What is the chemical structure of 3-iodo-n- ({2- [4- (2-methylpropanoyl) piperazin-1-yl] phenyl} carbamothioyl) benzamide

This is the name of an organic compound. To deduce its chemical structure according to this name, it is necessary to analyze it layer by layer according to the naming rules of organic chemistry. In "3 - iodo - n - {2 - [4 - (2 - methylpropanoyl) piperazin - 1 - yl] phenyl} carbamothioyl] benzamide", "3 - iodo" shows that there is an iodine atom substituted at the 3rd position of the benzamide phenyl ring. "n - {2 - [4 - (2 - methylpropanoyl) piperazin - 1 - yl] phenyl} carbamothioyl" part, "carbamothioyl" is a thioformyl group, which is attached to the benzamide nitrogen atom. "{ 2 - [4 - (2 - methylpropanoyl) piperazin - 1 - yl] phenyl} "indicates that the benzene ring connected on the other side of the thiocarbamoyl group has a substituent at the 2 position, and this substituent is" [4 - (2 - methylpropanoyl) piperazin - 1 - yl] ", that is, the 4 position of the piperazine ring is connected with 2-methylpropionyl group, and the 1 position of the piperazine ring is connected with the 2 position of the benzene ring.

According to the ancient text of "Tiangong Kaiwu", the structure of this compound can be regarded as a benzamide parent. The benzene ring has three iodine atoms, the nitrogen atom is connected to thiocarbamoyl, and the thiocarbamoyl is connected to a benzene ring. The benzene ring is connected to a piperazine ring at two sites, and the piperazine ring is quaternary at 2-methylpropionyl. In this way, the chemical structure of this compound can be outlined by combing the naming rules.

What are the physical properties of 3-iodo-n- ({2- [4- (2-methylpropanoyl) piperazin-1-yl] phenyl} carbamothioyl) benzamide

3 - iodo - n - ({2 - [4 - (2 - methylpropanoyl) piperazin - 1 - yl] phenyl} carbamothioyl) benzamide, this is an organic compound. To know its physical properties in detail, please listen to me.

Looking at its appearance, it is usually in solid form, but due to preparation conditions or impurities, the appearance may be slightly different. Its melting point is within a specific temperature range, which is crucial for the identification and purification of the compound. Because the melting point is an inherent property of the compound, the melting point of different compounds is different, so its purity and characteristics can be preliminarily determined.

In terms of solubility, its solubility may vary in organic solvents. Organic solvents such as common chloroform and dichloromethane may have good solubility to them. This property is conducive to the synthesis, separation and purification of the compound, and also facilitates its operation as a reactant or product in organic synthesis reactions. In water, its solubility is poor, because the molecular structure of the compound contains more hydrophobic groups, which makes it interact weakly with water molecules.

Its density is also one of the important physical properties. Although the specific value needs to be determined by precise experiments, the density is related to the behavior of the compound when mixed with other substances in practical applications. For example, in solution systems, the density affects its distribution and sedimentation.

As for the volatility of the compound, due to its relatively complex structure and large molecular weight, the volatility is weak. This property makes the compound relatively stable during storage and use, and is not easy to be lost due to volatilization.

Furthermore, the compound may have a certain refractive index, which can reflect the interaction between its molecular structure and molecules. In the field of optical materials or analysis and detection, the determination of refractive index can assist in the identification of the compound and its purity.

In summary, the physical properties of 3-iodo-n- ({2 - [4 - (2 - methylpropanoyl) piperazin - 1 - yl] phenyl} carbamothioyl) benzamide, such as appearance, melting point, solubility, density, volatility and refractive index, are of great significance for its research, application and operation in related fields.

What is the main use of 3-iodo-n- ({2- [4- (2-methylpropanoyl) piperazin-1-yl] phenyl} carbamothioyl) benzamide

3-Iodo-n- ({2- [4- (2-methylpropanoyl) piperazin-1-yl] phenyl} carbamothioyl) benzamide is an organic compound. This compound may have important uses in the field of medicinal chemistry.

In modern pharmaceutical research and development, specific organic compounds are often used as cornerstones to explore their biological activities and pharmacological effects. In the structure of 3-iodo-n- ({2- [4- (2-methylpropanoyl) piperazin-1-yl] phenyl} carbamothioyl) benzamide, iodine atoms, benzamide groups, and piperazine-containing structural parts may all affect its activity.

The structure of piperazine is commonly found in a variety of biologically active molecules, or can bind to specific targets in organisms, such as some receptors, enzymes, etc. The modification of 2-methylpropionyl groups on piperazine may change the spatial configuration and electron cloud distribution of the molecule, which in turn affects its affinity with the target.

