As a leading 3-Iodo-1H-Pyrazolo[3,4-D]Pyrimidin-4-Amine supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the chemical structure of 3-iodo-1h-pyrazolo [3,4-d] pyrimidin-4-amine?
3-Iodo-1H-pyrazolo [3,4-d] pyrimidin-4-amine is an organic compound. Its chemical structure consists of three key units: a pyrazolopyrimidine ring, an iodine atom, and an amino group.
Pyrazolopyrimidine ring is formed by fusing a pyrazolopyrimidine ring with a pyrimidine ring. The pyrazolopyrimidine ring has a five-membered structure and contains two adjacent nitrogen atoms. The pyrimidine ring is a six-membered ring with two interposition nitrogen atoms. The two fused in a specific way to form a unique pyrazolopyrimidine skeleton, giving the compound special spatial structure and electronic properties. This ring system is common in many bioactive molecules and drugs, and has a significant impact on biological activity due to its interaction with specific targets in vivo.
Iodine atoms are attached to specific positions in the pyrazolopyrimidine ring. Iodine atoms have large relative atomic weight and unique electronegativity, and their introduction will change the distribution of molecular electron clouds and steric resistance. This may affect the physicochemical properties of molecules, such as fat solubility, polarity, etc., and then affect the ability of compounds to bind to biological targets and the absorption, distribution, metabolism and excretion processes in vivo.
Amino (-NH2O) is also connected to the pyrazolopyrimidine ring. Amino groups are basic and can participate in the formation of hydrogen bonds, which has a significant impact on the water solubility, biological activity and interaction with targets of molecules. It can bind to specific groups of biological targets through hydrogen bonds or other non-covalent interactions to enhance the affinity of compounds with targets and achieve specific biological activities.
Overall, the interaction of various parts in the chemical structure of 3-iodo-1H-pyrazolo [3,4-d] pyrimidin-4-amine determines its physicochemical properties and biological activities, which is of great significance in pharmaceutical chemistry and related fields.
What are the main physical properties of 3-iodo-1h-pyrazolo [3,4-d] pyrimidin-4-amine?
3-Iodine-1H-pyrazolo [3,4-d] pyrimidine-4-amine, this is an organic compound. Its physical properties are quite critical and are related to many chemical and industrial applications.
First of all, the appearance of this compound is often solid, mostly powdery or crystalline, with fine and uniform texture and white to light yellow color. This color feature is useful for identification and quality judgment.
Besides the melting point, its melting point is extremely important for determining purity and thermal stability. Accurate determination of melting point requires the help of professional instruments, such as melting point meters. In general, the melting point of the compound is within a certain range. If the melting point deviates too much from the theoretical value, it may suggest that its purity is questionable.
Solubility is also a key property. In common organic solvents, their solubility varies. In polar organic solvents, such as dimethyl sulfoxide (DMSO) and N, N-dimethylformamide (DMF), it often exhibits good solubility and can be uniformly dispersed to form a solution; in non-polar solvents, such as n-hexane and toluene, the solubility is poor. This difference in solubility has a great impact on the separation, purification and choice of reaction medium of the compound.
In addition, although the density of this compound is not widely concerned about properties, it is also important in some specific applications, such as where the relationship between mass and volume is involved. Accurate determination of density requires specific experimental methods and instruments, and its values are of great significance for understanding the molecular stacking and compactness of compounds.
In summary, the physical properties of 3-iodine-1H-pyrazolo [3,4-d] pyrimidine-4-amine, such as appearance, melting point, solubility and density, are all indispensable factors for its application and research in chemical synthesis, drug development and materials science.
In which fields is 3-iodo-1h-pyrazolo [3,4-d] pyrimidin-4-amine used?
3-Iodo-1H-pyrazolo [3,4-d] pyrimidin-4-amine, Chinese name 3-iodo-1H-pyrazolo [3,4-d] pyrimidin-4-amine, has applications in medicine, materials science and other fields.
In the field of medicine, it is an important intermediate in organic synthesis, which can be chemically modified and structurally optimized to create new drug molecules. Numerous studies have focused on the biological activities of compounds containing pyrazolopyrimidine structures, which show significant affinity and inhibitory activity for a variety of enzymes and receptors. For example, for some protein kinases, these compounds can selectively inhibit their activity, thereby regulating cell signaling pathways. Cancer cell proliferation, differentiation and apoptosis are closely related to signaling pathways, so 3-iodine-1H-pyrazolo [3,4-d] pyrimidine-4-amine may be used in the development of anti-cancer drugs. In the field of antivirus, compounds containing such structures have also shown potential application value in the inhibition of key enzymes for specific viral replication.
