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What are the main uses of 3-nitro-4-iodo-benzonitrile?
3-Nitro-4-iodine-benzonitrile is a key intermediate in organic synthesis and has important uses in many fields.
First, in the field of medicinal chemistry, this compound can be the cornerstone of the creation of new drugs. By means of organic synthesis, using it as the starting material, through ingeniously designed reaction steps, complex molecular structures with specific pharmacological activities can be built. For example, small molecule inhibitors targeting specific disease targets can be synthesized by modifying their functional groups, opening up new avenues for the development of new drugs.
Second, in the field of materials science, 3-nitro-4-iodine-benzonitrile also has extraordinary performance. Using this as a raw material, through polymerization or other chemical transformations, functional materials with special photoelectric properties can be prepared. Such materials may be applied to organic Light Emitting Diodes (OLEDs), solar cells and other fields, contributing to the improvement of material properties.
Furthermore, in the fine chemical industry, this compound can be used to synthesize high-end dyes, fragrances and other fine chemicals. Due to its unique chemical structure, through appropriate derivatization, the product can be given more excellent color stability, aroma persistence and other characteristics to meet the market demand for high-quality fine chemicals.
In summary, 3-nitro-4-iodine-benzonitrile, with its unique chemical structure, plays an indispensable role in the fields of medicinal chemistry, materials science, and fine chemicals, and is of great significance to the development of related industries.
What are 3-nitro-4-iodo-benzonitrile synthesis methods?
The synthesis method of 3-nitro-4-iodine-benzonitrile is an important topic in the field of organic synthesis. There are many common synthesis paths, and the main ones are selected to be described here.
First, benzonitrile is used as the starting material. First, benzonitrile is nitrified. In this case, mixed acid (a mixture of sulfuric acid and nitric acid) can be used as the nitrifying reagent. Under suitable temperature and reaction conditions, the aromatic ring of benzonitrile undergoes an electrophilic substitution reaction, and nitro is introduced at the 3rd position to generate 3-nitrobenzonitrile. Subsequently, 3-nitrobenzonitrile is iodized. In this step, iodine is often combined with a suitable oxidizing agent. For example, in the presence of an oxidizing agent such as hydrogen peroxide, iodine reacts with 3-nitrobenzonitrile to introduce iodine atoms at the 4th position to obtain the target product 3-nitro-4-iodine-benzonitrile. The advantage of this route is that the starting material is easy to obtain and the reaction steps are relatively clear.
Second, halogenated benzene derivatives can also be used as starting materials. If 4-halogenated benzonitrile (such as 4-chlorobenzonitrile) is used as an example, a nitrification reaction is carried out first, and a nitro group is introduced at the 3rd position. Then a halogen exchange reaction is used to replace the chlorine atom at the 4th position with an iodine negative This halogen exchange reaction often needs to be carried out in the presence of specific solvents and catalysts, such as potassium iodide as the iodine source, in polar aprotic solvents (such as DMF, etc.), at appropriate temperatures, through this series of steps to synthesize 3-nitro-4-iodine-benzonitrile. The characteristics of this approach are that some halogenated benzene derivatives are relatively inexpensive and some reaction conditions are milder.
Or start from nitrobenzene derivatives. Using 3-nitro-4-halogenated nitrobenzene as the raw material, the nitro group is first reduced to an amino group, and then the cyano group is introduced and the iodine atom is retained through diazotization and iodization reactions, and the final product is synthesized. However, this method is relatively cumbersome and requires high control of reaction conditions.
The above synthesis methods have their own advantages and disadvantages. In practical application, it is necessary to comprehensively consider many factors such as raw material availability, reaction cost, yield and purity requirements, and choose the optimal path to achieve efficient synthesis of 3-nitro-4-iodine-benzonitrile.
What are the physical properties of 3-nitro-4-iodo-benzonitrile?
