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What is the chemical structure of 3-iodo 1h-indazole-6-carboxylic Acid?
3-Iodine-1H-indazole-6-carboxylic acid, its chemical structure can be separated. This compound belongs to indazole derivatives, containing indazole parent nucleus. For 1H-indazole, it has a five-membered and six-membered heterocyclic ring structure with a nitrogen atom located at the first position of the indole cyclopyrrole part.
Looking at its structure, there is a carboxyl group (-COOH) connected to the 6 position of the indazole parent nucleus. This carboxyl group is acidic and can participate in many chemical reactions, such as salt formation, esterification, etc. There is an iodine atom (-I) connected at the 3rd position. The iodine atom has a large atomic radius and electronegativity, which affects the electron cloud distribution and spatial structure It can change the polarity of the molecule, and the iodine atom can be used as the leaving group of the nucleophilic substitution reaction, giving the compound unique reactivity.
From this perspective, the chemical structure of 3-iodine-1H-indazole-6-carboxylic acid, with the combination of the indazole parent nucleus, carboxyl group and iodine atom, presents specific physical and chemical properties, which may have potential applications in organic synthesis, medicinal chemistry and other fields.
What are the main uses of 3-iodo 1h-indazole-6-carboxylic Acid?
3-Iodo-1H-indazole-6-carboxylic acid, which is 3-iodo-1H-indazole-6-carboxylic acid, is widely used. In the field of pharmaceutical research and development, it is often a key intermediate. Taking the creation of new anti-tumor drugs as an example, researchers hope to develop drugs that can precisely act on specific targets of tumor cells by modifying and modifying their chemical structures. By virtue of its unique structure, it interacts with relevant receptors or enzymes in tumor cells, or interferes with tumor cell signal transduction pathways, achieving the purpose of inhibiting tumor cell proliferation and inducing apoptosis.
In the field of organic synthesis, 3-iodine-1H-indazole-6-carboxylic acids can participate in many reactions. For example, in metal-catalyzed cross-coupling reactions, iodine atoms can be used as leaving groups to couple with organic molecules containing other functional groups to construct organic compounds with more complex structures, laying the foundation for the synthesis of new organic materials with specific functions and structures. When constructing complex cyclic compounds containing indazole structures, their carboxyl groups can participate in cyclic reactions to enrich the structural diversity of organic compounds.
In the field of materials science, based on its structural properties, specific chemical modifications and polymerization reactions can prepare materials with unique photoelectric properties for use in organic Light Emitting Diodes (OLEDs), solar cells and other devices, or to improve device performance and efficiency.
From this perspective, 3-iodine-1H-indazole-6-carboxylic acids have important application value in many fields such as medicine, organic synthesis and materials science, promoting technological development and innovation in various fields.
What are the physical properties of 3-iodo 1h-indazole-6-carboxylic Acid?
3-Iodine-1H-indazole-6-carboxylic acid, this is an organic compound. Its physical properties are quite unique, let me tell them one by one.
Looking at its appearance, under room temperature and pressure, it usually appears as a white to light yellow solid powder. This form is easy to store and transport, and is also conducive to subsequent chemical operations.
When it comes to the melting point, it is about a specific temperature range, which is of great significance for its physical state transition under different conditions. The determination of the melting point provides a key basis for the study of the thermal stability and phase transition characteristics of the compound.
In terms of solubility, it shows a certain solubility in common organic solvents, such as dimethyl sulfoxide (DMSO), N, N-dimethyl formamide (DMF), etc. However, in water, the solubility is relatively limited. This difference in solubility has a great impact in the process of chemical synthesis and separation and purification. Good solubility in organic solvents helps it participate in various organic reactions, and the limited solubility in water makes it necessary to consider carefully when dealing with aqueous phases.
In addition, the density of this compound is also one of its important physical properties. Although the exact density value varies slightly according to the specific measurement conditions, its density characteristics affect its distribution and behavior in the mixture. In chemical production and experimental research, it is related to the ratio of materials and the uniformity of the reaction system.
