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What is the chemical structure of 3-iodo-n- (3-methoxyphenyl) benzamide?
For 3-iodo-n- (3-methoxyphenyl) benzamide, there is a compound of benzamide. To clarify its chemical properties, first analyze the meaning of its name.
"3-iodo", there is an iodine atom substituted on the 3-position of benzamide. "Benzamide" is the name of benzamide, which is the parent nucleus of benzene, that is, benzene is related to the formamide group. And "n- (3-methoxyphenyl) " means that the nitrogen atom (N) is connected to a 3-methoxyphenyl group.
In terms of benzamide, there is a basic framework of benzamide, and one of benzene has a formamide group (- CONH). In the third position of benzene, there is an iodine atom (I) to replace it. In addition, the 3-methoxyphenyl group on the nitrogen atom, that is, the methoxy group (-OCH), is located in the third position of the phenyl group.
Therefore, the reduction of 3-iodo-n- (3-methoxyphenyl) benzamide is based on the mother of benzamide. There is an iodine atom at the third position of benzene, and the nitrogen atom is connected to the 3-methoxyphenyl group to form a specific empty form. This type has a crucial impact on the performance of the reaction.
What are the main uses of 3-iodo-n- (3-methoxyphenyl) benzamide?
3-Iodo-n- (3-methoxyphenyl) benzamide, Chinese name or 3-iodine-N- (3-methoxyphenyl) benzamide. This compound has a wide range of uses and is often used as an intermediate in organic synthesis in the field of medicinal chemistry to prepare drug molecules with specific biological activities. Because its structure contains iodine atoms and methoxy groups, iodine atoms can introduce other functional groups through nucleophilic substitution and other reactions, laying the foundation for the construction of complex drug structures; methoxy groups can adjust the electron cloud density of molecules, affecting the ability of drugs to bind to targets and metabolic processes in vivo.
In the field of materials science, it can participate in the preparation of functional organic materials. For example, by appropriate reaction modification, it can become a material component with photoelectric properties, which may have application potential in the fields of organic Light Emitting Diode (OLED) and organic solar cells. Its structural properties may endow the material with unique electrical and optical properties, such as changing the molecular conjugation system, regulating the material's luminous wavelength and efficiency.
In addition, in scientific research and exploration, it is used as a substrate to study the mechanism of organic reactions. Because it contains a variety of activity check points and can participate in a variety of types of organic reactions, chemists can study its reaction process, gain a deep understanding of various reaction mechanisms, explore new synthesis methods, and provide theoretical and practical basis for the development of organic synthetic chemistry. In conclusion, although 3-iodine-N- (3-methoxyphenyl) benzamide is an organic compound, it shows important application value in many fields. With the deepening of research, more potential uses may be discovered.
What is the synthesis method of 3-iodo-n- (3-methoxyphenyl) benzamide?
To prepare 3-iodo-n- (3-methoxyphenyl) benzamide, the following ancient method can be used.
First take 3-methoxyaniline and prepare a solution with an appropriate organic solvent, such as dichloromethane. Under a low temperature and stirring environment, slowly add benzoyl chloride dropwise. This process needs to pay attention to changes in temperature and do not overreact. Benzoyl chloride and 3-methoxyphenyl aniline are acylated to form N- (3-methoxyphenyl) benzamide. In this reaction, an appropriate amount of acid binding agent, such as triethylamine, needs to be added to absorb the hydrogen chloride generated by the reaction, so as to promote the reaction to proceed forward.
After the acylation reaction is completed, N- (3-methoxyphenyl) benzamide is purified by conventional separation methods, such as extraction, column chromatography, etc.
Then, the purified N- (3-methoxyphenyl) benzamide is redissolved in a suitable solvent, such as glacial acetic acid. Add an appropriate amount of iodine source, such as iodine elemental substance, and a suitable oxidant, such as hydrogen peroxide. Under mild heating and stirring conditions, an iodization reaction occurs. Iodine atoms replace hydrogen atoms at specific positions on the benzene ring to form the target product 3-iodo-n- (3-methoxyphenyl) benzamide.
