3 Iodo 4 Hydroxybenzoicacid
Iodobenzene

3-iodo-4-hydroxybenzoicacid

Fengxi Chemical

Specifications

HS Code

972045

Name 3-iodo-4-hydroxybenzoic acid
Chemical Formula C7H5IO3
Molar Mass 266.02 g/mol
Appearance Solid
Physical State At Room Temp Solid
Solubility In Water Slightly soluble
Odor Odorless (usually)
Acidity Pka Around 3.0 (approximate for phenolic -OH)
Melting Point 197 - 200 °C
Color White to off - white
Chemical Formula C7H5IO3
Molar Mass 266.02 g/mol
Appearance Solid
Odor Odorless (usually)
Solubility In Water Slightly soluble
Solubility In Organic Solvents Soluble in some organic solvents like ethanol
Melting Point 165 - 167 °C
Boiling Point Decomposes before boiling
Acidity Pka Around 3 - 4 (approximate, depending on conditions)
Color White to off - white
Name 3-iodo-4-hydroxybenzoic acid
Molecular Formula C7H5IO3
Molecular Weight 266.017 g/mol
Appearance Solid
Color Off - white to light yellow
Melting Point 184 - 186 °C
Solubility In Water Slightly soluble
Solubility In Organic Solvents Soluble in ethanol, DMSO, etc.
Pka Around 3.05
Boiling Point Decomposes before boiling
Cas Number 533-83-5
Chemical Formula C7H5IO3
Molar Mass 266.02 g/mol
Appearance Solid
Solubility In Water Slightly soluble
Melting Point 205 - 207 °C
Boiling Point Decomposes
Pka 2.77
Odor Odorless
Color White to off - white
Packing & Storage
Packing 100 - gram pack of 3 - iodo - 4 - hydroxybenzoic acid in air - tight chemical - grade pouch.
Storage 3 - iodo - 4 - hydroxybenzoic acid should be stored in a cool, dry place. Keep it in a tightly sealed container to prevent moisture absorption and exposure to air, which could potentially lead to degradation. Store away from heat sources and incompatible substances, such as strong oxidizing agents. Ensure the storage area is well - ventilated to minimize any potential build - up of fumes.
Shipping 3 - iodo - 4 - hydroxybenzoic acid is shipped in well - sealed, corrosion - resistant containers. Packaging adheres to chemical transport regulations. Shipment is via approved carriers, ensuring proper handling to prevent damage and leakage during transit.
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3-iodo-4-hydroxybenzoicacid 3-iodo-4-hydroxybenzoicacid 3-iodo-4-hydroxybenzoicacid
General Information
Frequently Asked Questions
What are the chemical properties of 3-iodine-4-hydroxybenzoic acid?
3-pentanone-4-carboxylphenylacetamide is one of the organic compounds. Its chemical properties are particularly complex and are described in detail below.
First of all, its physical properties, under normal conditions, 3-pentanone-4-carboxylphenylacetamide is a white to light yellow crystalline powder with a certain melting point, about [X] ° C. This melting point characteristic can be used to identify this substance. Its solubility in water is limited, but it has better solubility in some organic solvents, such as ethanol and acetone. This difference in solubility is due to the difference between its molecular structure and the interaction between solvent molecules.
As for chemical properties, its molecules contain ketone groups, carboxyl groups and amide groups, which give it unique chemical reactivity. Ketone groups have the typical properties of carbonyl groups, and nucleophilic addition reactions can occur. In the case of Grignard reagents, negatively charged hydrocarbons in Grignard reagents will attack the carbonyl carbons of ketone groups, form new carbon-carbon bonds, and then derive various alcohols. This reaction is often used in organic synthesis to build carbon skeletons.
Carboxyl groups are acidic and can neutralize with bases to form corresponding carboxylic salts and water. For example, when reacted with sodium hydroxide, the hydrogen atom of the carboxyl group is replaced by sodium ions to form a sodium salt of 3-pentanone-4-carboxyphenylacetamide. This sodium salt has a significant increase in solubility in water due to its enhanced ionic properties. This property may have applications in pharmaceutical preparations and other fields, which can improve the water solubility of drugs.
The amide group is relatively stable, but under strong acid or strong base and heating conditions, hydrolysis reaction will occur. In acidic media, amide groups are hydrolyzed to form carboxylic acids and ammonium salts; in alkaline media, carboxylic salts and ammonia (or amines) are formed. This hydrolysis reaction is a common transformation pathway for amide compounds, which is helpful to analyze their stability and degradation products in different environments.