Benzamide groups may also participate in the interaction with biological macromolecules, or exert their effects through hydrogen bonds, van der Waals forces, etc. The introduction of iodine atoms may enhance the lipid solubility of molecules, promote their transmembrane transport, and affect the absorption, distribution, metabolism and excretion of compounds in vivo. Therefore, 3-iodo-n- ({2- [4- (2-methylpropanoyl) piperazin-1-yl] phenyl} carbamothioyl) benzamide is very likely to be used as a potential lead compound for medical researchers to further explore and develop new drugs to deal with various diseases, such as tumors and neurological diseases, which may be of great significance to the development of human health.

What is the synthesis method of 3-iodo-n- ({2- [4- (2-methylpropanoyl) piperazin-1-yl] phenyl} carbamothioyl) benzamide

3 - iodo - n - ({2 - [4 - (2 - methylpropanoyl) piperazin - 1 - yl] phenyl} carbamothioyl) benzamide is an organic compound, and the synthesis of this compound requires certain steps and methods.

First, prepare 2 - [4 - (2 - methylpropanoyl) piperazine - 1 - yl] aniline. 2 - chloroaniline and 1 - (2 - methylpropanoyl) piperazine can be subjected to nucleophilic substitution under appropriate reaction conditions, catalyzed by suitable bases and catalysts. In this reaction, the base can be selected from potassium carbonate, etc., and the solvent can be acetonitrile or N, N-dimethylformamide, etc., heated and stirred for a certain period of time to promote the reaction. After separation and purification, 2 - [4- (2-methylpropionyl) piperazine-1-yl] aniline can be obtained.

Second, the above-mentioned product is reacted with sulfur phosgene to prepare 2- [4- (2-methylpropionyl) piperazine-1-yl] phenyl isothiocyanate. Under the conditions of low temperature and the presence of acid binding agent, such as in the presence of triethylamine, in a suitable solvent such as dichloromethane, sulfur phosgene is slowly added dropwise, and the reaction is carried out for a period of time. After treatment, the target product can be obtained.

Furthermore, 3-iodobenzoic acid is reacted with the above-mentioned isothiocyanate. In a suitable solvent, such as pyridine, the two react to form 3-iodo-n- ({2 - [4 - (2 - methylpropanoyl) piperazin-1 - yl] phenyl} carbamothioyl) benzamide. The reaction process needs to control the temperature and reaction time. After the reaction, the pure target compound can be obtained by extraction, column chromatography and other purification methods.

The whole synthesis process requires fine control of the reaction conditions, including temperature, time, ratio of reactants and purification steps, etc., in order to effectively and with high purity obtain 3-iodo-n- ({2- [4- (2-methylpropanoyl) piperazin-1-yl] phenyl} carbamothioyl) benzamide.

What are the potential side effects of 3-iodo-n- ({2- [4- (2-methylpropanoyl) piperazin-1-yl] phenyl} carbamothioyl) benzamide

3 - iodo - n - ({2 - [4 - (2 - methylpropanoyl) piperazin - 1 - yl] phenyl} carbamothioyl) benzamide is a rather complex organic compound. Its potential hidden side effects, although there is no direct corresponding record in ancient books, are deduced from the perspective of pharmacological research today, or there are the following categories.

First, the effect on the digestive system. It may cause epigastric discomfort, just like the accumulation of diet in Zhongjiao, causing abdominal fullness and frequent belching of gas. In severe cases, or if the spleen and stomach are dysfunctional and diarrhea occurs, it is all due to the stimulation of the gastrointestinal mucosa by drugs, which disturbs the normal way of gastric and spleen elevation and descent.

Furthermore, in the blood system, there may be latent risk. or cause changes in platelet count, just like the disorder of qi and blood operation, affecting the coagulation and circulation of blood, making the human body coagulation dysfunction, slight collision is easy to see skin ecchymosis, like blood disorder, overflowing outside the veins.

And the liver may also be affected by it. The liver is mainly draining, and this drug may interfere with its function of draining, causing abnormal liver function indicators, such as increased transaminase, just like the liver's qi is not smooth, unable to metabolize poisons normally, and then affect the regulation of the whole body's qi.

On the nervous system, or make people feel restless, unable to sleep at night, as if the mind is disturbed and cannot be at peace. It may also make people dizzy, just like the clear sun does not rise, the turbid yin is committed, and the clear orifice is disturbed.

However, it is necessary to clarify, this is based on today's pharmacological cognition, which may be different from the description of specific diseases contained in ancient books. It is for reference only. When taking medicine, you must carefully review the advantages and disadvantages and follow the doctor's advice.