3 Iodo Benzamid

The chemical structure of 3-iodo-benzamide is as follows:
This compound belongs to the category of benzamide derivatives. Its base is a benzene ring. The benzene ring is a planar hexagonal structure composed of six carbon atoms in the form of conjugated double bonds. On the benzene ring, many positions can be replaced by different groups.
In 3-iodo-benzamide, the position 3 of the benzene ring (according to the benzene ring carbon atom numbering convention, the carbon atom connected to the formamide group is the position 1, and the order is numbered), is replaced by an iodine atom. As a halogen element, iodine atoms have a large atomic radius and high electronegativity. Its introduction into the benzene ring has a great impact on the electron cloud distribution and chemical properties of the benzene ring. Because of its significant electron-absorbing induction effect, it can cause the electron cloud density of the benzene ring to decrease, especially the electron cloud density of the adjacent and para-position, which in turn affects the electrophilic substitution reaction activity and regioselectivity involved in the benzene ring.
Furthermore, the formamide group (-CONH _ 2) connected to the benzene ring is an amide functional group. Among the amide groups, the carbonyl group (C = O) has strong electron-withdrawing properties, while the amino group (-NH _ 2) has a donor-electron conjugation effect. The interaction of these two effects makes the amide group exhibit unique chemical properties. The formamide group is connected to the benzene ring, and the electron cloud distribution of the benzene ring is affected by the conjugation effect and induction effect. At the same time, the benzene ring also reacts on the formamide group, affecting its own reactivity. For example, in hydrolysis, condensation and other reactions, the reaction rate and conditions will be affected by this structural relationship.
Overall, the chemical structure of 3-iodobenzamide, through the interaction of the benzene ring, iodine atom and formamide group, endows the compound with unique physical and chemical properties, and has important research and application value in organic synthesis, medicinal chemistry and other fields.

3-Iodo-benzamid is an organic compound whose Chinese name is 3-iodobenzamide. This substance has specific physical properties, which are described as follows:
1. ** Appearance and properties **: At room temperature and pressure, 3-iodobenzamide often appears as a white to light yellow crystalline powder. This morphology is due to the interaction between molecules, and its structure results in an orderly arrangement of molecules, which in turn appears as a powdery solid. Many organic compounds also have this appearance due to similar intermolecular forces and crystal structures. This is the basis for preliminary identification.
2. ** Melting point and boiling point **: The melting point is about 185-189 ° C. At this temperature, the molecule is energized enough to overcome the lattice energy, the lattice structure disintegrates, and the substance is converted from solid to liquid. The melting point is specific and can be used for purity identification. The melting point of pure products is sensitive, and the melting point is reduced and the melting range is widened when impurities are present. Its boiling point is restricted by intermolecular forces, including van der Waals forces and hydrogen bonds. Accurate boiling point data may vary due to differences in experimental conditions. Usually boiling at higher temperatures requires more energy to overcome the attractive forces between molecules for gasification.
3. ** Solubility **: 3-iodobenzamide is slightly soluble in water. Water is a polar solvent, and the polarity of the compound is limited. According to the principle of "similar miscibility", the polarity mismatch makes the interaction between the two weak and difficult to dissolve. However, it is soluble in some organic solvents, such as dichloromethane, N, N-dimethylformamide (DMF), etc. The polarity and molecular structure of organic solvents are compatible with 3-iodobenzamide, and can form effective intermolecular interactions with it to achieve dissolution. This property is commonly used in organic synthesis and separation and purification.
4. ** Density **: Density is related to the weight of a unit volume of material, and the density of 3-iodobenzamide is related to the molecular weight and the degree of packing. Although the exact value may need to be determined experimentally, it can be speculated based on the structure and similar compounds. Due to the iodine-containing atoms, the relative mass is large, and their density may be higher than that of common hydrocarbon compounds. When it comes to quantitative treatment of substances and phase separation operations, density is an important consideration.

