3 Iodobenzoic Acid Ethyl Ester

The main use of ethyl 3-pentanone butyrate, in "Tiangong Kaiji", its use is quite wide.
First, in the production of fragrances, the function is obvious. This substance can be used as a fragrance to add to a variety of products, such as perfumes, aromatherapy, cosmetics, etc. Because of its unique smell, it can give products a special fragrance, increase the level and richness of its aroma, make the aroma more attractive, and the user feels its elegant and pleasant taste.
Second, in the field of medicine, it is also useful. In the synthesis process of some drugs, ethyl 3-pentanone butyrate can be used as a key intermediate. With its special chemical structure, it participates in the construction of drug molecules and helps to synthesize compounds with specific pharmacological activities, which is of great significance to drug research and development and production, or can promote the birth of new drugs to solve diseases.
Third, in the field of organic synthesis, this substance is a commonly used raw material. Organic chemists can use its special functional groups and reactivity to construct complex organic molecular structures through various chemical reactions. Such as participating in esterification reactions, condensation reactions, etc., provide a basis for the synthesis of diverse organic compounds, promote the development of organic synthetic chemistry, and have a profound impact on many related fields such as materials science and fine chemistry. It can derive many new materials and fine chemicals with special properties.

There are many methods for the synthesis of ethyl 3-bromopyruvate, and the advantages and disadvantages of each method are different. In the context of "Tiangong Kaiwu", in terms of ancient methods, there are the following common ones.
First, pyruvate is used as the starting material, and it is obtained by bromination and esterification. First, pyruvate and bromine are brominated under appropriate conditions. During this bromination process, attention should be paid to the temperature of the reaction, the amount of bromine and the rate of addition. If the temperature is too high, side reactions will occur and the product will be impure; improper bromine dosage will also affect the yield. After the bromination reaction is completed, the obtained bromopyruvate acid is esterified with ethanol under the action of a catalyst. The commonly used catalysts are protonic acids such as sulfuric acid, but they also have the disadvantages of corroding equipment and complicated post-processing. The raw materials of this route are easy to obtain, but the steps are slightly complicated, and the bromination process needs to be carefully controlled.
Second, ethyl acetoacetate is used as the raw material, and it is synthesized through two steps of bromination and decarboxylation. Ethyl acetoacetate reacts with bromine, which is relatively mild, and bromine atoms selectively replace methylene hydrogen atoms with higher activity. After that, under specific conditions, the decarboxylation reaction is carried out to remove the carboxyl group, and the target product is ethyl 3-bromopyruvate. The advantage of this route is that the reaction conditions are easier to control, there are fewer side reactions, and the yield is relatively considerable. However, the cost of ethyl acetoacetate may be slightly higher than that of pyruvate, and the decarboxylation step also needs to precisely adjust the reaction conditions to ensure the purity and yield of the product.
Third, diethyl malonate is used as the starting material and prepared through a series of reactions. Diethyl malonate is first introduced into a suitable substituent through substitution reaction, and then through hydrolysis, decarboxylation and other steps, and finally brominated to obtain ethyl 3-bromopyruvate. This path has many steps, long routes, complex processes, and strict requirements on reaction conditions and operations. However, its advantage is that it can achieve precise modification of the product structure through ingenious design of substitution reactions, which is quite valuable under specific needs.

Ethyl 3-hydroxybutyrate is an organic compound. Its physical properties are particularly critical, as follows:
Looking at its properties, under room temperature and pressure, ethyl 3-hydroxybutyrate is a colorless to light yellow transparent liquid. Its appearance is clear, and there are no impurities visible to the naked eye, highlighting its pure state.
Smell its smell, this substance emits a pleasant fruity smell, fresh but not pungent, just like the wonderful fusion of natural fruity aromas, which is pleasant to smell.
In terms of its boiling point, it is between 145-148 ° C. At this temperature, ethyl 3-hydroxybutyrate changes from liquid to gaseous state. This property is crucial in chemical operations such as distillation and separation, so that its physical state changes can be precisely controlled to achieve effective purification and application.
Measure its melting point, which is about -40 ° C. When the temperature drops below the melting point, the substance will solidify into a solid state. The physical transformation characteristics at this low temperature need to be carefully considered during storage and transportation to ensure its morphological stability.
Looking at its solubility, ethyl 3-hydroxybutyrate can be miscible with organic solvents such as ethanol and ether, which is an important basis for its wide application in organic synthesis and chemical production. In these solvents, it can be uniformly dispersed and participate in various chemical reactions, which greatly expands its application scope. At the same time, it has a certain solubility in water, but its solubility is relatively limited. This characteristic also affects its behavior and application scenarios in different systems.
Its density is about 1.009 - 1.013 g/cm ³, which is slightly heavier than water. This density characteristic plays an important role in indicating the separation and stratification of mixtures, and can be effectively separated from other substances by means of density differences.