After the reaction is completed, the crude product can be obtained through cooling, crystallization, filtration and other steps. Then through fine purification methods such as recrystallization, impurities are removed, the purity of the product is improved, and the final pure 3-iodo-n- (3-methoxyphenyl) benzamide is obtained. The whole process, pay attention to the control of the conditions of each step of the reaction to ensure the smooth progress of the reaction to obtain the ideal yield and purity.
What are the physical properties of 3-iodo-n- (3-methoxyphenyl) benzamide
3-Iodo-N- (3-methoxyphenyl) benzamide is an organic compound with specific physical properties. It is mostly in a solid state at room temperature. Due to the interaction between molecules such as van der Waals forces and hydrogen bonds, the molecules are arranged in an orderly manner, resulting in a solid state.
When it comes to the melting point, the melting point of this compound may be in a specific range due to the interaction of iodine atoms, methoxy groups and benzamide groups in the molecular structure. Iodine atoms have a large atomic radius and relatively high atomic weight, which increases the intermolecular force; methoxy groups can participate in electronic effects and affect the intermolecular bonding force; benzamide groups can form hydrogen bonds, which further strengthen the intermolecular interaction. The combination of various factors increases the melting point.
Looking at its solubility, because the molecule contains polar amide groups and methoxy groups, it can form hydrogen bonds with polar solvents such as water and alcohols, and may have a certain solubility in polar solvents. However, the molecule also contains non-polar benzene rings and iodine atoms, which limit its solubility in water. The solubility in non-polar solvents such as toluene and dichloromethane is better.
The appearance of this compound is often white to pale yellow powder or crystalline solid, and the color is derived from the electron transition in the molecular structure. The presence of benzene rings and conjugated systems allows electrons to transition between different energy levels, absorb and emit light of specific wavelengths, and exhibit specific colors. The physical properties of 3-Iodo-N- (3-methoxyphenyl) benzamide are determined by its molecular structure, which are of great significance for its application in organic synthesis, medicinal chemistry and other fields.
What are the precautions for 3-iodo-n- (3-methoxyphenyl) benzamide during use?
3-Iodo-n- (3-methoxyphenyl) benzamide is an organic compound, and many things need to be paid attention to during use.
First of all, safety precautions are extremely important. This compound contains iodine and benzene ring structures, or may be toxic and irritating. When taking it, be sure to wear appropriate protective equipment, such as laboratory clothes, gloves and goggles, to prevent it from coming into contact with the skin and eyes. If you come into contact inadvertently, rinse with plenty of water immediately and seek medical attention according to the specific situation. Operate in a well-ventilated place, preferably in a fume hood, to avoid inhaling its dust or volatile gases, as it may cause respiratory discomfort or even more serious health problems.
Secondly, storage should not be ignored. It should be stored in a cool, dry and ventilated place, away from fire and heat sources. Due to its chemical properties or high activity, improper storage conditions may cause it to deteriorate or cause dangerous reactions. It should be stored separately from oxidants, acids and other substances to prevent accidents caused by interaction.
Furthermore, it is crucial to accurately control the dosage and reaction conditions when using it. In view of the complex chemical reactions it participates in, the dosage, reaction temperature, time and solvent selection all have a profound impact on the reaction results. It is necessary to accurately weigh and add according to the specific reaction requirements, and strictly control the reaction conditions to ensure the smooth progress of the reaction, obtain the expected products, and avoid side reactions.
In addition, in-depth understanding of its chemical properties is indispensable. Knowing its stability under different conditions, the types of reactions that may occur, etc., can help to take correct operation methods and coping strategies during use. If subsequent product treatment is involved, appropriate methods should also be selected according to its characteristics to ensure environmental safety and human health.