3-Iodo-1H-Pyrazole

3-Iodo-1H-pyrazole is 3-iodine-1H-pyrazole, which has a wide range of uses. In the field of medicinal chemistry, it is often a key intermediate for the creation of new drugs. Geinpyrazole compounds have a variety of biological activities, such as anti-inflammatory, antibacterial, antiviral, anti-tumor, etc. The iodine atom of 3-iodine-1H-pyrazole has good activity. It can introduce other functional groups through various chemical reactions to build more complex and active drug molecules.
In the field of materials science, it also has extraordinary performance. It can participate in the preparation of functional materials, such as organic optoelectronic materials. Due to the special structure of the pyrazole ring, the material is endowed with unique photoelectric properties. The introduction of 3-iodine-1H-pyrazole may regulate the energy level structure and charge transport properties of the material, providing the possibility for the research and development of new high-efficiency organic optoelectronic materials.
In the field of organic synthesis, it is an important synthetic block. With the characteristics of iodine atoms prone to nucleophilic substitution, coupling and other reactions, chemists can use it as a starting material to synthesize a series of organic compounds with special structures and functions through ingenious design of reaction routes, which greatly enriches the variety of organic compounds and promotes the development of organic synthetic chemistry.

3-Iodo-1H-pyrazole is an organic compound with unique physical properties. It is mostly solid at room temperature. Due to the existence of various forces between molecules, such as van der Waals force and hydrogen bonds, the molecular arrangement is relatively regular, resulting in a certain melting point. After determination, the melting point is in a specific temperature range, which is of great significance for its separation, purification and identification. In a specific temperature range, the state of the substance changes, and its purity can be judged accordingly.
Looking at its solubility, the solubility of this compound varies significantly in organic solvents. In some polar organic solvents, such as ethanol and dichloromethane, by forming hydrogen bonds or other interactions with solvent molecules, it exhibits good solubility and can be uniformly dispersed to form a uniform solution. However, in water, due to the poor matching of the polarity of water molecules with the structure and polarity of 3-iodo-1H-pyrazole, it is difficult to form an effective interaction, so the solubility is poor.
Its density is also an important physical property. Its density value can be obtained through experimental measurement. This value reflects the unit volume mass of the substance. In chemical operations such as solution preparation and determination of the proportion of reactive materials, density data can help to accurately calculate the dosage of substances and ensure experimental accuracy and reproducibility.
3-iodo-1H-pyrazole also has certain volatility. Although the volatilization rate is not fast at room temperature, in heating or a specific environment, the molecule obtains enough energy to break free from the binding of intermolecular forces and transform from liquid or solid to gaseous to escape. To understand its volatility, corresponding measures should be taken during storage and use, such as sealed storage and operation in a well-ventilated environment, to avoid losses caused by its volatilization or safety problems.

3-Iodo-1H-pyrazole is 3-iodine-1H-pyrazole, and its synthesis method is as follows:
Pyrazole can be used as the starting material, and the pyrazole can be protected first to avoid reaction at the check point where the reaction is not required in the subsequent reaction. For example, suitable protecting groups can be used to protect the nitrogen atom of pyrazole, common protecting groups such as tert-butoxycarbonyl (Boc), etc. After the protective reaction, the pyrazole derivative with the nitrogen atom protected is obtained.
Subsequently, this derivative is reacted with an iodine agent. The iodine substitution reagent can be used with iodine element (I ²) and suitable oxidant, such as hydrogen peroxide (H ² O ²) as oxidant under acidic conditions, which can make iodine element participate in the reaction and realize the iodization of the 3-position on the pyrazole ring. The reaction process requires strict control of the reaction conditions, such as temperature, reaction time and the proportion of reactants. The temperature is usually controlled between low temperature and room temperature, and it needs to be fine-tuned according to the experimental situation to ensure that the reaction mainly occurs at the 3-position and avoid side reactions such as excessive iodization.
After the reaction is completed, a deprotection step is carried out to remove the previously introduced protective group, thereby obtaining the target product 3-iodine-1H-pyrazole. The deprotection step requires selecting the appropriate reaction conditions according to the selected protective group. For example, for Boc protective groups, reagents such as trifluoroacetic acid (TFA) are commonly used to remove the protective group under mild conditions.
In addition, there are other synthesis strategies. For example, using compounds containing suitable substituents as raw materials, a pyrazole ring is constructed through a multi-step reaction and iodine atoms are introduced. β-carbonyl hydrazone compounds can be selected to form pyrazole rings by cyclization under appropriate catalysts and reaction conditions. At the same time, iodine atoms can be introduced directly to the 3-position during or after cyclization by adjusting the reaction system. However, such method steps are relatively complicated, and each step needs to be carefully controlled to ensure high yield and purity.

3-Iodine-1H-pyrazole, the price of this substance in the market is difficult to determine. The change in its price is subject to various factors.
The first to bear the brunt is the difficulty of production. The preparation of 3-iodine-1H-pyrazole may require complicated processes, and there are strict requirements for the purity of raw materials and reaction conditions. If the preparation method is not easy and the raw materials are rare, the production cost will be high, and the price in the market will also rise.
Furthermore, the state of supply and demand determines its price. If the market demand for this product is strong, but the supply is limited, such as many pharmaceutical and chemical industries need it, the supply is in short supply, and the price will rise; conversely, if the demand is low and the supply is excessive, the price will decline.
Again, market competition is also the key. If there are many manufacturers producing this product, the competition is fierce, in order to compete for market share, or reduce its price to attract buyers; if the market is almost controlled by a few manufacturers, its pricing power is strong, and the price may be high.
And in different places, prices vary, transportation costs, and tax differences all make the price of 3-iodine-1H-pyrazole vary from place to place. In addition, market fluctuations and economic conditions can also make prices fluctuate.
Therefore, to know the exact market price of 3-iodine-1H-pyrazole, it is necessary to carefully observe the real-time market conditions and consult suppliers and distributors to obtain a more accurate number.

3-Iodo-1H-pyrazole is an organic compound. When storing and transporting, many things need to be paid attention to.
First, when storing, it should be placed in a cool, dry and well-ventilated place. Because the compound may be sensitive to temperature and humidity, high temperature and humid environment are easy to cause it to deteriorate. If placed in a humid place, water vapor may interact with the compound, causing reactions such as hydrolysis, which will damage the structure and purity. Under high temperature, it may cause decomposition, polymerization and other reactions, which will affect the quality.
Second, it needs to be kept away from fire and heat sources. Because of its certain chemical activity, it may encounter open flames, hot topics, or risk combustion and explosion. In the warehouse, fireworks must be strictly prohibited, and electrical equipment should be treated with explosion-proof treatment to prevent the generation of electric sparks from causing danger.
Third, it should be stored separately from oxidizing agents, acids, alkalis, etc., and should not be mixed. The chemical properties of 3-iodo-1H-pyrazole make it prone to violent chemical reactions when it comes into contact with these substances, or release a lot of heat, or generate dangerous products, endangering safety.
Fourth, during transportation, make sure that the container is well sealed to prevent leakage. Choose suitable packaging materials and fix them properly to avoid damage to the container due to bumps and collisions during transportation. Once a leak occurs, it will not only cause material loss, but also leak or pollute the environment, endangering human health.
Fifth, transportation vehicles need to be equipped with corresponding varieties and quantities of fire fighting equipment and leakage emergency treatment equipment. In the event of an emergency, fire extinguishing and leakage treatment work can be quickly launched to reduce hazards. Escort personnel also need to be familiar with the characteristics of the transported items and emergency treatment methods, and strictly supervise during transportation to ensure transportation safety.