As a leading 3-Iodobenzenmethanamine Hydrochloride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
3-iodobenzenmethanamine chemical structure of hydrochloride
3-Iodoaniline hydrochloride, its chemical structure is as follows. First look at the benzene ring, which is a common core structure of organic compounds. It has a six-membered ring shape and contains conjugated double bonds, and its properties are stable. At No. 3 of the benzene ring, there are iodine atoms connected. The iodine atoms are relatively heavy relative to the atoms and have a certain electronegativity, which affects the electron cloud distribution of the benzene ring, which can change the reactivity and chemical properties of the benzene ring. There is also a -CH -2 NH -2 group connected to the benzene ring, that is, a benzamide group. -CH -2 - is methylene and plays a linking role; -NH -2 is an amino group, which is basic and can react with acids. The name of this compound contains hydrochloride, which is because the amino group reacts with hydrochloric acid to After the formation of hydrochloride, the physical and chemical properties of the compound also change, such as the solubility in water usually increases. Overall, the chemical structure of 3-iodoaniline hydrochloride is composed of a benzene ring, an iodine atom at position 3, and a benzene ring connected to the benzene ring and the salt-forming part of hydrochloric acid. Each part affects each other to determine the unique chemical properties and reactivity of the compound.
What are the physical properties of 3-iodobenzenmethanamine Hydrochloride?
3-Iodoaniline hydrochloride is one of the organic compounds. Its physical properties are quite important, and it is related to many characteristics and uses of this substance.
Looking at its appearance, under room temperature and pressure, it often appears white to white crystalline powder. This form is easy to observe and use, and also reflects the order of its internal molecular arrangement.
Solubility is one of the key physical properties. In water, 3-iodoaniline hydrochloride has a certain solubility. Water is a common solvent, and this solubility allows the compound to participate in the reactions or applications of many aqueous systems. Due to the polarity of water, it interacts with some groups in the compound to cause it to disperse in water. In organic solvents such as ethanol and acetone, it also dissolves to varying degrees. Ethanol has moderate polarity and can form hydrogen bonds and other forces between molecules of the compound, so it is soluble.
Melting point is also a significant physical property. Its melting point is in a specific temperature range. At this temperature, the compound changes from solid to liquid. The determination of melting point can not only be used to identify the purity of the substance, but also is crucial for the study of its phase change and stability under specific temperature conditions. Higher melting points indicate strong intermolecular forces and relatively stable structure.
In addition, the density of 3-iodoaniline hydrochloride, although often not the primary concern, is also meaningful in some precise stoichiometry and phase equilibrium studies. Its density reflects the mass of the substance in a unit volume. When mixed with other substances, it affects the relationship between the total volume and mass of the system.
Furthermore, the compound may have a specific odor. Although odor is not the key to determining its chemical activity, it affects the perception of personnel in the operation and use environment, and some special odors may be related to specific functional groups in the molecular structure.
In summary, the physical properties of 3-iodoaniline hydrochloride, from appearance, solubility, melting point, density to odor, have their own characteristics and are related to each other. It is of great significance in chemical research, industrial production and related application fields.
What are the main uses of 3-iodobenzenmethanamine hydrochloride?
3-Iodoaniline hydrochloride is a genus of organic compounds. It has a wide range of uses and is often a key intermediate in drug synthesis in the field of medicinal chemistry. Due to the characteristics of phenyl ring and amine and iodine atoms, functional groups can be added by chemical reactions to construct molecular structures with specific pharmacological activities.
In the field of materials science, it also has its uses. Or due to the unique molecular structure, after appropriate modification and treatment, it can be used as a raw material for functional materials, such as materials with special photoelectric properties.
Furthermore, it is an important reagent in organic synthesis chemistry experiments. Chemists use it to participate in various organic reactions, such as nucleophilic substitution, coupling reactions, etc., to synthesize complex organic molecules and expand the variety and application of organic compounds. All of this highlights the important uses of 3-iodoaniline hydrochloride in many fields, and is an indispensable substance for chemical research and industrial production.
