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What is the main use of 3-iodo-1h-pyrazolo [3,4-d] pyrimidin-4-ylamine?
3-Iodo-1H-pyrazolo [3,4-d] pyrimidin-4-ylamine is an organic compound with a wide range of uses in the field of modern medicine and materials science.
In the field of pharmaceutical research and development, it is often a key intermediate for the creation of new drugs. Due to its unique chemical structure, it can be closely bound to specific targets in organisms. For example, in the study of anti-tumor drugs, the compound can precisely act on key proteins related to tumor cell proliferation. After ingenious modification and modification, it is expected to develop new anti-cancer drugs with high efficiency and low toxicity, providing a new way to overcome cancer problems. In the exploration of antiviral drugs, it can interact with key enzymes of virus replication by virtue of its own structure, inhibit virus replication, and contribute to the development of antiviral drugs.
In the field of materials science, 3-iodo-1H-pyrazolo [3,4-d] pyrimidin-4-ylamine can be used to prepare special functional materials. Because of its specific optoelectronic properties, it has made a name for itself in the field of organic optoelectronic materials. For example, when preparing organic Light Emitting Diode (OLED), the introduction of this compound can optimize the luminous efficiency and stability of the material, improve the display performance of OLED, and make the screen clearer and more colorful. In the development of sensor materials, it can specifically react with specific detection substances, and achieve high-sensitivity detection of target substances through signal changes. It has broad prospects in the fields of environmental monitoring and bioanalysis.
What are the physical properties of 3-iodo-1h-pyrazolo [3,4-d] pyrimidin-4-ylamine
3-Iodo-1H-pyrazolo [3,4-d] pyrimidin-4-ylamine is an organic compound. Its physical properties are related to appearance, melting point, boiling point, solubility and many other aspects.
Looking at its appearance, if there is no significant influence of other groups, it is usually in a solid state. Because the molecule contains polar groups such as nitrogen and amino groups, or has a certain polarity, but also contains iodine atoms and aromatic heterocycles, the overall polarity is not very high.
When it comes to melting points, the melting points of organic nitrogen-containing heterocyclic compounds are often affected by intermolecular forces. There are hydrogen bonds between the molecules of this compound, and the amino group can be used as a hydrogen bond donor and receptor, which enhances the intermolecular forces and increases the melting point. However, the introduction of iodine atoms, or due to the large atoms, affects the tight accumulation of molecules, and also affects the melting point. Therefore, its melting point or at a specific range, but the exact value needs to be determined experimentally.
In terms of boiling point, molecular polarity and relative molecular weight are the key factors. The relative molecular weight of this compound increases due to the presence of iodine atoms, and the hydrogen bond between molecules enhances the intermolecular force, and the boiling point also increases.
In terms of solubility, it contains polar amino groups, or is slightly soluble in water. In organic solvents, such as methanol, ethanol and other polar organic solvents, because they can form hydrogen bonds with amino groups, their solubility may be better; in non-polar organic solvents such as n-hexane, the solubility may be poor, because the molecular polarity is different from that of non-polar solvents.
In addition, the stability of the compound may be characterized by the structure of the iodine atom and the heterocyclic ring. The C-I bond of the iodine atom is relatively active, which may cause the compound to participate in the reaction under specific conditions, which affects its stability. The aromatic heterocyclic structure endows a certain degree of conjugate stability, making it stable under general conditions.
What is the synthesis method of 3-iodo-1h-pyrazolo [3,4-d] pyrimidin-4-ylamine
To obtain the synthesis method of 3-iodo-1H-pyrazolo [3,4-d] pyrimidin-4-ylamine, the following steps can be followed.
First, the appropriate starting material is obtained, and the nitrogen-containing heterocyclic compound is the base, in which the construction of the pyrazolopyrimidine skeleton is the key. The basic structure of pyrazolopyrimidine can be initially established by active pyrimidine derivatives and nitrogen-containing nucleophiles under suitable reaction conditions.