3-Nitro-4-iodo-benzonitrile, that is, 3-nitro-4-iodobenzonitrile, is an organic compound. Its physical properties are as follows:
Looking at its appearance, under room temperature and pressure, it is mostly white to light yellow crystalline powder. This color characteristic is quite common in organic compounds and can be an important basis for identifying the substance.
When it comes to the melting point, it is between 148 ° C and 152 ° C. The melting point is the inherent physical property of the substance. Within this temperature range, the compound gradually melts from a solid state to a liquid state. This characteristic has key guiding value in the purification, identification and setting of specific chemical reaction conditions of the compound.
As for solubility, it shows a certain solubility in common organic solvents, such as dichloromethane, N, N-dimethylformamide (DMF), dimethyl sulfoxide (DMSO), etc. In dichloromethane, with its halogenated hydrocarbon properties, it can interact with 3-nitro-4-iodobenzonitrile molecules through van der Waals force and other interactions to achieve good mutual solubility; in strong polar organic solvents such as DMF and DMSO, because the compound molecules contain polar groups, such as nitro and cyano, they form hydrogen bonds or dipole-dipole interactions with solvent molecules, and then dissolve them. However, its solubility in water is poor, because water is a strong polar solvent, and although the compound contains polar groups, the overall carbon skeleton is large and hydrophobic, which makes it difficult to overcome its own intermolecular forces when interacting with water molecules, so it is difficult to dissolve in water.
These physical properties have a profound impact on its application in the field of organic synthesis. If the synthesis route is designed, the appropriate reaction temperature and post-treatment method should be selected according to its melting point characteristics; its solubility characteristics are related to the screening of the reaction solvent to ensure the smooth progress of the reaction. At the same time, it also provides important factors for the design of the product separation and purification steps.
What are the chemical properties of 3-nitro-4-iodo-benzonitrile?
3-Nitro-4-iodine-benzonitrile, this is an organic compound. Its chemical properties are particularly important and useful in the field of organic synthesis.
Looking at its structure, the nitro group, iodine atom and cyano group are all connected to the benzene ring. Nitro has strong electron absorption, which can reduce the electron cloud density of the benzene ring and reduce the activity of the electrophilic substitution reaction of the benzene ring, but it can enhance the nucleophilicity of the adjacent and para-carbon atoms. This property plays a key role in many nucleophilic substitution reactions. For example, when reacting with nucleophilic reagents, the presence of nitro groups affects the reaction check point and reaction rate.
The iodine atom is also an important functional group, and its carbon-iodine bond has Iodine atoms are large in size and steric resistance cannot be ignored. In organic synthesis, carbon-iodine bonds can be converted into other functional groups through reduction, coupling and other reactions. For example, it can participate in the Ullmann reaction or Suzuki reaction to form carbon-carbon bonds, providing a way for the synthesis of complex organic molecules.
Cyanyl (-CN) has unique properties and can be hydrolyzed to form carboxyl groups (-COOH). After reduction, amino groups (-NH2O) can be obtained. It is an important starting group for the construction of diverse functional groups in organic synthesis.
This compound exhibits unique chemical properties due to the interaction of these functional groups, and has potential applications in medicinal chemistry, materials science, and other fields, laying the foundation for the synthesis of organic compounds with specific functions.
What is the price range of 3-nitro-4-iodo-benzonitrile in the market?
The price of 3-nitro-4-iodobenzonitrile in the market varies depending on factors such as quality, source, and purchase quantity. If you buy a small amount based on past market conditions, the price may be around tens of yuan to hundreds of yuan per gram. However, this is only a rough estimate, and the market conditions are volatile and fluctuate from time to time.
If you buy in bulk, the bargaining power will become stronger due to the increase in quantity, and the price per gram may be reduced to within tens of yuan. And the prices offered by different merchants are also different. Some merchants may have different prices due to cost control and marketing strategies.
If you want to know the exact price, you can consult the chemical raw material supplier, reagent sales firm, or study the price of each merchant on the chemical product trading platform to obtain a more accurate price range.