What are the synthetic methods of 3-iodobenzenmethanamine Hydrochloride?
To prepare 3-iodoaniline hydrochloride, the following method can be used.
First, 3-iodobenzoic acid is used as the starting material, and thionyl chloride is often co-heated with it to carry out an acylation reaction. Among them, thionyl chloride is both a reactant and a solvent. The two are miscible, heated to reflux, and after a few times, 3-iodobenzoyl chloride is formed. The reaction is violent, and it needs to be controlled at temperature and operated in a fume hood to prevent harmful gases from escaping. After the reaction is completed, the excess thionyl chloride is distilled under reduced pressure to obtain pure 3-iodobenzoyl chloride.
Dilute 3-iodobenzoyl chloride with a suitable organic solvent (such as dichloromethane) at a low temperature (usually 0-5 ° C), slowly drop into an organic solvent containing excess ammonia (such as ether), and the aminolysis reaction begins to generate 3-iodobenzamide. This step requires controlling the dripping speed and temperature to prevent the reaction from being too dramatic. After dripping, move to room temperature and stir for a few more times to make the reaction complete. The reaction solution is washed with dilute acid (such as hydrochloric acid), then washed with water. After drying with anhydrous sodium sulfate, the solvent is distilled under reduced pressure to obtain 3-iodobenzamide. After
, the reduction reaction of 3-iodobenzamide is carried out. Using lithium aluminum hydride as the reducing agent, in an anhydrous organic solvent (such as tetrahydrofuran), heat and reflux. The carbonyl oxygen in the amide is extracted from the lithium aluminum hydride, and after a series of conversions, 3-iodoaniline is produced. This reduction reaction is violent and sensitive to water, so it is necessary to ensure that the system is anhydrous. After the reaction is completed, carefully add water to quench the excess aluminum hydride lithium, and then adjust the pH to acidic with inorganic acid (such as hydrochloric acid) to form a salt of 3-iodoaniline to obtain a 3-iodoaniline hydrochloride solution. After concentration, crystallization, filtration, drying and other steps, pure 3-iodoaniline hydrochloride crystals can be obtained.
Or there are other methods. For example, starting with 3-iodobenzyl bromide, react with sodium cyanide in a suitable solvent (such as N, N-dimethylformamide) by heating to obtain 3-iodophenylacetonitrile. Then reduce 3-iodoaniline with lithium aluminum hydride to obtain 3-iodoaniline, and then salt to obtain 3-iodoaniline hydrochloride. These methods have their own advantages and disadvantages. The practical operation needs to be based on the availability of raw materials, cost, yield and other factors.
3-iodobenzenmethanamine Hydrochloride during storage and transportation
3-Iodoaniline hydrochloride is a chemical substance. When storing and transporting, many matters need to be paid attention to.
The first word of storage must be placed in a cool and dry place. This may be due to its nature. It is afraid of moisture and heat. If it is in a warm and humid place, it may deteriorate. How can a delicate flower survive for a long time if it is placed under the scorching sun and rainstorm? The storage place must be well ventilated to prevent the accumulation of harmful gases and damage its quality. And it needs to be placed separately from oxidizing agents, acids and other substances. If these substances meet with it, or react violently, such as dry wood and fire, it is very dangerous.
As for transportation, it should not be ignored. The packaging must be solid and firm, just like putting a sturdy armor on it to prevent the package from being damaged due to collisions and vibrations on the way. The transportation process should be kept stable and avoid violent actions such as sudden braking and sharp turns. If the fragile equipment on the vehicle is accompanied, you must drive with caution. The transportation vehicle should also be clean and free of other chemical residues, otherwise it may be mixed with it and damage its purity.
Furthermore, whether it is storage or transportation, the relevant personnel must be familiar with the characteristics of this material and emergency treatment methods. In case of leakage and other things, it can be handled quickly and properly, so as not to cause a major disaster. If you march for battle, soldiers must know the art of war and contingency strategies, so as to be safe. Only in this way can we ensure that 3-iodoaniline hydrochloride is safe during storage and transportation.