3-pentanone-4-carboxylphenylacetamide has potential application value in many fields such as medicine and materials science due to its special chemical properties, but it needs to be further studied to fully explore it.
What are the preparation methods of 3-iodine-4-hydroxybenzoic acid?
Fu3-bromo-4-fluorobenzoic acid is also an important intermediate in organic synthesis. The methods of its preparation are numerous in the past and present.
First, 4-fluorobenzoic acid is used as the starting material and prepared by bromination reaction. The brominating reagents used here are usually liquid bromine, N-bromosuccinimide (NBS), etc. When liquid bromine is used as a brominating agent, it is usually required to be used in appropriate solvents, such as dichloromethane and carbon tetrachloride, and catalyzed by Lewis acids such as ferric chloride and ferric bromide. During the reaction, the temperature and the ratio of the reactants are controlled to obtain a higher yield. The reaction mechanism is the electrophilic substitution of the benzene ring by the positive bromide ion. When NBS is used as the brominating agent, the reaction conditions are relatively mild, and the free radical reaction is often initiated by benzoyl peroxide, which can reduce the occurrence of side reactions.
Second, starting from 3-bromo-4-fluorotoluene, 3-bromo-4-fluorobenzoic acid is prepared by oxidation reaction. Commonly used oxidants include potassium permanganate, potassium dichromate, etc. Taking potassium permanganate as an example, the methyl group of toluene is oxidized to a carboxyl group under alkaline conditions. However, this process requires careful control of the reaction conditions. Due to the strong oxidation of potassium permanganate, if the conditions are improper, bromine and fluorine atoms on the benzene ring are easily oxidized or replaced, thereby reducing the yield. There are also those who use mild oxidizing agents, such as oxygen or air, to catalyze oxidation with transition metal catalysts. This method is more green and environmentally friendly, but requires higher catalyst requirements, and the reaction conditions need to be precisely regulated.
Third, it is obtained from the coupling reaction of halogenated aromatics through metal catalysis and then carboxylation. For example, 3-bromo-4-fluorohalobenzene (such as chlorobenzene) is used to make Grignard reagent with metal magnesium, and then reacts with carbon dioxide to obtain the target product 3-bromo-4-fluorobenzoic acid after acidification. In this process, the preparation of Grignard reagents requires an anhydrous and oxygen-free environment, otherwise it is easy to cause reaction failure. In addition, metal catalysts such as palladium and nickel can also be used to achieve carboxylation through the reaction of halogenated aromatics with carbon monoxide and nucleophiles, but such methods require high reaction equipment and operation.
What are the main uses of 3-iodine-4-hydroxybenzoic acid?
The main use of 3-pentanone-4-furanoacetic acid is related to the field of medicine and chemical industry.
In the field of medicine, it can be a key intermediate. Because of its unique structure, it can be chemically modified to participate in the synthesis of many drugs. For example, some compounds with specific biological activities are prepared, and this substance may be used as a starting material. Through a series of reactions, specific functional groups are introduced to build a complex drug molecular structure. For example, in the development of anti-tumor drugs, researchers may use its special structure to ingeniously design reactions to endow new compounds with targeting and cytotoxicity, so as to achieve the effect of treating tumors.
In the field of chemical industry, it is also useful in the field of organic synthesis. It can be used as a precursor for the synthesis of special functional materials. For example, through polymerization or copolymerization with other monomers, polymer materials with specific properties are made, such as materials with selective adsorption or separation properties for specific substances, which are used in chemical separation and purification. Or used to synthesize materials with special optical and electrical properties, which contribute to the development of optoelectronic devices.
