3 Iodobenzoyl Chloride

3-Iodobenzoyl chloride, which has a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate.
In 3-iodobenzoyl chloride, the chlorine atom is very active, and it is easy to undergo nucleophilic substitution reactions with many nucleophilic reagents. For example, when it encounters alcohols, it can form 3-iodobenzoate esters, which are often indispensable in the preparation of fragrances, plasticizers, etc. It can also react with amines to form 3-iodobenzoamide substances. The synthesis of many biologically active drugs and pesticide ingredients depends on this.
Furthermore, it has also contributed to the field of materials science. By reacting with polymer monomers containing specific functional groups, 3-iodobenzoyl groups can be introduced into the main chain or side chain of the polymer, giving the polymer unique properties, such as changing its solubility and thermal stability, and then expanding the application of the polymer in different fields.
In addition, in the field of dye chemistry, 3-iodobenzoyl chloride can be used as an important building block for the construction of dye molecular structures. Through a series of chemical reactions, dyes with specific colors and properties can be constructed for use in textile, printing and dyeing industries to meet diverse dyeing needs.
In summary, 3-iodobenzoyl chloride plays a crucial role in organic synthesis, materials science, dye chemistry, and other fields, and its contribution to the development of related industries is particularly crucial.

3-Iodobenzoyl chloride is an important raw material in organic synthesis. Looking at its physical properties, this substance is mostly liquid at room temperature, with a certain volatility and a pungent smell. Its boiling point is in a specific range, usually around [X] ° C. This property is very critical in the separation and purification process, and can be separated by distillation according to its boiling point difference.
In addition, the melting point of 3-iodobenzoyl chloride is also an important physical parameter, about [X] ° C. The characteristics of the melting point are related to its physical state at different temperatures, and should be paid attention to when storing and using. In addition, its density is about [X] g/cm ³, and the value of the density has a great influence on operations such as metering and mixing. In actual chemical production or experimental operations, precise consideration of the density can ensure that the proportions of each ingredient are appropriate and the reaction proceeds smoothly.
In terms of solubility, 3-iodobenzoyl chloride is insoluble in water, but soluble in a variety of organic solvents, such as common ether, chloroform, dichloromethane, etc. This solubility characteristic provides a basis for the selection of organic synthesis reaction systems. Many organic reactions need to be carried out in organic solvents. Its good solubility of organic solvents allows it to fully contact and mix with many reactants, promoting efficient reactions.
Its appearance is often colorless to light yellow liquid, and the appearance characteristics such as color and transparency can be used as a reference for preliminary judgment of its purity. If the impurity content is too high, it may cause the color to deepen and the transparency to decrease. In the process of quality control, appearance observation is an important preliminary detection method. All these physical properties are of great significance for the application of 3-iodobenzoyl chloride in the field of organic synthesis.

3-Iodobenzoyl chloride, its unique chemical properties, allow me to explain it in detail for you.
This is an organic compound with the general properties of halogenated benzoyl chloride. In its molecule, the iodine atom is connected to the structure of benzoyl chloride, which makes the properties unique.
First talk about its reactivity, which is extremely active. The acid chloride group is active and prone to nucleophilic substitution. When encountering alcohols, it reacts quickly, with raw esters and hydrogen chloride. In this process, the hydroxyl oxygen of the alcohol attacks the carbonyl carbon of the acid chloride, and the chlorine leaves to form an ester. If reacted with ethanol, ethyl 3-iodobenzoate and hydrogen chloride are obtained.
In case of amines, nucleophilic substitution also occurs, and amides are produced. The nitrogen atom of amines has strong nucleophilicity, attacking carbonyl carbons, and chlorine leaves to form amide bonds. Like reacting with methylamine, 3-iodobenzamide can be obtained.
Hydrolysis is also common. In water, acid chloride hydrolyzes to produce 3-iodobenzoic acid and hydrogen chloride. This is because the oxygen nucleophilic of water molecules attacks carbonyl carbons, and chlorine is separated.
In addition, iodine atoms also have an effect. Although it is relatively stable, under certain conditions, reactions such as substitution can occur, which affect the reaction path and product structure of molecules.
Its chemical properties are active and diverse, and it is an important raw material and intermediate in the field of organic synthesis. It participates in the preparation of many organic compounds.

The synthesis of 3-iodobenzoyl chloride is an important topic in the field of organic synthesis. There are various methods. The most common ones are obtained by using 3-iodobenzoic acid as the starting material and interacting with chlorination reagents.
Commonly used chlorination reagents, such as thionyl chloride ($SOCl_2 $). During this reaction, 3-iodobenzoic acid reacts with thionyl chloride under appropriate conditions. Generally speaking, it needs to be carried out under heating and in the presence of a catalyst. The catalyst is usually N, N-dimethylformamide (DMF) and the like.
At the beginning of the reaction, 3-iodobenzoic acid is placed in the reaction vessel, an appropriate amount of thionyl chloride is added, and a little DMF is dropped. Heating heats up the reaction system, and the sulfur atoms in the thionyl chloride are electrophilic and can attack the hydroxyl oxygen atoms of the carboxyl group of 3-iodobenzoic acid to form an intermediate. Then a series of transformations of the intermediate occurs, and the hydroxyl groups are replaced by chlorine atoms. At the same time, sulfur dioxide and hydrogen chloride gas escape system is formed to obtain 3-iodobenzoyl chloride.
In addition, oxalyl chloride ($ (COCl) _2 $) can also be used instead of thionyl chloride as a chlorination reagent. The reaction conditions are similar to the former. Oxalyl chloride reacts with 3-iodobenzoic acid under the action of catalyst, and generates the target product 3-iodobenzoyl chloride through a similar mechanism, while by-producing carbon monoxide and carbon dioxide gas. These two methods have their own advantages and disadvantages. Sulfuryl chloride is cheap and easy to obtain, and the post-treatment is relatively simple. Oxalyl chloride has high reactivity and the reaction time may be shortened, but oxalyl chloride is relatively toxic and needs to be operated with caution.

3-Iodobenzoyl chloride is a commonly used reagent in organic chemistry. When storing and transporting, there are indeed many key points to pay attention to.
First of all, in terms of storage, because of its strong chemical activity, it must be stored in a cool, dry and well-ventilated place. This reagent is extremely sensitive to humidity and is prone to hydrolysis in contact with water, resulting in deterioration. Therefore, the humidity of the storage environment should be strictly controlled. Ideally, the relative humidity should be less than 60%. When storing, use a well-sealed container, such as a glass bottle or a specific plastic container, to isolate moisture and air. At the same time, keep away from fire and heat sources, because the lid may cause decomposition or other dangerous chemical reactions when heated. In addition, it should be stored separately from oxidizing agents, reducing agents, alkalis and other substances to avoid dangerous reactions caused by mutual contact.
As for transportation, due to its certain hazards, relevant transportation regulations and standards must be followed. The transportation container should be strong and sealed to ensure that no leakage occurs during transportation. At the same time, a clear and standardized label of hazardous chemicals should be posted on the container to warn the transporter and other relevant personnel. During transportation, severe vibration and collision should be avoided to prevent the container from being damaged. For long-distance transportation, it is also necessary to consider the change of ambient temperature and take appropriate temperature control measures to prevent the adverse effects of high or low temperature on the reagent. In conclusion, the storage and transportation of 3-iodobenzoyl chloride must be treated with caution, and relevant regulations must be strictly followed to ensure its quality and safety.