The choice of temperature, solvent and catalyst is very important in controlling the reaction conditions. The use of polar aprotic solvents, such as N, N-dimethylformamide (DMF) or dimethylsulfoxide (DMSO), can improve the solubility and reactivity of the reactants. The reaction temperature depends on the specific reaction process, or room temperature, or moderate heating is required, generally controlled between 50 ° C and 150 ° C.
After building a pyrazolopyrimidine skeleton, an iodization reaction is carried out to introduce iodine atoms. Commonly used iodizing reagents, such as iodine elemental substance (I _ 2), are paired with appropriate oxidizing agents, such as hydrogen peroxide (H _ 2O _ 2) or nitric acid (HNO _ 3). Under acidic or neutral conditions, iodine atoms are selectively attached to the target position. In this step, the fine regulation of the reaction conditions is related to the purity and yield of the iodine-substituted product.
Finally, the resulting product is aminated. Suitable amination reagents, such as ammonia derivatives, can be used to achieve amination at the 4-position under alkali catalysis. The choice of base is also critical, such as weak bases such as potassium carbonate (K 2O CO), sodium carbonate (Na 2O CO), or strong bases such as potassium tert-butyl alcohol (t-BuOK), depending on the activity of the reaction substrate.
The whole process of synthesis, after each step of the reaction, it needs to be separated and purified, such as column chromatography, recrystallization, etc., to ensure the purity of the product, and then successfully obtain 3-iodo-1H-pyrazolo [3,4-d] pyrimidin-4-ylamine.
What is the price of 3-iodo-1h-pyrazolo [3,4-d] pyrimidin-4-ylamine in the market?
I have not heard the price of 3-iodo-1h-pyrazolo [3,4-d] pyrimidin-4-ylamine in the market. This is a fine chemical, and its price often varies depending on purity, order of magnitude, supply and demand.
If you ask for its price, you can ask at the chemical mall and reagent supplier. Many online platforms, such as Sinopharm Reagent Network, Search Banner Reagent Network, etc., may have this product for sale, and you can check the price of its different specifications. If you need to buy in large quantities, you can also negotiate directly with the manufacturer, or you can get a better price.
In addition, you can also read industry information and market survey reports to know the market conditions and price trends of this chemical. However, I have not personally observed the detailed price today. If you want to know the exact price, you need to follow the above route.
What are the safety and toxicity of 3-iodo-1h-pyrazolo [3,4-d] pyrimidin-4-ylamine?
3-Iodo-1H-pyrazolo [3,4-d] pyrimidin-4-ylamine, this is an organic compound. However, its safety and toxicity require detailed investigation of various scientific data to know.
The safety of chemicals often involves many ends. The first to bear the brunt is the impact on human health. If exposed to this compound, or absorbed through the skin, inhaled its dust or vapor, or accidentally ingested, it can lead to different consequences. In animal experiments, some similar structural compounds containing iodine and nitrogen heterocycles may interfere with the normal physiological functions of the human body. Such as affecting the nervous system, causing dizziness, fatigue, and mental loss; damaging the respiratory system, causing coughing, asthma, and even breathing difficulties; even worse, causing damage to important organs such as the liver and kidneys, affecting their normal metabolism and excretion functions.
Furthermore, it is related to environmental toxicity. If this compound is released into the environment, it may affect the activity and community structure of soil microorganisms, thereby interfering with the material cycle and energy flow of soil ecosystems; in water bodies, it may pose a threat to aquatic organisms, affecting the survival, reproduction and growth of fish, plankton, etc., and disrupting the aquatic ecological balance.
However, based on its name alone, it is difficult to determine its specific safety and toxicity details. It is necessary to consult professional chemical literature, chemical safety technical specifications (MSDS), or refer to the research results of professional scientific research institutions in order to obtain accurate safety and toxicity information and provide a solid basis for its proper use, storage and disposal.