Furthermore, in the fragrance industry, because of its unique chemical structure, or through reaction to generate compounds with special aromas. After formulation, it can be used in the production of perfumes, fragrances and other products, giving them a unique fragrance and improving product quality and market competitiveness. In conclusion, 3-pentanone-4-furanoacetic acid, with its unique structure, has important uses in many fields such as medicine, chemical industry, and fragrance, and is an indispensable substance for the development of related industries.
What is the market price of 3-iodine-4-hydroxybenzoic acid?
3-Pentanone-4-fluorophenylacetyl amino acid is in the market, and its price is determined, which is related to many things. Looking at the records of various herbs, the price of everything is determined by its source, the difficulty of making it, and the state of supply.
If this compound has a wide source and is easy to produce, its price is flat. If it is taken from ordinary materials, the method of making it is simple, the labor is saved, and it enters the market, the price must be close to the people. However, if the source is thin, it is difficult to obtain, and the technology of making it is complicated, such as the treasure of the deep mountains, it needs to be involved in risk, and if it is refined with many twists and turns, the price must be high.
The state of demand and supply is also the main reason. If everyone in the city wants this thing, and there are many people in need, but there are few suppliers, the so-called "rare things are expensive", and the price rises. On the contrary, if there are few people in the market, and the supply exceeds the demand, the merchant will sell the goods or reduce the price.
Also, the price varies depending on the time. If the seasons change, it has an impact on the price of various things. Whenever it is used at a high price, the price may be high; if it is not in time, the price may be low.
Furthermore, the distance of the land also depends on the price. If the origin is close to the city and the transportation cost is saved, the price can be reduced; if it is far away in other places, the transshipment of Lawton will cost a lot, and the price will increase.
Therefore, in order to know the market price of 3-pentanone-4-fluorophenylacetyl amino acid, it is necessary to look at the abundance of the source, the difficulty of preparation, the state of supply, and the change of time and place.
What are the precautions for storing and transporting 3-iodine-4-hydroxybenzoic acid?
Glyceraldehyde 3-phosphate is a key intermediate product in the process of glycolysis. Many things need to be paid attention to when storing and transporting.
First, temperature has a significant impact. This substance is quite sensitive to temperature, and high temperature can easily cause its stability to be poor, molecular structure to be damaged, or cause decomposition and deterioration. Therefore, it should be stored in a low temperature environment, usually refrigerated at 2-8 ° C to maintain its activity and structural integrity. For long-term storage, lower freezing temperatures, such as -20 ° C or even -80 ° C.
Second, the pH environment should not be underestimated. 3-Glyceraldehyde phosphate is stable within a specific pH range, and its chemical properties can be changed in an acidic or alkaline environment. Generally speaking, its environment should be maintained close to the physiological pH, about 7.2-7.4. This purpose can be achieved by buffers, such as phosphate buffers, to stabilize its pH and prevent it from being inactivated due to abnormal pH.
Third, avoid contact with oxidants and reducing agents. The chemical structure of glyceraldehyde phosphate makes it easy to react with oxidation and reducing agents, thereby changing its chemical properties and affecting its function. The storage and transportation process should be kept away from such substances, and the packaging materials should also have good chemical stability and do not react with glyceraldehyde 3-phosphate.
Fourth, to prevent microbial contamination. Microorganisms may use glyceraldehyde 3-phosphate as a nutrient source, causing it to deteriorate. The storage container must be clean and sterile, and the transportation process should also ensure that the environment is clean. If necessary, an appropriate amount of preservatives can be added, but it should be noted that the preservatives cannot affect the properties and functions of glyceraldehyde 3-phosphate.
Fifth, the transportation process should be smooth. Violent vibration or turbulence or damage the structure of glyceraldehyde 3-phosphate, causing damage to its activity. It should be stabilized with appropriate packaging materials to avoid excessive vibration during transportation.