3 Iodo 5 Phenyl 1 Benzofuran

3-Iodo-5-phenyl-1-benzofuran is also a benzofuran compound. Its chemical properties are derived from the parent nucleus of benzofuran. Benzofuran, a benzofuran compound, is fused from a benzofuran.
In this compound, in the third position of the parent nucleus of benzofuran, the iodine atom replaces the upper atom. The iodine atom, one of the elements of the group B group, has a large atom and low performance, and can often play an important role in the reaction of benzofuran.
Furthermore, the phenyl group is substituted in the fifth position. Phenyl groups are formed by removing one atom from benzene. Benzene is a highly common plane. It is aromatic, and its sub-cloud distribution is uniform, and it is characterized by phase. The introduction of phenyl groups, the sub-cloud density distribution of the benzofuran parent nucleus, and the immediate impact.
Therefore, the chemical reaction of 3-iodo-5-phenyl-1-benzofuran is composed of the benzofuran parent nucleus, the iodine atom at 3 positions, and the phenyl group at 5 positions. This is especially useful for the specific physical and chemical properties of the compounds. It may have its own special uses in the fields of synthesis, physicochemical production, etc.

3-Iodo-5-phenyl-1-benzofuran is an organic compound with unique physical properties. It is a solid and exists stably at room temperature and pressure. In terms of melting point, because the melting point of an organic compound is often closely related to its intermolecular forces, the benzene ring and other groups in the molecular structure of the compound interact, resulting in its melting point being within a certain range. However, the exact value needs to be accurately determined by experiments.
In terms of solubility, due to its hydrophobic groups such as benzene ring, the solubility in water is extremely low, because water is a polar solvent, and the polarity of this compound is weak, following the principle of "similar miscibility". However, in organic solvents, such as common dichloromethane, chloroform, tetrahydrofuran, etc., because these organic solvents are adapted to the intermolecular forces of the compound, they have good solubility, which is crucial in organic synthesis and separation and purification steps.
The appearance is mostly white to light yellow crystalline powder, and this appearance characteristic is affected by its molecular arrangement and crystal structure. In terms of optical properties, the conjugate system in the molecular structure makes it possible to exhibit certain ultraviolet absorption characteristics, which can be used for spectral analysis and identification.
In terms of density, it is determined by its molecular composition and accumulation method. Although the specific value also needs to be determined experimentally, it can be roughly inferred based on similar structural compounds, and the relative density may be within a certain range. These physical properties play a key guiding role in the processing, separation, and identification of compounds in many fields such as organic synthesis and drug development.

3-Iodo-5-phenyl-1-benzofuran, this is an organic compound with a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate. Through various chemical reactions, such as coupling reactions, it can be cleverly converted into compounds with more complex structures and unique functions. It is like building a delicate pavilion, which can be used as a cornerstone and built layer by layer. In the field of medicinal chemistry, due to the specific chemical structure or potential biological activity, it can become the starting point for the development of new drugs, just like exploring unknown treasures. Starting from this compound, it may be possible to find a weapon against diseases. In terms of materials science, it may participate in the preparation of materials with special optical and electrical properties, adding a different color to the material world, just like embroidering a unique pattern on the brocade of materials, making it stand out in fields such as optoelectronic devices. In short, although 3-iodo-5-phenyl-1-benzofuran seems ordinary, it actually plays an important role in many scientific fields, like a point person hidden behind the scenes, silently promoting various fields.

The synthesis method of 3-iodine-5-phenyl-1-benzofuran has been explored by Sian Da in the past, and now it is described in detail by Jun.
First, benzofuran is used as the initial material, and iodine atoms and phenyl groups are introduced under specific reaction conditions. First, benzofuran is placed in a suitable reaction vessel and dissolved in a suitable organic solvent, such as dichloromethane and tetrahydrofuran. Adding an appropriate amount of catalysts, such as some metal salt catalysts, such as cuprous iodide, etc., this catalyst can effectively promote the reaction. Then, slowly add iodine-containing reagents, such as iodine elemental substance combined with appropriate oxidant, or directly use specific organic iodine reagents, so that the iodine atoms can be smoothly connected to the specific position of benzofuran. As for the introduction of phenyl groups, the arylation reaction can be used to select suitable phenyl halides, such as bromobenzene or chlorobenzene, under the catalytic system of alkali and corresponding metals, to achieve the combination of phenyl groups and benzofurans, so as to obtain the target product.
Second, benzofuran backbone can also be constructed by multi-step reaction of benzofuran derivatives and furan derivatives, and iodine atoms and phenyl groups can be introduced simultaneously. First, the benzofuran derivative is connected to the furan derivative through a condensation reaction to form the basic structure of benzofuran. In the process of building the skeleton, the reaction conditions can be adjusted in a timely manner, and a specific substituent guide group can be introduced to facilitate the precise integration of subsequent iodine atoms and phenyl groups. After the skeleton is formed, iodine atoms and phenyl groups are introduced respectively according to the similar method described above. Although this approach is a little more complicated, the structure of the product can be more finely regulated.
Third, there are other heterocyclic compounds as starting materials, which can be converted into benzofuran derivatives through structural modification. First, the heterocyclic parent is functionalized and a suitable substituent is introduced to create conditions for subsequent conversion into benzofuran structures. Through cyclization reaction, the core structure of benzofuran is formed, and then iodine atoms are introduced through halogenation reaction, and phenyl groups are introduced through arylation reaction. This method requires in-depth understanding and mastery of heterocyclic chemistry in order to skillfully use it to achieve the synthesis of the target product.
All synthesis methods have advantages and disadvantages, and it is necessary to choose carefully according to the actual situation, such as the availability of raw materials, the difficulty of reaction, and the purity requirements of the product.

3-Iodo-5-phenyl-1-benzofuran is an organic compound. In organic synthesis reactions, the common types of reactions are as follows:
One is a nucleophilic substitution reaction. Because of its high activity in the structure of iodine atoms, it is easy to be replaced by nucleophilic reagents. For example, when encountering a nucleophilic reagent containing hydroxyl and amino groups, the iodine atom will be replaced by a hydroxyl or amino group, and then a new compound will be formed. The principle of this reaction is that the nucleophilic reagent is rich in electrons and attacks the partially positively charged iodine atom, replacing the iodine ion. The process is like a warrior holding a sharp blade, accurately picking off the target, so that the molecular structure can be remodeled.
The second is a coupling reaction. 3-Iodo-5-phenyl-1-benzofuran can participate in coupling reactions such as Suzuki. Under the action of suitable catalysts and bases, it is coupled with boron-containing reagents to achieve the construction of carbon-carbon bonds. This reaction is like building a bridge, relying on the power of catalysts to closely connect the two originally separated parts and expand the skeleton of the molecule. Suzuki coupling reaction conditions are relatively mild, with excellent selectivity, and is widely used in the synthesis of complex organic molecules.
The third is cyclization reaction. In view of its own structural characteristics, under specific conditions, cyclization reactions can occur inside molecules, further building more complex cyclic structures. The interaction of different groups in the molecule is like a dancer dancing on the stage, approaching and hugging each other, and finally forming a unique ring dance step. This not only enriches the spatial structure of the molecule, but also may endow it with unique physical and chemical properties.
The above are the common reaction types of 3-iodo-5-phenyl-1-benzofuran. Different reactions need to be reasonably selected and regulated according to specific conditions and target products.