In the field of materials science, due to its unique molecular structure, it has specific photoelectric properties. In the research of organic optoelectronic materials, it can be used as a construction unit to participate in the preparation of organic Light Emitting Diode (OLED), organic solar cells and other materials. The atoms in its structure, such as nitrogen and iodine, can adjust the molecular electron cloud distribution and energy level structure, so that the material has suitable charge transport and luminescence properties. For example, in the design of OLED materials, this structure can be introduced to optimize the electron injection and transport efficiency of the light-emitting layer molecules, and improve the luminous efficiency and stability of the device. In organic solar cells, the energy level matching of the active layer material can be adjusted to enhance the absorption of sunlight and the efficiency of charge separation, thereby improving the photoelectric conversion efficiency of the battery.
What are the synthesis methods of 3-iodo-1h-pyrazolo [3,4-d] pyrimidin-4-amine
The synthesis method of 3-iodine-1H-pyrazolo [3,4-d] pyrimidine-4-amine is important in the field of chemical synthesis. There are various methods, and each has its own advantages and disadvantages, which need to be selected according to the actual situation.
First, starting from pyrazolo [3,4-d] pyrimidine, the amino group can be introduced first, and then halogenated to form an iodine substitute. In a specific solvent, pyrazolo [3,4-d] pyrimidine and ammonia sources, such as liquid ammonia or organic amines, can be connected to the fourth position of the pyrimidine ring under the action of appropriate temperature and catalyst. Then, under suitable reaction conditions, the target product can be obtained by halogenation with iodine-substituted reagents, such as N-iodine succinimide (NIS). The steps of this pathway are clear, but the halogenation steps or side reactions are not high in yield.
Second, the pyrazolo [3,4-d] pyrimidine skeleton can also be constructed by cyclization with starting materials containing iodine and amino groups. For example, a hydrazine compound containing iodine and a pyrimidine derivative containing carbonyl groups are catalyzed by acid or base, and are formed by condensation and cyclization. This method has high efficiency in constructing the target structure in one step, but the synthesis of starting materials is more complicated and costly.
Third, transition metal catalysis is also commonly used. Transition metals such as palladium and copper are used as catalysts to couple iodine-containing halides with nitrogen-containing heterocyclic precursors. If palladium catalysis is used, in the presence of suitable ligands, bases and solvents, iodine aromatics are coupled with pyrazolopyrimidine precursors to precisely synthesize products. This method has good selectivity and mild conditions, but the cost of catalysts is high, which may limit its large-scale application.
When synthesizing 3-iodine-1H-pyrazolo [3,4-d] pyrimidine-4-amine, considering the availability of starting materials, cost, reaction conditions, yield, purity and other factors, comprehensive trade-offs, choose the best synthesis path to achieve efficient and economical synthesis purposes.
What is the market outlook for 3-iodo-1h-pyrazolo [3,4-d] pyrimidin-4-amine?
3-Iodo-1H-pyrazolo [3,4-d] pyrimidin-4-amine is an organic compound. The exploration of its market prospects needs to be viewed from multiple perspectives.
From the perspective of the pharmaceutical field, such nitrogen-containing heterocyclic compounds often have unique biological activities and have attracted much attention in drug development. Due to the fact that the targets of many diseases have an affinity with specific heterocyclic structures, this compound may be modified and used to develop new therapeutic drugs, such as anti-cancer and anti-virus. Today, there is a huge demand for the treatment of cancer and viral infections, and the market potential for the successful development of drugs based on this compound is huge.
In the field of materials science, organic heterocyclic compounds containing iodine and nitrogen may emerge in the field of optoelectronic materials. With the vigorous development of electronic products and optoelectronic devices, the demand for new functional materials is increasing day by day. If this compound can exhibit unique optoelectronic properties, such as good fluorescence properties or charge transport ability, it will definitely find a place in organic Light Emitting Diode (OLED), solar cells and other fields, and the market prospect is quite promising.
However, its market prospect also faces challenges. The difficulty and high cost of synthesizing such compounds are key factors restricting their large-scale production and marketing activities. And new compounds entering the market need to go through a strict approval process, especially in the field of medicine, which is time-consuming and laborious, adding to the uncertainty of marketing activities.
In summary, 3-iodo-1H-pyrazolo [3,4-d] pyrimidin-4-amine has promising prospects in the field of medicine and materials science, but in order to fully tap the market potential, it is still necessary to overcome many difficulties such as synthesis and approval.