3-Chloro-tyrosine ethyl ester amide is an organic compound with unique chemical properties. The following is described in the style of ancient proverbs:
In this compound, the chlorine atom is attached to the tyrosine ethyl ester amide structure. The chlorine atom is active, giving the substance a different reactivity. During the nucleophilic substitution reaction, the chlorine atom can be attacked by the nucleophilic reagent, causing chlorine to be replaced and new compounds to be derived.
The part of tyrosine ethyl ester amide contains an amino group, a carboxyl group and its remaining functional groups. The amino group is basic and can form salts with acids; the carboxyl group is acidic and can neutralize with bases. The two can participate in a variety of condensation reactions, such as dehydration and condensation with other compounds containing carboxyl or amino groups to form peptide bonds or amide bonds to build more complex molecular structures.
Its ester group part can be hydrolyzed in an acid-base environment. In acidic media, hydrolysis is slow; in alkali, hydrolysis is rapid and thorough, resulting in corresponding acids and alcohols.
In addition, the spatial structure and electron cloud distribution of the compound also affect its chemical properties. The interaction between atoms in the molecule makes the activity of each functional group change, which is fully apparent in the selectivity and rate of chemical reactions. It may change the electron cloud density in some parts due to electronic effects such as conjugation effect and induction effect, which affects the difficulty and check point of the reaction.
In summary, 3-chlorotyrosine ethyl ester amide has rich chemical properties due to the functional groups such as chlorine atom, amino group, carboxyl group and ester group, and may be of extraordinary use in organic synthesis and other fields.

In the storage and transportation of ethyl 3-hydroxybutyrate, the following things should be paid attention to:
First, when storing, you must choose a cool and ventilated warehouse. Because of its flammability, high temperature or danger, cool ventilation can reduce the risk of explosion. Warehouse temperature should be controlled in an appropriate range, not too high. And should be away from fire and heat sources, which can easily cause combustion and cause serious accidents.
Second, it should be stored separately from oxidants, acids and bases, and should not be mixed. Due to the active chemical properties of ethyl 3-hydroxybutyrate, mixed storage with oxidants, or violent chemical reactions, such as oxidation reactions, can cause fires or even explosions.
Third, the storage area should be equipped with leakage emergency treatment equipment and suitable containment materials. If there is a leak, it can be dealt with in time to prevent its spread from causing greater harm.
Fourth, when transporting, make sure that the container does not leak, collapse, fall or damage. Because it is a liquid, if the container is damaged, it is easy to leak, pollute the environment, and increase the risk of explosion.
Fifth, the transportation vehicle should be equipped with the corresponding variety and quantity of fire fighting equipment and leakage emergency treatment equipment. In case of fire and other emergencies on the way, it can be put out in time. It is best to transport in the morning and evening in summer. In summer, the temperature is high, and it is transported at noon. Due to the high temperature, its volatilization intensifies, and the risk of explosion increases greatly. The temperature in the morning and evening
Sixth, protect against sun exposure, rain exposure, and high temperature during transportation. Exposure, rain exposure, and high temperature all affect its stability, or cause quality changes, or even cause danger.
Seventh, road transportation should be driven according to the specified route, and do not stop in residential areas and densely populated areas. Because of its certain danger, if it stops in a crowded place, in case of leakage or explosion, it will cause a large number of casualties and property losses.