodopyridine to leak. The transportation tool must be clean, dry and free of other chemical residues. During transportation, the temperature and humidity should be controlled to avoid extreme conditions. The escort personnel should also be familiar with its nature and emergency treatment methods. In case of emergencies, they can respond in time to ensure the safety of transportation.
All of these are crucial for the storage and transportation of 3-hydroxy-2-iodopyridine, and must be kept in mind to ensure its quality and safety.

3-Hydroxy-2-iodopyridine, the price of this product in the market varies for many reasons.
Its price depends first on purity. If the purity is high, it is almost flawless, and the price can be extremely high. If the purity is slightly inferior and contains some impurities, the price is slightly lower. Generally speaking, the price per gram of high purity may reach several hundred yuan.
Furthermore, the supply and demand of the market also affect the price. If there are many people who want it, and the supply is small, the price will increase; if the supply exceeds the demand, the price will decrease.
In addition, the cost of production is also a major factor. If the production process is complicated, rare raw materials and exquisite skills are required, the price will be high; if the production is easy, the cost is low, and the price is also low.
And the supplier of supply and the quantity of purchase are affected. Wholesale by large merchants, if the quantity is large, the price may be given; if you buy a small amount, the price may be slightly higher.
Overall, the market price of 3-hydroxy-2-iodopyridine fluctuates between tens of yuan and hundreds of yuan per gram, and the actual price must be determined according to the current market situation, specific quality and quantity.