3-Iodo-benzamide, or 3-iodobenzamide, is useful in many fields such as medicine and materials science.
In the field of medicine, it is a key intermediate in drug synthesis. Because iodine atoms have unique electronic properties and steric resistance, they can significantly change the physicochemical properties and biological activities of compounds. Taking the development of anti-tumor drugs as an example, researchers often use 3-iodobenzamide as a starting material and introduce specific functional groups into molecules through a series of chemical reactions to optimize the targeting and affinity of drugs to tumor cells, thereby improving the efficacy and reducing side effects. In the creation of antibacterial drugs, 3-iodobenzamide participates in the construction of compound structures, which may enhance the ability of drugs to bind to key bacterial targets, hinder bacterial growth and reproduction, and exert antibacterial effects.
In the field of materials science, 3-iodobenzamide also plays an important role. In the preparation of organic optoelectronic materials, due to the good conjugation of benzamide structure, iodine atoms can adjust the distribution of molecular electron clouds, so the organic molecules constructed on this basis may have excellent optoelectronic properties. For example, when used in organic Light Emitting Diodes (OLEDs), it can improve the luminous efficiency and stability of the device; when used in organic solar cells, it can enhance the absorption of light and the efficiency of charge transfer, and improve the photoelectric conversion efficiency of the battery.
In addition, in the field of chemical research, 3-iodobenzamide acts as an organic synthesis block, providing rich possibilities for researchers to carry out various organic reaction studies. Its iodine atoms can participate in various reactions such as nucleophilic substitution and coupling, and help to synthesize complex and diverse organic compounds, laying the foundation for the exploration of new reaction methodologies and the development of new functional materials.

The synthesis method of 3-iodo-benzamid (3-iodobenzamide), let me explain in detail.
First, benzoic acid can be started. First, benzoic acid and thionyl chloride are co-heated. This step is to convert the carboxyl group into an acid chloride. The reaction is violent, and the temperature needs to be carefully controlled to prevent side reactions. When benzoic acid encounters thionyl chloride, it reacts quickly in case of dry wood from fire to form benzoyl chloride. After the reaction is completed, the excess sulfinyl chloride is removed, and then the obtained benzoyl chloride is mixed with iodoaniline. In a suitable organic solvent, such as dichloromethane, in a mild alkaline environment, such as the presence of triethylamine, the two slowly react. After the nucleophilic substitution process, 3-iodobenzamide is finally obtained. This process is like building a delicate castle, and every step needs to be precisely controlled.
Second, aniline can also be started from aniline. Aniline is first introduced into the iodine atom with iodine elemental substance under the action of a specific catalyst, such as the combination of potassium iodide and hydrogen peroxide, so that the amino ortho-position is smoothly introduced into the iodine atom to obtain iodoaniline. Then, iodoaniline and benzoyl chloride react under conditions similar to the above, and 3-iodobenzamide can also be obtained. This path, such as a circuitous path, although there are a few steps, if it is operated properly, it can also achieve the goal smoothly.
Third, 3-iodobenzoic acid is used as the starting material. It is reacted with dichlorosulfoxide, converted into the corresponding acid chloride, and then reacted with ammonia or amines, and the reaction conditions, such as temperature and reactant ratio, can also be successfully synthesized 3-iodobenzamide. This is a way to find another way, each with its own subtlety. The way of synthesis is ever-changing. It is necessary to weigh the pros and cons according to the actual situation and choose the best method.

3-Iodo-benzamid is a kind of organic compound. In today's market, its prospects are promising, because it has important uses in various fields.
In the field of medicine, this compound may be a key raw material for the creation of new drugs. In view of the general trend of today's pharmaceutical development, the demand for novel and highly effective drugs is increasing. 3-Iodo-benzamid has a unique chemical structure, which may provide a new way for the development of specific drugs for specific diseases, such as tumors and cardiovascular diseases. Doctors and pharmacists are working hard to explore its role in drug synthesis. Over time, it may lead to the development of many new and good medicines, benefiting patients all over the world.
In the field of materials science, it has also emerged. With the rapid development of science and technology, there is a hunger for high-performance materials. 3-Iodo-benzamid can be involved in the preparation of special polymers and functional materials. For example, in the development of high-performance insulating materials used in electronic devices, or lightweight and high-strength composites required in the aerospace field, it may play an important role. Materials scientists are deeply studying its properties and reaction characteristics, hoping to develop more new materials with excellent properties to meet the stringent requirements of different fields.
Furthermore, in the level of scientific research and exploration, 3-Iodo-benzamid is also an indispensable research object. Through in-depth research on it, researchers can enhance their understanding of the mechanism of organic chemistry and expand the boundaries of chemical science. Its unique chemical properties may inspire the discovery of new chemical reactions, injecting new vitality into the development of organic synthetic chemistry.
However, its market prospects are not smooth sailing. On the one hand, the process of synthesizing this compound may still be complex and costly. If large-scale industrial production is to be realized, it is urgent to reduce costs and optimize the process. On the other hand, its potential impact on the environment and human body during application also needs to be studied and evaluated in detail. Only by properly addressing such issues can we ensure that its market prospects continue to improve and its potential value can be fully realized in various fields.