Furthermore, its stability cannot be ignored. It can exist relatively stably in a normal temperature, dry and dark environment. However, in case of extreme conditions such as high temperature, humidity or strong light irradiation, decomposition or other chemical reactions may occur, causing changes in its structure and properties. This stability feature requires attention when storing and using the compound to ensure that its quality and performance are not affected.
What are the synthesis methods of 3-iodo 1h-indazole-6-carboxylic Acid
3-Iodo-1H-indazole-6-carboxylic Acid, that is, 3-iodine-1H-indazole-6-carboxylic acid, has many synthesis methods, which are described in detail below.
First, indazole is used as the starting material. First, the indazole is protected to reduce the activity of the hydrogen atom at a specific position and avoid unnecessary reactions. After that, a suitable iodine substitution reagent is selected, such as iodine elemental substance combined with a suitable oxidant, and under appropriate reaction conditions, such as specific temperature and solvent environment, the 3 position of the indazole is iodated. After the iodine generation is completed, a carboxyl group is introduced by a specific method, such as hydrolysis under suitable basic conditions, to obtain 3-iodine-1H-indazole-6-carboxylic acid.
Second, you can start from a benzene ring derivative containing a specific substituent. Through a multi-step reaction, the indazole ring structure is first constructed. For example, the substituent on the benzene ring is used to form an indazole skeleton through a cyclization reaction. Subsequently, on the basis of the formed indazole ring, through suitable halogenation reaction conditions, an iodine atom is introduced at the No. 3 position, and then the subsequent carboxylation reaction is carried out to obtain the target product.
Third, some compounds containing indazole structure fragments are used as starting materials. If the substituents of the starting compound at positions 3 and 6 can be converted by appropriate reactions, then a reasonable reaction step can be taken, such as first converting the position 6 into a group that can further react to form a carboxyl group, and then introducing iodine atoms at position 3, and then obtaining 3-iodine-1H-indazole-6-carboxylic acid after subsequent treatment.
During the synthesis process, attention should be paid to the precise control of the reaction conditions at each step, including temperature, reaction time, reactant ratio, etc., to ensure that the reaction proceeds in the desired direction and improve the yield and purity of the target product. At the same time, the identification of the structure of the intermediate product and the final product is also crucial, which can be confirmed by analytical methods such as nuclear magnetic resonance and mass spectrometry.
3-What is the market outlook for iodo 1h-indazole-6-carboxylic Acid?
3-Iodine-1H-indazole-6-carboxylic acid, this substance has promising prospects in the field of pharmaceutical and chemical industry.
Looking at the current trend of pharmaceutical research and development, targeted drugs have attracted much attention. 3-Iodine-1H-indazole-6-carboxylic acid has a unique structure and can be used as a key intermediate for the creation of targeted anti-cancer drugs. Cancer is a difficult problem in today's medicine. Targeted drugs precisely act on cancer cells and can reduce damage to normal cells. This compound may be modified and modified to obtain highly active and highly selective anti-cancer ingredients, opening up a new path for cancer treatment. Market demand will increase with the increase in anti-cancer drug research and development.
Furthermore, it also has potential in the research and development of new anti-infective drugs. The drug resistance of pathogens such as bacteria and viruses is increasing, and the research and development of new anti-infective drugs is imminent. The structural characteristics of this compound may endow it with antibacterial and antiviral activities. After in-depth research and development, it may become a new type of anti-infective drug, which will add a sharp tool to the anti-infective treatment, and the market prospect is broad.
In the field of chemical materials, 3-iodine-1H-indazole-6-carboxylic acid may be used to synthesize special functional materials. Such as photoelectric materials, with the development of miniaturization and high performance of electronic equipment, the demand for new photoelectric materials This compound may be introduced into functional groups through specific reactions to obtain materials with special photoelectric properties, which are used in organic Light Emitting Diodes, solar cells, etc., to meet the development needs of related industries, and the market potential is huge.
However, its market development also faces challenges. The synthesis process needs to be optimized to reduce costs, yield, and increase market competitiveness. And the research and development process requires strict experiments and approval, which is time-consuming and laborious. However, overall, 3-iodine-1H-indazole-6-carboxylic acid has more opportunities than challenges in the pharmaceutical and chemical fields, and the market prospect is bright. It is expected to become an important force to promote the development of related industries.